Proposed Registration Decision PRD2019-13, Cyantraniliprole and Ference Insecticide

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Pest Management Regulatory Agency
18 December 2019
ISSN: 1925-0886 (PDF version)
Catalogue number: H113-9/2019-13E-PDF (PDF version)

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To obtain a full copy of Proposed Registration Decision PRD2019-13, Cyantraniliprole and Ference Insecticide please contact our publications office.

Should you require further information please contact the Pest Management Information Service.

Summary

Table of Contents

Proposed Registration Decision for Cyantraniliprole

Health Canada’s Pest Management Regulatory Agency (PMRA), under the authority of the Pest Control Products Act, is proposing registration for the sale and use of Cyantraniliprole Technical and Ference Insecticide, containing the technical grade active ingredient cyantraniliprole, to control or supress a variety of insects on turf (golf courses and sod farms only), outdoor ornamentals and greenhouse ornamentals. The use of cyantraniliprole on turf (golf courses and sod farms only) is a new use for this active ingredient.

Cyantraniliprole is currently registered to control a variety of insect pests on fruits and vegetables, oilseeds, greenhouse ornamentals and outdoor ornamentals. For details, see Proposed Registration Decision PRD2013-09, Cyantraniliprole, and Registration Decision RD2013-25, Cyantraniliprole.

An evaluation of available scientific information found that, under the approved conditions of use, the health and environmental risks and the value of the pest control products are acceptable.

This summary describes the key points of the evaluation, while the Science Evaluation of Proposed Registration Decision PRD2019-13, Cyantraniliprole and Ference Insecticide provides detailed technical information on the human health, environmental and value assessments of cyantraniliprole and Ference Insecticide.

What Does Health Canada Consider When Making a Registration Decision?

The key objective of the Pest Control Products Act is to prevent unacceptable risks to people and the environment from the use of pest control products. Health or environmental risk is considered acceptable if there is reasonable certainty that no harm to human health, future generations or the environment will result from use or exposure to the product under its proposed conditions of registration. The Act also requires that products have value when used according to the label directions. Conditions of registration may include special precautionary measures on the product label to further reduce risk.

To reach its decisions, the PMRA applies modern, rigorous risk-assessment methods and policies. These methods consider the unique characteristics of sensitive subpopulations in humans (for example, children) as well as organisms in the environment. These methods and policies also consider the nature of the effects observed and the uncertainties when predicting the impact of pesticides. For more information, please refer to the following:

Before making a final registration decision on Cyantraniliprole Technical and Ference Insecticide, Health Canada’s PMRA will consider any comments received from the public in response to this PRD2019-13. Health Canada will then publish a Registration Decision on cyantraniliprole and Ference Insecticide, which will include the decision, the reasons for it, a summary of comments received on the proposed registration decision and Health Canada’s response to these comments.

For more details on the information presented in this summary, please refer to the Science Evaluation of PRD2019-13.

What Is Cyantraniliprole?

Cyantraniliprole is a diamide insecticide, Mode of Action (MoA) Group 28 that is active by ingestion and contact. Diamides affect ryanodine receptors in insect muscle, causing paralysis and death of the insect. It is the active ingredient in the commercial class product Ference Insecticide.

Health Considerations

Can Approved Uses of Cyantraniliprole Affect Human Health?

Ference Insecticide, containing cyantraniliprole, is unlikely to affect your health when used according label directions.

Potential exposure to cyantraniliprole may occur through the diet (food and water), when handling and applying the end-use product, or during contact with treated surfaces. When assessing health risks, two key factors are considered:

The dose levels used to assess risks are established to protect the most sensitive human population (for example, children and nursing mothers). As such, sex and gender are taken into account in the risk assessment. Only uses for which the exposure is well below levels that cause no effects in animal testing are considered acceptable for registration.

Toxicology studies in laboratory animals describe potential health effects from varying levels of exposure to a chemical and identify the dose where no effects are observed. The health effects noted in animals occur at doses more than 100-times higher (and often much higher) than levels to which humans are normally exposed when pesticide products are used according to label directions.

In laboratory animals, cyantraniliprole was of low acute toxicity via the oral, dermal, and inhalation routes of exposure. It was non-irritating to the skin, non- to minimally irritating to the eye, and did not cause an allergic skin reaction.

The acute toxicity of Ference Insecticide, containing cyantraniliprole, was low via the oral, dermal, and inhalation routes of exposure. Ference Insecticide was not irritating to the skin or eye, and did not cause an allergic skin reaction.

Registrant-supplied short- and long-term (lifetime) animal toxicity tests, as well as information from the published scientific literature, were assessed for the potential of cyantraniliprole to cause neurotoxicity, immunotoxicity, chronic toxicity, cancer, reproductive and developmental toxicity, and various other effects. The most sensitive endpoints for risk assessment were effects on the liver. There was no evidence to suggest that the young animal was more sensitive than the adult animal to cyantraniliprole. The risk assessment protects against the effects noted above and other potential effects by ensuring that the level of exposure to humans is well below the lowest dose at which these effects occurred in animal tests.

Residues in Water and Food

An update to the dietary risk assessment was not required for this major new use on turf because the cumulative maximum application rate remains the same as that currently registered (PRD2013-09, Cyantraniliprole and RD2013-25, Cyantraniliprole).

Risks in Residential and Other Non-Occupational Environments

Residential and non-occupational risks are not of concern when cyantraniliprole is used according to the proposed label directions.

Ference Insecticide can be applied as a spray application to turf in golf courses. Therefore, there is the potential for adults and youth to be exposed via the dermal route to treated turf in golf courses.

The exposure assessments conducted for adults and youth when contacting turf treated with cyantraniliprole did not identify risks of concern when the label directions are followed.

Occupational Risks From Handling Cyantraniliprole

Occupational risks are not of concern when cyantraniliprole is used according to the proposed label directions.

Applicators who mix, load and apply Ference Insecticide to turf (golf courses and sod farms only), and workers entering treated turf can come in direct contact with cyantraniliprole residues on the skin and/or through inhalation. Therefore, the label specifies that anyone mixing/loading and applying cyantraniliprole must wear a long-sleeved shirt, long pants, chemical-resistant gloves, shoes and socks. The label prohibits workers from entering treated sod farms for 12 hours after application and from entering all other treated turf areas until sprays have dried.

Taking into consideration label directions and precautionary statements, it was determined that the risks to these individuals are not of concern.

For bystanders, exposure is considered negligible since the potential for drift is expected to be minimal. Therefore, health risks to bystanders are not of concern.

Environmental Considerations

What Happens When Cyantraniliprole Is Introduced Into the Environment?

When cyantraniliprole is used according to the label directions, the risks to the environment have been determined to be acceptable.

Cyantraniliprole can enter the environment when it is used as an insecticide for control of a large number of pests in a variety of crops. Ference Insecticide will be used on turf (golf courses and sod farms only), greenhouse and outdoor ornamentals as a foliar, soil drench application, or by chemigation. Cyantraniliprole is systemic and, therefore, can reach pollen and nectar through movement inside the plant. In both soil and water cyantraniliprole transforms quickly. There is a total of eight major transformation products formed in soil and/or water. The degradation of the major transformation products ranges from not persistent to persistent. Cyantraniliprole and its transformation products have the potential to leach through the soil profile to enter ground water.

When used according to the label directions, cyantraniliprole and its transformation products do not present a risk of concern to soil dwelling organisms, birds and mammals, aquatic plants, algae, fish, and amphibians. Cyantraniliprole may pose risks of concern to aquatic invertebrates, terrestrial plants, beneficial arthropods, and bees; therefore, preventative measures and use restrictions are required on the product label.

Taking into consideration the preventative measures and use restrictions on the label, it was determined that the risks to these organisms are not of concern.

Value Considerations

What Is the Value of Ference Insecticide?

Ference Insecticide controls or suppresses numerous insect pests of turf on golf courses and sod farms.

Ference Insecticide is a new commercial class product that is applied to turf on golf courses and sod farms only for the control or suppression of chinch bugs, black cutworm, fall armyworm, European crane fly and various beetle pests. The product provides a new tool for use against the listed pests of golf course and sod farm turf.

Measures to Minimize Risk

Labels of registered pesticide products include specific instructions for use. Directions include risk-reduction measures to protect human and environmental health. These directions must be followed by law.

The key risk-reduction measures being proposed on the label of Cyantraniliprole Technical and Ference Insecticide to address the potential risks identified in this assessment are as follows.

Key Risk-Reduction Measures

Human Health

As direct contact with cyantraniliprole on the skin or through inhalation can occur, anyone mixing, loading and applying Ference Insecticide to turf using ground application equipment must wear a long-sleeved shirt, long pants, chemical-resistant gloves, shoes and socks. Chemical-resistant gloves are not required during application within a closed cab.

Environment

Next Steps

Before making a final registration decision on cyantraniliprole and Ference Insecticide, Health Canada’s PMRA will consider any comments received from the public in response to PRD2019‑13. Health Canada will accept written comments on PRD2019-13 up to 45 days from the date of its publication. Please forward all comments to Publications. Health Canada will then publish a Registration Decision, which will include its decision, the reasons for it, a summary of comments received on the proposed decision and Health Canada’s response to these comments.

Other Information

When Health Canada makes its registration decision, it will publish a Registration Decision on cyantraniliprole and Ference Insecticide (based on the Science Evaluation of PRD2019-13). In addition, the test data referenced in PRD2019-13 will be available for public inspection, upon application, in the PMRA’s Reading Room (located in Ottawa).

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