About the Revised In Commerce List (R-ICL)

The Revised In Commerce List (R-ICL) is comprised of substances which were in products that were regulated under the Food and Drugs Act (F&DA) and that were in Canadian commerce between January 1, 1987 and September 13, 2001.

The nomination process for the R-ICL formally closed on November 3, 2019. Manufacturers and importers who wish to market a new substance for use in F&DA regulated products in Canada that is not already listed on the R-ICL or the Domestic substances list (DSL) must submit a notification under the New Substances Notification Regulations (NSNR) (Chemicals and Polymers) or NSNR (Organisms).

The R-ICL was initially posted on May 3, 2013, and is periodically revised to reflect updates and corrections.

All substances on the R-ICL are subject to the Canadian Environmental Protection Act (CEPA) and appropriate action may be taken at any time under that Act in respect to substances on the R-ICL that pose a risk to human health or the environment.

Substances on the R-ICL have been prioritized by the Government of Canada to identify priority substances that require further evaluation to determine whether they present a risk to human health or the environment (Results of the prioritization of the Revised In Commerce List). Substances identified for further evaluation to determine whether they may pose a significant risk may be subject to a more rigorous assessment, which involves further information gathering. DSL listed substances that previously appeared on the R-ICL were removed from the R-ICL because these substances are considered to be existing substances in Canada. It should be noted that results and decisions made during categorization of the DSL in accordance with Section 73 of CEPA were not revisited, and these substances will continue to be managed as existing substances.

Additional information

  1. The substance names for chemicals and polymers that appear on the R-ICL are according to either the Chemical Abstracts Service (CAS) nomenclature, or the International Union of Pure and Applied Chemistry (IUPAC) nomenclature, or in the case of a living organism, acceptable international codes of nomenclature and standard taxonomic sources
  2. The term "substance identifier" can refer to:
    1. a CAS Registry Number (CAS RN)Footnote1;
    2. an Enzyme Commission (EC) Number assigned by the International Union of Biochemistry and Molecular Biology (IUBMB)
    3. an International Numbering System for Food Additives Number (INS Number)
    4. an acceptable identifier for living organisms,
  3. Where multiple substance identifiers (CAS RNs) are listed for a substance by CAS, the bold font and an asterisk (*) indicates the substance identifier which has most recently been assigned by CAS.

Contact information

Environmental Assessment Unit 1
Health Canada
Mail stop PL 4905B
Ottawa, ON K1A 0K9
Telephone: 1-877-216-1904 (in Canada) or 613-960-7366
Fax: 613-952-5354
E-mail: hc.eau-uee.sc@canada.ca

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