Proposed Maximum Residue Limit PMRL2020-44, Pydiflumetofen
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The online consultation is now closed
Pest Management Regulatory Agency
25 November 2020
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2020-44E-PDF (PDF version)
Under the authority of the Pest Control Products Act, Health Canada’s Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on various commodities to the product labels of A19649 Fungicide, containing pydiflumetofen, MIRAVIS Neo Fungicide, containing pydiflumetofen, azoxystrobin and propiconazole, A20560 Fungicide, containing pydiflumetofen and fludioxonil, and A20259 Fungicide , containing pydiflumetofen and difenoconazole, are acceptable. The specific uses approved in Canada are detailed on the labels of A19649 Fungicide (PCP No. 33018), MIRAVIS Neo Fungicide (PCP No. 33022), A20560 Fungicide (PCP No. 33021) and A20259 Fungicide (PCP No. 33020). Consultation on the maximum residue limits (MRL) for difenoconazole is being conducted under a separate action while relevant MRLs for azoxystrobin, fludioxonil and propiconazole can be found in the Maximum Residue Limit Database.
The evaluation of these pydiflumetofen applications indicated that the end-use products have value and the human health and environmental risks associated with their proposed uses are acceptable.
Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.
In addition, the PMRA is proposing to establish MRLs for pydiflumetofen on citrus fruits (crop group 10) (revised), sorghum grain and cottonseeds (crop subgroup 20C) (revised) to permit the import and sale of food containing such residues. The PMRA has determined the quantity of residues that are likely to remain in or on the imported commodities when pydiflumetofen is used according to label directions in the exporting country, and that such residues will not be a concern to human health.
Consultation on the proposed MRLs for pydiflumetofen is being conducted via this document (see Next steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.
To comply with Canada’s international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada’s Notification Authority and Enquiry Point.
The proposed MRLs, to be added to the MRLs already established for pydiflumetofen, are as follows.
|Common name||Residue definition||MRL (ppm)Table 1: Tablenote 1||Food commodity|
|Pydiflumetofen||3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]-1H-pyrazole-4-carboxamide||50||Brassica leafy greens (crop subgroup 4-13B)|
|10||Garden beet tops, radish tops|
|5.0||Bushberries (crop subgroup 13-07B)|
|3.0||Brassica head and stem vegetable group (crop group 5-13), sorghum|
|2.0||Green onions (crop subgroup 3-07B), cherries (crop subgroup 12-09A)|
|1.0||Edible-podded legume vegetables (crop subgroup 6A), citrus fruits (crop group 10) (revised), peaches (crop subgroup 12-09B), low growing berries (crop subgroup 13-07G) (except lowbush blueberries) and dried prune plums|
|0.6||Plums (crop subgroup 12-09C)|
|0.5||Root vegetable (crop subgroup 1A), sunflowers (crop subgroup 20B) (revised)|
|0.4||Cottonseeds (crop subgroup 20C) (revised)|
|0.2||Bulb onions (crop subgroup 3-07A), pome fruits (crop group 11-09)|
|0.1||Succulent shelled pea and bean (crop subgroup 6B)|
|0.07||Tree nuts (crop group 14-11)|
MRLs are proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides section of the Canada.ca website.
MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.
International situation and trade implications
Pydiflumetofen is an active ingredient that is concurrently being registered in Canada and the United States for use on various crops. The MRLs proposed for pydiflumetofen in Canada are the same as corresponding American tolerances, except for citrus peel and commodities in crop group 2, in accordance with Table 2.
American tolerances are listed inthe Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide.A listing of established Codex MRLsFootnote 1 is available on the Codex Alimentarius Pesticide Index webpage, by pesticide or commodity.
|Food commodity||Canadian MRL (ppm)||American Tolerance (ppm)||Codex MRLs
(Vegetable, leaves of root and tuber, group 2)
|Garden beet tops||10||Not established|
|Citrus peel||1.5||Not established||Not established|
The PMRA invites the public to submit written comments on the proposed MRLs for pydiflumetofen up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.
Summary of field trial data used to support the proposed maximum residue limits
Residue data for pydiflumetofen in various crops were submitted to support the domestic use of A19649 Fungicide on sunflower seeds (CSG 20B); MIRAVIS Neo Fungicide for use on edible-podded legume vegetables (CSG 6A), succulent shelled pea and bean (CSG 6B), bushberries (CSG 13-07B); A20560 Fungicide for use on bulb vegetables (CG 3-07), bushberries (CSG 13-07B) and low growing berries (CSG 13-07G); A20259 Fungicide for use on root vegetables (CSG1A), bulb vegetables (CG3-07), Brassica leafy greens (CSG4-13B), Brassica head and stem vegetables (CG5-13), pome fruits (CG11-09), stone fruits (CG12-09) and tree nuts (CG14-11). Residue data for pydiflumetofen in sorghum, citrus fruits (CG 10) (revised) and cotton (CSG 20C) were submitted to support the maximum residue limits for imports. In addition, processing studies in treated sugar beets, oranges, apples, pears, plums, almonds, sorghum, sunflower seeds and cotton seeds were reviewed to determine the potential for concentration of residues of pydiflumetofen into processed commodities.
Maximum residue limits
The recommendation for maximum residue limits (MRLs) for pydiflumetofen was based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRLs for various crops.
|Commodity||Application method/ Total application rate
(g a.i./ha)Table A1 Footnote 1
|Preharvest interval (days)||Lowest average field trial residues
|Highest average field trial residues
|Experimental processing factor|
|Radish tops||Foliar broadcast/ 298–305||7||0.121||5.08||Not required|
|Radish roots (CSG 1A)||Foliar broadcast/ 298–305||7||0.013||0.166||Not required|
|Foliar broadcast/ 299–309||6–14||0.015||0.102||Not required|
|Sugar beet roots (CSG1A)||Foliar broadcast/ 293–311||6–28||0.016||0.135||Molasses: 0.6×
Refined sugar <0.07×
|Sugar beet tops||Foliar broadcast/ 293–311||6–14||0.763||6.270||Not required|
|Dry bulb onion (CSG3-07A)||Foliar broadcast/ 372–384||6–10||<0.010||0.121||Not required|
|Green onion (CSG3-07B)||Foliar broadcast/ 370–381||7||0.276||1.070||Not required|
|Mustard greens (CSG4-13B)||Foliar broadcast/ 398–411||0–3||0.868||28.60||Not required|
|Broccoli (CG5-13)||Foliar broadcast/ 364–386||0||0.417||1.430||Not required|
|Cabbage (CG5-13)||Foliar broadcast/ 370–376||0||0.302||0.992||Not required|
|Cauliflower (CG5-13)||Foliar broadcast/ 373–377||0–9||0.039||0.365||Not required|
|Edible podded bean (CSG 6A)||Foliar broadcast/
|Edible podded pea (CSG 6A)||Foliar broadcast/
|Succulent shelled bean (CSG 6B)||Foliar broadcast/
|Succulent shelled pea (CSG 6B)||Foliar broadcast/
|Grapefruit (CG 10R)||Foliar broadcast/
|Lemon (CG 10R)||Foliar broadcast/
|Orange/Tangerine (CG 10R)||Foliar broadcast/
|Apples (CG11-09)||Foliar broadcast/ 196–207||28–32||0.015||0.112||Juice: 0.1×
Canned apple: 0.03×
Dried apple: 0.4×
Apple sauce: 0.1×
|Pears (CG11-09)||Foliar broadcast/ 191–207||29–31||0.019||0.115||Juice: 0.1×
Canned pear: 0.1×
Dried pear: 0.6×
|Cherries (sweet and tart)
|Foliar broadcast/ 295–315||0–2||0.143||1.650||Not required|
|Foliar broadcast/ 298–317||0–3||0.089||0.782||Not required|
|Foliar broadcast/ 295–312||0–6||0.060||0.354||Dried prune plum: 2.8×
|Foliar broadcast/ 301–307||14||<0.01||0.032||Crude almond oil: 0.4×
Roasted almonds: 0.4×
|Pecan nutmeat (CG14-11)||Foliar broadcast/ 301–306||14–15||<0.01||0.015||Not required|
|Sorghum grain||Foliar broadcast/
|28–40||0.016||0.370||Refined oil: 0.06×|
|Cotton undelinted seeds (CSG 20C)||Foliar broadcast/
|28–38||<0.010||0.291||Refined oil: 0.03×|
Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover residues of pydiflumetofen. Residues of pydiflumetofen in these crop commodities at the proposed MRLs will not pose an unacceptable risk to any segment of the population, including infants, children, adults and seniors.
- Footnote 1
The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.
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