Proposed Maximum Residue Limit PMRL2021-28, Pyroxasulfone

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Pest Management Regulatory Agency
20 July 2021
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2021-28E-PDF (PDF version)

Under the authority of the Pest Control Products Act, Health Canada's Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on bulb onion, leek, peppermint and spearmint to the product label of Pyroxasulfone 85 WG Herbicide and peppermint and spearmint to the product label of Zidua SC Herbicide, both containing technical grade pyroxasulfone, are acceptable. The specific uses approved in Canada are detailed on the labels of Pyroxasulfone 85 WG Herbicide and Zidua SC Herbicide, Pest Control Products Act Registration Numbers 30572 and 32542, respectively.

The evaluation of these pyroxasulfone applications indicated that the end-use products have value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Consultation on the proposed MRLs for pyroxasulfone is being conducted via this document (see Next steps). A summary of the field trial data used to support the proposed MRLs can be found in Appendix I.

To comply with Canada's international trade obligations, consultation on the proposed MRLs is also being conducted internationally by notifying the World Trade Organization, as coordinated by the Canada's Notification Authority and Enquiry Point.

The proposed MRLs, to be added to the MRLs already established for pyroxasulfone are as follows.

Table 1 Proposed maximum residue limits for pyroxasulfone
Common name Residue definition MRL (ppm)Table 1 Footnote 1 Food commodity
Pyroxasulfone 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]sulfonyl]-4,5-dihydro-5,5-dimethylisoxazole; and the metabolites [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanesulfonic acid; 5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid; [5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanesulfonic acid; and 3-[1-carboxy-2-(5,5-dimethyl-4,5-dihydroisoxazol-3-ylthio)ethylamino]-3-oxopropanoic acid (expressed as parent equivalents) 0.7 Peppermint oil, spearmint oil
0.2 Peppermint tops, spearmint tops
0.15 Bulb vegetables (crop group 3-07)
Table 1 Footnote 1

ppm = parts per million

Table 1 Return to footnote 1 referrer

An MRL is proposed for each commodity included in the listed crop groupings in accordance with the Residue Chemistry Crop Groups webpage in the Pesticides and Pest Management section of the Canada.ca website.

MRLs established in Canada may be found using the Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for established MRLs, regulated under the Pest Control Products Act, both for pesticides or for food commodities.

International situation and trade implications

The MRLs proposed for pyroxasulfone in Canada are the same as corresponding American tolerances as listed in the Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. Currently, there are no Codex MRLsFootnote 1 listed for pyroxasulfone in or on any commodity on the Codex Alimentarius Pesticide Index webpage.

Next steps

The PMRA invites the public to submit written comments on the proposed MRLs for pyroxasulfone up to 75 days from the date of publication of this document. Please forward your comments to Publications.

The PMRA will consider all comments received before making a final decision on the proposed MRLs. Comments received will be addressed in a separate document linked to this PMRL. The established MRLs will be legally in effect as of the date that they are entered into the Maximum Residue Limit Database.

Appendix I

Summary of field trial data used to support the proposed maximum residue limits

Residue data for pyroxasulfone were submitted to support the use of Pyroxasulfone 85 WG Herbicide on bulb vegetables, peppermint and spearmint and the use of Zidua SC Herbicide on peppermint and spearmint. In addition, a processing study in treated mint was reviewed to determine the potential for concentration of residues of pyroxasulfone into processed commodities.

Maximum residue limits

The recommendation for maximum residue limits (MRLs) for pyroxasulfone was based upon the submitted field trial data, and the guidance provided in the OECD MRL Calculator. Table A1 summarizes the residue data used to calculate the proposed MRLs for the raw agricultural commodities.

Table A1 Summary of field trial and processing data used to support the MRLs
Commodity Application method/ Total application rate
(g a.i./ha)Table A1 Footnote 1
Preharvest interval (days) Lowest average field trial residues
(ppm)
Highest average field trial residues
(ppm)
Experimental processing factor
Dry Bulb Onions Foliar broadcast application/113–149 72–75 <0.05 <0.05 Not required
Green Onions Foliar broadcast application/150 59 <0.05 <0.05 Not required
Peppermint/spearmint Broadcast application/289–315 84–147 <0.05 0.076 Peppermint and spearmint oil: <0.5×–18×Table A1 Footnote 2
Table A1 Footnote 1

g a.i./ha = grams of active ingredient per hectare

Table A1 Return to footnote 1 referrer

Table A1 Footnote 2

Reflects the range of processing factors for each analyte: 12× for pyroxasulfone, <0.5× for metabolite M-1 and 18× for metabolite M-28. Metabolites M-3 and M-25 were assigned processing factors of 1× since residues were <LOQ in both the tops and oil, and a processing factor could not be calculated.

Table A1 Return to footnote 2 referrer

Following the review of all available data, MRLs as proposed in Table 1 are recommended to cover total residues of pyroxasulfone. Total residues of pyroxasulfone in these crop commodities at the proposed MRLs will not pose an unacceptable risk to any segment of the population, including infants, children, adults and seniors.

Footnote 1

The Codex Alimentarius Commission is an international organization under the auspices of the United Nations that develops international food standards, including MRLs.

Return to footnote 1 referrer

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