Updated guidance for infection prevention and control in health care settings when COVID-19 is suspected or confirmed – April 2024
On this page
- Introduction
- Preamble
- Background
- Risk and transmission
- Aim and scope
- Hierarchy of controls
- Screening and surveillance
- Patient placement and accommodation
- Personal protective equipment
- Routine practices and additional precautions
- Aerosol exposure and aerosol-generating medical procedures (AGMPs)
- Discontinuation of additional precautions
- Masking for source control
- Visitors
- Footnotes
- References
Introduction
Preamble
This document updates the previous guidance document "Update with consideration of omicron: Interim COVID-19 infection prevention and control in the healthcare setting when COVID-19 is suspected or confirmed-December 23, 2021" with revised recommendations for:
- considerations and implementation of masking for source control
- administrative controls for screening and surveillance of COVID-19
- visitation
Background
This document, which updates previous national Infection Prevention and Control (IPC) guidance developed for health care settings for IPC interventions to prevent and control COVID-19, was informed using expert advice from the National Advisory Committee on Infection Prevention and Control (NAC-IPC), by reviewing available scientific evidence and completion of an environmental scan of international, provincial and territorial guidance.
For the purposes of this document, the term "patient" includes persons receiving health care who are traditionally/routinely referred to as patients, clients or residents.
Risk and transmission
SARS-CoV-2 proved to be a rapidly mutating virus, with the development of multiple variants impacting transmissibility, and vaccine effectiveness. Factors affecting the risk of acquisition of healthcare-associated SARS-CoV-2 infections include:
- SARS-CoV-2 incidence in the community
- Population-level immunity based on recent SARS-CoV-2 infection and/or vaccination
- Ventilation within the facility
- Infection prevention and control (IPC) measures in place, including, but not limited to, hand hygiene, proper use of personal protective equipment (PPE), cleaning and disinfection
- Source masking by healthcare workers (HCWs), patients, and visitors
- Proximity and duration of exposure
- Proximity, crowding, and the quality of ventilation in patient rooms (e.g., single and multi-bed rooms) and waiting areas
- Signs and symptoms (e.g., coughing, sneezing)
- Clinical disease progression/course, including viral load
Respiratory particles (respiratory droplets and small aerosol particlesFootnote a) continue to be the primary source of transmission for SARS-CoV-2. Infections can occur when respiratory mucosa (eyes, nose or mouth) are exposed to infectious respiratory particles. Individuals who are infected with SARS-CoV-2 virus can release infectious respiratory particles in a range of sizes when talking, breathing, singing, exercising, coughing, sneezing. These particles can remain suspended in the air and be inhaled into the respiratory tract of another person and cause infection. It is also assumed that some degree of contact transmission occurs through contaminated surfaces or objects.
Aim and scope
The Public Health Agency of Canada (PHAC) develops national evidence-informed IPC guidance to complement provincial and territorial public health efforts in monitoring, preventing, and controlling healthcare-associated infections. Guidance will evolve with new scientific evidence, as well as with careful consideration of implications for practice in areas of uncertainty. National-level guidance should always be used in conjunction with relevant provincial, territorial and local policies and regulations. PHAC guidance does not supersede provincial, territorial, and local policies and regulations. PHAC will continue to consider new evidence as it becomes available. This guidance is for all healthcare settings (acute care, long-term care, home care and ambulatory/outpatient care). For guidance on public health measures for COVID-19, please refer to Coronavirus disease (COVID-19) - Canada.ca
Hierarchy of controls
Continue to implement and re-evaluate the hierarchy of controls within the healthcare environment including:
Engineering controls
- Heating, ventilation and air condition systems which are properly installed and regularly inspected and maintained. Ventilation/air exchanges should meet Canadian Standards Association (CSA) standards, and where possible, optimized to reduce the risk of transmission in closed spaces. The use of portable HEPA filters may be considered by IPC and facilities personnel to supplement existing ventilation strategies, especially in areas where ventilation does not meet CSA standards and where transmission has been a persistent problem.
Administrative controls
- Organizational risk assessment
- Organizational risk assessments are completed and repeated as the factors affecting transmission change, to determine potential risks for contamination and transmission of SARS-CoV-2 to HCWs, other staff, patients and visitors in all healthcare settings
- Source masking
- Consider implementation of source masking based on epidemiological and clinical factors and/or organizational risk assessment (refer to Masking for source control)
- Facilities should ensure availability of medical masks for all HCWs, patients, and visitors at facility entry points and throughout the facility for use as required
- Screening and surveillance (refer to Screening and surveillance)
- Patient placement and accommodation (refer to Patient placement and accommodation)
- Environmental cleaning, waste, and linen management
- Waste and soiled linen are managed according to facility environmental cleaning policies and procedures
- The care environment is adequately cleaned and disinfected using Health Canada approved hospital or healthcare disinfectants
- Occupational health and safety (OHS)
- HCW IPC education and training, testing and monitoring for compliance are in place, tracked, recorded, and kept up-to-date
- COVID-19 vaccines are promoted and offered as per national, provincial/territorial, or local guidelines
- Processes and written procedures, using inclusive and non-stigmatizing language are used, to reflect the organizational risk assessment and are in place to reduce HCW exposures to COVID-19
- HCWs, other staff, and workers with signs or symptoms of COVID-19 are not recommended to return to the healthcare setting until they have been cleared to do so according to local and jurisdictional public health guidance and facility OHS policies
- Details pertaining to national immunization recommendations are available at: National Advisory Committee on Immunization (NACI): Statements and publications - Canada.ca
- Policies are in place to manage visitors with signs or symptoms of COVID-19 (refer to Visitors)
Screening and surveillance
- Active (e.g., screeners at facility entrances) or passive (e.g., through self-reporting) screening of staff, visitors, and patients at facility access points are in place as per local and jurisdictional public health guidance and facility IPC policies
- Screening may include signage (accessible and multilingual as required) posted at all points of public and patient access, automated processes, questioning at appointment booking or upon registration, use of apps, etc.
- Processes are in place to promptly identify and manage all individuals, including inpatients, with signs or symptoms of COVID-19 infection
- Signage (accessible and multilingual as required) should be posted at all points of public and patient access to instruct patients and visitors to alert staff upon arrival if they have any signs or symptoms of COVID-19
- Signage should direct visitors not to visit if they are experiencing signs or symptoms of COVID-19 or any other communicable infection or if they have been instructed and/or required to isolate
Patient placement and accommodation
A patient who is suspected or confirmed to have COVID-19 should be cared for in a single room, on precautions with a toilet and sink designated for their use. If no single rooms are available, cohorting patients with confirmed COVID-19 could be considered in consultation with IPC. All facilities should have a pre-established cohorting plan.
Clear signage (universal infographics/multilingual as required) indicating Droplet and Contact precautions with appropriate PPE (for COVID-19) should be in place, and posted in such a way that is clearly visible to all entering the patient room or bed space.
Posters illustrating the correct method for donning on and doffing PPE should be considered for display inside and outside of each room of a patient who is suspected or confirmed to have COVID-19 for easy visual cues.
Personal protective equipment
Recommended PPE for all patient encounters should be based on a Point of Care Risk Assessment (PCRA) which should include consideration of:
- Patients not yet clinically evaluated (e.g., emergency areas)
- Likelihood of exposure to SARS-CoV-2 and other pathogens based on:
- specific interaction (e.g., requirement of extensive or prolonged close proximity)
- specific task (e.g., performance of higher risk examinations, such as those of the mouth, nose, and throat)
- specific patient factors (e.g., patient's ability to tolerate a mask), patient signs, symptoms, and behaviours (such as shouting, coughing, or heavy breathing)
- specific environment
- A PCRA may include:
- community epidemiology of SARS-CoV-2
- ventilation
Recommended PPE for direct care of patients with suspected or confirmed COVID-19:
- Fit-tested, seal-checked N95 respirator
- Eye protection (e.g., goggles or face shield)
- Gown
- Gloves
Every HCW should have access to a fit-tested respirator, so that they can put it on quickly if the need is identified during the PCRA.
Consider implementing universal use of respirators for all HCWs during all patient care encounters in specific units or areas of facility at higher risk of SARS-CoV-2 transmission, e.g., COVID-19 designated units, emergency departments, open space critical care areas, areas with high frequency of aerosol-generating medical procedures (AGMPs), etc.
Routine practices and additional precautions
Routine practices, including hand hygiene, are in place for the care of all patients. In addition to routine practices, droplet and contact precautions with appropriate PPE for COVID-19 should be used when caring for patients with suspected or confirmed COVID-19. Please refer to PHAC's Routine Practices and Additional Precautions for Preventing the Transmission of Infection in Healthcare Settings (2013) guidance document.
Information should be provided to staff, visitors, and patients who are asked to wear a respirator or medical mask about the importance of performing hand hygiene prior to putting on, and after removing or touching their mask, to reduce risk of self-contamination.
Individuals should also be informed about the steps for proper hand hygiene, and that wearing a respirator or medical mask does not lessen the need to adhere to other measures to reduce SARS-CoV-2 transmission.
Communication materials for visitors should consider the needs of diverse populations such as those with disabilities and those who may not be fluent in either English or French.
Aerosol exposure and aerosol-generating medical procedures (AGMPs)
Historically, certain medical procedures, known as AGMPs, were thought to pose a higher risk for HCWs on the basis of case–control studies, mainly from SARS-CoV-1, which reported associations between selected procedures and HCW infections. As evidence is evolving it remains prudent to continue to use fit-tested, seal-checked N95 respirators, eye protection, gowns and gloves for all AGMPs on patients with suspected or confirmed COVID-19.
Discontinuation of additional precautions
The duration and discontinuation of additional precautions for an individual patient or unit (where precautions may be universally applied during a COVID-19 outbreak) should be determined on a case-by-case basis, in consultation with the IPC program and in accordance with local, provincial or territorial public health guidance and organizational policies. The duration of additional precautions for a symptomatic patient with COVID-19 should be for a minimum of 10 days from onset of symptoms (and a minimum of 10 days from first positive testing for patients who remain asymptomatic), and may be longer dependent upon duration of symptoms, disease severity and the presence of any underlying immunocompromising conditions.
Masking for source control
Medical masks can be worn by HCWs, staff, patients, visitors, caregivers, and any other individual present in the healthcare setting for the purpose of protecting others by preventing the spread of bacteria and virus to others. This is known as masking for source control. This can be applied at the individual level (e.g., individual with respiratory signs or symptoms) or more broadly (e.g., all HCWs, visitors, and patients). Masks used for the purpose of source control should be of medical grade and well-fitting.
Individual masking for source control
- Source control is recommended for individuals in health care settings who have suspected or confirmed COVID-19, or with symptoms and signs of a respiratory infection.
- Patients with suspected or confirmed COVID-19 or respiratory infection should wear a well-fitting medical mask when outside of their room or bedspace (in multi-bedded rooms)
- HCWs with suspected or confirmed COVID-19, or with symptoms and signs of a respiratory infection, should wear a well-fitting medical mask and refer to their facility's OHS policies
Broader masking for source control
- Based on the epidemiological and clinical context, facilities should consider implementing broad masking for source control for all HCWs, visitors, and patients in clinical areas and spaces where HCWs, other staff, and visitors may come into contact with patients (e.g., patient rooms, clinical units, hallways, elevators, waiting rooms).
- The decision to implement broader masking for source control should be made in consideration of the following epidemiological and clinical factors:
- Epidemiological context, including:
- Increasing community transmission
- Facility/unit outbreaks of COVID-19 or other respiratory infections
- Increasing hospitalizations and ICU admissions
- Increasing staff COVID-19 cases
- Clinical context, including working:
- With immunocompromised persons or those at greater risk of acquiring an infection
- In clinical areas/units at higher risk of SARS-CoV-2 transmission (e.g., COVID-19 designated units, emergency departments, open space critical care areas, oncological units, hemodialysis units, etc.)
- Epidemiological context, including:
If implementing broad masking for source control, consider the impact on persons with cognitive impairment or where masks could impede communication or otherwise hinder the ability to provide equitable care.
Implementation of broad source masking may vary based on jurisdictional and facility-specific context, including organizational risk assessment.
Patients who are unable or unwilling to mask should not be denied care. Protocols should be in place to allow for the safe assessment and treatment of symptomatic, unmasked patients. Patient masking is not recommended for paediatric patients two years of age or younger or for any patient unable to tolerate masking for medical or developmental reasons.
Visitors
Visitation policies and restrictions may vary across jurisdictions and facilities depending on the degree of local transmission of SARS-CoV-2. Policies should aim to balance the risk of introduction and transmission of SARS-CoV-2, and the promotion of patient and family-centered care including physical, psychological, emotional and spiritual needs of patients.
Visitors exhibiting signs or symptoms of an acute respiratory infection, including COVID-19, should not enter the facility. However, if visitation is required (e.g., end of life decisions), refer to institutional policies and procedures.
IPC information including the importance of adherence to IPC measures should be provided to visitors.
Communication materials for patients and visitors should address the needs of diverse populations such as those with disabilities and those who may not be fluent in either English or French.
Footnotes
- Footnote 1
-
There is a transition away from the use of the terms "droplet" and "aerosol" as evidence suggests that respiratory particles exist on a continuum of sizes. As these terms are still commonly used in practice, they are included for clarity and to ensure appropriate application of IPC precautions.
References
- Adenaiye, O. O., Lai, J., Bueno de Mesquita, P. J., Hong, F., Youssefi, S., German, J., Tai, S. H. S., Albert, B., Schanz, M., Weston, S., Hang, J., Fung, C., Chung, H. K., Coleman, K. K., Sapoval, N., Treangen, T., Berry, I. M., Mullins, K., Frieman, M.,... Milton, D. K. (2022). Infectious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection. Clinical Infectious Diseases, 75(1), e241-e248. 10.1093/cid/ciab797
- Alexander Wilhelm, Marek Widera, Katharina Grikscheit, Tuna Toptan, Barbara Schenk, Christiane Pallas, Melinda Metzler, Niko Kohmer, Sebastian Hoehl, Fabian A. Helfritz, Timo Wolf, Udo Goetsch, & Sandra Ciesek. (2021). Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies. medRxiv,, 2021.12.07.21267432. 10.1101/2021.12.07.21267432
- Alghounaim, M., Caya, C., Alothman, K., Alhasawi, A., & Papenburg, J. (2022). SARS-CoV-2 Clinical Characteristics and Viral Shedding in Kuwait. Medical Principles and Practice, 31(1), 93-97. 10.1159/000521408
- Alsved, M., Matamis, A., Bohlin, R., Richter, M., Bengtsson, P. -., Fraenkel, C. -., Medstrand, P., & Löndahl, J. (2020). Exhaled respiratory particles during singing and talking. Aerosol Science and Technology, 54(11), 1245-1248. 10.1080/02786826.2020.1812502
- Arai, T., Mukai, S., Kazama, R., Ogawa, Y., Nishida, K., Hatanaka, K., & Gohma, I. (2022). Persistent viral shedding of severe acute respiratory syndrome coronavirus 2 after treatment with bendamustine and rituximab: A case report. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 28(6), 810-813. 10.1016/j.jiac.2022.01.014
- Asadi, S., Wexler, A. S., Cappa, C. D., Barreda, S., Bouvier, N. M., & Ristenpart, W. D. (2019). Aerosol emission and superemission during human speech increase with voice loudness. Springer Science and Business Media LLC. 10.1038/s41598-019-38808-z
- Asadi, S., Wexler, A. S., Cappa, C. D., Barreda, S., Bouvier, N. M., & Ristenpart, W. D. (2020). Effect of voicing and articulation manner on aerosol particle emission during human speech. Public Library of Science (PLoS).
- Batra, A., Clark, J. R., Kang, A. K., Ali, S., Patel, T. R., Shlobin, N. A., Hoffman, S. C., Lim, P. H., Orban, Z. S., Visvabharathy, L., Graham, E. L., Sullivan, D. P., Muller, W. A., Chou, S. H. -., Ungvári, Z., Koralnik, I. J., & Liotta, E. M. (2022). Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients. GeroScience, 44(3), 1241-1254. 10.1007/s11357-022-00561-z
- Bourouiba, L. (2020). Turbulent Gas Clouds and Respiratory Pathogen Emissions
Potential Implications for Reducing Transmission of COVID-19. JAMA Insights, 323(18)10.1001/jama.2020.4756 - Brooks, J., Beezhold, D., Noti, J., Coyle, J., Derk, R., Blanchere, F., & Lindsley, W. (2021). Maximizing Fit for Cloth and Medical Procedure Masks to Improve Performance and Reduce SARS-CoV-2 Transmission and Exposure, 2021. Morbidity and Morality Weekly Report, 70(7) https://www.cdc.gov/mmwr/volumes/70/wr/mm7007e1.htm
- Brown, J., Gregson, F. K. A., Shrimpton, A., Cook, T. M., Bzdek, B. R., Reid, J. P., & Pickering, A. E. (2020). A quantitative evaluation of aerosol generation during tracheal intubation and extubation. Wiley. 10.1111/anae.15292
- Buonanno, G., Stabile, L., & Morawska, L. (2020). Estimation of airborne viral emission: Quanta emission rate of SARS-CoV-2 for infection risk assessment. Https://Pubmed.Ncbi.Nlm.Nih.Gov/32416374/, 10.1016/j.envint.2020.105794
- Chan, P., & Fang, C. (2020). The role of ventilation in tuberculosis control.120(6)10.1016/j.jfma.2020.11.003
- Chan, V., Hoi-Lam Ng, H., Rahman, L., Tang, A., Tange, K., Mok, A., Lui, J., Ho, K., Chan, S., Wong, S., Teoh, A., Chan, A., Wong, M., Yuan, Y., & Teoh, J. (2021). Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies.49(7)10.1097/CCM.0000000000004965
- Chen, W., Ling, W., Lu, C., Hao, Y., Lin, Z., Ling, L., Huang, J., Li, G., & Yan, G. (2009). Which preventive measures might protect health care workers from SARS? BMC Public Health, https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-9-81#citeas
- Chen, W., Zhang, N., Wei, J., Yen, H., & Li, Y. (2020). Short-range airborne route dominates exposure of respiratory infection during close contact. Building and Environment, 176, 106859. 10.1016/j.buildenv.2020.106859
- Cheng, V. C., Fung, K. S., Siu, G. K., Wong, S. C., Cheng, L. S., Wong, M. S., Lee, L. K., Chan, W. M., Chau, K. Y., Leung, J. S., Chu, A. W., Chan, W. S., Lu, K. K., Tam, K. K., Ip, J. D., Leung, K. S., Lung, D. C., Tse, H., To, K. K., & Yuen, K. Y. (2021). Nosocomial Outbreak of Coronavirus Disease 2019 by Possible Airborne Transmission Leading to a Superspreading Event. Clinical Efectious Diseases, 76(6) https://doi.org/10.1093/cid/ciab313
- Chopoorian, A., Banada, P., Reiss, R., Elson, D., Desind, S., Park, C., Banik, S., Hennig, E., Wats, A., Togba, A., Wei, A., Daivaa, N., Palo, L., Hirsch, M., Campbell, C., Saiganesh, P., Alland, D., & Xie, Y. L. (2023). Persistence of SARS-CoV-2 in saliva: Implications for late-stage diagnosis and infectious duration. Public Library of Science (PLoS). 10.1371/journal.pone.0282708
- Coleman, K. K., Tay, D. J. W., Tan, K. S., Ong, S. W. X., Than, T. S., Koh, M. H., Chin, Y. Q., Nasir, H., Mak, T. M., Chu, J. J. H., Milton, D. K., Chow, V. T. K., Tambyah, P. A., Chen, M., & Tham, K. W.Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Respiratory Aerosols Emitted by Patients With Coronavirus Disease 2019 (COVID-19) While Breathing, Talking, and Singing. Clinical Efectious Diseases, 74(10), 1722-1728. https://doi.org/10.1093/cid/ciab691
- Crawford, C., Vanoli, E., Decorde, B., Lancelot, M., Duprat, C., Josserand, C., Jilesen, J., Bouadma, L., & Timsit, J. F. (2021). Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure. Scientific Reports, 118(1), 11778. https://doi.org/10.1038/s41598-021-91265-5
- Doung-Ngern, P., Suphanchaimat, R., Panjangampatthana, A., Janekrongtham, C., Ruampoom, D., Daochaeng, N., Eungkanit, N., Pisitpayat, N., Srisong, N., Yasopa, O., Plernprom, P., Promduangsi, P., Kumphon, P., Suangtho, P., Watakulsin, P., Chaiya, S., Kripattanapong, S., Chantian, T., Bloss, E., Namwat, C., … Limmathurotsakul, D. (2020). Case-Control Study of Use of Personal Protective Measures and Risk for SARS-CoV 2 Infection. Emerging Infectious Diseases, 26(11), 2607–2616. https://doi.org/10.3201/eid2611.203003
- Echternach, M., Gantner, S., Peters, G., Westphalen, C., Benthaus, T., Jakubaß, B., Kuranova, L., Döllinger, M., & Kniesburges, S. (2020). Impulse Dispersion of Aerosols during Singing and Speaking: A Potential COVID-19 Transmission Pathway. American Journal of Respiratory and Critical Care Medicine, 202(11), 1584–1587. https://doi.org/10.1164/rccm.202009-3438LE
- Edwards, D. A., Ausiello, D., Salzman, J., Devlin, T., Langer, R., Beddingfield, B. J., Fears, A. C., Doyle-Meyers, L. A., Redmann, R. K., Killeen, S. Z., Maness, N. J., & Roy, C. J. (2021). Exhaled aerosol increases with COVID-19 infection, age, and obesity. Proceedings of the National Academy of Sciences of the United States of America, 118(8) https://doi.org/10.1073/pnas.2021830118
- European Centre for Disease Control. (2023). Implications for the EU/EEA of the spread of the
SARS-CoV-2 Omicron XBB.1.5 sub-lineage. https://www.ecdc.europa.eu/sites/default/files/documents/TAB-Implications%20for%20the%20EU-EEA%20of%20the%20spread%20of%20the%20SARS-CoV-2%20Omicron%20XBB.1.5%20sub-lineage.pdf - Fennelly, K. P. (2020). Particle sizes of infectious aerosols: implications for infection control. The Lancet, 8(9), 914-924. https://doi.org/10.1016/S2213-2600(20)30323-4
- Gaeckle, N. T., Lee, J., Park, Y., Kreykes, G., Evans, M. D., & Hogan, C. J., Jr. (2020). Aerosol Generation from the Respiratory Tract with Various Modes of Oxygen Delivery. American Journal of Respiratory and Critical Care Medicine, 202(8), 1115–1124. https://doi.org/10.1164/rccm.202006-2309OC
- Goldberg, L., Levinsky, Y., Marcus, N., Hoffer, V., Gafner, M., Hadas, S., Kraus, S., Mor, M., & Scheuerman, O. (2021). SARS-CoV-2 Infection Among Health Care Workers Despite the Use of Surgical Masks and Physical Distancing-the Role of Airborne Transmission. Open Forum Infectious Diseases, 8(3) https://doi.org/10.1093/ofid/ofab036
- Greenhalgh, T., Jimenez, J. L., Prather, K. A., Tufekci, Z., Fisman, D., & Schooley, R. (2021). Ten scientific reasons in support of airborne transmission of SARS-CoV-2. Lancet (London, England), 397(10285), 1603–1605. https://doi.org/10.1016/S0140-6736(21)00869-2
- Hamner, L., Dubbel, P., Capron, I., Ross, A., Jordan, A., Lee, J., Lynn, J., Ball, A., Narwal, S., Russell, S., Patrick, D., & Leibrand, H. (2020). High SARS-CoV-2 Attack Rate Following Exposure at a Choir Practice - Skagit County, Washington, March 2020. Morbidity and Morality Weekly Report, 69(19), 606-610. https://doi.org/10.15585/mmwr.mm6919e6
- Hause, A. M., Baggs, J., Marquez, P., Myers, T. R., Gee, J., Su, J. R., Zhang, B., Thompson, D., Shimabukuro, T. T., Shay, D. K., Walensky, R. P., Houry, D., Jernigan, D. B., Bunnell, R., Layden, J., & Iademarco, M. F.COVID-19 Vaccine Safety in Children Aged 5-11 Years -United States, November 3-December 19, 2021
- He, S., Fang, Y., Yang, J., & Wang, W. (2022). Association between immunity and viral shedding duration in non-severe SARS-CoV-2 Omicron variant-infected patients.10.3389/978-2-8325-2252-3
- Huang, J., Shen, H., Sun, C., Chen, W., Chen, Y., Feng, J., & Yang, K. (2022). COVID-19-associated pulmonary aspergillosis is associated with increased in-hospital mortality and prolonged SARS-CoV-2 viral shedding. Journal of the Formosan Medical Association, 121(12), 2617-2625. 10.1016/j.jfma.2022.07.006
- Huang, P., Wu, T., Cheng, C., Chen, C., Huang, C., Tsao, K., Lin, C., Chung, T., Lai, C., Yang, C. -. T., Chen, Y., Chiu, C., Huang, L., Chiu, Y., Hou, K., Chen, M., Huang, Y., Tsai, L., Su, Y.,... Wu, Y. (2022). A hospital cluster of COVID-19 associated with a SARS-CoV-2 superspreading event. Journal of Microbiology, Immunology and Infection, 55(3), 436-444. 10.1016/j.jmii.2021.07.006
- Jacob, J. T., Baker, J. M., Fridkin, S. K., Lopman, B. A., Steinberg, J. P., Christenson, R. H., King, B., Leekha, S., O'Hara, L. M., Rock, P., Schrank, G. M., Hayden, M. K., Hota, B., Lin, M. Y., Stein, B. D., Caturegli, P., Milstone, A. M., Rock, C., Voskertchian, A., Reddy, S. C., … Harris, A. D. (2021). Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel. JAMA Network Open, 4(3) https://doi.org/10.1001/jamanetworkopen.2021.1283
- Jefferson, T., Spencer, E. A., Conly, J. M., Rosca, E. C., Maltoni, S., Brassey, J., Onakpoya, I. J., Evans, D. H., Heneghan, C. J., & Plüddemann, A. (2023). Viral cultures, cycle threshold values and viral load estimation for assessing SARS-CoV-2 infectiousness in haematopoietic stem cell and solid organ transplant patients: a systematic review. The Journal of Hospital Infection, 132, 62-72. 10.1016/j.jhin.2022.11.018
- Johansson, M. A., Quandelacy, T. M., Kada, S., Prasad, P. V., Steele, M., Brooks, J. T., Slayton, R. B., Biggerstaff, M., & Butler, J. C. (2021). SARS-CoV-2 Transmission From People Without COVID-19 Symptoms. JAMA Network Open, 4(1), e2035057. 10.1001/jamanetworkopen.2020.35057
- Jung, J., Kim, J. Y., Park, H., Park, S., Lim, J. S., Lim, S. Y., Bae, S., Lim, Y., Kim, E. O., Kim, J., Park, M., & Kim, S. (2022a). Transmission and Infectious SARS-CoV-2 Shedding Kinetics in Vaccinated and Unvaccinated Individuals. JAMA Network Open, 5(5), e2213606. 10.1001/jamanetworkopen.2022.13606
- Jung, J., Lee, J., Kim, S., Park, S., Lim, Y., Kim, E. O., Park, H., Park, M., & Kim, S. (2022b). Evaluation of In-Hospital Cluster of COVID-19 Associated With a Patient With Prolonged Viral Shedding Using Whole-Genome Sequencing. Journal of Korean Medical Science, 37(39), e289. 10.3346/jkms.2022.37.e289
- Kang, S. W., Park, H., Kim, J. Y., Park, S., Lim, S. Y., Lee, S., Bae, J., Kim, J., Bae, S., Jung, J., Kim, M. J., Chong, Y. P., Lee, S., Choi, S., Kim, Y. S., Yun, S., Park, M., & Kim, S. (2022). Clinical scoring system to predict viable viral shedding in patients with COVID-19. Journal of Clinical Virology, 157, 105319. 10.1016/j.jcv.2022.105319
- Kang, S., Kim, J. Y., Park, H., Lim, S. Y., Kim, J., Chang, E., Bae, S., Jung, J., Kim, M. J., Chong, Y. P., Lee, S., Choi, S., Kim, Y. S., Park, M., & Kim, S. (2022). Comparison of secondary attack rate and viable virus shedding between patients with SARS‐CoV‐2 Delta and Omicron variants: A prospective cohort study. Wiley. 10.1002/jmv.28369
- Karan, A., Klompas, M., Tucker, R., Baker, M., Vaidya, V., & Rhee, C. (2022). The Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission from Patients With Undiagnosed Coronavirus Disease 2019 (COVID-19) to Roommates in a Large Academic Medical Center. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 74(6), 1097-1100. 10.1093/cid/ciab564
- Kawasuji, H., Takegoshi, Y., Kaneda, M., Ueno, A., Miyajima, Y., Kawago, K., Fukui, Y., Yoshida, Y., Kimura, M., Yamada, H., Sakamaki, I., Tani, H., Morinaga, Y., & Yamamoto, Y. (2020). Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients. PloS One, 15(12), e0243597. 10.1371/journal.pone.0243597
- Kaya, B. S., Yılmam, İ, Çakır Edis, E., Karabulut, D., Elmaslar Mert, T., Eryıldız, C., & Demir, M. (2022). Case of Prolonged Viral Shedding: Chronic, Intermittan COVID-19? Turkish Thoracic Journal, 23(1), 85-88. 10.5152/TurkThoracJ.2022.21141
- Kim, D. Y., Lin, M. Y., Jennings, C., Li, H., Jung, J. H., Moore, N. M., Ghinai, I., Black, S. R., Zaccaro, D. J., Brofman, J., & Hayden, M. K. (2022). Duration of Replication-Competent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Shedding Among Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19). Oxford University Press (OUP). 10.1093/cid/ciac405
- Klompas, M., Baker, M. A., Griesbach, D., Tucker, R., Gallagher, G. R., Lang, A. S., Fink, T., Cumming, M., Smole, S., Madoff, L. C., & Rhee, C. (2021a). Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From Asymptomatic and Presymptomatic Individuals in Healthcare Settings Despite Medical Masks and Eye Protection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 73(9), 1693-1695. 10.1093/cid/ciab218
- Klompas, M., Baker, M. A., Rhee, C., Tucker, R., Fiumara, K., Griesbach, D., Bennett-Rizzo, C., Salmasian, H., Wang, R., Wheeler, N., Gallagher, G. R., Lang, A. S., Fink, T., Baez, S., Smole, S., Madoff, L., Goralnick, E., Resnick, A., Pearson, M.,... Morris, C. A. (2021b). A SARS-CoV-2 Cluster in an Acute Care Hospital. Annals of Internal Medicine, 174(6), 794-802. 10.7326/M20-7567
- Klompas, M., Baker, M., & Rhee, C. (2021c). What Is an Aerosol-Generating Procedure? JAMA Surgery, 156(2), 113-114. 10.1001/jamasurg.2020.6643
- Klompas, M., Ye, S., Vaidya, V., Ochoa, A., Baker, M. A., Hopcia, K., Hashimoto, D., Wang, R., & Rhee, C. (2022). Association Between Airborne Infection Isolation Room Utilization Rates and Healthcare Worker Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections in 2 Academic Hospitals. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 74(12), 2230-2233. 10.1093/cid/ciab849
- Kuznetsova, N. A., Ogarkova, D. A., Gushchin, V. A., Antipyat, N. А, Bacalin, V. V., Burgasova, O. A., Vasilchenko, L. A., Samkov, A. A., Simakova, Y. V., Divisenko, E. V., Siniavin, A. E., Tkachuk, A. P., Kolobukhina, L. V., Shidlovskaya, E. V., Tyurin, I. N., Kruzhkova, I. S., Zlobin, V. I., Nikiforova, M. A., Odnoralov, M. A., & Gintsburg, A. L. (2023). Evaluation of the dynamics of detection of viable SARS-CoV-2 (Coronaviridae: Betacoronavirus: Sarbecovirus) in biological samples obtained from patients with COVID-19 in a health care setting, as one of the indicators of the infectivity of the virus. Voprosy Virusologii, 68(2), 105-116. 10.36233/0507-4088-160
- Lee, J., Yun, K. W., Jeong, H., Kim, B., Kim, M. J., Park, J. H., Shin, H. S., Oh, H. S., Sung, H., Song, M. G., Cho, S. I., Kim, S. Y., Kang, C. K., Choe, P. G., Park, W. B., Kim, N. J., Oh, M., Choi, E. H., Park, S.,... Seong, M. (2022). SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients. Virulence, 13(1), 1242-1251. 10.1080/21505594.2022.2101198
- Lee, L. Y. W., Rozmanowski, S., Pang, M., Charlett, A., Anderson, C., Hughes, G. J., Barnard, M., Peto, L., Vipond, R., Sienkiewicz, A., Hopkins, S., Bell, J., Crook, D. W., Gent, N., Walker, A. S., Peto, T. E. A., & Eyre, D. W. (2022). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectivity by Viral Load, S Gene Variants and Demographic Factors, and the Utility of Lateral Flow Devices to Prevent Transmission. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 74(3), 407-415. 10.1093/cid/ciab421
- Leung, N. H. L. (2021). Transmissibility and transmission of respiratory viruses. Nature Reviews.Microbiology, 19(8), 528-545. 10.1038/s41579-021-00535-6
- Leung, N. H. L., Chu, D. K. W., Shiu, E. Y. C., Chan, K., McDevitt, J. J., Hau, B. J. P., Yen, H., Li, Y., Ip, D. K. M., Peiris, J. S. M., Seto, W., Leung, G. M., Milton, D. K., & Cowling, B. J. (2020). Respiratory virus shedding in exhaled breath and efficacy of face masks. Nature Medicine, 26(5), 676-680. 10.1038/s41591-020-0843-2
- Leung, N. H. L., Xu, C., Ip, D. K. M., & Cowling, B. J. (2015). Review Article: The Fraction of Influenza Virus Infections That Are Asymptomatic: A Systematic Review and Meta-analysis. Epidemiology (Cambridge, Mass.), 26(6), 862-872. 10.1097/EDE.0000000000000340
- Leung, W. F., Chorlton, S., Tyson, J., Al-Rawahi, G. N., Jassem, A. N., Prystajecky, N., Masud, S., Deans, G. D., Chapman, M. G., Mirzanejad, Y., Murray, M. C. M., & Wong, P. H. P. (2022). COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report. International Journal of Infectious Diseases, 114, 178-182. 10.1016/j.ijid.2021.10.045
- Li, R., Jin, C., Zhang, L., Kong, D., Hu, K., Xuan, M., Liu, Q., Li, S., Zhang, K., & Xue, Y. (2023). Clinical characteristics and risk factors analysis of viral shedding time in mildly symptomatic and asymptomatic patients with SARS-CoV-2 Omicron variant infection in Shanghai. Environ Earth Sci, 10.3389/fpubh.2022.1073387
- Li, Z., Zhong, Q., Li, W., Zhang, D., Wang, W., Yang, F., & He, K. (2022). Clinical characteristics of patients with confirmed and asymptomatic SARS-CoV-2 infection in China. PloS One, 17(8), e0273150. 10.1371/journal.pone.0273150
- Lindsley, W. G., Derk, R. C., Coyle, J. P., Martin, S. B. J., Mead, K. R., Blachere, F. M., Beezhold, D. H., Brooks, J. T., Boots, T., & Noti, J. D. (2021). Efficacy of Portable Air Cleaners and Masking for Reducing Indoor Exposure to Simulated Exhaled SARS-CoV-2 Aerosols - United States, 2021. MMWR.Morbidity and Mortality Weekly Report, 70(27), 972-976. 10.15585/mmwr.mm7027e1
- Liu, K., Yang, X., Feng, C., Chen, M., Zhang, C., & Wang, Y. (2022). Clinical features and independent predictors for recurrence of positive SARS‐CoV‐2 RNA: A propensity score‐matched analysis. Journal of Medical Virology, 94(4), 1402-1411. 10.1002/jmv.27450
- Liu, W., Tang, F., Fang, L., De Vlas, S. J., Ma, H., Zhou, J., Looman, C. W. N., Richardus, J. H., & Cao, W. (2009). Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Tropical Medicine & International Health, 14(Suppl 1), 52-59. 10.1111/j.1365-3156.2009.02255.x
- Loeb, M., McGeer, A., Henry, B., Ofner, M., Rose, D., Hlywka, T., Levie, J., McQueen, J., Smith, S., Moss, L., Smith, A., Green, K., & Walter, S. D. (2004). SARS among critical care nurses, Toronto. Emerging Infectious Diseases, 10(2), 251-255. 10.3201/eid1002.030838
- Loudon, R. G., & Roberts, R. M. (1967). Droplet expulsion from the respiratory tract. The American Review of Respiratory Disease, 95(3), 435-442. 10.1164/arrd.1967.95.3.435
- Ma, H., Wang, H., Fang, L., Jiang, J., Wei, M., Liu, W., Zhao, Q., Ma, J., & Cao, W. (2004). A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 25(9), 741-744.
- Maan, I., Paraskevopoulou, S. M., Cwynarski, K., Shrestha, M., Waters, L., Miller, R., & Ahmed, N. (2022). Prolonged SARS-CoV-2 shedding in a person living with advanced HIV and diffuse large B-cell lymphoma: a case report. Informa UK Limited. 10.1080/23744235.2022.2055136
- Marks, M., Millat-Martinez, P., Ouchi, D., Roberts, C. H., Alemany, A., Corbacho-Monné, M., Ubals, M., Tobias, A., Tebé, C., Ballana, E., Bassat, Q., Baro, B., Vall-Mayans, M., G-Beiras, C., Prat, N., Ara, J., Clotet, B., & Mitjà, O. (2021). Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study. The Lancet.Infectious Diseases, 21(5), 629-636. 10.1016/S1473-3099(20)30985-3
- McEllistrem, M. C., Clancy, C. J., Buehrle, D. J., Singh, N., Lucas, A., Sirianni, V., & Decker, B. K. (2021). SARS-CoV-2 is associated with high viral loads in asymptomatic and recently symptomatic healthcare workers. PloS One, 16(3), e0248347. 10.1371/journal.pone.0248347
- Meiring, S., Tempia, S., Bhiman, J. N., Buys, A., Kleynhans, J., Makhasi, M., McMorrow, M., Moyes, J., Quan, V., Walaza, S., du Plessis, M., Wolter, N., von Gottberg, A., & Cohen, C. (2022). Prolonged Shedding of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at High Viral Loads Among Hospitalized Immunocompromised Persons Living With Human Immunodeficiency Virus (HIV), South Africa. Clinical Infectious Diseases, 75(1), e144-e156. 10.1093/cid/ciac077
- Miller, S. L., Nazaroff, W. W., Jimenez, J. L., Boerstra, A., Buonanno, G., Dancer, S. J., Kurnitski, J., Marr, L. C., Morawska, L., & Noakes, C. (2021). Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale superspreading event. Indoor Air, 31(2), 314-323. 10.1111/ina.12751
- Morawska, L., Johnson, G. R., Ristovski, Z. D., Hargreaves, M., Mengersen, K., Corbett, S., Chao, C. Y. H., Li, Y., & Katoshevski, D. (2009). Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities. Journal of Aerosol Science, 40(3), 256-269. 10.1016/j.jaerosci.2008.11.002
- Moritz, E. D., McKay, S. L., Tobolowsky, F. A., LaVoie, S. P., Waltenburg, M. A., Lecy, K. D., Thornburg, N. J., Harcourt, J. L., Tamin, A., Folster, J. M., Negley, J., Brown, A. C., McDonald, L. C., & Kutty, P. K. (2022). Repeated antigen testing among severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–positive nursing home residents. Infection Control and Hospital Epidemiology, 43(12), 1918-1921. 10.1017/ice.2021.370
- Nardell, E. A., & Nathavitharana, R. R. (2020). Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection. Jama, 324(2), 141-142. 10.1001/jama.2020.7603
- Nomura, T., Kitagawa, H., Kakimoto, M., Kaiki, Y., Nazmul, T., Miyamori, D., Omori, K., Shigemoto, N., Ito, M., Sakaguchi, T., & Ohge, H. (2022a). Duration of infectious viral shedding in patients with mild to moderate COVID-19 treated with REGN-CoV2. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 28(7), 912-917. 10.1016/j.jiac.2022.03.013
- Nomura, T., Kitagawa, H., Omori, K., Shigemoto, N., Kakimoto, M., Nazmul, T., Shime, N., Sakaguchi, T., & Ohge, H. (2022b). Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 28(1), 19-23. 10.1016/j.jiac.2021.09.006
- Nussenblatt, V., Roder, A. E., Das, S., de Wit, E., Youn, J., Banakis, S., Mushegian, A., Mederos, C., Wang, W., Chung, M., Pérez-Pérez, L., Palmore, T., Brudno, J. N., Kochenderfer, J. N., & Ghedin, E. (2022). Yearlong COVID-19 Infection Reveals Within-Host Evolution of SARS-CoV-2 in a Patient With B-Cell Depletion. The Journal of Infectious Diseases, 225(7), 1118-1123. 10.1093/infdis/jiab622
- O'Kelly, E., Arora, A., Pirog, S., Ward, J., & Clarkson, P. J. (2021). Comparing the fit of N95, KN95, surgical, and cloth face masks and assessing the accuracy of fit checking. PloS One, 16(1), e0245688. 10.1371/journal.pone.0245688
- Oksanen, L. A. H., Sanmark, E., Oksanen, S. A., Anttila, V., Paterno, J. J., Lappalainen, M., Lehtonen, L., & Geneid, A. (2021a). Sources of healthcare workers' COVID-19 infections and related safety guidelines. International Journal of Occupational Medicine and Environmental Health, 34(2), 239-249. 10.13075/ijomeh.1896.01741
- Oksanen, L. A. H., Sanmark, E., Oksanen, S. A., Anttila, V., Paterno, J. J., Lappalainen, M., Lehtonen, L., & Geneid, A. (2021b). Sources of healthcare workers' COVID-19 infections and related safety guidelines. International Journal of Occupational Medicine and Environmental Health, 34(2), 239-249. 10.13075/ijomeh.1896.01741
- O'Neil, C. A., Li, J., Leavey, A., Wang, Y., Hink, M., Wallace, M., Biswas, P., Burnham, C. D., Babcock, H. M., & Centers for Disease Control and Prevention Epicenters Program. (2017). Characterization of Aerosols Generated During Patient Care Activities. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 65(8), 1335-1341. 10.1093/cid/cix535
- Papineni, R. S., & Rosenthal, F. S. (1997). The size distribution of droplets in the exhaled breath of healthy human subjects. Journal of Aerosol Medicine : The Official Journal of the International Society for Aerosols in Medicine, 10(2), 105-116. 10.1089/jam.1997.10.105
- Pei, L., Gao, Z., Yang, Z., Wei, D., Wang, S., Ji, J., & Jiang, B. (2006). Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao.Yi Xue Ban = Journal of Peking University.Health Sciences, 38(3), 271-275.
- Pitak-Arnnop, P., Tangmanee, C., Meningaud, J., & Neff, A. (2022). Prolonged viral shedding identified from external splints and intranasal packings in immediately cured COVID-19 patients with nasal fractures: A retrospective study. Journal of Stomatology, Oral and Maxillofacial Surgery, 123(3), 287-291. 10.1016/j.jormas.2022.04.003
- Randall, K., Ewing, E. T., Marr, L. C., Jimenez, J. L., & Bourouiba, L. (2021). How did we get here: what are droplets and aerosols and how far do they go? A historical perspective on the transmission of respiratory infectious diseases. Interface Focus, 11(6), 20210049. 10.1098/rsfs.2021.0049
- Sajgalik, P., Garzona-Navas, A., Csécs, I., Askew, J. W., Lopez-Jimenez, F., Niven, A. S., Johnson, B. D., & Allison, T. G. (2021). Characterization of Aerosol Generation During Various Intensities of Exercise. Chest, 160(4), 1377-1387. 10.1016/j.chest.2021.04.041
- Schijven, J., Vermeulen, L. C., Swart, A., Meijer, A., Duizer, E., & de Roda Husman, A. M. (2021). Quantitative Microbial Risk Assessment for Airborne Transmission of SARS-CoV-2 via Breathing, Speaking, Singing, Coughing, and Sneezing. Environmental Health Perspectives, 129(4), 47002. 10.1289/EHP7886
- Shah, A., Wood, R., Gribben, C., Caldwell, D., Bishop, J., Weir, A., Kennedy, S., Reid, M., Smith-Palmer, A., Goldberg, D., McMenamin, J., Fischbacher, C., Robertson, C., Hutchinson, S., McKeigue, P., Colhoun, H., & McAllister, D. (2020). Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: nationwide linkage cohort study. Bmj, 371, m3582. 10.1136/bmj.m3582
- Sheward, D. J., Kim, C., Ehling, R. A., Pankow, A., Castro Dopico, X., Dyrdak, R., Martin, D. P., Reddy, S. T., Dillner, J., Karlsson Hedestam, G. B., Albert, J., & Murrell, B. (2022). Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study. The Lancet.Infectious Diseases, 22(6), 813-820. 10.1016/S1473-3099(22)00129-3
- Sickbert-Bennett, E. E., Samet, J. M., Clapp, P. W., Chen, H., Berntsen, J., Zeman, K. L., Tong, H., Weber, D. J., & Bennett, W. D. (2020). Filtration Efficiency of Hospital Face Mask Alternatives Available for Use During the COVID-19 Pandemic. JAMA Internal Medicine, 180(12), 1607-1612. 10.1001/jamainternmed.2020.4221
- Stadnytskyi, V., Anfinrud, P., & Bax, A. (2021). Breathing, speaking, coughing or sneezing: What drives transmission of SARS-CoV-2? Journal of Internal Medicine, 290(5), 1010-1027. 10.1111/joim.13326
- Stadnytskyi, V., Bax, C. E., Bax, A., & Anfinrud, P. (2020). The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proceedings of the National Academy of Sciences of the United States of America, 117(22), 11875-11877. 10.1073/pnas.2006874117
- Stockwell, R. E., Ballard, E. L., O'Rourke, P., Knibbs, L. D., Morawska, L., & Bell, S. C. (2019). Indoor hospital air and the impact of ventilation on bioaerosols: a systematic review. The Journal of Hospital Infection, 103(2), 175-184. 10.1016/j.jhin.2019.06.016
- Tang, J. W., Marr, L. C., Li, Y., & Dancer, S. J. (2021). Covid-19 has redefined airborne transmission. BMJ (Clinical Research Ed.), 373, n913. 10.1136/bmj.n913
- Teleman, M. D., Boudville, I. C., Heng, B. H., Zhu, D., & Leo, Y. S. (2004). Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore. Epidemiology and Infection, 132(5), 797-803. 10.1017/s0950268804002766
- Thornton, C. S., Huntley, K., Berenger, B. M., Bristow, M., Evans, D. H., Fonseca, K., Franko, A., Gillrie, M. R., Lin, Y., Povitz, M., Shafey, M., Conly, J. M., & Tremblay, A. (2022). Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values. Springer Science and Business Media LLC. 10.1186/s13756-022-01067-1
- Tran, K., Cimon, K., Severn, M., Pessoa-Silva, C. L., & Conly, J. (2012). Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PloS One, 7(4), e35797. 10.1371/journal.pone.0035797
- Trannel, A. M., Kobayashi, T., Dains, A., Abosi, O. J., Jenn, K. E., Meacham, H., Sheeler, L. L., Etienne, W., Kukla, M. E., Alsuhaibani, M., Holley, S., Strandberg, K., Marra, A. R., Kritzman, J., Ford, B., Wellington, M., Diekema, D. J., & Salinas, J. L. (2022). Coronavirus disease 2019 (COVID-19) incidence after exposures in shared patient rooms in a tertiary-care center in Iowa, July 2020-May 2021. Infection Control and Hospital Epidemiology, 43(12), 1910-1913. 10.1017/ice.2021.313
- Villaseñor-Echavarri, R., Gomez-Romero, L., Martin-Onraet, A., Herrera, L. A., Escobar-Arrazola, M. A., Ramirez-Vega, O. A., Barrientos-Flores, C., Mendoza-Vargas, A., Hidalgo-Miranda, A., Vilar-Compte, D., & Cedro-Tanda, A. (2023). SARS-CoV-2 Genome Variations in Viral Shedding of an Immunocompromised Patient with Non-Hodgkin's Lymphoma. MDPI AG. 10.3390/v15020377
- Wilson, N. M., Marks, G. B., Eckhardt, A., Clarke, A. M., Young, F. P., Garden, F. L., Stewart, W., Cook, T. M., & Tovey, E. R. (2021). The effect of respiratory activity, non-invasive respiratory support and facemasks on aerosol generation and its relevance to COVID-19. Anaesthesia, 76(11), 1465-1474. 10.1111/anae.15475
- World Health Organization. (2023a). COVID-19 Epidemiological Update - 24 November 2023. https://www.who.int/publications/m/item/covid-19-epidemiological-update---24-november-2023
- World Health Organization. (2023b). Infection prevention and control in the context of COVID-19: a guideline, 21 December 2023. https://www.who.int/publications/i/item/WHO-2019-nCoV-IPC-guideline-2023.4
- 100. Yang, L., Zhong, J., Wang, W., Zhou, F., Tong, Z., Zheng, Y., & Chen, X. (2023). Yang et al., 202310.5144/0256-
- Yin Mo, David W. Eyre, Sheila F. Lumley, Timothy M. Walker, Robert H. Shaw, Denise O'Donnell, Lisa Butcher, Katie Jeffery, Christl A. Donnelly, Oxford COVID infection review team, & Ben S. Cooper. (2021). Transmission dynamics of SARS-CoV-2 in the hospital setting. medRxiv, , 2021.04.28.21256245. 10.1101/2021.04.28.21256245
- Yin, Y., Zeng, T., Lai, M., Luan, Z., Wang, K., Ma, Y., Hu, Z., Wang, K., & Peng, Z. (2023). Impact of antibody-level on viral shedding in B.1.617.2 (Delta) variant-infected patients analyzed using a joint model of longitudinal and time-to-event data. American Institute of Mathematical Sciences (AIMS). 10.3934/mbe.2023390
- Zhang, X., Zhang, L., Zhang, K., Chen, Y., & Wang, L. (2023). Immunocompromised states caused the prolonged duration of viral shedding in middle‐aged and elderly hemodialysis patients infected with the Omicron variant of COVID‐19. Therapeutic Apheresis and Dialysis, 27(4), 720-725. 10.1111/1744-9987.13969
- Zhong, W., Yang, X., Jiang, X., Duan, Z., Wang, W., Sun, Z., Chen, W., Zhang, W., Xu, J., Cheng, J., Yuan, X., & Li, Y. (2023). Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2.10.3389/978-2-8325-2252-3
- Zhou, X., Huang, X., Sun, T., Jin, X., Tian, Z., Xue, M., Kang, J., Gao, B., Xu, A., Chen, Y., Jia, Y., & Liu, S. (2023). Chronological changes of viral shedding in adult inpatients with Omicron infection in Shanghai, China. Frontiers in Immunology, 14, 1090498. 10.3389/fimmu.2023.1090498
Page details
- Date modified: