About the Revised In Commerce List (R-ICL)

The Revised In Commerce List (R-ICL) is comprised of:

  1. substances from the In Commerce sub-lists whose identity has been verified by Health Canada prior to the nomination process; and
  2. substances accepted for addition to the R-ICL during the Phase I and Phase II of the voluntary nomination process for which substance identity and eligibility criteria have been verified.

The R-ICL was initially posted on May 3, 2013 and is periodically updated to reflect new nominations, updates and corrections. Please contact us for enquires related to substances on the R-ICL.

Substances on the R-ICL may continue in Canadian commerce in Food and Drugs Act (FDA) regulated products, however, they continue to be subject to the authority of the Canadian Environmental Protection Act, 1999 (CEPA 1999). Immediate and appropriate action will be taken if, at any time, substances on the R-ICL are deemed to be a risk to human health or the environment. It should be noted that substances which are neither on the R-ICL nor on the Domestic Substances List (DSL) are subject to the notification requirements of the New Substances Notification Regulations (NSNR) of CEPA 1999. In addition, substances which are on the R-ICL are also subject to notification requirements under the NSNR of CEPA 1999 for product use patterns beyond the scope of the FDA.

Substances on the R-ICL have been prioritized by the Government of Canada to identify priority substances that require further evaluation to determine whether they present a risk to human health or the environment (Results of the prioritization of the Revised In Commerce List ). Substances identified for further evaluation to determine whether they may pose a significant risk are subject to a more rigorous assessment, which involves further information gathering. DSL listed substances appearing on the R-ICL have been removed from the R-ICL because these substances are considered to be under the purview of the DSL.  It should be noted that results and decisions made during categorization of the DSL in accordance with Section 73 of CEPA 1999 were not revisited, and will continue to be managed as existing substances.

The In Commerce sub-lists, with well-defined substances, continue to be available to be used as proof of in commerce by those who wish to nominate a substance or substances to the R-ICL. Relying on sub-lists for proof of in commerce, between 1987 and 2001, must clearly demonstrate that the nomination matches the sub-list entry.  All substances nominated to the R-ICL must be concisely identified with a proper scientific name and Chemical Abstracts Service Registry Number (CAS RN).

Additional information

  1. The substance names for chemicals and polymers that appear on the R-ICL are according to either the CAS RN nomenclature, or the International Union of Pure and Applied Chemistry (IUPAC) nomenclature, or in the case of a living organism, acceptable international codes of nomenclature and standard taxonomic sources
  2. The term "substance identifier" can refer to:
    1. a CAS RN
    2. an Enzyme Commission (EC) Number assigned by the International Union of Biochemistry and Molecular Biology (IUBMB)
    3. an International Numbering System for Food Additives Number (INS Number)
    4. an acceptable identifier for living organisms, or
    5. an ICL Confidentiality Number (ICL CN) in instances where confidentiality has been claimed for the identity of the substance
  3. Where multiple substance identifiers (CAS RNs) are listed for a substance by CAS, the bold font indicates the substance identifier which has most recently been assigned by CAS.

  4. Substances do not need to be nominated to the R-ICL if they meet the Guidelines for the Notification and Testing of New Substances: Chemicals and Polymers, Version 2005 description of Naturally Occurring SubstancesFootnote 1  (for further information please consult the Guidance Document obtainable at: RICL-LRSC @hc-sc.gc.ca)
  5. Substances used as food additives (for example, colours and flavours), and novel foods (for example, genetically modified organisms) that do not meet the criteria of a naturally occurring substance should be nominated to the R-ICL, if eligible for listing. Food additives known to be eligible for addition to the R-ICL, however, have already been added using Health Canada records. Each food additive requires only one unique listing on the R-ICL (for example, a food additive made from soybean or genetically modified soybean is considered a single food additive). Nomination is not solicited for food or drink represented for consumption by human beings (for example, flour, wheat bran, cumin powder) as defined by the FDA, other than novel food or food additives as defined by the Food and Drug Regulations under the FDA

Revised In Commerce List contact information

Environmental Assessment Unit 2
Health Canada
269 Laurier Avenue, 5th Floor, PL4905B
Ottawa, Ontario, Canada
K1A 0K9
Telephone: 1-877-216-1904 or 613-960-7366
Facsimile: 1-613-952-5354
E-mail: RICL-LRSC @hc-sc.gc.ca

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