New substances risk assessment summaries: chemicals and polymers

Background

Adopted pursuant to the provisions of the Canadian Environmental Protection Act, 1999 (CEPA), the New Substances Notification Regulations (Chemicals and Polymers) [NSNR (Chemicals and Polymers)] require new substances to undergo an assessment of their potential adverse effects on the environment and human health to determine whether they have potential to pose a risk before they enter the Canadian marketplace.

Any company or individual who plans to manufacture or import a new substance into Canada is subject to notification under the regulations and must provide the New Substances (NS) program with a New Substances Notification (NSN) package containing all information prescribed in those regulations prior to import or manufacture. For more information, please consult the Guidelines for the Notification and Testing of New Substances: Chemicals and Polymers.

Risk assessments on new substances are conducted by Environment and Climate Change Canada and Health Canada. These assessments include consideration of information on physical and chemical properties, hazards, uses and exposure to determine whether a substance is or may become toxic to human health or environment as set out in section 64 of CEPA, and, if harm is suspected, to apply the required control measures.

The qualifiers used in the risk assessment summaries (such as low, moderate, high) to describe hazard are generally aligned with those used in other jurisdictions (such as the United States Environmental Protection Agency) and with the Global Harmonized System of Classification and Labelling of Chemicals. All experimental and calculated values are listed as ranges to protect confidential business information.

For a more detailed overview of how environmental and human health risk assessments are conducted for chemicals and polymers, please consult the following supporting documentation:

Initiative to promote transparency

Environment and Climate Change Canada and Health Canada are looking to increase the transparency of the NS program by publishing summaries of environmental and human health risk assessment reports for new substances that are chemicals or polymers. Risk assessment summaries of new substances that are living organisms have been published since 2005.

On average, the NS program receives up to 500 chemical and polymer notifications annually. Risk assessment summaries will be published on a regular basis for notifications where control measures are applied (including Significant New Activities, Ministerial Conditions, and Ministerial Prohibitions) and the most complete notifications (schedules 5, 6, 10 and 11), except for schedule 9 Reduced Regulatory Requirement (RRR) polymers.

RRR polymers have a high number average molecular weight and low percent of low molecular weight components (less than 1000 daltons), which are chemically stable and do not contain certain reactive or cationic moieties associated with human health or environmental concerns. The high molecular weight of these polymers prevents them from crossing biological membranes. Therefore, they are considered to be of low concern, which allows for fewer regulatory information requirements under the NSNR (Chemicals and Polymers) than for non-RRR polymers. Once added to the Domestic Substances List (DSL), it is listed with a "P" Flag, which means it must be re-notified if a non-RRR version of the polymer is being proposed for manufacture or import.

These summaries provide an overview of information examined during the assessment period, and the conclusions and regulatory decisions that were made. The key elements found in the summaries include:

  • the substance identity,
  • its use,
  • its hazard
  • its exposure
  • its environmental fate,
  • the assessment of its ecological risk,
  • the assessment of its human health risk, and
  • the regulatory decisions

The risk assessment does not include an assessment of the potential exposure and health risks specifically associated with occupational exposure. It is not relevant to nor does it preclude an assessment against the hazard criteria for Workplace Hazardous Materials Information System that are specified in the Controlled Products Regulations or the Hazardous Products Regulations for products intended for workplace use.

Comments

If you have any questions or comments concerning the publication of new substances risk assessment summaries, please contact the New Substances program.

Telephone: 1-800-567-1999 (Toll Free in Canada); or 1-819-938-3232 (Outside of Canada)

Email: eccc.substances.eccc@canada.ca

New substances risk assessment summaries

The summaries are listed according to the date the risk assessment period was completed for each NSN.

Where the substance identity is not considered to be confidential, it is identified by its chemical name and Chemical Abstract Services Registry Number (CAS RN). Masked names are allowed by to protect confidential business information. The Department of the Environment assigns each confidential substance a confidential accession number (CAN), which is used to identify the substance in place of the CAS RN.

The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the Government of Canada when the information and the reports are required by law or administrative policy, is not permitted without the prior, written permission of the American Chemical Society.

New substances with associated control measures have had a notice or order applied in the Canada Gazette. If a potential risk is identified upon completion of the risk assessments, a notice will be published in Part I of the Canada Gazette to manage this risk. If this substance is then added to the DSL, an order may then be published in Part II of the Canada Gazette to ensure that the control measure is maintained.

Substances assessed in 2019
Substance name or masked name CAS RN / (CAN) Date assessment period completed Related notice or order

Poly(oxy-1,2-ethanediyl), α-(carboxymethyl)-ω-hydroxy-, C12-16-alkyl ethers

2242034-97-3

February 2019

-

2-Butenedioic acid (2Z)-, homopolymer, potassium salt

26099-08-1

February 2019

-

Sulfonic acids, C20-24-alkane hydroxy and C20-24-alkene, sodium salts

97766-43-3

February 2019

Ministerial Condition No. 19725

1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, polymer with 1,1'-methylenebis[isocyanatobenzene]

113184-29-5

February 2019

-
2-Pyrrolidinone, 1-butyl- 3470-98-2 February 2019 Ministerial Condition No. 19770

Benzene, 1,2-bis(hexyloxy)-4-(triphenylmethyl)-

1391350-92-7

February 2019

-

2-Propenoic acid, 2-isocyanatoethyl ester

13641-96-8

February 2019

-

Oil, polymer with 2,3-dihydroxypropyl stearate and 1,1'-methylenebis[4-isocyanatobenzene]

(19357-5)

March 2019

-

Oil, polymer with 2,3-dihydroxypropyl stearate and 1,1'-methylenebis[isocyanatobenzene]

(19358-6)

March 2019

-

Benzoic acid, 2-benzoyl-, methyl ester

606-28-0

April 2019

Ministerial Condition No. 19823

Castor oil, polymer with diethylene glycol, phthalic anhydride and trimethylolethane

68783-29-9

April 2019

-

Amines, bis(C11-14-branched and linear alkyl), 3-[[bis(2-methylpropoxy)phosphinothioyl]thio]-2-methylpropanoates

1255680-66-0

April 2019

-
Amines, bis(hydrogenated palm-oil alkyl)hydroxy 1374859-51-4 May 2019 -

Oxirane, 2-methyl-, polymer with oxirane, ether with alkyl triol, polymer with α-hydro-ω-hydroxypoly[oxy(methyl-1,2 ethanediyl)] and 1,1'-methylenebis[isocyanatobenzene]

(19373-1)

May 2019

-
Carbomonocycledicarboxylic acid, polymers with pentaerythritol, diethylene glycol, phthalic anhydride, tetraethylene glycol, triethylene glycol (19378-6) May 2019 -
Substances assessed in 2017
Substance name or masked name CAS RN / (CAN) Date assessment period completed Related notice or order
2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, polymer with methyl 2-methyl-2-propenoate, carboxylate (19116-0) January 2017 -
Benzoic acid, hydroxyl, mono-alkyl derivatives, calcium salts (2:1) (19165-3) January 2017 -
Benzenepropanamide, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, N-C16-18-alkyl derivatives 1235487-96-3 January 2017 -
2-Propenoic acid, diester with 2,2'-[oxybis(methylene)]bis[2-ethyl-1,3-propanediol], polymer with dimethyl carbonate, 1,2-ethanediol, 1,6-hexanediol, 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid and 1,1'-methylenebis[4-isocyanatocyclohexane], alkyl-2-[[2-(hydroxyalkyl)-2-[[(1-oxo-alkenyl)oxy]alkyl]alkoxy]alkyl]-alkanediyl diacrylate-blocked, compounds with triethylamine (19118-2) January 2017 -
Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)bis- 929-59-9 February 2017 -
Aluminum phosphite 56287-23-1 February 2017 -
Glycerides, alkyl and alkynyl, esters with polyethylene glycol ether with glycerol (3:1) (19204-2) March 2017 -
Glycerides, alkyl and alkynyl, esters with polyalkylene glycol ether with glycerol (3:1) (19207-5) March 2017 -
Phosphoric acid, dipentyl ester, polymers with derivatized carbomonocycle alkyl ketone-substituted aldehyde polymer, isopropyl alcohol titanium(4+) salt and pentyl dihydrogen phosphate (16383-3) March 2017 -
Amides, tall-oil fatty, N-(hydroxyethyl), ethoxylated 501019-85-8 March 2017 -
Alkylalcohol, reaction products with phosphorus oxide, compounds with alkylalkaneamine (19170-8) March 2017 -
Isocyanic acid, polymethylenepolyphenylene ester, polymer with α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and 2-methyloxirane polymer with oxirane ether with 1,1',1'',1'''-[(methylimino)bis(3,1-propanediylnitrilo]tetrakis[2-propanol] (4:1) 1826089-67-1 March 2017 -
2,5-Furandione, polymer with ethene and alkene, heteromonocycle alkyl imide (19164-2) March 2017 -
1,1'-Biphenyl, bis(1-methylethyl)- 69009-90-1 March 2017 Significant New Activity/Order
N,N'-Alkylenebismorpholine (19173-1) April 2017 -
1,3-Benzenedicarboxylic acid, polymer with 1,4-benzenedicarboxylic acid, 2,2-dimethyl-1,3-propanediol, dodecanedioic acid, 1,2-ethanediol, hexanedioic acid, 1,6-hexanediol, 1,6-hexanederivative, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropanoate, 1,3-isobenzofurandione, 1,1'-methylenebis[isocyanatobenzene] and α,α',α"-1,2,3-propanetriyltris[ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)]] (19180-8) April 2017 -
Hexanedioic acid, polymer with hydroxylalkyl alkanediol, alkanoate, polymer with polymethylenepolyphenylene isocyanate (19185-3) April 2017 -
Benzoic acid, 2-benzoyl-, methyl ester 606-28-0 June 2017 Ministerial Condition No. 19007
1-Butanamine, N-butyl-N-[(triethoxysilyl)methyl]- 35501-23-6 June 2017 -
Phenol, 4-branched alkyl derivatives sulfurized, calcium salts, overbased (19194-2) June 2017 -
Hexanoic acid, 3,5,5-trimethyl-, 2,2,6,6-tetramethyl-1-[2-[(3,5,5-trimethyl-1-oxohexyl)oxy]ethyl]-4-piperidinyl ester 1445870-18-7 July 2017 -
Bisphenol dicyanate (10841-5) July 2017 Ministerial Condition No. 19067
Benzenesulfonic acid, mono-C20-24 alkyl derivs., magnesium salts 231297-75-9 July 2017 -
1,2-Hexanediol 6920-22-5 August 2017 -
Amides, from dialkyleneamine and rape oil (19201-9) August 2017 -
Butanedioic acid, 2-methylene-, telomer with sodium phosphinate (1:1), sodium zinc salt 1662663-05-9 August 2017 -
D-Glucitol, 1-deoxy-1-(methylamino)-, N-(C16-18 and C18-unsaturated acyl) derivatives 1591782-99-8 August 2017 -
D-Glucitol, 1-deoxy-1-(methylamino)-, N-coco acyl derivatives 1591783-13-9 August 2017 -
Hexafluoroalkene (19190-8) August 2017 -
Ethanol, 2-amino-, reaction products with carbon dioxide 174125-97-4 August 2017 -
Formaldehyde, homopolymer, reaction products with N-propyl-1-propanamine 1374859-50-3 August 2017 -
Alkyltrimethoxysilyl-1-butanamine (16880-5) September 2017
-
Carbonoperoxoic acid, O,O-(1,1-dimethylpropyl) O-(2-ethylhexyl) ester 70833-40-8 September 2017 -
Amines, coco alkyl, ethoxylated, compounds with polyethylene glycol monooleyl ether phosphate 120968-16-3 October 2017 -
Quaternary ammonium compounds, benzylalkyldimethyl, salts with bentonite (19214-2) October 2017 Significant New Activity Notice No. 19179
Quaternary ammonium compounds, dialkyldimethyl, salts with bentonite (19215-3) October 2017 Significant New Activity Notice No. 19180
Quaternary ammonium compounds, bis(derivative oil alkyl)dimethyl, salts with smectite group minerals (19216-4) October 2017 Significant New Activity Notice No. 19182
Quaternary ammonium compounds, benzylalkyldimethyl, salts with smectite group minerals (19217-5) October 2017 Significant New Activity Notice No. 19184
Quaternary ammonium compounds, dialkyldimethyl, salts with smectite group minerals (19218-6) October 2017 Significant New Activity Notice No. 19186
1,3-Dioxolan-2-one, polymer with 1,4-butanediol and 1,6-hexanediol 149295-53-4 October 2017 -
Fatty acids, tall-oil, reaction products with bisphenol A, epichlorohydrin, glycidyl tolyl ether and triethylenetetramine 186321-96-0 October 2017 Ministerial Condition No. 19233
Benzenesulfonic acid, (alkenediyl)bis[[[(hydroxyalkyl)amino]-(phenylamino)- triazin-2-yl]amino]-, N-(hydroxyalkyl) derivs., salts (19277-5) November 2017 -
Amides, tallow, N,N-bis(2-hydroxypropyl) 1454803-04-3 November 2017 -
Octadecanoic acid, 12-hydroxy-, reaction product with alkenediamine and alkanoic acid (19241-9) December 2017 -
Octadecanoic acid, 12-hydroxy-, reaction product with alkanoic acid and alkanediamine (19243-1) December 2017 -
Substances assessed in 2016
2-Propenoic acid, alkylalkyl ester, reaction products with 2-phenoxyalkanol- and polypropylene glycol mono-alkyl ether-blocked alkylenetriamine- 1,6-diisocyanatohexanealkyleneimine-2-oxepanone-tetrahydro-2H-pyran-2-one polymer ester with polyalkylene glycol mono-alkyl ether (19175-3)

December 2016

-
Dodecanedioic acid, polymer with butyl 2-methyl-2-propenoate, hexanedioic acid, 1,6-hexanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 2-hydroxyethyl 2-methyl-2-propenoate, 1,1'-methylenebis[4-isocyanatobenzene], methyl 2-methyl-2-propenoate and 2-methyl-2-propenoic acid 709654-72-8

December 2016

-
Poly[oxy(methyl-1,2-ethanediyl)], α-hydro-ω-hydroxy-, polymer with 1,1'-methylenebis[4-isocyanatobenzene] and α,α',α''-(1,2,3-propanetriyl)tris[ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)]] 51447-37-1 December 2016 -
Substance name or masked name CAS RN / (CAN) Date assessment period completed Related notice or order
Phenol, 2-(1,1-dimethylethyl)-6-methyl-4-[3-[[2,4,8,10-tetrakis(1,1-dimethylethyl)dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl]oxy]propyl]- 203255-81-6 January 2016 -

Poly(oxy-1,2-ethanediyl), α,α'-(iminodi-2,1-ethanediyl)bis[ω-hydroxy-, N-[3-(C10-16-alkyloxy)propyl] derivatives, di-Et sulfate-quaternized

70983-58-3

January 2016

Ministerial Condition No. 18419

Poly(oxy-1,2-ethanediyl), α,α'-(iminodi-2,1-ethanediyl)bis[ω-hydroxy-, N-[3-(C10-16-alkyloxy)propyl] derivatives, di-Et sulfate-quaternized

70983-58-3

January 2016

Ministerial Condition No. 18420

Phosphoric acid, mixed esters with 2-ethyl-1-hexanol and polyethylene glycol monotridecyl ether, potassium salts

68937-46-2

January 2016

-

1-​Propanamine, 3-​(triethoxysilyl)​-​, reaction products with trimethoxymethylsila​ne and 2-​[[3-​(trimethoxysilyl)​propoxy]​methyl]​oxirane

474530-85-3

January 2016

-

Alcohols, C2-33, manufactured of, by-products from, overheads

876065-86-0

February 2016

-

D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts

1362053-75-5

February 2016

-

Isooctadecanoic acid, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester

109884-54-0

February 2016

-

Butanedioic acid, 2-methylene-, telomer with phosphinic acid and sodium 4-ethenylbenzenesulfonate (1:1), sodium salt

1803423-39-3

March 2016

-

1,2-cyclohexanedicarboxylic acid, 1-butyl 2-(phenylmethyl) ester

1200806-67-2

March 2016

Ministerial Condition No. 18554

Silsesquioxanes, 3-[[(3,5-dimethyl-heteromonocycle-l-yl]carbonyl]amino] propyl Pr, polymers with silicic acid (H4SiO4) tetra-Et ester, alkyl ether- and hydroxyl-terminated (19226-4) April 2016 -

Poly[oxy(methyl-1,2-ethanediyl)], α-[2-[[3-ethoxy-1-ethoxycarbonyl)-3-oxopropyl]amino]methylethyl]-ω-[2[[3-ethoxy-1-(ethoxycarbonyl)-3-oxopropyl]amino]methylethoxy]-

152637-10-0

April 2016

-

Butanedioic acid, 2-[[(alkylalkyl)amino]methyl]-, 1,4-bis(polyalkylalkyl) ester

(19008-0)

April 2016

-

2-Propenoic acid, 2-methyl-,2-[(1,1-dimethylethyl)amino]ethyl ester, polymer with methyl 2-methyl-2-propenoate, 2-propenoic acid and N-(1,1,3,3-tetramethylbutyl)-2-propenamide

164292-06-2

April 2016

-

2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, polymer with ethenylbenzene, 2-ethylhexyl 2-propenoate, 2-methylpropyl 2-methyl-2-propenoate and 3-(substituted silyl)propyl 2-methyl-2-propenoate, 2,2'-(1,2-diazenediyl)bis[2-methylbutanenitrile]-initiated

(19117-1)

April 2016

-

2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, polymer with butyl 2-propenoate, 2-ethylhexyl 2-propenoate and 2-propenoic acid, ester with alpha-[[[3-(substituted amino)methylphenyl]amino]carbonyl]-omega-methoxypoly(oxy-1,2-ethanediyl), 2,2'-azobis[2-methylbutanenitrile]-initiated

(18888-6)

April 2016

-

Phenol, 4-ethenyl-, acetate

2628-16-2

April 2016

-

Boron phosphate (B(PO4))

13308-51-5

April 2016

Significant New Activity Notice 18494

Phenol, 4-ethenyl-acetate, homopolymer, 2,2'-substitutedbis(dimethylalkanenitrile)-initiated, hydrolyzed (19228-6) May 2016 -

2-Imidazolidinone, 1-(2-hydroxyethyl)-

3699-54-5

May 2016

-

2-Imidazolidinone, 1-(2-hydroxyethyl)-

3699-54-5

May 2016

-

Quaternary ammonium compounds, benzylalkyldimethyl, salts with bentonite

(19227-5)

May 2016

-

Quaternary ammonium compounds, benzylbis(derivatized alkyl)methyl, bis(derivatized alkyl)dimethylammonium salts with sepiolite

(19017-0)

May 2016

-

Quaternary ammonium compounds, benzylbis(derivatized alkyl)methyl, bis(derivatized alkyl)dimethylammonium salts with smectite-group minerals

(19018-1)

May 2016

-

Fatty acids, C12-20, 1,2,2,6,6-pentamethyl-4-piperidinyl esters

1357160-95-2

May 2016

Significant New Activity/Order

Ethanediamide, bis[3-(diisopolyalkylamino)propyl]-

(19016-8)

May 2016

-

Pyrrolo[3,4-c]pyrrole-1,4-dione, 3,6-bis[4-(1,1-dimethylethyl)phenyl]-2,5-dihydro-

84632-59-7

May 2016

-

Poly(oxy-1,2-ethanediyl), ɑ-(isoalkyl)-ω-hydroxy-

(19127-2)

May 2016

-

Oxirane, methyl-, polymer with oxirane, ether with 1,2,3-propanetriol (3:1), polymer with 1,3-diisocyanatomethylbenzene and ɑ-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)]

69039-34-5

May 2016

-

Oxirane, methyl-, polymer with oxirane, ether with 1,2,3-propanetriol (3:1), polymer with ɑ-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane

85784-12-9

May 2016

-

Dioxadithiatetradecanedioic acid, 4,11-dimethyl-1,14-bis(2-ethylhexyl) ester

(19004-5)

May 2016

-
Hexanedioic acid, polymer with 1,2-ethanediol and 1-isocyanato-2-[(4-isocyanatophenyl)methyl]benzene 925206-99-1

May 2016

-
1,3-Propanediol, 2,2-bis(hydroxymethyl)-, polymer with oxirane 30599-15-6

May 2016

-
Phenol, 4-ethenyl-, acetate, homopolymer, 2,2'-substitutedbis(2,4-dimethylalkanenitrile)-initiated, hydrolyzed, 1-ethoxyethyl ethers (19232-0) May 2016 -
2-propenoic acid, 1,1-dialkylalkyl ester polymer with ethenylbenzene and 4-ethenylphenyl acetate, hydrolyzed (19183-1) May 2016 -
Butanedioic acid, 2-methylene-, telomer with sodium phosphinate (1:1), sodium zinc salt

1662663-05-9

June 2016

-

2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-

6642-31-5

June 2016

-
Silsesquioxanes, 3-isocyanatopropyl Pr, polymers with silicic acid (H4SiO4) tetra-Et ester, alkoxy- and hydroxy-terminated, polymers with 2,2'-(1 ,2-diazenediyl)bis[2-methylbutanenitrile]-initiated 2-ethylhexyl acrylate-2-hydroxyethyl methacrylate-iso-Bu methacrylate-styrene-3-(trisubstitutedsilyl)propyl methacrylate polymer, reaction products with 3,5-dimethyl-heteromonocycle (19229-7) June 2016 -
1-Propanaminium, N,N,N-trimethyl-3-[(1-oxo-2-propen-1-yl)amino]-, chloride (1:1), polymer with ethenamine and 2-propenamide, hydrochloride 1659307-53-5 June 2016 -
1-Propanaminium, 2-hydroxy-N-(2-hydroxypropyl)-N,N-dimethyl-, diesters with C18-unsaturated fatty acids, Me sulfates 1810046-45-7 July 2016 -
Isooctadecanamide 83052-84-0 July 2016 -
1-Hexadecanol, 2-dodecyl- 72388-18-2 July 2016 -
1-Octadecanol, 2-tetradecyl- 32582-32-4 July 2016 -
2-Propenoic acid, 2-methyl-, alkyl ester, polymer with alkyl 2-propenoate, ethenylbenzene and heteromonocycle methyl 2-methyl-2-propenoate, 2,2'-(1,2-diazenediyl) bis[2-methylbutanenitrile]-initiated (19230-8) July 2016 -
Linseed oil, maleated, 2-[(2-methyl-1-oxo-2-propen-1-yl)oxy] ethyl ester, ester with polyalkylene glycol mono-Me ether, compounds with 2-(dimethylamino)ethanol (19038-3) July 2016 -
2-Propenoic acid, polymer with sodium phosphinate (1:1), mixed salt (19087-7) July 2016 -
2-Oxepanone, polymer with 2,4-diisocyanato-1-methylbenzene and tetrahydro-2H-pyran-2-one, polyalkyl ester, 1H-imidazole-1-alkaneamine-blocked (19049-5) July 2016 -
Waste plastics, poly(ethylene terephthalate), depolymerized with diethylene glycol, alkanepolyol, polyalkylene polyol and polyethylene polyol (19181-9) August 2016 -
Waste plastics, poly(ethylene terephthalate), depolymerized with diethylene glycol, polyalkylene polyol and polyethylene polyol (19182-0) August 2016 -
Benzenesulfonic acid, polyalkyl deriatives, calcium salts (19082-2) August 2016 -
Methanol, potassium salt 865-33-8 August 2016 -
1,2,4-Benzenetricarboxylic acid, 1,2,4-trinonyl ester 35415-27-1 August 2016 -
Fatty acids, unsaturated, dimers, polymers with bisphenol A diglycidyl ether, formaldehyde, phenol, fatty acids and triethylenetetramine (19052-8) August 2016 -
Benzoic acid, 4-[(4-chlorobenzoy)amino]-, sodium salt (1:1) 1489170-67-3 September 2016 -
2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,6-bis(1,1-dimethylethyl)-4-methylphenoxy]- 80693-00-1 September 2016 -
2-Propenoic acid, 2-methyl-, 2-(2-butoxyethoxy)ethyl ester 7328-22-5 September 2016 -
Ethanol, 2-[[2-(2-hydroxyethoxy)ethyl]methylamino]- 68213-98-9 September 2016 -
Cashew, nutshell liquid, polymer with 1,3-benzenedimethane substituted, bisphenol A, epichlorohydrin and formaldehyde (19090-1) September 2016 -
Alkenes, polymers with 2,5-furandione and 1,2-ethanediol (19231-9) September 2016 -
Amines, (2-ethylhexyl)(hydrogenated tallow alkyl)methyl 1078712-76-1 September 2016 -
1,3-Benzenedicarboxylic acid, polymer with 1,4-benzenedicarboxylic acid, 2,2-dimethyl-1,3-propanediol, dodecanedioic acid, 1,2-ethanediol, hexanedioic acid, 1,6-hexanediol, hexane derivative, α-hydro-ω-hydroxypoly(oxyalkanediyl), 3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropanoate, 1,3-isobenzofurandione, 1,1'-methylenebis[isocyanatobenzene] and α,α',α"-1,2,3-propanetriyltris[ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)]] (19091-2) October 2016 -
Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl, polymer with diisocyanato-1-methylbenzene, 2-oxepanone and tetrahydro-2H-pyran-2-one, polyalkylene glycol mono-Bu ether-blocked (19095-6) October 2016 -
1,3-Benzenedicarboxylic acid, polymer with 1,4-benzenedicarboxylic acid, 2,2-dimethyl-1,3-propanediol, dodecanedioic acid, alkanediol, hexanedioic acid, 1,6-hexanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropanoate, 1,3-isobenzofurandione, 1,1'-methylenebis[isocyanatobenzene], 2-oxepanone and 2,2'-oxybis[ethanol] (19104-6) October 2016 -

Poly[oxy(methyl-1,2-ethanediyl)], α,α',α"-1,2,3-propanetriyltris[ω-hydroxy-, polymer with α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)] and 1,1'-methylenebis[isocyanatobenzene]

150409-28-2

November 2016

-

Heteromonocycle, 2-methyl-, polymer with oxirane, carboxymethyl octadecyl ether

(19100-2)

November 2016

Significant New Activity/Order

Heteromonocycle, 2-methyl-, polymer with oxirane, carboxymethyl hexadecyl ether

(19101-3)

November 2016

Significant New Activity/Order

2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,6-bis(1,1-dimethylethyl)-4-methylphenoxy]-

80693-00-1

November 2016

-

2-Propenoic acid, 2-methyl-, 2-(2-butoxyethoxy)ethyl ester

7328-22-5

November 2016

-

Amines, (2-ethylhexyl)(hydrogenated tallow alkyl)methyl

1078712-76-1

November 2016

-

Ethanol, 2-[[2-(2-hydroxyethoxy)ethyl]methylamino]-

68213-98-9

November 2016

-

Cashew, nutshell liquid, polymer with 1,3-benzenedimethane substituted, bisphenol A, epichlorohydrin and formaldehyde

(19090-1)

November 2016

-
2-Propenoic acid, butyl ester, polymer with 1,3-cyclohexanedimethanamine, reaction products with Bu glycidyl ether 1257085-86-1 November 2016 -
1,4-Benzenedicarboxylic acid, polymer with 2,2-dimethyl-1,3-propanediol, dodecanedioic acid, alkanediol, hexanedioic acid, 1,6-hexanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 1,3-isobenzofurandione, 1,1'-methylenebis[4-isocyanatobenzene], 2-oxepanone and 2,2'-oxybis[ethanol] (19108-1) November 2016 -
Dodecanedioic acid, polymer with 2,2-dimethyl-1,3-propanediol, alkanediol, hexanedioic acid, 1,6-hexanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 1,1'-methylenebis[4-isocyanatobenzene] and α,α',α"-1,2,3-propanetriyltris[ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)]] (19107-0) November 2016 -
Dodecanedioic acid, polymer with butyl 2-methyl-2-propenoate, hexanedioic acid, alkanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 2-hydroxyethyl 2-methyl-2-propenoate, 1,1'-methylenebis[4-isocyanatobenzene], methyl 2-methyl-2-propenoate, 2-methyl-2-propenoic acid and 2-oxepanone (19109-2) November 2016 -
1,4-Benzenedicarboxylic acid, polymer with dodecanedioic acid, 1,2-ethanediol, hexanedioic acid, 1,6-hexanediol, hexane derivative, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 1,3-isobenzofurandione, 1,1'-methylenebis[4-isocyanatobenzene] and 2,2'-oxybis[ethanol] (19106-8) November 2016 -
Siloxanes and silicones, 3-[(2-aminoalkyl)amino]alkyl, alkoxy, alkoxy alkyl, alkoxy-terminated (19245-3) November 2016 -
Benzamide, 3,3'-[(2-chloro-1,4-phenylene-)bis[imino(1-acetyl-2-oxo-2,1-ethanediyl)azo]]bis[4-methyl- 253430-12-5 December 2016 -

2-propanol, 1-[bis(2-hydroxyethyl)amino]-

6712-98-7

December 2016

Significant New Activity/Order

1-Propanaminium, 3-amino-N-(carboxymethyl)-N,N-dimethyl-, N-C8-18 acyl derivatives, inner salts

97862-59-4

December 2016

Ministerial Condition No. 18685

Summaries of substances assessed in 2015
Substance name or masked name CAS RN / (CAN) Date assessment period completed Related notice or order
2-Propenoic acid, telomer with alkanediol mono-2-propenoate and sodium phosphinate (1:1) ammonium salt (18850-4) January 2015 -
Hexanedioic acid, polymer with 1,3-isobenzofurandione and 1,2-propanediol, diisodecyl ester 68511-08-0 January 2015 -
Poly[oxy(alkyl-alkanediyl)], α-hydro-ω-hydroxy-, polymer with 5-isocyanato-1-(isocyanatomethyl)-1, 3, 3-trimethylcyclohexane, 2-hydroxyethyl methacrylate-blocked (18881-8) February 2015 -
Coconut oil, reaction products with boric acid (H3BO3), diethanolamine and polyol (18829-1) February 2015 -
Zirconium, chloro hydroxy lactate oxo sodium complexes 174206-15-6 March 2015 -
Hexanedioic acid, mixed 4-methyl-2-propylhexyl and 5-methyl-2-propylhexyl and 2-propylheptyl esters 1043888-25-0 March 2015 Significant New Activity/Order
Poly(oxy-1,2-ethanediyl), α-undecyl-ω-hydroxy-branched and linear, ethers with 1,2-decanediol (1:1) 501019-90-5 March 2015 -
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides, reaction products with polyethylenepolyamines and tall-oil fatty acids, humates hydrochlorides 68910-55-4 March 2015 -
Butanedioic acid, 2-hydroxy-, sodium salt (1:?) 3105-51-9 March 2015 -
Phosphorodithioic acid, O,O-bis(2-methylpropyl) ester, trialkylamine salt (18679-4) March 2015 -
Benzenedicarboxylic acid, polymer with (chloroalkyl) oxirane, 2,2-dimethyl-1,3-propanediol, hexanedioic acid, 2-[[ 3-hydroxy-2,2-bis[[(1-oxo-2-propenyl)oxy]methyl]propoxy]methyl]-2-(hydroxymethyl)-1,3-propanediyl di-2-propenoate, 3-hydroxy-2-(hydroxymethyl-2-methylpropanoic acid, 1,1'-methylenebis [4-isocyanatocyclohexane], (alkylalkylidene)bis[phenol] and 2-propenoic acid, dipentaerythritol pentaacrylate-blocked, compounds with triethylamine (18862-7) April 2015 -
D-Glucitol, 1-deoxy-1-(methylamino)-, N-C8-10 acyl derivatives 1591782-62-5 April 2015 -
D-Glucitol, 1-deoxy-1-(methylamino)-, N-C12-14 acyl derivatives 287735-50-6 April 2015 -
Hexanedioic acid, polymer with (chloroalkyl)oxirane polymer with (alkylalkylidene)bis[phenol] 2-propenoate, 1,6-diisocyanatohexane, 2,2-dimethyl-1,3-propanediol, 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane and alkyltriyltris[ω-hydroxypoly[oxy(alkyl-alkyldiyl)]] 2-propenoate (18856-1) April 2015 -
2-Propenoic acid, tetraester with 2,2'-[oxybis(methylene)]bis[2-(hydroxymethyl)-1,3-propanediol], polymer with (chloroalkyl) oxirane polymer with (alkylalkylidene)bis[phenol] 2-propenoate, 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid and 1,1'-methylenebis[4-isocyanatocyclohexane], dipentaerythritol pentaacrylate-blocked, compounds with triethylamine (18857-2) April 2015 -
Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymers with (alkylalkylidene)bis[phenol]-(chloroalkyl) oxirane polymer acrylate, 1,1'-methylenebis[4-isocyanatocyclohexane] and poly[oxy(alkyl-alkyldiyl)], alkytriyltris[ω-hydroxy-, 2-propenoate, poly[oxy(alkyl-alkyldiyl)], alkytriyltris[ω-hydroxy-, diacrylate-blocked, compounds with triethylamine (18858-3) April 2015 -
Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with 1,6-diisocyanatohexane and alkanetriyltris[ω-hydroxypoly[oxo(alkyl-alkanediyl)]] 2-propenoate, 2-hydroxyl-3-[(1-oxo-2-propen-1-yl)oxy]propyl neodecanoate-blocked (18878-5) April 2015 -
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides, compounds with attapulgite 68953-57-1 April 2015 -
Tall oil, polymerized, oxidized 68815-17-8 April 2015 -
Alkyl alcohol triester with boric acid (H3BO3) (18880-7) April 2015 -
Amines, tallow alkyl, reaction products with cyclohexylamine and 1,1'-methylenebis[isocyanatobenzene] 1078712-83-0 May 2015 -
Poly[oxy(alkyl-alkanediyl)], α-hydro-ω-hydroxy-, polymer with 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane, 2-hydroxyethyl methacrylate-blocked (18881-8) May 2015 -
Alcohols, C12-22, distillation residues 1476777-83-9 May 2015 -
Alkanoic acid, mixed polyesters with ethylalkanoic acid, alkanoic acid, pentaerythritol and alkanoic acid (18585-0) May 2015 -
2,5-Furandione, telomer with 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bis(benzene) and ethenylbenzene, 3-(dimethylamino)propyl imide, imide with polyethylene-polypropylene glycol 2-aminopropyl Me ether, 2-(alkyloxymethyl) oxirane-quaternized, benzoates (salts) (18872-8) May 2015 -
2,5-Furandione, telomer with ethenylbenzene and (1-methylethyl)benzene, 3-(dimethylamino)propyl imide, imide with polyethylene-polypropylene glycol 2-aminopropyl Me ether, 2-(alkyloxmethyl) oxirane-quaternized, benzoates (salts) (18886-4) May 2015 -
Formaldehyde, reaction products with 1,3-benzenedimethanamine and p-tert-butyl phenol 158800-93-2 May 2015 -
Poly(oxy-1,2-ethanediyl), α-undecyl-ω-hydroxy-branched and linear, ethers with 1,2-decanediol (1:1) 501019-90-5 May 2015 -
1,3-Benzenedicarboxylic acid, polymer with butyl 2-methyl-2-propenoate, hexanedioic acid, alkanediol, α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 2-hydroxyethyl 2-methyl-2-propenoate, 1,1`-methylenebis[4-isocyanatobenzene], methyl 2-methyl-2-propenoate, 2-methyl-2-propenoic acid and 2-oxepanone (18864-0) May 2015 -
1,3-Isobenzofurandione, polymer with alkanediol and α-hydro-ω-hydroxypoly (oxy-1,2-ethanediyl) ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 2-propenoate (18870-6) May 2015 -
Silicic acid, sodium salt, hydrolysis products with 1-[(substitutedmethoxy)alkyl]silanetriol (18923-5) June 2015 Significant New Activity/Order
Dodecanedioic acid, 1,12-bis[2-[4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy]ethyl]ester 1482217-03-7 June 2015 -
Benzenesulfonic acid, 5-[[ 4,6-bis[bis(2-hydroxyethyl)amino ]-1,3,5-triazin-2-yl]amino ]-2-[2-[ 4-[[ 4-[bis(2-hydroxyethyl)amino ]-6-(phenylamino )-1,3,5-triazin-2-yl]amino ]-2-sulfophenyl]ethenyl]-, sodium salt (1:2) 1351757-36-2 June 2015 -
Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[[ 4,6-bis[bis(2-hydroxyethyl)amino ]-1,3,5-triazin-2-yl]amino ]-,sodium salt (1:2) 3654-78-2 June 2015 -
1,5-Disubstitutedpentane, 2-methyl-, polymer with 1,4-cyclohexamedimethanol, 1,3-benzenedicarboxylic acid, zinc oxide modified (14843-2) June 2015 -
2,5-furandione, polymer with alkene, hexaneperoxoic acid, 2-ethyl-, 1,1-dimethylpropyl ester-initiated (19054-1) June 2015 -
Alkyl acid, N-[4-[[4-[2-[4[[4-[bis alkanolamino]-6[(2,5-disulfophenyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl]-3-sulfophenyl]amino]-6-[(2,5-disulfophenyl)amino]-1,3,5-triazin-2-yl]-, sodium salt (1:8) (19211-9) July 2015 -
Substituted benzene, 2,2'-[1 ,2-ethenediylbis[(3-sulfo-4,1-phenylene)imino[6-[bis aminoalkanol]-1,3,5-triazine-4,2-diyl]iminollbis-, hexasodium salt (19212-0) July 2015 -
Alkyl diacid, N,N'-[1 ,2,-ethenediylbis[(3-sulfo-4,1,-phenylene)imino[6-[(2,5-disulfophenyl)amino]-1,3,5-triazine-4,2-diyl]]]bis-, decasodium salt (19213-1) July 2015 -
Butanedioic acid, mono(mixed alken-1-yl and polyisobutylene) derivatives, ethylene esters (18908-8) July 2015 -
Alcohols, C12-18, ethoxylated, reaction products with 1,6-diisocyanatohexane and polyethylene-polypropylene glycol 72968-35-5 August 2015 Ministerial Condition No. 17432
1,2-Benzenedicarboxylic acid, mixed C8-11-alkyl and 2-ethylhexyl and hexyl and isononyl diesters 1415043-91-2 August 2015 Ministerial Condition No. 18111
Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with diamine and 1,1'-methylenebis [4-isocyanatocyclohexane], pentaerythritol triacrylate-blocked, compounds with triethylamine (18884-2) August 2015 -
1,4-Cyclohexanedicarboxamide, N1,N1,N4,N4-tetrakis (2-hydroxyethyl)-, trans- 1215841-86-3 August 2015 -
Alkenes, C11-C13, C12 rich, reaction products with alkene carbonate, phenol and sulfur, calcium salts (19210-8) August 2015 -
4-Phytase 9001-89-2 August 2015 -
1,4-Cyclohexanedimethanol, polymer with (chloromethyl)oxirane 71463-68-8 September 2015 -
Butanoic acid, 3-hydroxy-, butyl ester 53605-94-0 September 2015 -
Formaldehyde polymers with substituted-carbonmonocycle, (tetraalkenyl) derivatives (18944-8) September 2015 -
Tall oil, maleated 68152-93-2 September 2015 -
1,3-Butadiene, homopolymer, maleated 179005-14-2
September 2015 -
Hexanedioic acid, polymer with heteropolycycledione, polymethylenepolyphenylene derivative and 1,2-propanediol (18893-2) September 2015 -
Zirconium, chloro hydroxy lactate oxo sodium complexes 174206-15-6 September 2015 -
1,2-Alkanediamine, N1,N2-bis(2-aminoethyl)- polymer with N1-(2-aminoethyl)-1,2-ethanediamine, 2-(chloromethyl)oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis(oxirane) and α,α '-[(1-methylethylidene)di-4,1-phenylene]bis[omega-hydroxypoly(oxy-1,2-ethanediyl)], reaction products with 2-[(C12-14-alkyoxy)methyl]oxirane and glycidyl Ph ether (19011-3) September 2015 -
Phenol, polymer with formaldehyde, glycidyl ether, polymers with polyethylene glycol, polypropylene glycol and polyethylenpolyamine, reaction products with 2-[(C12-14-alkyloxy)methyl]oxirane (19128-3) September 2015 -
Aldehyde, polymer with N1-(2-aminoethyl)-1,2-ethanediamine, N1,N2-bis(2-aminoethyl)-1,2-ethanediamine, 2,2'-[1,2-bulanediylbis(oxymethylene)]bis[oxirane], 2,2'-[(1-methylethylidene)bis[phenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane], reaction products with glycidyl Ph ether and glycidyl o-tolyl ether, acetates (salts) (19129-4) September 2015 -
Oxirane, 2,2'-[(1-methylethyldiene)bis(4,1-phenyleneoxymethylene)]bis-homopolymer, ester with α-[3-carboxy-1-oxo(tetrapropenyl)propyl]-ω-[3-carboxy-1-oxo(tetrapropenyl)propoxy]poly(oxy-1,2-ethanediyl) 444796-55-8 September 2015 -
Benzene, polyalkene derivatives, sulfonated, sodium salts (17584-7) September 2015  
Peroxide, bis(4-methylbenzoyl) 895-85-2 September 2015  
1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, (2R)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) 36687-82-8 October 2015 -
Benzene, 1,3,5-tris(1-methylethyl)- 717-74-8 October 2015 -
1,2-propanediol, 1,2-dibenzoate 19224-26-1 October 2015
Ministerial Condition No. 18178
Polyphosphoric acids, esters with polyalkanolamine, compounds with alkylpyridines (19253-1) October 2015 -
1,2,3,4-Butanetetracarboxylic acid, polymer with 2,2-bis(hydroxymethyl)-1,3-propanediol and 3-hydroxy-2,2-dimethylpropanal, 1,2,2,6,6-pentamethyl-4-piperidinyl ester 101357-36-2 October 2015 -
1,3-Dioxolane-4-methanol, 2-methyl-2-(2-methylpropyl)- 5660-53-7 November 2015 -
Sodium, [μ4-(tricyclo[1.1.0.02,4]tetrasilane-1,2,3,4-tetrayl)]poly- (18924-6) November 2015 -
D-glucopyranose, oligomeric, heptyl glycosides 1627851-18-6 November 2015 -
9-Dodecenoic acid, methyl ester 39202-17-0 November 2015 -
1,2-cyclohexanedicarboxylic acid, 1-butyl 2-(phenylmethyl) ester 1200806-67-2 November 2015 Ministerial Condition No. 18306
Substituted polyalkane tetra-alkyl amine (18942-6) November 2015 -
Benzenesulfonic acid, mono-sec-alkyl derivatives, magnesium salts (18954-0) December 2015 -
2,5-Furandione, polymer with 2,2-dimethyl-1,3-propanediol and 1,2-ethanediol, alkenyloxy ethyl ester (19055-2) December 2015 -
9-Decenoic acid, methyl ester 25601-41-6 December 2015 -
2,4-Imidazolidinedione, 1,3-bis(2-hydroxyethyl)-5,5-dimethyl- 26850-24-8 December 2015 -
1,3-Dioxolane-4-methanol, 2-methyl-2-(2-methylpropyl) 5660-53-7 December 2015 -
Butanedioic acid, 2-methylene-, telomer with sodium phosphinate (1:1), sodium salt, decarboxylated 1663489-58-4 December 2015 -
Carbamic acid, [(polyalkoxysilyl)alkyl]-polyalkylalkanediyl ester (19003-4) December 2015 -
Alkanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, polymer with 1,6-diisocyanatohexane, 1,2-ethanediamine and 1,1'-methylenebis[4-isocyanatocyclohexane], pentaerythritol triacrylate-blocked, compounds with triethylamine (18941-5) December 2015 -
Phosphorous acid, triphenyl ester, polymer with α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], C10-16-alkyl esters 1227937-46-3 December 2015 -
Substances assessed in 2010
Substance name or masked name CAS RN / (CAN) Date assessment period completed Related notice or order
Acetic acid, 1,1-dimethylethyl ester 540-88-5 February 2010 -
Poly(oxy-1,2-ethanediyl), α-monoalkyl ethers-ω-mono-(hydrogen maleate)

(16329-3)

May 2010

Significant New Activity/Order [PDF]
Aromatic isocyanate polymer, alkoxy-alkylamine blocked (18215-8) August 2010 Significant New Activity/Order [PDF]
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