Proposed Maximum Residue Limit PMRL2015-54, Flumioxazin

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Pest Management Regulatory Agency
10 November 2015
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2015-54E-PDF (PDF version)

Under the authority of the  Pest Control Products Act, Health Canada's Pest Management Regulatory Agency (PMRA) has concluded that the addition of spring wheat and dry chickpeas, the addition of new application timing for dry field peas and the change in the rotational interval for spring wheat and dry field peas to the product labels of Flumioxazin 51WDG Herbicide and Valtera Herbicide, containing technical grade flumioxazin, is acceptable. The specific uses approved in Canada are detailed on the labels of Flumioxazin 51WDG Herbicide and Valtera Herbicide, Pest Control Products Act Registration Numbers 29235 and 29230, respectively.

The evaluation of this flumioxazin application indicated that the end-use product has value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRL for flumioxazin is being conducted via this document (see Next Steps, the last section of this document). A summary of the field trial data used to support the proposed MRL can be found in Appendix I.

To comply with Canada's international trade obligations, consultation on the proposed MRL is also being conducted internationally by notifying the  World Trade Organization, as coordinated by the  Canada's Notification Authority and Enquiry Point.

The proposed MRL, to replace or be added to the MRLs already established for flumioxazin, is as follows.

Table 1: Proposed Maximum Residue Limits for Flumioxazin
Common Name Residue Definition MRL (ppm)Table 1 footnote 1 Food Commodity

Table 1 footnotes

Table 1 footnote 1

ppm = parts per million.

Return to table 1 footnote 1 referrer

Flumioxazin 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl-1-yl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione 0.02 Wheat grain

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International Situation and Trade Implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data. For livestock commodities, differences in MRLs can also be due to different livestock feed items and practices.

Table 2 compares the MRL proposed for flumioxazin in Canada with corresponding American tolerance and Codex MRL.Footnote 1 American tolerances are listed in the  Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. Currently, there are no Codex MRLs listed for flumioxazin in or on any commodity on the Codex Alimentarius  Pesticide Residues in Food webpage.

Table 2: Comparison of Canadian MRL, American Tolerance and Codex MRL (where different)
Food Commodity Canadian MRL
(ppm)
American Tolerance
(ppm)
Codex MRL
(ppm)
Wheat grain 0.02 0.40 None

Next Steps

The PMRA invites the public to submit written comments on the proposed MRL for flumioxazin up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRL. Comments received will be addressed in a separate document linked to this PMRL. The established MRL will be legally in effect as of the date that it is entered into the Maximum Residue Limit Database.

Appendix I

Summary of Field Trial Data Used to Support the Proposed Maximum Residue Limit

Residue data for flumioxazin in spring wheat were submitted to support the domestic use of Flumioxazin 51WDG Herbicide and Valtera Herbicide on spring wheat. Previously reviewed residue data from field trials conducted in/on dry field peas and dry beans were reassessed in the framework of this petition to support the domestic use of Flumioxazin 51WDG Herbicide and Valtera Herbicide on dry chickpeas and the addition of new application timing for dry field peas. In addition, a processing study in treated wheat was to determine the potential for concentration of residues of flumioxazin into processed commodities.

Maximum Residue Limit(s)

The recommendation for a maximum residue limit (MRL) for flumioxazin was based upon the submitted field trial data, and the guidance provided in the  OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRL for spring wheat.

Table A1: Summary of Field Trial and Processing Data Used to Support MRL
Commodity Application Method/ Total Application Rate
(g ai/ha)Table A1 footnote 1
Preharvest Interval (days) Maximum Residues
(ppm)
Minimum Residues
(ppm)
Experimental Processing Factor

Table A1 footnotes

Table A1 footnote 1

g ai/ha = grams of flumioxazin ingredient per hectare

Return to table A1 footnote 1 referrer

Spring wheat grain Soil application 5-8 days prior to planting/ 102.7-109.5 98-133 <0.02 <0.02 0.14 (flour)
0.94 (bran)
1.0 (germ)

Based on the dietary burden and residue data, no MRLs for flumioxazin are proposed in milk, eggs, fat, meat and meat by-products of cattle, goats, hogs, horses, poultry and sheep.

Following the review of all available data, the MRL as proposed in Table 1 is recommended to cover residues of flumioxazin. Residues of flumioxazin in these crop commodities at the proposed MRL will not pose an unacceptable risk to any segment of the population, including infants, children, adults, seniors and females.

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