Maternal-Infant Research on Environmental Chemicals (MIREC) follow-up studies

As part of the MIREC research platform, several follow-up studies were done. These studies tracked the child's growth and development in various ways.

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The MIREC-ID (Infant Development) study

In MIREC-ID, about 500 families from the MIREC study were invited to take part in a follow-up study. The aims of MIREC-ID were to:

  • examine the possible links between prenatal exposure to various environmental chemicals and:
    • infant behaviors
    • infant sensory development
    • infant size at birth and at 6 months of age
    • early markers of sexual development in newborns
  • identify factors that may alter the infant's vulnerability to environmental chemicals such as:
    • breastfeeding
    • socio-economic factors
    • mother's background and health

The MIREC-CD3 (Child Development at 3 years) and MIREC-CD Plus (Early Childhood Biomonitoring and Neurodevelopment) studies

Up to 800 families from the MIREC study took part in various segments of the MIREC-CD3 and MIREC-CD Plus studies. The specific aims of these studies were to:

  • study the possible links between prenatal exposures to various environmental chemicals and child brain development at around 3 years of age, including:
    • language tests
    • behavioural tests
    • cognitive tests (such as IQ)
  • measure child's growth and physical development and examine possible links to prenatal environmental chemical exposures
  • analyze the blood and urine of young children for various environmental chemicals (such as metals, phthalates and BPA)

The MIREC-ENDO (Pubertal Timing, Endocrine and Metabolic Function) study

The goal is to recruit about 1,000 families from the MIREC study to take part in MIREC-ENDO. The aims of this study are to:

  • measure current exposure to more persistent environmental chemicals in MIREC children
  • measure exposure to various new environmental chemicals (not measured before in MIREC) in stored maternal urine samples
  • assess whether prenatal exposure to higher levels of various environmental chemicals, as well as other prenatal factors (such as gestational diabetes), are related to the onset and progression of puberty or changes in metabolism and growth in children
  • explore the effect of maternal health problems and exposure to environmental chemicals during the MIREC pregnancy on long-term maternal health (such as blood pressure, blood sugar)
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