Proposed Maximum Residue Limit PMRL2017-16, Pyroxasulfone
Pest Management Regulatory Agency
16 May 2017
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2017-16E-PDF (PDF version)
Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on various commodities to the product label of Pyroxasulfone 85 WG Herbicide, containing technical grade pyroxasulfone, is acceptable. The specific uses approved in Canada are detailed on the label of Pyroxasulfone 85 WG Herbicide, Pest Control Products Act Registration Number 30572.
The evaluation of this pyroxasulfone application indicated that the end-use product has value and the human health and environmental risks associated with the new uses are acceptable.
Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.
In addition, the PMRA is proposing to establish MRLs for pyroxasulfone on peanut commodities to permit the import and sale of food containing such residues. The PMRA has determined the quantity of residues that are likely to remain in or on the imported commodities when pyroxasulfone is used according to label directions in the exporting country, and that such residues will not be a concern to human health.
Consultation on the proposed MRL for Pyroxasulfone is being conducted via this document (see Next Steps). A summary of the field trial data used to support the proposed MRL can be found in Appendix I.
To comply with Canada's international trade obligations, consultation on the proposed MRL is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.
The proposed MRL, to replace or be added to the MRLs already established for Pyroxasulfone, is as follows.
|Common Name||Residue Definition||MRL (ppm)Table 1 footnote 1||Food Commodity|
|Pyroxasulfone||3-[(5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole, and the metabolites [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanesulfonic acid (M-1); 5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (M-3); [5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanesulfonic acid (M-25); and 3-[1-carboxy-2-(5,5-dimethyl-4,5-dihydroisoxazol-3-ylthio)ethylamino]-3-oxopropanoic acid (M-28)||0.3||Peanuts|
|0.15||Dried shelled pea and bean, except soybean (crop subgroup 6C)|
MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides and Pest Management section of Health Canada’s website.
MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.
International Situation and Trade Implications
MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data.
Pyroxasulfone is an active ingredient that is concurrently being registered in Canada and the United States for use pre- and/or early post-emergence on various dry peas and dry beans, flaxseeds and peanuts. The MRLs proposed for pyroxasulfone in Canada are the same as corresponding tolerances to be promulgated in the United States.
Once established, the American tolerances for pyroxasulfone will be listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide.
The PMRA invites the public to submit written comments on the proposed MRLs for pyroxasulfone up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.
Summary of Field Trial Data Used to Support the Proposed Maximum Residue Limit
Residue data for pyroxasulfone in dry peas, dry beans, and flax were submitted to support the domestic use of Pyroxasulfone 85 WG Herbicide on chickpeas, lentils, field peas, and flax. Residue data for pyroxasulfone in peanuts were submitted to support the maximum residue limit on imported peanuts. In addition, processing studies in treated flax and peanuts were reviewed to determine the potential for concentration of residues of pyroxasulfone into processed commodities.
Maximum Residue Limits
The recommendation for a maximum residue limit (MRL) for Pyroxasulfone was based upon the previously submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the revised/proposed MRL for dry shelled peas and beans.
|Commodity||Application Method/ Total Application Rate
(g a.i./ha)Table 3 footnote 1.1
|Preharvest Interval (days)||Lowest Average Field Trial Residues
|Highest Average Field Trial Residues
|Experimental Processing Factor|
|Dry peas||Soil/pre-emergent + foliar/post-emergent 298-306||74-90||<0.064||0.088||Not applicable|
|Dry beans||Soil/pre-emergent + foliar/post-emergent
|Flaxseed||Soil/pre-emergent + foliar/post-emergent
|74-139||<0.064||<0.064||No quantifiable residues were observed at exaggerated rates.|
|Maturity||<0.064||0.116||Peanut oil: 0.5×|
Following the review of all available data, an MRL as proposed in Table 1 are recommended to cover residues of pyroxasulfone. Residues of pyroxasulfone in these crop commodities at the proposed MRLs will not pose an unacceptable risk to any segment of the population, including infants, children, adults and seniors.
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