Proposed Maximum Residue Limit PMRL2020-20, Flupyradifurone

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Pest Management Regulatory Agency
11 August 2020
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2020-20E-PDF (PDF version)

Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on various commodities to the product labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, containing technical grade flupyradifurone, is acceptable. The specific uses approved in Canada are detailed on the labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, Pest Control Products Act Registration Numbers 33696 and 31451, respectively.

The evaluation of these flupyradifurone applications indicated that the end-use products have value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limits (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for flupyradifurone is being conducted via this document (see Next Steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.

To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.

The proposed MRLs, to replace or be added to the MRLs already established for flupyradifurone, are as follows.

Table 1 Proposed maximum residue limits for flupyradifurone
Common name Residue definition MRL (ppm)Table 1 Footnote 1 Food commodity
Flupyradifurone 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone 0.1 Fat of cattle, goats, horses and sheepTable 1 Footnote 2
0.07 MilkTable 1 Footnote 2
0.03 Rapeseeds (revised) (crop subgroup 20A)
Table 1 Footnote 1

ppm = parts per million

Table 1 Return to footnote 1 referrer

Table 1 Footnote 2

The MRLs are proposed to replace the currently established MRLs of 0.06 ppm.

Table 1 Return to footnote 2 referrer

MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides section of the Canada.ca website.

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International situation and trade implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data. For livestock commodities, differences in MRLs can also be due to different livestock feed items and practices.

Table 2 compares the MRLs proposed for flupyradifurone in Canada with corresponding American tolerances and Codex MRLs.Footnote 1 American tolerances are listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. A listing of established Codex MRLs is available on the Codex Alimentarius Pesticide Index webpage, by pesticide or commodity.

Table 2 Comparison of Canadian MRLs, american tolerances and Codex MRLs (where different)
Food commodity Proposed Canadian MRL (ppm) American tolerance (ppm) Codex MRL
(ppm)
Rapeseeds (revised) (crop subgroup 20A) 0.03 Not established Not established
Milk 0.07 0.15 0.7
Fat of cattle, goats, horses and sheep 0.1 0.20 (fat of cattle, goats, horses and sheep) 1

Next steps

The PMRA invites the public to submit written comments on the proposed MRLs for flupyradifurone up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.

Appendix I

Summary of field trial data used to support the proposed maximum residue limits

Residue data for flupyradifurone in canola were submitted to support the domestic use of BYI 02960 200SL Insecticide on rapeseeds (revised) (crop subgroup 20A) and BYI 02960 480 FS on rapeseeds (revised) (crop subgroup 20A). In addition, processing studies in soybeans and cotton were reassessed to determine the potential for concentration of residues of flupyradifurone into processed commodities.

Maximum residue limits

The recommendation for maximum residue limits (MRLs) for flupyradifurone was based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRL for rapeseeds (revised) (crop subgroup 20A).

Table A1 Summary of field trial data used to support MRLs
Commodity Application method/total application rate
(g a.i./ha)Table A1 Footnote 1
Preharvest interval (days) Lowest average field trial residues
(ppm)
Highest average field trial residues
(ppm)
Experimental processing factor
Canola Seed + Foliar/
254–289
60–170 <0.010 0.024 Not required
Table A1 Footnote 1

g a.i./ha = grams of active ingredient per hectare

Table A1 Return to footnote 1 referrer

Based on the dietary burden and residue data, MRLs of 0.1 ppm in fat of cattle, goats, horses and sheep and 0.07 ppm in milk to cover residues of flupyradifurone are also proposed.

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of flupyradifurone. Residues of flupyradifurone in these crop/livestock commodities at the proposed MRLs will not

Footnote 1

The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.

Return to footnote 1 referrer

Pest Management Regulatory Agency
11 August 2020
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2020-20E-PDF (PDF version)

Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on various commodities to the product labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, containing technical grade flupyradifurone, is acceptable. The specific uses approved in Canada are detailed on the labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, Pest Control Products Act Registration Numbers 33696 and 31451, respectively.

The evaluation of these flupyradifurone applications indicated that the end-use products have value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limits (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for flupyradifurone is being conducted via this document (see Next Steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.

To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.

The proposed MRLs, to replace or be added to the MRLs already established for flupyradifurone, are as follows.

Table 1 Proposed maximum residue limits for flupyradifurone
Common name Residue definition MRL (ppm)Table 1 Footnote 1 Food commodity
Flupyradifurone 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone 0.1 Fat of cattle, goats, horses and sheepTable 1 Footnote 2
0.07 MilkTable 1 Footnote 2
0.03 Rapeseeds (revised) (crop subgroup 20A)
Table 1 Footnote 1

ppm = parts per million

Table 1 Return to footnote 1 referrer

Table 1 Footnote 2

The MRLs are proposed to replace the currently established MRLs of 0.06 ppm.

Table 1 Return to footnote 2 referrer

MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides section of the Canada.ca website.

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International situation and trade implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data. For livestock commodities, differences in MRLs can also be due to different livestock feed items and practices.

Table 2 compares the MRLs proposed for flupyradifurone in Canada with corresponding American tolerances and Codex MRLs.Footnote 1 American tolerances are listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. A listing of established Codex MRLs is available on the Codex Alimentarius Pesticide Index webpage, by pesticide or commodity.

Table 2 Comparison of Canadian MRLs, american tolerances and Codex MRLs (where different)
Food commodity Proposed Canadian MRL (ppm) American tolerance (ppm) Codex MRL
(ppm)
Rapeseeds (revised) (crop subgroup 20A) 0.03 Not established Not established
Milk 0.07 0.15 0.7
Fat of cattle, goats, horses and sheep 0.1 0.20 (fat of cattle, goats, horses and sheep) 1

Next steps

The PMRA invites the public to submit written comments on the proposed MRLs for flupyradifurone up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.

Appendix I

Summary of field trial data used to support the proposed maximum residue limits

Residue data for flupyradifurone in canola were submitted to support the domestic use of BYI 02960 200SL Insecticide on rapeseeds (revised) (crop subgroup 20A) and BYI 02960 480 FS on rapeseeds (revised) (crop subgroup 20A). In addition, processing studies in soybeans and cotton were reassessed to determine the potential for concentration of residues of flupyradifurone into processed commodities.

Maximum residue limits

The recommendation for maximum residue limits (MRLs) for flupyradifurone was based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRL for rapeseeds (revised) (crop subgroup 20A).

Table A1 Summary of field trial data used to support MRLs
Commodity Application method/total application rate
(g a.i./ha)Table A1 Footnote 1
Preharvest interval (days) Lowest average field trial residues
(ppm)
Highest average field trial residues
(ppm)
Experimental processing factor
Canola Seed + Foliar/
254–289
60–170 <0.010 0.024 Not required
Table A1 Footnote 1

g a.i./ha = grams of active ingredient per hectare

Table A1 Return to footnote 1 referrer

Based on the dietary burden and residue data, MRLs of 0.1 ppm in fat of cattle, goats, horses and sheep and 0.07 ppm in milk to cover residues of flupyradifurone are also proposed.

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of flupyradifurone. Residues of flupyradifurone in these crop/livestock commodities at the proposed MRLs will not

Footnote 1

The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.

Return to footnote 1 referrer

Pest Management Regulatory Agency
11 August 2020
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2020-20E-PDF (PDF version)

Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on various commodities to the product labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, containing technical grade flupyradifurone, is acceptable. The specific uses approved in Canada are detailed on the labels of BYI 02960 200SL Insecticide and BYI 02960 480 FS, Pest Control Products Act Registration Numbers 33696 and 31451, respectively.

The evaluation of these flupyradifurone applications indicated that the end-use products have value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limits (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for flupyradifurone is being conducted via this document (see Next Steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.

To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.

The proposed MRLs, to replace or be added to the MRLs already established for flupyradifurone, are as follows.

Table 1 Proposed maximum residue limits for flupyradifurone
Common name Residue definition MRL (ppm)Table 1 Footnote 1 Food commodity
Flupyradifurone 4-[[(6-chloro-3-pyridinyl)methyl](2,2-difluoroethyl)amino]-2(5H)-furanone 0.1 Fat of cattle, goats, horses and sheepTable 1 Footnote 2
0.07 MilkTable 1 Footnote 2
0.03 Rapeseeds (revised) (crop subgroup 20A)
Table 1 Footnote 1

ppm = parts per million

Table 1 Return to footnote 1 referrer

Table 1 Footnote 2

The MRLs are proposed to replace the currently established MRLs of 0.06 ppm.

Table 1 Return to footnote 2 referrer

MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides section of the Canada.ca website.

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International situation and trade implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data. For livestock commodities, differences in MRLs can also be due to different livestock feed items and practices.

Table 2 compares the MRLs proposed for flupyradifurone in Canada with corresponding American tolerances and Codex MRLs.Footnote 1 American tolerances are listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. A listing of established Codex MRLs is available on the Codex Alimentarius Pesticide Index webpage, by pesticide or commodity.

Table 2 Comparison of Canadian MRLs, american tolerances and Codex MRLs (where different)
Food commodity Proposed Canadian MRL (ppm) American tolerance (ppm) Codex MRL
(ppm)
Rapeseeds (revised) (crop subgroup 20A) 0.03 Not established Not established
Milk 0.07 0.15 0.7
Fat of cattle, goats, horses and sheep 0.1 0.20 (fat of cattle, goats, horses and sheep) 1

Next steps

The PMRA invites the public to submit written comments on the proposed MRLs for flupyradifurone up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.

Appendix I

Summary of field trial data used to support the proposed maximum residue limits

Residue data for flupyradifurone in canola were submitted to support the domestic use of BYI 02960 200SL Insecticide on rapeseeds (revised) (crop subgroup 20A) and BYI 02960 480 FS on rapeseeds (revised) (crop subgroup 20A). In addition, processing studies in soybeans and cotton were reassessed to determine the potential for concentration of residues of flupyradifurone into processed commodities.

Maximum residue limits

The recommendation for maximum residue limits (MRLs) for flupyradifurone was based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRL for rapeseeds (revised) (crop subgroup 20A).

Table A1 Summary of field trial data used to support MRLs
Commodity Application method/total application rate
(g a.i./ha)Table A1 Footnote 1
Preharvest interval (days) Lowest average field trial residues
(ppm)
Highest average field trial residues
(ppm)
Experimental processing factor
Canola Seed + Foliar/
254–289
60–170 <0.010 0.024 Not required
Table A1 Footnote 1

g a.i./ha = grams of active ingredient per hectare

Table A1 Return to footnote 1 referrer

Based on the dietary burden and residue data, MRLs of 0.1 ppm in fat of cattle, goats, horses and sheep and 0.07 ppm in milk to cover residues of flupyradifurone are also proposed.

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of flupyradifurone. Residues of flupyradifurone in these crop/livestock commodities at the proposed MRLs will not

Footnote 1

The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.

Return to footnote 1 referrer

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