Proposed Maximum Residue Limit PMRL2016-33, Cyazofamid

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Pest Management Regulatory Agency
6 July 2016
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2016-33E-PDF (PDF version)

Under the authority of the  Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of a new use on hops and caneberries (Crop Subgroup 13-07A) to the product label of Cyazofamid 400 SC Fungicide, containing technical grade cyazofamid, is acceptable. The specific uses approved in Canada are detailed on the label of Cyazofamid 400 SC Fungicide, Pest Control Products Act Registration Number 27984.

The evaluation of this cyazofamid application indicates that the end-use product has value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for cyazofamid is being conducted via this document (see Next Steps, the last section of this document). A summary of the field trial data used to support the proposed MRL can be found in Appendix I.

To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by Canada’s Notification Authority and Enquiry Point.

The proposed MRLs, to be added to the MRLs already established for cyazofamid, are as follows.

Table 1 Proposed Maximum Residue Limit for Cyazofamid
Common Name Residue Definition MRL (ppm).Table 1 footnote 1 Food Commodity
Cyazofamid 4-chloro-2-cyano-N,N-dimethyl-5-(4- methylphenyl)-1H-imidazole-1- sulfonamide, including the metabolite 4-chloro-5-(4-methylphenyl)-1H-imidazole- 2-carbonitrile 10 Hops (dried)
0.02 Caneberries (Crop Subgroup 13-07A)

Table 1 footnotes

Table 1 footnote 1

ppm = parts per million

Return to table 1 footnote 1 referrer

MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides and Pest Management section of Health Canada’s website.

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International Situation and Trade Implications

The MRL proposed for cyazofamid on hops in Canada is the same as the corresponding American tolerance as listed in the Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. Currently, there are no American tolerances as listed for cyazofamid on Caneberry Crop Subgroup 13-07A in the Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide, and there are no Codex MRLs Footnote 1 listed for kasugamycin in or on any commodity on the Codex Alimentarius Pesticide Residues in Food webpage.

Next Steps

The PMRA invites the public to submit written comments on the proposed MRLs for cyazofamid up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.

Appendix I

Summary of Field Trial Data Used to Support the Proposed Maximum Residue Limits

Residue data for cyazofamid in/on hops were submitted to support the domestic use of Cyazofamid 400 SC Fungicide on hops.  A previously reviewed confined crop rotational study for cyazofamid was reassessed in the framework of the petition for Caneberries (Crop Subgroup 13-07A).

Maximum Residue Limits

The recommendation for the maximum residue limits (MRLs) for cyazofamid were based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRL for hops (dried). An MRL of 0.02 ppm is proposed for residues of cyazofamid in/on caneberries (Crop Subgroup 13-07A).

Table A1 Summary of Field Trial Data Used to Support the MRL on Hops
Commodity Application Method/ Total Application Rate (g a.i./ha)Table 2 footnote 1 Preharvest Interval (days) Lowest Average Field Trial Residues (ppm) Highest Average Field Trial Residues(ppm)
Hops Foliar application/
477-497
2-4 3.16 7.51

Table 1 footnotes

Table 1 footnote

g a.i./ha = grams of active ingredient per hectare

Return to table 1 footnote 1 referrer

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of kasugamycin. Residues of kasugamycin in these commodities at the proposed MRLs will not pose an unacceptable risk to any segment of the population, including infants, children, adults and seniors.

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