Monocyclic and Bicyclic Sesquiterpenes Group
These substances were identified for action under the Chemicals Management Plan (CMP). This screening assessment focuses on 16 substances, referred to collectively under the CMP as the Monocyclic, and Bicyclic Sesquiterpenes Group, which are a part of the larger Terpenes and Terpenoids Group.
| Substance group | Subgroup | CAS RN | Common name | DSL name | Draft screening assessment | Risk management scope | Proposed conclusion on section 64 criteria | Follow-up activities |
|---|---|---|---|---|---|---|---|---|
| Monocyclic and Bicyclic Sesquiterpenes Group | 1 | 495-62-5 | Bisabolene | Cyclohexene, 4-(1,5-dimethyl-4-hexenylidene)-1-methyl- | HTML | None | Does not meet | None planned at this time |
| 1 | 8001-61-4Note de bas de page a, Note de bas de page b | Copaiba balsam | Balsams, copaiba | |||||
| 1 | 8007-08-7Note de bas de page a, Note de bas de page b | Ginger oil | Oils, ginger | |||||
| 1 | 17627-44-0 | Alpha-bisabolene | Cyclohexene, 4-(1,5-dimethyl-1,4-hexadienyl)-1-methyl- | |||||
| 1 | 65113-99-7 | Sandalore | 3-Cyclopentene-1-butanol, α,β,2,2,3-pentamethyl- | |||||
| 1 | 107898-54-4 | Santol pentenol | 4-Penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)- | |||||
| 2 | 87-44-5 | Beta-caryophyllene | Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene, [1R-(1R,4E,9S)]- | |||||
| 2 | 88-84-6 | Guaiene | Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)- | |||||
| 2 | 3691-12-1 | Alpha-guaiene | Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethenyl)-, [1S-(1α,4α,7α)]- | |||||
| 2 | 4630-07-3 | Valencene | Naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, [1R-(1α,7β,8aα)]- | |||||
| 2 | 68917-29-3Note de bas de page b | T & T clove oil | Terpenes and terpenoids, clove oil | HTML | Meets one or more of the criteria | Refer to risk management scope | ||
| 3 | 489-86-1 | Guaiol | 5-Azulenemethanol, 1,2,3,4,5,6,7,8-octahydro-α,α,3,8-tetramethyl-,[3S-(3α,5α,8α)]- | None | Does not meet | None planned at this time | ||
| 3 | 639-99-6 | Elemol | Cyclohexanemethanol, 4-ethenyl-α,α,4-trimethyl-3-(1-methylethenyl)-, [1R-(1α,3α,4β)]- | |||||
| 3 | 22451-73-6 | Bulnesol | 5-Azulenemethanol, 1,2,3,3a,4,5,6,7-octahydro-α,α,3,8-tetramethyl-, [3S-(3α,3aβ,5α)]- | |||||
| Individual | 489-84-9 | Guaiazulene | Azulene, 1,4-dimethyl-7-(1-methylethyl)- | HTML | Meets one or more of the criteria | Refer to risk management scope | ||
| Individual | 8006-87-9Note de bas de page a, Note de bas de page b | Sandalwood oil | Oils, sandalwood | |||||
|
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| Date | Activity |
|---|---|
| May 2022 | Anticipated publication of the final screening assessment and proposed risk management approach. |
| May 8, 2021 | Publication and start of 60-day public comment period on the Draft Screening Assessment for Terpenes and Terpenoids Monocyclic and Bicyclic Sesquiterpenes Group and the Risk Management Scope for Certain Terpenes and Terpenoids within the Monocyclic and Bicyclic Sesquiterpenes Group. The related notice was published in the Canada Gazette, Part I: Vol. 155, No. 19. |
Background
The screening assessment focuses on 16 substances referred to as the Monocyclic and Bicyclic Sesquiterpenes Group. It consists of 14 substances that have been divided into 3 subgroups based on chemical structure, properties, and/or toxicity, as well as 2 individual substances namely sandalwood oil and guaiazulene. These 16 substances are a part of a larger group of 76 substances referred to collectively under the CMP as the Terpenes and Terpenoids Group.
Three of these 76 substances were subsequently determined to be of low concern to both human health and the environment through other approaches. The conclusions for CAS RN 25428-43-7 is provided in the Final Screening Assessment for the Rapid Screening of Substances with Limited General Population Exposure. Conclusions for CAS RNs 29350-73-0 and 68916-97-2 are provided in the Final Screening Assessment of Substances Identified as Being of Low Concern using the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances.
Fifteen of these 76 substances (CAS RNs 80-56-8, 1113-21-9, 8000-46-2, 8002-09-3, 8006-64-2, 8007-01-0, 8007-02-1, 8008-31-9, 8008-52-4, 8008-57-9, 8014-19-5, 8015-77-8, 8016-85-1, 8021-28-1 and 9005-90-7) were assessed as a part of the Acyclic, Monocyclic, and Bicyclic Monoterpenes Group.
Twelve of these 76 substances (CAS RNs 8006-78-8, 8016-88-4, 8022-96-6, 8024-43-9, 8024-08-6, 80-54-6, 91-51-0, 37677-14-8, 52474-60-9, 52475-86-2, 65405-84-7 and 66327-54-6) were assessed as a part of the Phenylpropanoids and Aldehydes Group.
Decisions on the remaining 30 substances will be communicated in separate risk assessments.
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