Aluminum salts final content: chapter 2

2. Summary of information critical to assessment of "toxic" under CEPA 1999

• 2.1 Identity and physical/chemical properties
• 2.2 Entry characterization
  • 2.2.1 Production, import, export and use
    • 2.2.1.1 Aluminum chloride
    • 2.2.1.2 Aluminum nitrate
    • 2.2.1.3 Aluminum sulphate
  • 2.2.2 Sources and releases
    • 2.2.2.1 Natural sources
    • 2.2.2.2 Anthropogenic sources
• 2.3 Exposure characterization
  • 2.3.1 Environmental fate
    • 2.3.1.1 Air
    • 2.3.1.2 Water
    • 2.3.1.3 Sediment
    • 2.3.1.4 Soil
    • 2.3.1.5 Biota
  • 2.3.2 Environmental concentrations
    • 2.3.2.1 Air
      • 2.3.2.1.1 Ambient air
      • 2.3.2.1.2 Indoor air
    • 2.3.2.2 Water
      • 2.3.2.2.1 Surface water
      • 2.3.2.2.2 Drinking water
    • 2.3.2.3 Sediment
    • 2.3.2.4 Soil
    • 2.3.2.5 Biota
    • 2.3.2.6 Food
    • 2.3.2.7 Consumer products
      • 2.3.2.7.1 Prescription and non-prescription drugs
      • 2.3.2.7.2 Cosmetics
    • 2.3.2.8 Vaccines
  • 2.3.3 Toxicokinetics: human and experimental animals
    • 2.3.3.1 Absorption
      • 2.3.3.1.1 Oral absorption
      • 2.3.3.1.2 Dermal absorption
      • 2.3.3.1.3 Inhalation absorption
      • 2.3.3.1.4 Parenteral administration
      • 2.3.3.1.5 Summary of estimates of aluminum bioavailability
      • 2.3.3.1.6 Integrating bioavailability in human health risk assessment
    • 2.3.3.2 Distribution
    • 2.3.3.3 Elimination
• 2.4 Effects characterization
  • 2.4.1 Ecotoxicology
    • 2.4.1.1 Aquatic organisms
      • 2.4.1.1.1 Pelagic
      • 2.4.1.1.2 Benthic
    • 2.4.1.2 Terrestrial organisms
  • 2.4.2 Experimental mammal studies
    • 2.4.2.1 Acute toxicity
    • 2.4.2.2 Short-term toxicity (duration of exposure less than 90 days)
    • 2.4.2.3 Subchronic and chronic toxicity (exposure duration greater than 90 days, non-cancer endpoints)
    • 2.4.2.4 Reproductive and developmental toxicity
    • 2.4.2.5 Carcinogenicity
    • 2.4.2.6 Genotoxicity
  • 2.4.3 Human studies
    • 2.4.3.1 Human case studies of exposure to aluminum
    • 2.4.3.2 Epidemiological studies of aluminum exposure via drinking water
    • 2.4.3.3 Epidemiological investigations of exposure to aluminum in antacids, antiperspirants or food
    • 2.4.3.4 Epidemiological investigations of exposure to aluminum in vaccines
    • 2.4.3.5 Epidemiological investigations of occupational exposure to aluminum
  • 2.4.4 Mode of action of toxic effects of aluminum