ARCHIVED - Rabies
Nationally notifiable since 1927
1.0 National Notification
Only confirmed cases of disease should be notified.
2.0 Type of Surveillance
Routine case-by-case notification to the federal level
3.0 Case Classification
3.1 Confirmed case
Clinical evidence of illness with laboratory confirmation of infection:
- detection of viral antigen in an appropriate clinical specimen, preferably the brain or the nerves surrounding hair follicles in the nape of the neck, by immunofluorescence
- isolation of rabies virus from saliva, cerebrospinal fluid (CSF), or central nervous system tissue using cell culture or laboratory animal
- detection of rabies virus RNA in an appropriate clinical specimen
3.2 Probable case
Clinical evidence of illness with laboratory evidence:
- demonstration of rabies-neutralizing antibody titre ≥ 5 (complete neutralization) in the serum or CSF or an unvaccinated person
4.0 Laboratory Comments
Negative results do not rule out rabies infection because viral material may not be detectable (e.g. early in infection). CSF frequently remains negative.
The presence of rabies-neutralizing antibodies can indicate an exposure to rabies virus antigen or passive immunization.
Negative serologic results do not rule out a rabies infection because antibody levels may not surpass the detection threshold (0.5 IU) and seroconversion is usually very late.
5.0 Clinical Evidence
Rabies is an acute encephalomyelitis that almost always progresses to coma or death within 10 days after the first symptom.
6.0 ICD Code(s)
6.1 ICD-10 Code(s)
- Sylvatic rabies
- Urban rabies
- Rabies, unspecified
6.2 ICD-9 Code(s)
7.0 Type of International Reporting
Probable case definitions are provided as guidelines to assist with case finding and public health management, and are not for national notification purposes.
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