Tobacco and Colorectal Cancer

Cigarettes cause colorectal cancer.Footnote 1Footnote 2Footnote 3

Key facts about tobacco use and colorectal cancer

View health-related messages for all tobacco product packaging.

What is colorectal cancer?

The colon and rectum are part of the large intestine or large bowel. The colon absorbs water and nutrients from digested food and passes waste (stool or feces) to the rectum.

Cancers that occur in the colon or rectum are grouped together as colorectal cancer.Footnote 10

Most colorectal cancers start as a growth on the inner lining of the colon or rectum. These growths are called polyps. Some polyps can become cancerous, and if not treated, can spread cancer to other parts of the body. Footnote 9

Symptoms of colorectal cancer often only appear when the cancer has advanced. They include constipation, diarrhea, bright red or very dark blood in the stool, fatigue, and unexplained weight loss.Footnote 11

Treatments for colorectal cancer include surgery to remove part of the colon or rectum, radiation, or chemotherapy depending on the severity and location of the cancer.Footnote 12

How does tobacco use increase the risk of colorectal cancer?

Some of the chemicals in tobacco smoke are carcinogenic, meaning they can cause genetic changes in cells of the colon and rectum, leading to the development of colorectal cancer.Footnote 1

These chemicals or their metabolites are carried through the blood stream to the large bowel and stored in the colon and rectum prior to defecation. This can increase the development of polyps in the colon and rectum.Footnote 1

How does quitting reduce the risk of colorectal cancer?

Quitting smoking reduces the risk of colorectal cancer.Footnote 2 The risk further decreases the earlier someone quits, and the longer they remain smoke-free.Footnote 6

Quitting is one of the best ways to avoid the development of colorectal cancer and other tobacco-related diseases.Footnote 2

If someone who smokes has colorectal cancer, quitting can still benefit them. Quitting smoking can improve recovery for cancer patients.Footnote 1

Continuing to smoke after a cancer diagnosis can lower chances of survival and increase the risk for other cancers caused by tobacco smoke, such as lung cancer.Footnote 1

Health benefits of quitting tobacco use at any age

Quitting tobacco use reduces the risk of premature death, improves health, and enhances quality of life.Footnote 2 Quitting at any age is beneficial to one's health.Footnote 2 Even people who have smoked or used tobacco heavily for many years benefit from it.Footnote 2Footnote 13 Quitting is the most important thing someone who smokes can do to improve their health.

Read more about the benefits of quitting smoking.

Call for free help to quit

Call the toll-free pan-Canadian quit line at 1-866-366-3667. Quit line counselling, alone or in combination with cessation medications, increases success in quitting.Footnote 2

Footnotes

Footnote 1

U.S. Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014.

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Footnote 2

U.S. Department of Health and Human Services. Smoking Cessation: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2020.

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Footnote 3

International Agency for Research on Cancer. IARC Monographs. Personal habits and indoor combustions. Volume 100E: A review of human carcinogens. Lyon, France; 2012.

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Footnote 4

Botteri E, Borroni E, Sloan E et al. Smoking and colorectal cancer risk, overall and by molecular subtypes: A Meta-Analysis. The American Journal of Gastroenterology. 2020;115(12):1940-1949. doi: 10.14309/ajg.0000000000000803.

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Footnote 5

Amitay EL, Carr PR, Jansen L. et al. Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways. Br J Cancer. 2020;122:1604–1610. https://doi.org/10.1038/s41416-020-0803-0

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Footnote 6

Lindsay M. Hannan, Eric J. Jacobs and Michael J. Thun. The association between cigarette smoking and risk of colorectal cancer in a large prospective cohort from the United States. Cancer Epidemiol, Biomarkers Prev. 2009;18(12):3362–7. doi: 10.1158/1055-9965.EPI-09-0661.

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Footnote 7

Liang P, Chen T, Giovannucci E. Cigarette smoking and colorectal cancer incidence and mortality: Systematic review and meta‐analysis. Int J Cancer. 2009;124(10):2406-15. doi: 10.1002/ijc.24191.

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Footnote 8

Brenner DR, Poirier A, Woods RR, Ellison LF, Billette JM, Demers AA, Zhang SX, Yao C, Finley C, Fitzgerald N, Saint-Jacques N. Projected estimates of cancer in Canada in 2022. CMAJ. 2022 May 2;194(17):E601-7.

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Footnote 9

Canadian Cancer Statistics Advisory Committee. Canadian Cancer Statistics 2021. Toronto, ON: Canadian Cancer Society; 2021. cancer.ca/Canadian-Cancer-Statistics-2021-EN.

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Footnote 10

American Society of Clinical Oncology. Colorectal Cancer: Introduction. Published January 2021. Accessed May 2, 2022. https://www.cancer.net/cancer-types/colorectal-cancer/introduction

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Footnote 11

American Society of Clinical Oncology. Colorectal Cancer: Symptoms and Signs. Published January 2021. Accessed May 2, 2022. https://www.cancer.net/cancer-types/colorectal-cancer/symptoms-and-signs

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Footnote 12

American Society of Clinical Oncology. Colorectal Cancer: Types of Treatment. Published January 2021. Accessed May 2, 2022. https://www.cancer.net/cancer-types/colorectal-cancer/types-treatment

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Footnote 13

U.S. Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004.

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