Proposed Maximum Residue Limit PMRL2020-43, Indaziflam

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Pest Management Regulatory Agency
25 November 2020
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2020-43E-PDF (PDF version)

Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the label amendment allowing grazing and haying of non-cropland vegetation immediately following one application of Esplanade SC Herbicide, containing indaziflam, is acceptable. The specific label amendment approved in Canada is detailed on the label of Esplanade SC Herbicide, Pest Control Products Act Registration Number 31333.
The evaluation of this indaziflam application indicated that the end-use product has value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limits (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for indaziflam is being conducted via this document (see Next steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.

To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.

The proposed MRLs, to be added to the MRLs already established for indaziflam, are as follows.

Table 1: Proposed Maximum Residue Limits for Indaziflam
Common name Residue definition MRL (ppm)Table 1: Tablenote 1 Food commodity
Indaziflam N-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine 0.15 Meat by products of cattle, goats, horses and sheep
0.05 Fat of cattle, goats, horses and sheep
0.01 Meat of cattle, goats, horses and sheep; milk
Table 1 Footnote 1

ppm = parts per million

Table 1 Return to footnote 1 referrer

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International situation and trade implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the crop field trials used to generate residue chemistry data. For livestock commodities, differences in MRLs can also be due to different livestock feed items and practices.

Table 2 compares the MRLs proposed for indaziflam in Canada with the corresponding American tolerances and Codex MRLs.Footnote 1 American tolerances are listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide.Currently, there are no corresponding Codex MRLs listed for indaziflam in or on any commodity on the Codex Alimentarius Pesticide Index webpage.

Table 2 Comparison of Canadian MRLs, American Tolerances and Codex MRLs (where different)
Food commodity Canadian MRL (ppm) American Tolerance (ppm) Codex MRL (ppm)
Meat byproducts of cattle, goats, horses and sheep 0.15 0.2 Not Established
Fat of cattle, goats, horses and sheep 0.05 0.07 Not established

Next steps

The PMRA invites the public to submit written comments on the proposed revisions and revocations of MRLs for acephate and methamidophos up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed revisions and revocations of MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database. The revocation of MRLs will take effect to allow sufficient time for legally treated commodities to clear the channels of trade.

Appendix I

Summary of field trial data used to support the proposed maximum residue limits

Residue data for indaziflam in/on grass forage and hay were submitted to support the label amendment of this active on the Esplanade SC Herbicide label. The amendment allows grazing and hay production immediately following one application on non-croplands for weed control. Residue data from field trials conducted in the United States were submitted to support the domestic use of Esplanade SC on non-cropland vegetation. Indaziflam was applied to pasture grass at the registered application rate, and harvested immediately following application according to label directions. In addition, a dairy cattle feeding study involving treated feed was reviewed to determine the potential for transfer of residues of indaziflam into ruminant commodities.

Maximum residue limits

The recommendation for maximum residue limits (MRLs) for indaziflam was based upon the submitted field trial data for pasture grass and the ruminant feeding study.

Table A1 Summary of field trial data used to support MRLs on animal commodities.
Commodity Application method/
Total application rate
(g a.i./ha)Table A1 Footnote 1
Preharvest Interval (days) Lowest average field trial residuesTable A1 Footnote 2
Highest Average field trial residuesTable A1 Footnote 2
Grass foliage At green-up / 72–76 0 3.04 17.1
Grass hay 0–89 <0.01 20.4
Table 1 Footnote 1

g a.i./ha = grams of active ingredient per hectare

Table A1 Return to footnote 1 referrer

Table 1 Footnote 2

Combined residues of indaziflam and 1-fluoroethyl diaminotriazine (FDAT), expressed as parent equivalents.

Table A1 Return to footnote 2 referrer

Based on the dietary burden calculated using the residue data in Table A1, MRLs of 0.01 ppm in milk and meat of cattle, goats, horses and sheep; 0.05 ppm in fat of cattle, goats, horses and sheep; and 0.15 ppm in meat byproducts of cattle, goats, horses and sheep to cover residues of indaziflam are proposed.

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of indaziflam. Residues of indaziflam in these livestock commodities at the proposed MRLs will not pose an unacceptable risk to any segment of the population, including infants, children, adults, and seniors.


Footnote 1

The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.

Return to footnote 1 referrer

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