Page 8: Human Antimicrobial Use Report – 2014 - Appendix B – Additional community pharmacy dispensing data

Appendix B – Additional community pharmacy dispensing data

Table B.1: Dollars spent (in millions) on antimicrobial products dispensed by community pharmacies in Canada; oral antimicrobials (2004-2009), oral and parenteral antimicrobials (2010-2014)
Antimicrobial	Rank	DIRI	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014
Table b.1 - Footnote * Ranked from greatest to least dollars spent in 2014. Return to first Table b.1 - Footnote * referrer Antimicrobials were removed from this table if they represented <0.5% of dollars spent in 2014. These are: amikacin, ampicillin, bacampicillin, bacitracin, cefaclor, cefepime, cefotaxime, cefoxitin, ceftobiprole, chloramphenicol, daptomycin, demeclocycline, dicloxacillin, fidaxomicin, flucloxacillin, fusidic acid, gatifloxacin, gemifloxacin, gentamicin, grepafloxacin, Imipenem and cilastatin, kanamycin, lincomycin, methenamine hippurate, methenamine mandelate, nalidixic acid, neomycin, ofloxacin, oxacillin, penicillin g, piperacillin, pivampicillin, pivmecillinam, spiramycin, streptomycin, sulfadiazine, sulfadiazine and trimethoprim, sulfamethizole, sulfamethoxazole, sulfapyridine, sulfisoxazole, sulfonamides, combinations with other antibacterials (excl. trimethoprim), telithromycin, ticarcillin and clavulanic acid, and tigecycline.
Amoxicillin	1	-	69.11	75.57	75.90	76.51	95.43	100.15	107.32	121.33	118.57	118.84	126.57
Amoxicillin and enzyme inhibitor	7	-	18.62	20.18	20.96	22.08	23.13	24.09	21.84	27.23	27.17	29.29	31.90
Azithromycin	5	-	85.39	93.40	75.21	64.71	64.26	64.32	58.54	57.70	54.23	47.29	46.82
Cefadroxil	23	-	1.97	2.02	2.28	2.43	2.58	2.76	2.50	2.30	3.15	3.48	3.97
Cefazolin	24	-	-	-	-	-	-	-	1.78	1.83	1.52	2.73	3.15
Cefixime	20	-	4.24	4.40	4.31	4.86	5.32	5.67	7.04	7.97	8.55	9.46	6.10
Cefprozil	13	-	36.61	38.96	38.85	33.32	26.41	25.45	24.16	21.54	17.11	14.44	14.75
Ceftazidime	33	-	-	-	-	-	-	-	0.48	0.61	0.41	0.79	1.26
Ceftriaxone	27	-	-	-	-	-	-	-	0.87	0.99	1.10	1.98	2.62
Cefuroxime	15	-	15.50	15.71	14.74	14.34	13.86	14.11	12.72	13.61	12.40	12.78	13.59
Cephalexin	3	-	26.38	27.81	29.34	29.85	38.11	39.02	40.76	45.10	47.29	50.38	52.91
Ciprofloxacin	4	-	85.23	72.50	72.24	73.76	74.12	72.26	74.11	71.15	63.59	55.85	52.41
Clarithromycin	2	-	106.88	121.68	125.49	127.81	120.48	121.65	119.95	126.32	117.39	97.45	85.04
Clindamycin	10	-	21.50	22.34	24.45	25.73	26.16	26.19	29.33	27.32	24.43	22.94	22.58
Cloxacillin	21	-	7.20	6.30	5.97	5.56	6.67	6.35	8.24	6.17	6.12	5.58	5.12
Colistin	32	^{Table b.1 - Footnote *}	-	-	-	-	-	-	2.81	2.37	2.40	2.31	2.23
Doxycycline	9	-	8.46	8.87	9.99	11.47	12.45	13.03	15.50	17.53	18.93	23.46	27.94
Ertapenem	19	^{Table b.1 - Footnote *}	-	-	-	-	-	-	0.61	1.01	1.33	5.58	6.56
Erythromycin	28	-	9.39	8.31	7.92	6.89	6.22	5.47	5.42	4.02	3.57	2.89	2.46
Fosfomycin	35	^{Table b.1 - Footnote *}	0.18	0.14	0.11	0.07	0.01	0.03	0.02	0.00	0.02	0.37	1.09
Levofloxacin	18	-	25.67	19.35	15.85	19.03	21.23	18.80	13.00	11.77	10.37	9.55	9.82
Linezolid	22	^{Table b.1 - Footnote *}	2.28	3.06	2.90	3.26	3.29	3.47	3.80	3.71	3.92	4.56	4.00
Meropenem	30	^{Table b.1 - Footnote *}	-	-	-	-	-	-	0.34	0.58	0.58	1.89	2.27
Metronidazole	12	-	8.32	8.59	9.35	9.29	9.74	10.11	12.70	13.43	14.03	14.42	14.98
Minocycline	11	-	34.75	35.06	35.30	34.97	32.59	30.56	33.05	30.68	26.60	23.48	21.62
Moxifloxacin	6	^{Table b.1 - Footnote *}	20.71	25.15	31.53	35.78	36.49	38.17	38.46	40.24	37.80	34.67	32.50
Nitrofurantoin	8	-	12.88	13.80	15.36	16.62	18.29	20.30	22.70	25.06	27.36	28.13	29.81
Norfloxacin	29	-	10.74	9.84	9.07	7.80	7.17	6.38	5.60	4.42	3.47	2.75	2.43
Penicillin V	14	-	13.88	13.82	13.86	13.86	15.03	15.28	14.32	12.99	12.55	12.85	14.72
Piperacillin and tazobactam	25	^{Table b.1 - Footnote *}	-	-	-	-	-	-	1.02	1.42	0.88	2.77	3.14
Sulfamethoxazole and trimethoprim	16	-	13.93	13.03	13.03	13.12	13.33	13.41	15.17	14.44	13.81	14.79	13.56
Tetracycline	26	-	4.85	4.45	4.13	3.86	3.66	3.67	2.07	2.78	2.99	2.84	2.68
Tobramycin	31	^{Table b.1 - Footnote *}	-	-	-	-	-	-	2.24	2.24	1.81	1.97	2.27
Trimethoprim	34	-	1.12	1.01	1.03	1.04	0.98	1.16	1.27	1.29	1.34	1.29	1.24
Vancomycin	17	-	4.18	4.76	4.60	5.25	5.46	5.96	8.98	11.06	11.17	12.12	12.28
TOTAL	0	-	678.70	698.42	679.96	672.68	689.00	692.79	712.76	735.79	701.25	680.54	681.63

Table B.2: Dollars spent (000s) on antimicrobial products dispensed by retail pharmacies in Canadian provinces ^{Footnote v} , 2014
Antimicrobial	Rank	DIRI	BC	AB	SK	MB	ON	QC	NB	NS	PEI	NF
Table b.2 - Footnote * Ranked from greatest to least dollars spent in 2014. Return to first Table b.2 - Footnote * referrer Antimicrobials were removed from this table if they represented <0.5% of dollars spent in 2014. These are: amikacin, ampicillin, bacitracin, cefaclor, cefepime, cefotaxime, cefoxitin, ceftazidime, daptomycin, dicloxacillin, fidaxomicin, fosfomycin, fusidic acid, gentamicin, imipenem and cilastatin, lincomycin, methenamine mandelate, ofloxacin, oxacillin, penicillin g, piperacillin, spiramycin, streptomycin, sulfadiazine, ticarcillin and clavulanic acid, tigecycline, and trimethoprim.
Amoxicillin	1	-	13854.3	16686.8	5457.0	4698.2	54249.4	22147.5	2493.2	3341.3	478.1	3166.1
Amoxicillin and enzyme inhibitor	7	-	3483.7	4575.5	1015.9	1645.0	9660.5	8895.0	692.1	824.6	271.8	836.7
Azithromycin	5	-	3127.0	5008.7	2178.4	2600.4	20145.0	10632.3	976.6	885.3	206.2	1059.2
Cefadroxil	23	-	19.4	49.9	0.2	1.1	100.6	3770.1	26.6	0.9	0.1	0.0
Cefazolin	24	-	5.6	100.2	32.2	4.4	68.7	2660.6	106.5	167.3	1.5	0.8
Cefixime	20	-	967.0	1281.2	74.4	112.5	2092.2	1140.2	100.8	138.9	40.9	147.0
Cefprozil	13	-	84.8	1080.6	99.6	340.5	7100.0	5483.1	190.8	347.3	13.0	9.9
Ceftriaxone	27	-	130.9	68.5	35.3	8.3	451.3	1674.1	113.4	113.3	8.2	16.0
Cefuroxime	15	-	2354.1	1191.1	380.6	275.1	5129.6	2018.1	885.2	618.5	34.5	706.7
Cephalexin	3	-	8665.6	8866.8	3441.4	3018.1	20170.5	3651.9	1421.1	1872.1	301.1	1500.6
Ciprofloxacin	4	-	6383.0	5569.4	1672.2	1656.0	16362.4	16757.9	882.8	1306.6	186.6	1632.8
Clarithromycin	2	-	9109.8	11039.9	2212.3	1894.4	30645.8	24012.0	1747.2	2346.8	352.3	1678.9
Clindamycin	10	-	2510.6	2959.3	1102.2	1066.3	7292.7	6004.8	561.1	658.9	66.9	358.9
Cloxacillin	21	-	767.1	741.9	324.9	328.7	1479.3	897.4	154.3	179.3	31.8	213.3
Colistin	32	^{Table b.2 - Footnote *}	291.4	43.3	47.3	83.7	41.6	1505.4	109.9	55.5	0.0	47.5
Doxycycline	9	-	4974.6	3822.1	1830.6	864.5	9949.6	4386.7	551.7	1009.5	133.4	418.7
Ertapenem	19	^{Table b.2 - Footnote *}	9.7	109.1	0.0	0.6	51.8	6118.5	43.7	221.6	0.0	0.4
Erythromycin	28	-	531.8	293.0	246.5	141.3	792.9	175.3	56.0	116.2	46.9	64.3
Levofloxacin	18	-	374.1	1394.5	128.6	904.0	4249.6	2256.6	150.8	290.9	27.2	45.6
Linezolid	22	^{Table b.2 - Footnote *}	433.3	416.5	156.1	107.7	984.1	1820.3	22.4	24.1	11.7	24.8
Meropenem	30	^{Table b.2 - Footnote *}	1.1	10.3	0.0	1.7	35.8	2144.4	60.9	19.5	0.0	0.0
Metronidazole	12	-	1789.1	2068.7	576.1	447.8	6295.5	2485.6	334.1	477.0	59.3	449.2
Minocycline	11	-	2412.1	3153.8	223.8	872.5	7308.6	6345.5	350.9	615.5	54.5	284.8
Moxifloxacin	6	^{Table b.2 - Footnote *}	4082.2	2158.8	822.4	507.3	11519.3	11495.8	751.0	554.7	140.2	466.3
Nitrofurantoin	8	-	5044.7	3371.3	1436.3	783.7	13857.3	2957.9	670.5	1104.5	120.7	459.5
Norfloxacin	29	-	45.3	210.8	7.1	20.5	1729.5	77.0	187.5	53.8	14.6	82.3
Penicillin V	14	-	1867.0	1980.4	381.1	508.2	4729.8	4205.5	377.3	408.0	64.7	193.5
Piperacillin and tazobactam	25	^{Table b.2 - Footnote *}	0.0	14.9	1.2	0.7	8.1	2968.6	122.9	27.6	0.0	0.0
Sulfamethoxazole and trimethoprim	16	-	1855.9	1636.8	791.7	694.8	5088.6	2036.6	387.3	606.6	86.4	370.8
Tetracycline	26	-	348.5	194.3	79.1	105.8	1547.9	219.6	40.4	71.3	19.6	52.3
Tobramycin	31	^{Table b.2 - Footnote *}	84.1	82.4	43.3	75.0	448.9	1074.9	157.4	175.6	12.3	112.6
Vancomycin	17	-	728.0	963.4	153.2	85.3	1942.8	7413.3	379.6	523.7	24.6	69.7
TOTAL	0	-	77193.4	81787.3	25130.8	23914.4	247507.0	173798.5	15347.2	19445.4	2823.9	14678.3

Table B.3: Raw kilograms of active ingredient dispensed by retail pharmacies in Canada; oral antimicrobials (2004-2009), oral and parenteral antimicrobials (2010-2014)
Antimicrobial	Rank^{Table b.3 - Footnote *}	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014
Table b.3 - Footnote * Ranked from greatest to least mass of active ingredient dispensed in 2014. Return to Table b.3 - Footnote * referrer Antimicrobials were removed from this table if they represented <0.5% of mass of active ingredient dispensed in 2014. These are: amikacin, ampicillin, bacampicillin, bacitracin, cefaclor, cefepime, cefixime, cefotaxime, cefoxitin, ceftazidime, ceftobiprole, ceftriaxone, chloramphenicol, colistin, daptomycin, demeclocycline, dicloxacillin, ertapenem, fidaxomicin, flucloxacillin, fosfomycin, fusidic acid, gatifloxacin, gemifloxacin, gentamicin, grepafloxacin, imipenem and cilastatin, kanamycin, lincomycin, linezolid, meropenem, methenamine hippurate, methenamine mandelate, nalidixic acid, neomycin, norfloxacin, ofloxacin, oxacillin, penicillin g, piperacillin, Piperacillin and tazobactam, pivampicillin, pivmecillinam, spiramycin, streptomycin, sulfadiazine, sulfadiazine and trimethoprim, sulfamethizole, sulfamethoxazole, sulfapyridine, sulfisoxazole, sulfonamides, combinations with other antibacterials (excl. trimethoprim), telithromycin, ticarcillin and clavulanic acid, tigecycline, tobramycin, trimethoprim, and vancomycin.
Amoxicillin	1	49490	51633	52365	52454	53918	55135	57436	62975	61390	61745	65426
Amoxicillin and enzyme inhibitor	3	7478	8399	8941	9755	10523	10999	9670	12903	13886	15435	17108
Azithromycin	11	2670	2915	2876	2802	2869	2915	2880	3813	3828	3253	3304
Cefadroxil	20	707	730	821	875	926	983	874	779	1049	1151	1315
Cefazolin	22	-	-	-	-	-	-	161	236	286	1017	972
Cefprozil	12	4377	4589	4536	4183	4109	4095	4092	4188	3695	3328	3246
Cefuroxime	13	2677	2741	2606	2597	2573	2603	2265	2567	2505	2696	2868
Cephalexin	2	19626	20877	22183	22502	23148	22660	22409	24285	24894	25903	26339
Ciprofloxacin	5	12627	12952	13827	14436	14702	14280	14750	15229	14860	14243	13870
Clarithromycin	6	12731	14498	15258	16133	16560	16943	16734	17641	16755	14578	13185
Clindamycin	8	4447	4504	4983	5310	5558	5570	6162	6183	6130	6159	6198
Cloxacillin	14	6604	5868	5612	5165	4780	4383	5495	4040	3565	3073	2698
Doxycycline	17	820	864	930	1028	1117	1165	1397	1543	1658	1791	1945
Erythromycin	21	5223	4446	3961	3423	3297	2700	2554	1759	1653	1382	1183
Levofloxacin	19	1878	1678	1536	1474	1484	1425	1349	1392	1361	1378	1449
Metronidazole	7	5238	5311	5564	5588	5789	5921	6347	6393	6527	6644	6874
Minocycline	16	2396	2430	2470	2441	2463	2345	2543	2454	2218	2102	1955
Moxifloxacin	18	1231	1478	1828	2046	2049	2094	2076	2133	1971	1786	1664
Nitrofurantoin	15	1152	1211	1324	1390	1503	1625	1740	1862	1975	1992	2076
Penicillin V	9	7843	8046	8003	7852	7618	7511	6963	6131	5850	5434	5257
Sulfamethoxazole and trimethoprim	4	20518	18891	18554	18129	18177	18234	18212	18103	16928	16737	16712
Tetracycline	10	7829	7410	6871	6221	5840	5746	3125	3922	4105	3849	3625

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Date modified:: 2015-11-17