Page 8: Human Antimicrobial Use Report – 2014 - Appendix B – Additional community pharmacy dispensing data

Appendix B – Additional community pharmacy dispensing data

Table B.1: Dollars spent (in millions) on antimicrobial products dispensed by community pharmacies in Canada; oral antimicrobials (2004-2009), oral and parenteral antimicrobials (2010-2014)
Antimicrobial Rank  DIRI 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Amoxicillin 1 - 69.11 75.57 75.90 76.51 95.43 100.15 107.32 121.33 118.57 118.84 126.57
Amoxicillin and enzyme inhibitor 7 - 18.62 20.18 20.96 22.08 23.13 24.09 21.84 27.23 27.17 29.29 31.90
Azithromycin 5 - 85.39 93.40 75.21 64.71 64.26 64.32 58.54 57.70 54.23 47.29 46.82
Cefadroxil 23 - 1.97 2.02 2.28 2.43 2.58 2.76 2.50 2.30 3.15 3.48 3.97
Cefazolin 24 - - - - - - - 1.78 1.83 1.52 2.73 3.15
Cefixime 20 - 4.24 4.40 4.31 4.86 5.32 5.67 7.04 7.97 8.55 9.46 6.10
Cefprozil 13 - 36.61 38.96 38.85 33.32 26.41 25.45 24.16 21.54 17.11 14.44 14.75
Ceftazidime 33 - - - - - - - 0.48 0.61 0.41 0.79 1.26
Ceftriaxone 27 - - - - - - - 0.87 0.99 1.10 1.98 2.62
Cefuroxime 15 - 15.50 15.71 14.74 14.34 13.86 14.11 12.72 13.61 12.40 12.78 13.59
Cephalexin 3 - 26.38 27.81 29.34 29.85 38.11 39.02 40.76 45.10 47.29 50.38 52.91
Ciprofloxacin 4 - 85.23 72.50 72.24 73.76 74.12 72.26 74.11 71.15 63.59 55.85 52.41
Clarithromycin 2 - 106.88 121.68 125.49 127.81 120.48 121.65 119.95 126.32 117.39 97.45 85.04
Clindamycin 10 - 21.50 22.34 24.45 25.73 26.16 26.19 29.33 27.32 24.43 22.94 22.58
Cloxacillin 21 - 7.20 6.30 5.97 5.56 6.67 6.35 8.24 6.17 6.12 5.58 5.12
Colistin 32 Table b.1 - Footnote * - - - - - - 2.81 2.37 2.40 2.31 2.23
Doxycycline 9 - 8.46 8.87 9.99 11.47 12.45 13.03 15.50 17.53 18.93 23.46 27.94
Ertapenem 19 Table b.1 - Footnote * - - - - - - 0.61 1.01 1.33 5.58 6.56
Erythromycin 28 - 9.39 8.31 7.92 6.89 6.22 5.47 5.42 4.02 3.57 2.89 2.46
Fosfomycin 35 Table b.1 - Footnote * 0.18 0.14 0.11 0.07 0.01 0.03 0.02 0.00 0.02 0.37 1.09
Levofloxacin 18 - 25.67 19.35 15.85 19.03 21.23 18.80 13.00 11.77 10.37 9.55 9.82
Linezolid 22 Table b.1 - Footnote * 2.28 3.06 2.90 3.26 3.29 3.47 3.80 3.71 3.92 4.56 4.00
Meropenem 30 Table b.1 - Footnote * - - - - - - 0.34 0.58 0.58 1.89 2.27
Metronidazole 12 - 8.32 8.59 9.35 9.29 9.74 10.11 12.70 13.43 14.03 14.42 14.98
Minocycline 11 - 34.75 35.06 35.30 34.97 32.59 30.56 33.05 30.68 26.60 23.48 21.62
Moxifloxacin 6 Table b.1 - Footnote * 20.71 25.15 31.53 35.78 36.49 38.17 38.46 40.24 37.80 34.67 32.50
Nitrofurantoin 8 - 12.88 13.80 15.36 16.62 18.29 20.30 22.70 25.06 27.36 28.13 29.81
Norfloxacin 29 - 10.74 9.84 9.07 7.80 7.17 6.38 5.60 4.42 3.47 2.75 2.43
Penicillin V 14 - 13.88 13.82 13.86 13.86 15.03 15.28 14.32 12.99 12.55 12.85 14.72
Piperacillin and tazobactam 25 Table b.1 - Footnote * - - - - - - 1.02 1.42 0.88 2.77 3.14
Sulfamethoxazole and trimethoprim 16 - 13.93 13.03 13.03 13.12 13.33 13.41 15.17 14.44 13.81 14.79 13.56
Tetracycline 26 - 4.85 4.45 4.13 3.86 3.66 3.67 2.07 2.78 2.99 2.84 2.68
Tobramycin 31 Table b.1 - Footnote * - - - - - - 2.24 2.24 1.81 1.97 2.27
Trimethoprim 34 - 1.12 1.01 1.03 1.04 0.98 1.16 1.27 1.29 1.34 1.29 1.24
Vancomycin 17 - 4.18 4.76 4.60 5.25 5.46 5.96 8.98 11.06 11.17 12.12 12.28
TOTAL 0 - 678.70 698.42 679.96 672.68 689.00 692.79 712.76 735.79 701.25 680.54 681.63
Table B.2: Dollars spent (000s) on antimicrobial products dispensed by retail pharmacies in Canadian provinces Footnote v , 2014
Antimicrobial Rank DIRI BC AB SK MB ON QC NB NS PEI NF
Amoxicillin 1 - 13854.3 16686.8 5457.0 4698.2 54249.4 22147.5 2493.2 3341.3 478.1 3166.1
Amoxicillin and enzyme inhibitor 7 - 3483.7 4575.5 1015.9 1645.0 9660.5 8895.0 692.1 824.6 271.8 836.7
Azithromycin 5 - 3127.0 5008.7 2178.4 2600.4 20145.0 10632.3 976.6 885.3 206.2 1059.2
Cefadroxil 23 - 19.4 49.9 0.2 1.1 100.6 3770.1 26.6 0.9 0.1 0.0
Cefazolin 24 - 5.6 100.2 32.2 4.4 68.7 2660.6 106.5 167.3 1.5 0.8
Cefixime 20 - 967.0 1281.2 74.4 112.5 2092.2 1140.2 100.8 138.9 40.9 147.0
Cefprozil 13 - 84.8 1080.6 99.6 340.5 7100.0 5483.1 190.8 347.3 13.0 9.9
Ceftriaxone 27 - 130.9 68.5 35.3 8.3 451.3 1674.1 113.4 113.3 8.2 16.0
Cefuroxime 15 - 2354.1 1191.1 380.6 275.1 5129.6 2018.1 885.2 618.5 34.5 706.7
Cephalexin 3 - 8665.6 8866.8 3441.4 3018.1 20170.5 3651.9 1421.1 1872.1 301.1 1500.6
Ciprofloxacin 4 - 6383.0 5569.4 1672.2 1656.0 16362.4 16757.9 882.8 1306.6 186.6 1632.8
Clarithromycin 2 - 9109.8 11039.9 2212.3 1894.4 30645.8 24012.0 1747.2 2346.8 352.3 1678.9
Clindamycin 10 - 2510.6 2959.3 1102.2 1066.3 7292.7 6004.8 561.1 658.9 66.9 358.9
Cloxacillin 21 - 767.1 741.9 324.9 328.7 1479.3 897.4 154.3 179.3 31.8 213.3
Colistin 32 Table b.2 - Footnote * 291.4 43.3 47.3 83.7 41.6 1505.4 109.9 55.5 0.0 47.5
Doxycycline 9 - 4974.6 3822.1 1830.6 864.5 9949.6 4386.7 551.7 1009.5 133.4 418.7
Ertapenem 19 Table b.2 - Footnote * 9.7 109.1 0.0 0.6 51.8 6118.5 43.7 221.6 0.0 0.4
Erythromycin 28 - 531.8 293.0 246.5 141.3 792.9 175.3 56.0 116.2 46.9 64.3
Levofloxacin 18 - 374.1 1394.5 128.6 904.0 4249.6 2256.6 150.8 290.9 27.2 45.6
Linezolid 22 Table b.2 - Footnote * 433.3 416.5 156.1 107.7 984.1 1820.3 22.4 24.1 11.7 24.8
Meropenem 30 Table b.2 - Footnote * 1.1 10.3 0.0 1.7 35.8 2144.4 60.9 19.5 0.0 0.0
Metronidazole 12 - 1789.1 2068.7 576.1 447.8 6295.5 2485.6 334.1 477.0 59.3 449.2
Minocycline 11 - 2412.1 3153.8 223.8 872.5 7308.6 6345.5 350.9 615.5 54.5 284.8
Moxifloxacin 6 Table b.2 - Footnote * 4082.2 2158.8 822.4 507.3 11519.3 11495.8 751.0 554.7 140.2 466.3
Nitrofurantoin 8 - 5044.7 3371.3 1436.3 783.7 13857.3 2957.9 670.5 1104.5 120.7 459.5
Norfloxacin 29 - 45.3 210.8 7.1 20.5 1729.5 77.0 187.5 53.8 14.6 82.3
Penicillin V 14 - 1867.0 1980.4 381.1 508.2 4729.8 4205.5 377.3 408.0 64.7 193.5
Piperacillin and tazobactam 25 Table b.2 - Footnote * 0.0 14.9 1.2 0.7 8.1 2968.6 122.9 27.6 0.0 0.0
Sulfamethoxazole and trimethoprim 16 - 1855.9 1636.8 791.7 694.8 5088.6 2036.6 387.3 606.6 86.4 370.8
Tetracycline 26 - 348.5 194.3 79.1 105.8 1547.9 219.6 40.4 71.3 19.6 52.3
Tobramycin 31 Table b.2 - Footnote * 84.1 82.4 43.3 75.0 448.9 1074.9 157.4 175.6 12.3 112.6
Vancomycin 17 - 728.0 963.4 153.2 85.3 1942.8 7413.3 379.6 523.7 24.6 69.7
TOTAL 0 - 77193.4 81787.3 25130.8 23914.4 247507.0 173798.5 15347.2 19445.4 2823.9 14678.3
Table B.3: Raw kilograms of active ingredient dispensed by retail pharmacies in Canada; oral antimicrobials (2004-2009), oral and parenteral antimicrobials (2010-2014)
Antimicrobial RankTable b.3 - Footnote * 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Amoxicillin 1 49490 51633 52365 52454 53918 55135 57436 62975 61390 61745 65426
Amoxicillin and enzyme inhibitor 3 7478 8399 8941 9755 10523 10999 9670 12903 13886 15435 17108
Azithromycin 11 2670 2915 2876 2802 2869 2915 2880 3813 3828 3253 3304
Cefadroxil 20 707 730 821 875 926 983 874 779 1049 1151 1315
Cefazolin 22 - - - - - - 161 236 286 1017 972
Cefprozil 12 4377 4589 4536 4183 4109 4095 4092 4188 3695 3328 3246
Cefuroxime 13 2677 2741 2606 2597 2573 2603 2265 2567 2505 2696 2868
Cephalexin 2 19626 20877 22183 22502 23148 22660 22409 24285 24894 25903 26339
Ciprofloxacin 5 12627 12952 13827 14436 14702 14280 14750 15229 14860 14243 13870
Clarithromycin 6 12731 14498 15258 16133 16560 16943 16734 17641 16755 14578 13185
Clindamycin 8 4447 4504 4983 5310 5558 5570 6162 6183 6130 6159 6198
Cloxacillin 14 6604 5868 5612 5165 4780 4383 5495 4040 3565 3073 2698
Doxycycline 17 820 864 930 1028 1117 1165 1397 1543 1658 1791 1945
Erythromycin 21 5223 4446 3961 3423 3297 2700 2554 1759 1653 1382 1183
Levofloxacin 19 1878 1678 1536 1474 1484 1425 1349 1392 1361 1378 1449
Metronidazole 7 5238 5311 5564 5588 5789 5921 6347 6393 6527 6644 6874
Minocycline 16 2396 2430 2470 2441 2463 2345 2543 2454 2218 2102 1955
Moxifloxacin 18 1231 1478 1828 2046 2049 2094 2076 2133 1971 1786 1664
Nitrofurantoin 15 1152 1211 1324 1390 1503 1625 1740 1862 1975 1992 2076
Penicillin V 9 7843 8046 8003 7852 7618 7511 6963 6131 5850 5434 5257
Sulfamethoxazole and trimethoprim 4 20518 18891 18554 18129 18177 18234 18212 18103 16928 16737 16712
Tetracycline 10 7829 7410 6871 6221 5840 5746 3125 3922 4105 3849 3625

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