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Identification of risk assessment priorities - Results of the 2019 review

Official title: Identification of Risk Assessment Priorities (IRAP) - Results of the 2019 Review

Environment and Climate Change Canada

Health Canada

December 2020

Identification-risk-assessment-priorities-results-2019-review.pdf [PDF - 1.38 MB]

Background

Under Canada’s Chemicals Management Plan (CMP), Environment and Climate Change Canada (ECCC) and Health Canada (HC) assess the risks posed by chemicals to Canadians and their environment. Priorities for assessment under the Canadian Environmental Protection Act, 1999 (CEPA) were identified in 2006 (ECCC, HC 2017). Recognizing that new information continues to be generated that could help inform the identification of substances of concern, a regular review of available information is undertaken by HC and ECCC. The approach, known as the Identification of Risk Assessment Priorities (IRAP), is outlined in the “Approach for identification of chemicals and polymers as risk assessment priorities under Part 5 of the Canadian Environmental Protection Act, 1999 (CEPA 1999)” (Environment Canada, Health Canada 2014).

The cyclical IRAP approach is a systematic compilation and review of information from a large number of information sources. It enables the Government of Canada to communicate how emerging issues are tracked, and to identify and prioritize substances requiring further work. In the approach document, the process for identifying additional priorities is described in three steps: 

The approach used for the 2019 review is fundamentally similar to the approaches used in previous cycles (ECCC, HC 2015, 2016, 2018). This report describes the manner in which the approach was applied to this review, as well as the results. 

Scope of 2019 review

The scope of each review cycle identifies the range of substances considered for prioritization and the type of information used to support prioritization decisions. The 2019 review consisted of identifying new information that would constitute indicators of hazard or exposure for the following types of substances:

The 2019 review also included substances that were nominated as potential risk assessment candidates by HC or ECCC officials, based on knowledge acquired through research or expertise gained from previous assessments. These substances were considered for review even if they did not meet the scope criteria defined above (e.g., substances not on the DSL). Information found on toxic substances (i.e., on Schedule 1) through the review process will be considered further to determine if follow-up activities may be appropriate. 

Acquisition

The acquisition phase involves consideration of diverse information sources, including emerging technologies, to help identify and inform potential priorities. The number and types of sources consulted continues to evolve over time, as new sources are identified or previously identified sources expand and grow. Some sources may only be relevant for the prioritization of substances based on either ecological considerations or human health considerations, while others are relevant for both. Consequently, the same source may be considered or weighted differently for ecological and human health evaluation of substances. 

The sources represent a mix of national and international databases, assessments, and reports, which vary from highly specific to very broad sources of information used in risk assessment. A comprehensive list of the sources of information consulted in this review is provided in Appendix A. The following are examples of the types of information used to identify indicators of hazard or exposure for the 2019 review: 

Any new information from these sources is considered, in addition to the information compiled from previous IRAP review cycles.

After reviewing the pertinent information for approximately 23 000 substances within the scope of the 2019 IRAP review, approximately 16 000 substances were identified that had one or more types of information that required further evaluation under the approach. This included substances that had information on either hazard or exposure indicators, or a combination of the two.

Evaluation

Approximately 16 000 substances identified as candidates in the 2019 IRAP review were triaged to separate those that are unlikely to require further work based on information available at this time, from those that represent potential new priorities for assessment, or if further information is required to make that determination. 

The guiding principles and considerations that support this evaluation step are described in the “Approach for identification of chemicals and polymers as risk assessment priorities under Part 5 of the Canadian Environmental Protection Act, 1999 (CEPA 1999)” (Environment Canada, Health Canada 2014). 

Results and action

As a result of the evaluation, this IRAP review cycle identified 629 of the ~16 000 substances as having sufficient indicators of hazard or exposure to merit further activity, including i) requiring further scoping/problem formulation, ii) additional data gathering, or iii) monitoring of ongoing international activity. The remaining substances do not require further action at this time. The outcomes, and the number of evaluated substances that fall within each one, are shown in Table 1.

Table 1: Outcomes of the 2019 Review
2019 IRAP review outcome Total number of substances
Further scoping/problem formulation 85
Additional data gathering 443
Monitoring of ongoing international activity 101
No further action at this time 15 629

As Table 1 illustrates, 85 substances were identified, based on indications of both hazard and exposure, as needing more scoping as a next step before determining the most appropriate course of action. Accordingly, an outcome of further scoping/problem formulation was recommended.Footnote 1 This outcome entails an analysis of available data, data needs, areas of focus (e.g., ecological, human health, consumer products, or environmental media), potentially relevant legislation, possible substance groups, and other considerations to inform the most appropriate action for the candidate substance(s). The intent is to publish a summary of the results of this analysis for public comment. The 85 substances recommended for further scoping are proposed to be considered in 25 scoping exercises or problem formulation documents: 21 individual substances and 4 groups of substances (see Appendix B for the rationales and Appendix C for the substances included in the groups). During further scoping/problem formulation, these lists of  substances may be further refined by removing substances or expanding to include additional similar substances not currently listed. 

The need for additional data has been identified for 443 substances (see Appendix D). These substances were seen as having relevant hazard (442 substances) or exposure (1 substance) indicators, but require further data gathering to determine whether they could be priorities for risk assessment under CEPA (e.g., information is needed on the Canadian context). The most common scenario leading to a need for data gathering is when there is an indicator of hazard, yet the commercial status in Canada is uncertain. The options available for data gathering include, but are not limited to, addition to upcoming mandatory surveys conducted under section 71 of CEPA (e.g., DSL Inventory Updates, targeted surveys) as well as voluntary survey initiatives, research or surveillance and monitoring activities. Any data gathering results would then be considered in future review cycles.

Another 101 substances were identified as undergoing international activities (see Appendix E). Monitoring the outcomes of these international activities will inform what, if any, actions are required in future review cycles.

Finally, for the majority of substances evaluated within the 2019 IRAP review (15 629 substances), it was determined that there was not a sufficient basis for recommending further action at this time. These substances will continue to be considered in future IRAP review cycles.

References

Canada, Dept. of the Environment. 2017. Canada Environmental Protection Act, 1999: Notice with respect to substances included as part of the 2017 Inventory Update [PDF]. Canada Gazette, Part I, vol. 151, no. 2, p. 89-161. 

[ECCC] Environment and Climate Change Canada. 2017. Inventory Update data collected under the Canadian Environmental Protection Act, 1999, section 71: Notice with respect to certain substances on the Domestic Substances List. Data prepared by: Environment and Climate Change Canada, Health Canada; Existing Substances Program. 

[ECCC, HC] Environment and Climate Change Canada, Health Canada. 2015. Identification of risk assessment priorities: results of the 2015 review. Ottawa (ON): Government of Canada.

[ECCC, HC] Environment and Climate Change Canada, Health Canada. 2016. Identification of risk assessment priorities (IRAP): results of the 2016 review. Gatineau (QC): Government of Canada. 

[ECCC, HC] Environment and Climate Change Canada, Health Canada. 2017. Categorization of chemical substances. Gatineau (QC): Government of Canada. 

[ECCC, HC] Environment and Climate Change Canada, Health Canada. 2018. Identification of risk assessment priorities (IRAP): results of the 2017-18 review. Gatineau (QC): Government of Canada. 

Environment Canada, Health Canada. 2014. Approach for identification of chemicals and polymers as risk assessment priorities under Part 5 of the Canadian Environmental Protection Act, 1999 (CEPA 1999). Ottawa (ON): Government of Canada.

 

Appendix A. List of IRAP data sources

The following is a list of the sources considered within this IRAP review. The sources have been organized by the source type and category, as well as the main information they provided to the IRAP review; however, many represent sources of information for many streams within an IRAP review (e.g., a risk assessment may contain relevant information on use and volumes, consumer product indicators, monitoring and surveillance, and so on). It should be noted that the sources listed below reflect ones that are more readily searched systematically across all substances and that many additional sources may also be searched depending on the substance and the information available at the time of the review. For instance, an indication of use in consumer products may necessitate further searching for specific consumer products and availability to consumers in Canada (e.g., querying of Safety Data Sheet databases).

Hazard indicators

Exposure indicators

Use and volume data

Consumer exposure indicators

Biomonitoring

Environmental monitoring/surveillance

Assessments and international activity

Reports and assessments (e.g., risk assessments)

International activity

Appendix B. Substances/groups identified for further scoping/problem formulation

Substance (CAS RNa) or group nameNumber of substancesbRationale for recommending further scoping/problem formulation
Alkylated polyaromatic compounds (PACs)5PACs are part of polycyclic aromatic hydrocarbon (PAH) mixtures and are often more abundant than their parent compounds. Exposures may occur along with other PAHs, including far-field exposures from anthropogenic and natural sources. Consumer uses were identified for some PAC substances. There is also a large body of literature on the impacts (i.e., bioaccumulation, hazard and exposure) on the environment, as well as evidence of potential carcinogenicity concerns similar or consistent with other PAHs. PAHs were assessed as part of the 1994 Priority Substances List (PSL) and, as a result, are found on the List of Toxic Substances (CEPA Schedule 1); however, PACs were not considered as part of this assessment. 
Xylenes4These substances were previously assessed as part of the 1993 PSL xylenes assessment and found not to meet section 64 of CEPA. However, new uses not previously considered, including consumer uses, and large Canadian volumes have recently been identified from the 2017 Inventory Update (Canada 2017; ECCC 2017). There are also indications from biomonitoring data that Canadians may be exposed to these chemicals at levels greater than toxicologically defined exposure guidance values (e.g., US EPA IRIS reference dose value). Finally, there is international activity as they are part of an ongoing Community Rolling Action Plan (CoRAP) evaluation under the European Chemicals Agency (ECHA), in particular for neurotoxicity concerns. 
Organic flame retardants36This group contains a variety of substances that are structurally related to organic flame retardants previously assessed as toxic under the Chemicals Management Plan (CMP) or could potentially be used as flame retardants. Some of these substances have hazard or exposure indicators as well.
Glymes/glycol ethers19Some substances in this group have been previously assessed as part of the CMP or the 2003 PSL 2-methoxy ethanol, 2-ethoxy ethanol, 2-butoxy ethanol assessment. Some substances were found to meet section 64 of CEPA, while others did not. In addition, some are subject to Significant New Activity (SNAc) provisions under CEPA. Some substances also have Significant New Use Rules (SNUR) under the Toxic Substances Control Act (TSCA) in the US. There are concerns that other similar substances have not been assessed and that there may be consumer uses that were not explicitly considered by the PSL assessment. 
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride
(61-73-4)		1There is evidence of potential consumer exposure in Canada, including use in hair dyes, nail products, etc. This substance has also been identified as being active with the estrogen receptor and androgen receptor (as well as with steroidogenesis). 
Formamide, N,N-dimethyl-
(68-12-2)		1This substance was previously assessed in the 2001 PSL N,N-dimethylformamide assessment, and found not to meet section 64 of CEPA. However, there is evidence of changes in the hazard profile of the substance compared to that evaluated in the PSL assessment. There is also evidence of consumer uses not previously considered. 
Ethene, trichloro-
(79-01-6)		1This substance was previously assessed in the 1993 PSL trichloroethylene assessment and, as a result, is on the List of Toxic Substances (CEPA Schedule 1). There is now evidence of use since the 1993 PSL report in non-regulated sectors, such as consumer products, which were not previously considered and are not covered by existing risk management.
2-Furanmethanol, tetrahydro-
(97-99-4)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. Potential consumer uses have been identified, and the substance has also been classified as category 1B (presumed human reproductive toxicant, largely based on animal evidence) through ECHA's Globally Harmonized System of Classification and Labelling of Chemicals (GHS). 
Benzene, (1-methylethenyl)-
(98-83-9)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. There are potential consumer uses, and it is anticipated to be a genotoxic carcinogen. 
Benzenamine, N,N,4-trimethyl-
(99-97-8)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2016) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. There are potential consumer uses, as well as indications of high hazard: the International Agency for Research on Cancer (IARC) has classified it as a Group 2B carcinogen (i.e., possibly carcinogenic to humans), as well as having a GHS classification for repeat dose toxicity. 
Benzene, ethenyl-
(100-42-5)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2016) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. In addition, this substance was previously assessed in the 1993 PSL Styrene assessment, and in a follow-up report in 2003, and it was found not to meet section 64 of CEPA. The evaluation of carcinogenicity in the PSL assessment concluded that available "studies have limitations that preclude firm conclusions being drawn with respect to the carcinogenicity of styrene." Since then, this substance has been upgraded under IARC to a Group 2A carcinogen (i.e., probably carcinogenic in humans). In addition, there are current indications of consumer use and exposure that were not explicitly considered in the PSL assessment or follow-up report. 
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-
(117-39-5)		1There is evidence of consumer exposure to this substance in Canada (e.g., use in personal care products). It has also been identified as being active with the estrogen receptor. 
Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-
(119-47-1)		1The substance was assessed as part of the CMP in 2009 and found not to meet section 64 of CEPA. However, there is now evidence of its use in consumer products in Canada. It was also reviewed as part of ECHA's CoRAP and concluded with Reproductive Toxicity (category 1B - presumed human reproductive toxicant, largely based on animal evidence). Endocrine disrupting (ED) effects have also been investigated as part of ECHA’s CoRAP with the following determination: evidence of ED effects was insufficient for the reproductive system, but that potential for thyroid effects could not be ruled out at this time. 
1,6-Octadiene, 7-methyl-3-methylene-
(123-35-3)		1There is evidence of consumer use (in foods and cosmetics). There is also evidence for high hazard (i.e., IARC Group 2B carcinogen: possibly carcinogenic to humans). 
Ethene, tetrachloro-
(127-18-4)		1This substance was previously assessed in the 1993 PSL tetrachloroethylene assessment and, as a result, is on the List of Toxic Substances (CEPA Schedule 1). There has since been international work on this substance. For example, the US EPA assessed this substance as "likely to be a human carcinogen" and toxic to the nervous system. Additional international work includes risk management measures based on human health concerns. There are also indications of potential uses and sources of exposure in Canada from use in non-regulated sectors, including consumer products, which were not previously considered, as well as indoor air sources. 
2-Propenoic acid, 3-phenyl-, (E)-
(140-10-3)		1There is evidence of direct exposure from consumer use in Canada to this substance, including use(s) in personal care products. It has also been identified as being active with the estrogen receptor. 
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-
(520-36-5)		1There is evidence of direct exposure from consumer use in Canada to this substance, including use(s) in personal care products. It has also been identified as being active with the estrogen receptor and steroidogenesis. 
2-Propenoic acid, 2-ethyl-2-[[(1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester
(15625-89-5)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. This substance has since been classified under IARC as a Group 2B carcinogen (i.e., possibly carcinogenic to humans). It also has broad and ubiquitous use in personal care products/cosmetics in Canada, the US and elsewhere. 
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, disodium salt
(17372-87-1)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. There is evidence of direct exposure, including use(s) in personal care products, in Canada to this substance. It has also been identified as being active with the estrogen and androgen receptors. 
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-
(97-77-8)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2016) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities.  A preliminary screening of the hazard and exposure data using a generic aquatic scenario suggests a potential risk. This substance is also in the same chemical class as thioperoxydicarbonic diamide [(H2N)C(S)]2S2), tetramethyl (CAS RN 137-26-8; TMTD), which has been recently assessed under the CMP with a toxic conclusion and has similar uses.  
Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-
(127-91-3)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. It is also on the List of Toxic Substances (Schedule 1) as a volatile organic compound that participates in atmospheric photochemical reactions. ECHA's CoRAP evaluation has concluded that this substance is "very toxic to aquatic life" and "very toxic to aquatic life with long-lasting effects" with the potential for less severe classifications if verified with experimental data. In addition, Japan's GHS is also indicating acute and chronic aquatic hazard. A preliminary screening of the hazard and exposure data using a generic aquatic scenario suggests a potential risk. 
2-Butenedioic acid (Z)-, bis(2-ethylhexyl) ester
(142-16-5)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2016) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. A preliminary screening of the hazard and exposure data using a generic aquatic scenario suggests a potential risk. 
Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-
(1222-05-5)		1This substance was previously identified for data gathering under IRAP (ECCC, HC 2015) and was subsequently part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities.  A preliminary screening of the hazard and exposure data using a generic aquatic scenario suggests a potential risk.  This substance has also been included on the NORMAN List of Emerging Substances. 
2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester
(6197-30-4)		1This substance was part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. There are also indications of inherent toxicity, persistence and bioaccumulation, as well as increasing Canadian tonnage. 
Refractory ceramic fibres 1These substances have been assessed as part of the 1993 PSL mineral fibres (man-made vitreous fibres) assessment, and as a result are on the List of Toxic Substances (CEPA Schedule 1). These substances were also part of the 2017 Inventory Update (Canada 2017; ECCC 2017) to identify Canadian use and quantities. New uses were identified that were not previously considered. 

a CAS RN: Chemical Abstracts Service Registry Number.

b During further scoping/problem formulation, the list of substances may be further refined or expanded to include additional similar substances not currently listed. Substance identities for the groups are listed in Appendix C.

Appendix C. Identity of substances within a group recommended for further scoping/problem formulation

CAS RNaSubstance namebGroup
56-49-5Benz[j]aceanthrylene, 1,2-dihydro-3-methyl- Alkylated PACsc
90-12-0Naphthalene, 1-methyl- Alkylated PACsc
91-57-6Naphthalene, 2-methyl- Alkylated PACsc
779-02-2Anthracene, 9-methyl- Alkylated PACsc
1321-94-4Naphthalene, methyl- Alkylated PACsc
95-47-6Benzene, 1,2-dimethyl- Xylenes
106-42-3Benzene, 1,4-dimethyl- Xylenes
108-38-3Benzene, 1,3-dimethyl- Xylenes
1330-20-7Benzene, dimethyl- Xylenes
78-43-31-Propanol, 2,3-dichloro-, phosphate (3:1)Organic flame retardants
79-94-7Phenol, 4,4'-(1-methylethylidene)bis[2,6-dibromo-Organic flame retardants
87-82-1Benzene, hexabromo-Organic flame retardants
87-83-2Benzene, pentabromomethyl- Organic flame retardants
101-02-0Phosphorous acid, triphenyl esterOrganic flame retardants
115-98-0Phosphonic acid, ethenyl-, bis(2-chloroethyl) ester Organic flame retardants
121-45-9Phosphorous acid, trimethyl esterOrganic flame retardants
122-52-1Phosphorous acid, triethyl ester Organic flame retardants
126-71-6Phosphoric acid, tris(2-methylpropyl) esterOrganic flame retardants
126-72-7Tris(2,3-dibromopropyl) phosphateOrganic flame retardants
126-73-8Phosphoric acid tributyl esterOrganic flame retardants
140-08-9Ethanol, 2-chloro-, phosphite (3:1) Organic flame retardants
306-52-5Ethanol, 2,2,2-trichloro-, dihydrogen phosphateOrganic flame retardants
512-56-1Phosphoric acid, trimethyl esterOrganic flame retardants
608-90-2PentabromobenzeneOrganic flame retardants
756-79-6Phosphonic acid, methyl-, dimethyl esterOrganic flame retardants
762-04-9Phosphonic acid, diethyl esterOrganic flame retardants
1241-94-7Phosphoric acid, 2-ethylhexyl diphenyl esterOrganic flame retardants
2524-03-0Phosphorochloridothioic acid, O,O-dimethyl esterOrganic flame retardants
2524-04-1Phosphorochloridothioic acid, O,O-diethyl esterOrganic flame retardants
3322-93-8Cyclohexane, 1,2-dibromo-4-(1,2-dibromoethyl)-Organic flame retardants
4351-70-6Phosphonic acid, [1-[[(2-chloroethoxy)(2-chloroethyl)phosphinyl]oxy]ethyl]-, 1-[bis(2-chloroethoxy)phosphinyl]ethyl 2-chloroethyl esterOrganic flame retardants
6145-73-91-Propanol, 2-chloro-, phosphate (3:1)Organic flame retardants
6294-34-4Phosphonic acid, (2-chloroethyl)-, bis(2-chloroethyl) esterOrganic flame retardants
6749-73-12-Propanol, 1,3-dichloro-, phosphite (3:1)Organic flame retardants
19186-97-1Tris[2,2-bis(bromomethyl)-3-bromopropyl]-phosphateOrganic flame retardants
26444-49-5Phosphoric acid, methylphenyl diphenyl esterOrganic flame retardants
33125-86-9Phosphoric acid, 1,2-ethanediyl tetrakis(2-chloroethyl) esterOrganic flame retardants
37853-59-1Benzene, 1,1'-[1,2-ethanediylbis(oxy)]bis[2,4,6-tribromo- Organic flame retardants
38051-10-4Phosphoric acid, 2,2-bis(chloromethyl)-1,3-propanediyl tetrakis(2-chloroethyl) ester Organic flame retardants
42757-55-1Benzene, 1,1'-sulfonylbis[3,5-dibromo-4-(2,3-dibromopropoxy)- Organic flame retardants
53461-82-8Phosphoric acid, oxydi-2,1-ethanediyl tetrakis(2-chloroethyl) esterOrganic flame retardants
58823-09-9Phosphonic acid, [2-[[(2-chloroethoxy)(2-chloroethyl)phosphinyl]oxy]ethyl]-, bis(2-chloroethyl) esterOrganic flame retardants
61090-89-92,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[3-bromo-2,2-bis(bromomethyl)propoxy]-, 3,9-dioxide Organic flame retardants
66108-37-0Phosphoric acid, 2,2-bis(bromomethyl)-3-chloropropyl bis[2-chloro-1-(chloromethyl)ethyl] esterOrganic flame retardants
95906-11-9Phenol, 2,4-bis(1,1-dimethylethyl)-, 1,1',1''-phosphateOrganic flame retardants
109-59-1Ethanol, 2-(1-methylethoxy)-Glymes/glycol ethers
109-86-4Ethanol, 2-methoxy-Glymes/glycol ethers
110-49-6Ethanol, 2-methoxy-, acetate Glymes/glycol ethers
110-71-4Ethane, 1,2-dimethoxy-Glymes/glycol ethers
110-80-5Ethanol, 2-ethoxy-Glymes/glycol ethers
111-76-2Ethanol, 2-butoxy-Glymes/glycol ethers
111-96-6Ethane, 1,1'-oxybis[2-methoxy-Glymes/glycol ethers
112-36-7Ethane, 1,1'-oxybis[2-ethoxy-Glymes/glycol ethers
112-49-22,5,8,11-TetraoxadodecaneGlymes/glycol ethers
112-73-2Butane, 1,1'-[oxybis(2,1-ethanediyloxy)]bis-Glymes/glycol ethers
143-24-82,5,8,11,14-PentaoxapentadecaneGlymes/glycol ethers
629-14-11,2-diethoxyethaneGlymes/glycol ethers
2807-30-9Ethanol, 2-propoxy-Glymes/glycol ethers
4353-28-03,6,9,12,15-PentaoxaheptadecaneGlymes/glycol ethers
23601-39-03,6,9,12,15,18-HexaoxaeicosaneGlymes/glycol ethers
24991-55-7Poly(oxy-1,2-ethanediyl), α-methyl-ω-methoxy-Glymes/glycol ethers
31885-97-9Poly(oxy-1,2-ethanediyl), α-butyl-ω-butoxy-Glymes/glycol ethers
51105-00-15,8,11,14,17,20-HexaoxatetracosaneGlymes/glycol ethers
63512-36-75,8,11,14-HexaoxaoctadecaneGlymes/glycol ethers

a CAS RN: Chemical Abstracts Service Registry Number.

b During further scoping/problem formulation, the list of substances may be further refined or expanded to include additional similar substances not currently listed.

c PACs: Polyaromatic compounds

Appendix D. Substances identified for hazard or exposure data gathering

CAS RNaSubstance nameRecommended data gathering
50-78-2Benzoic acid, 2-(acetyloxy)- Exposure
51-28-5Phenol, 2,4-dinitro-Exposure
51-30-91,2-Benzenediol,4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochlorideExposure
54-11-5Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-Exposure
55-63-01,2,3-Propanetriol, trinitrateExposure
57-27-2Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-(5α,6α)-Exposure
57-57-82-OxetanoneExposure
57-68-1Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-Exposure
57-83-0Pregn-4-ene-3,20-dioneExposure
58-55-91H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-Exposure
61-68-7Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-Exposure
63-25-21-Naphthalenol, methylcarbamateExposure
64-69-7Acetic acid, iodo-Exposure
65-45-2Benzamide, 2-hydroxy-Exposure
66-71-71,10-PhenanthrolineExposure
68-35-9Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-Exposure
75-01-4Ethene, chloro-Exposure
75-31-02-PropanamineExposure
75-83-2Butane, 2,2-dimethyl-Exposure
78-30-8Phosphoric acid, tris(2-methylphenyl) esterExposure
78-78-4Butane, 2-methyl-Exposure
79-29-8Butane, 2,3-dimethyl-Exposure
79-57-22-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,6β,12aα)]-Exposure
80-04-6Cyclohexanol, 4,4'-(1-methylethylidene)bis- Exposure
81-64-19,10-Anthracenedione, 1,4-dihydroxy-Exposure
82-45-19,10-Anthracenedione, 1-amino-Exposure
84-15-11,1':2',1''-TerphenylExposure
87-68-31,3-Butadiene, 1,1,2,3,4,4-hexachloro-Exposure
88-04-0Phenol, 4-chloro-3,5-dimethyl-Exposure
88-75-5Phenol, 2-nitro-Exposure
90-02-8Benzaldehyde, 2-hydroxy-Exposure
90-15-31-NaphthalenolExposure
91-53-2Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-Exposure
92-43-33-Pyrazolidinone, 1-phenyl-Exposure
92-94-41,1':4',1''-TerphenylExposure
93-65-2Propanoic acid, 2-(4-chloro-2-methylphenoxy)-Exposure
93-83-49-Octadecenamide, N,N-bis(2-hydroxyethyl)-, (Z)-Exposure
95-13-61H-IndeneExposure
95-32-9Benzothiazole, 2-(4-morpholinyldithio)-Exposure
97-86-92-Propenoic acid, 2-methyl-, 2-methylpropyl esterExposure
98-29-3Phenol, 2-(1-methylethyl)-4,6-dinitro-Exposure
98-85-1Benzenemethanol, α-methyl-Exposure
98-94-2Cyclohexanamine, N,N-dimethyl- Exposure
99-65-0Benzene, 1,3-dinitro-Exposure
99-85-41,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-Exposure
100-02-7Phenol, 4-nitro-Exposure
100-25-4Benzene, 1,4-dinitro-Exposure
100-47-0BenzonitrileExposure
100-61-8Benzenamine, N-methyl- Exposure
101-54-21,4-Benzenediamine, N-phenyl-Exposure
102-09-0Carbonic acid, diphenyl esterExposure
102-81-8Ethanol, 2-(dibutylamino)-Exposure
103-29-7Benzene, 1,1'-(1,2-ethanediyl)bis-Exposure
103-65-1Benzene, propyl-Exposure
104-51-8Benzene, butyl-Exposure
106-51-42,5-Cyclohexadiene-1,4-dioneExposure
106-93-4Ethane, 1,2-dibromo-Exposure
106-99-01,3-ButadieneExposure
107-03-91-PropanethiolExposure
107-06-2Ethane, 1,2-dichloro-Exposure
107-39-11-Pentene, 2,4,4-trimethylExposure
107-83-5Pentane, 2-methyl-Exposure
107-86-82-Butenal, 3-methyl-Exposure
108-18-92-Propanamine, N-(1-methylethyl)-Exposure
108-42-9Benzenamine, 3-chloro-Exposure
109-66-0PentaneExposure
109-72-8Lithium, butyl-Exposure
109-89-7Ethanamine, N-ethyl- Exposure
110-18-91,2-Ethanediamine, N,N,N',N'-tetramethyl-Exposure
111-44-4Ethane, 1,1'-oxybis[2-chloro-Exposure
111-65-9OctaneExposure
111-86-41-OctanamineExposure
111-92-21-Butanamine, N-butyl-Exposure
112-24-31,2-Ethanediamine, N,N'-bis(2-aminoethyl)-Exposure
112-41-41-DodeceneExposure
112-57-21,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-Exposure
114-26-1Phenol, 2-(1-methylethoxy)-, methylcarbamateExposure
115-18-43-Buten-2-ol, 2-methyl- Exposure
116-16-52-Propanone, 1,1,1,3,3,3-hexachloro-Exposure
117-08-81,3-Isobenzofurandione, 4,5,6,7-tetrachloro-Exposure
118-52-52,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl-Exposure
118-75-22,5-Cyclohexadiene-1,4-dione, 2,3,5,6-tetrachloro-Exposure
120-32-1Phenol, 4-chloro-2-(phenylmethyl)-Exposure
120-95-6Phenol, 2,4-bis(1,1-dimethylpropyl)-Exposure
121-29-9Cyclopropanecarboxylic acid, 3-(3-methoxy-2-methyl-3-oxo-1-propenyl)-2,2-dimethyl-, 2-methyl-4-oxo-3-(2,4-pentadienyl)-2-cyclopenten-1-yl ester, [1R-[1α[S(Z)],3β(E)]]-Exposure
122-34-91,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-diethyl-Exposure
122-40-7Heptanal, 2-(phenylmethylene)-Exposure
123-05-7Hexanal, 2-ethyl-Exposure
123-91-11,4-DioxaneExposure
124-65-2Arsinic acid, dimethyl-, sodium saltExposure
127-79-7Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-Exposure
130-37-02-Naphthalenesulfonic acid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium saltExposure
131-27-11,5-Naphthalenedisulfonic acid, 3-amino-Exposure
137-42-8Carbamodithioic acid, methyl-, monosodium saltExposure
138-86-3Cyclohexene, 1-methyl-4-(1-methylethenyl)-Exposure
140-88-52-Propenoic acid, ethyl esterExposure
142-84-71-Propanamine, N-propyl-Exposure
142-90-52-Propenoic acid, 2-methyl-, dodecyl esterExposure
143-18-09-Octadecenoic acid (Z)-, potassium saltExposure
147-24-0Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochlorideExposure
335-24-0Cyclohexanesulfonic acid, 1,2,2,3,3,4,5,5,6,6-decafluoro-4-(1,1,2,2,2-pentafluoroethyl)-, potassium salt (1:1)Hazard
359-83-12,6-Methano-3-benzazocin-8-ol,1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-,(2R,6R,11R)-rel-Exposure
463-82-1Propane, 2,2-dimethyl-Exposure
533-74-42H-1,3,5-Thiadiazine-2-thione, tetrahydro-3,5-dimethyl- Exposure
534-17-8Carbonic acid, dicesium saltExposure
534-52-1Phenol, 2-methyl-4,6-dinitro-Exposure
537-01-9Carbonic acid, cerium(3++) salt (3:2)Exposure
543-90-8Acetic acid, cadmium saltExposure
545-06-2Acetonitrile, trichloro-Exposure
546-89-4Acetic acid, lithium saltExposure
552-38-5Benzoic acid, 2-hydroxy-, monolithium saltExposure
554-13-2Carbonic acid, dilithium saltExposure
556-63-8Formic acid, lithium saltExposure
564-25-02-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,
(4S,4aR,5S,5aR,6R,12aS)-		Exposure
576-26-1Phenol, 2,6-dimethyl-Exposure
586-62-9Cyclohexene, 1-methyl-4-(1-methylethylidene)-Exposure
587-26-8Carbonic acid, lanthanum(3++) salt (3:2)Exposure
591-27-5Phenol, 3-amino-Exposure
591-76-4Hexane, 2-methyl-Exposure
609-93-8Phenol, 4-methyl-2,6-dinitro-Exposure
612-83-9[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-, dihydrochlorideExposure
623-08-5Benzenamine, N,4-dimethyl-Exposure
624-18-01,4-Benzenediamine, dihydrochlorideExposure
653-14-5Benzoic acid, 2-hydroxy-3,5-diiodo-, monolithium salt Exposure
723-46-6Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-Exposure
731-27-1Methanesulfenamide, 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-(4-methylphenyl)-Exposure
818-61-12-Propenoic acid, 2-hydroxyethyl esterExposure
828-00-21,3-Dioxan-4-ol, 2,6-dimethyl-, acetateExposure
836-30-6Benzenamine, 4-nitro-N-phenyl-Exposure
867-55-0Propanoic acid, 2-hydroxy-, monolithium saltExposure
882-33-7Disulfide, diphenylExposure
917-70-4Acetic acid, lanthanum(3++) saltExposure
1071-83-6Glycine, N-(phosphonomethyl)-Exposure
1085-98-9Methanesulfenamide, 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-phenyl-Exposure
1116-76-31-Octanamine, N,N-dioctyl-Exposure
1120-21-4UndecaneExposure
1138-52-9Phenol, 3,5-bis(1,1-dimethylethyl)- Exposure
1214-39-71H-Purin-6-amine, N-(phenylmethyl)-Exposure
1306-38-3Cerium oxide (CeO2)Exposure
1308-96-9Europium oxide (Eu2O3)Exposure
1310-65-2Lithium hydroxide (Li(OH))Exposure
1312-81-8Lanthanum oxide (La2O3)Exposure
1313-96-8Niobium oxide (Nb2O5)Exposure
1313-97-9Neodymium oxide (Nd2O3)Exposure
1314-36-9Yttrium oxide (Y2O3)Exposure
1314-37-0Ytterbium oxide (Yb2O3)Exposure
1314-61-0Tantalum oxide (Ta2O5)Exposure
1643-20-51-Dodecanamine, N,N-dimethyl-, N-oxideExposure
1717-00-6Ethane, 1,1-dichloro-1-fluoro-Exposure
1758-73-2Methanesulfinic acid, aminoimino-Exposure
1948-33-01,4-Benzenediol, 2-(1,1-dimethylethyl)-Exposure
2044-56-6Sulfuric acid, monododecyl ester, lithium saltExposure
2050-92-21-Pentanamine, N-pentyl-Exposure
2051-79-81,4-Benzenediamine, N4,N4-diethyl-2-methyl-, monohydrochloride Exposure
2094-99-7Benzene, 1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)-Exposure
2095-01-41,3-Benzenediamine, 4,6-diethyl-2-methyl-Exposure
2095-02-51,3-Benzenediamine, 2,4-diethyl-6-methyl-Exposure
2223-93-0Octadecanoic acid, cadmium saltExposure
2224-33-12-Butanone, O,O',O''-(ethenylsilylidyne)trioximeExposure
2226-96-21-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethylExposure
2244-21-51,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3-dichloro-, potassium salt Exposure
2439-10-3Guanidine, dodecyl-, monoacetateExposure
2447-57-6Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-Exposure
2528-36-1Phosphoric acid, dibutyl phenyl esterExposure
2634-33-51,2-Benzisothiazol-3(2H)-one Exposure
2687-94-71-Octyl-2-PyrrolidinoneExposure
2687-96-92-Pyrrolidinone, 1-dodecyl-Exposure
3006-82-4Hexaneperoxoic acid, 2-ethyl-, 1,1-dimethylethyl esterExposure
3033-77-0Oxiranemethanaminium, N,N,N-trimethyl-, chloride Exposure
3248-91-7Benzenamine, 4-[(4-amino-3-methylphenyl)(4-imino-3-methyl-2,5-cyclohexadien-1-ylidene)methyl]-2-methyl-, monohydrochlorideExposure
3332-27-21-Tetradecanamine, N,N-dimethyl-, N-oxideExposure
3396-11-0Acetic acid, cesium saltExposure
3495-36-1Formic acid, cesium saltExposure
3825-26-1Octanoic acid, pentadecafluoro-, ammonium saltExposure
3884-95-5Phenol, 2-(1,1,3,3-tetramethylbutyl)-Exposure
4111-54-02-Propanamine, N-(1-methylethyl)-, lithium saltExposure
4130-42-1Phenol, 2,6-bis(1,1-dimethylethyl)-4-ethyl-Exposure
4162-45-2Ethanol, 2,2'-[(1-methylethylidene)bis[(2,6-dibromo-4,1-phenylene)oxy]]bis- Exposure
4485-12-5Octadecanoic acid, lithium saltExposure
4499-91-6Docosanoic acid, lithium saltExposure
5895-52-3Carbonic acid, ytterbium(3++) salt (3:2)Exposure
6317-18-6Thiocyanic acid, methylene esterExposure
6362-80-7Benzene, 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bis-Exposure
6369-59-11,4-Benzenediamine, 2-methyl-, sulfateExposure
6471-78-9Benzenesulfonic acid, 4-amino-5-methoxy-2-methyl-Exposure
6531-45-9Propanoic acid, lithium salt Exposure
7128-91-81-Hexadecanamine, N,N-dimethyl-, N-oxideExposure
7435-02-1Octanoic acid, cerium saltExposure
7439-91-0LanthanumExposure
7439-93-2LithiumExposure
7439-94-3LutetiumExposure
7440-00-8NeodymiumExposure
7440-03-1NiobiumExposure
7440-10-0PraseodymiumExposure
7440-19-9SamariumExposure
7440-25-7TantalumExposure
7440-30-4ThuliumExposure
7440-45-1CeriumExposure
7440-64-4YtterbiumExposure
7440-65-5YttriumExposure
7440-74-6IndiumExposure
7447-41-8Lithium chloride (LiCl)Exposure
7550-35-8Lithium bromide (LiBr)Exposure
7620-77-1Octadecanoic acid, 12-hydroxy-, monolithium saltExposure
7637-03-8Sulfuric acid, ammonium cerium(4++) salt (4:4:1)Exposure
7647-17-8Cesium chloride (CsCl)Exposure
7647-18-9Antimony chloride (SbCl5)Exposure
7659-86-1Acetic acid, mercapto-, 2-ethylhexyl esterExposure
7705-14-8Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (±)-Exposure
7721-01-9Tantalum chloride (TaCl5)Exposure
7758-88-5Cerium fluoride (CeF3)Exposure
7772-99-8Tin chloride (SnCl2)Exposure
7782-65-2GermaneExposure
7782-89-0Lithium amide (Li(NH2))Exposure
7789-18-6Nitric acid, cesium saltExposure
7789-24-4Lithium fluoride (LiF)Exposure
7790-69-4Nitric acid, lithium saltExposure
7790-86-5Cerium chloride (CeCl3)Exposure
7791-03-9Perchloric acid, lithium saltExposure
8006-80-2Oils, sassafrasExposure
8052-41-3Stoddard solventExposure
9016-91-5Benzenesulfonic acid, ethenyl-, homopolymer, lithium saltExposure
10024-93-8Neodymium chloride (NdCl3)Exposure
10025-74-8Dysprosium chloride (DyCl3)Exposure
10035-10-6Hydrobromic acidExposure
10042-88-3Terbium chloride (TbCl3)Exposure
10099-58-8Lanthanum chloride (LaCl3)Exposure
10099-59-9Nitric acid, lanthanum(3++) saltExposure
10108-73-3Cerium (3+) nitrateExposure
10138-41-7Erbium chloride (ErCl3)Exposure
10138-52-0Gadolinium chloride (GdCl3)Exposure
10138-62-2Holmium chloride (HoCl3)Exposure
10168-81-7Nitric acid, gadolinium(3++) saltExposure
10294-54-9Sulfuric acid, dicesium saltExposure
10361-79-2Praseodymium chloride (PrCl3)Exposure
10361-82-7Samarium chloride (SmCl3)Exposure
10361-92-9Yttrium chloride (YCl3)Exposure
10361-93-0Nitric acid, yttrium(3++) saltExposure
10377-48-7Sulfuric acid, dilithium saltExposure
10377-51-2Lithium iodide (LiI)Exposure
12007-60-2Boron lithium oxide (B4Li2O7)Exposure
12008-21-8Lanthanum boride (LaB6), (OC-6-11)-Exposure
12014-56-1Cerium hydroxide (Ce(OH)4), (ß-4)-Exposure
12032-20-1Lutetium oxide (Lu2O3)Exposure
12033-62-4Tantalum nitride (TaN)Exposure
12036-32-7Praseodymium oxide (Pr2O3)Exposure
12036-44-1Thulium oxide (Tm2O3)Exposure
12037-29-5Praseodymium oxide (Pr6O11)Exposure
12057-24-8Lithium oxide (Li2O)Exposure
12060-08-1Scandium oxide (Sc2O3)Exposure
12060-58-1Samarium oxide (Sm2O3)Exposure
12061-16-4Erbium oxide (Er2O3)Exposure
12064-62-9Gadolinium oxide (Gd2O3)Exposure
12069-94-2Niobium carbide (NbC)Exposure
12070-06-3Tantalum carbide (TaC)Exposure
12439-78-0Ytterbium oxide sulfide (Yb2O2S)Exposure
12515-32-1Cerium tin oxide (Ce2Sn2O7)
12627-14-4Silicic acid, lithium saltExposure
13048-33-42-Propenoic acid, 1,1'-(1,6-hexanediyl) esterExposure
13171-00-1Ethanone, 1-[6-(1,1-dimethylethyl)-2,3-dihydro-1,1-dimethyl-1H-inden-4-yl]-Exposure
13453-69-5Boric acid (HBO2), lithium saltExposure
13453-87-7Sulfurous acid, dilithium saltExposure
13454-72-3Metaphosphoric acid (HPO3), cerium(3++) saltExposure
13454-94-9Sulfuric acid, cerium(3++) salt (3:2)Exposure
13587-19-4Tungstate (WO4²-), dicesium, (ß-4)-Exposure
13590-82-4Sulfuric acid, cerium(4++) salt (2:1)Exposure
13709-38-1Lanthanum fluoride (LaF3)Exposure
13709-49-4Yttrium fluoride (YF3)Exposure
13718-26-8Vanadate (VO3¹-), sodiumExposure
13824-95-8Hypobromous acid, lithium saltExposure
13840-33-0Hypochlorous acid, lithium salt Exposure
13952-84-62-ButanamineExposure
14054-87-6Europium, tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato-O,O']-Exposure
14475-17-3Carbonic acid, praseodymium salt Exposure
14475-18-4Carbonic acid, neodymium saltExposure
14484-64-1Iron, tris(dimethylcarbamodithioato-S,S')-, (OC-6-11)- Exposure
14552-19-3Europium, tris(4,4,4-trifluoro-1-phenyl-1,3-butanedionato-O,O')-Exposure
15087-24-8Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-(phenylmethylene)-Exposure
15467-06-89-Octadecenoic acid, 12-hydroxy-, monolithium salt, [R-(Z)]-Exposure
15687-27-1Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-Exposure
15785-09-8Cerium hydroxide (Ce(OH)3)Exposure
15879-93-3α-D-Glucofuranose, 1,2-O-(2,2,2-trichloroethylidene)-, (R)- Exposure
16774-21-3Cerate(2-), hexakis(nitrato-O)-, diammonium, (OC-6-11)- Exposure
16853-85-3Aluminate(1-), tetrahydro-, lithium, (ß-4)-Exposure
16871-90-2Silicate(2-), hexafluoro-, dipotassiumExposure
18390-55-1Phenol, 2,4,6-trinitro-, lithium saltExposure
19597-69-4Lithium azide (Li(N3))Exposure
19812-92-1[1,1'-Biphenyl]-4-ol, 4'-(1,1-dimethylethyl)-Exposure
19870-74-71H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,6β,7β,8aα)]-Exposure
21245-02-3Benzoic acid, 4-(dimethylamino)-, 2-ethylhexyl ester Exposure
21351-79-1Cesium hydroxide (Cs(OH))Exposure
21725-46-2Propanenitrile, 2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino]-2-methyl-Exposure
22288-41-1Propaneperoxic acid, 2, 2-dimethyl-,1,1,3,3,-tetramethylbutyl esterExposure
22750-57-8Cesium azide (Cs(N3))Exposure
22781-23-31,3-Benzodioxol-4-ol, 2,2-dimethyl-, methylcarbamate Exposure
22984-54-92-Butanone, O,O',O''-(methylsilylidyne)trioxime Exposure
24307-26-4Piperidinium, 1,1-dimethyl-, chlorideExposure
25155-30-0Benzenesulfonic acid, dodecyl-, sodium saltExposure
25327-89-3Benzene, 1,1'-(1-methylethylidene)bis[3,5-dibromo-4-(2-propenyloxy)-Exposure
25510-41-229H,31H-Phthalocyanine, dilithium saltExposure
25646-71-3Methanesulfonamide, N-[2-[(4-amino-3-methylphenyl)ethylamino]ethyl]-, sulfate (2:3Exposure
25646-77-9Ethanol, 2-[(4-amino-3-methylphenyl)ethylamino]-, sulfate (1:1) (salt)Exposure
25880-71-1Carbonic acid, samarium salt Exposure
26530-20-13(2H)-Isothiazolone, 2-octyl-Exposure
27193-28-8Phenol, (1,1,3,3-tetramethylbutyl)-Exposure
27253-30-1Neodecanoic acid, lithium saltExposure
28214-91-7Naphthalenesulfonic acid, dinonyl-, lithium saltExposure
29081-56-91-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, ammonium saltExposure
29590-42-92-Propenoic acid, isooctyl ester Exposure
29935-35-1Arsenate(1-), hexafluoro-, lithiumExposure
31810-89-69,10-Anthracenedione, 1,5-diaminobromo-4,8-dihydroxy-Exposure
33454-82-9Methanesulfonic acid, trifluoro-, lithium saltExposure
34036-80-12-Butanone, O,O'O''-(phenylsilylidyne)trioximeExposure
34895-26-62-Butenedioic acid (Z)-, lithium saltExposure
35342-16-67-Benzothiazolesulfonic acid, 2-[4-[(hexahydro-2,4,6-trioxo-5-pyrimidinyl)azo]phenyl]-6-methyl-, monolithium salt Exposure
38304-91-52,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxideExposure
38900-29-7Nonanedioic acid, dilithium saltExposure
38970-76-2Benzoic acid, 2-hydroxy-, dilithium saltExposure
41637-38-1Poly(oxy-1,2-ethanediyl), α,α'-[(1-methylethylidene)di-4,1-phenylene]bis[ω-[(2-methyl-1-oxo-2-propenyl)oxy]-Exposure
42200-33-92,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-Exposure
50594-66-6Benzoic acid, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-Exposure
51988-24-0Benzenesulfonic acid, 3-[[4-[(4-hydroxy-3-methylphenyl)azo]-3-methoxyphenyl]azo]-, monolithium saltExposure
52236-73-4Benzenesulfonic acid, 4-[(5-amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)azo]-2,5-dichloro-, monolithium salt Exposure
53169-23-6Cerium tin oxide (CeSnO4)Exposure
53320-86-8Silicic acid, lithium magnesium sodium saltExposure
53422-16-5Octadecanoic acid, 12-hydroxy-, methyl ester, lithium salt Exposure
53523-90-3Benzoic acid, 3,3'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)azo]]bis[6-hydroxy-5-methyl-, tetralithium saltExposure
55965-84-93(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazoloneExposure
56968-08-2Glycine, N-[(2-hydroxy-5-nonylphenyl)methyl]-N-methyl-, monosodium saltExposure
57583-54-7Phosphoric acid, 1,3-phenylene tetraphenyl esterExposure
58478-76-5Octadecanoic acid, 12-hydroxy-, calcium lithium saltExposure
61788-45-2Amines, hydrogenated tallow alkylExposure
61788-56-5Naphthenic acids, lithium saltsExposure
61790-20-3Naphthenic acids, rare earth saltsExposure
61790-33-8Amines, tallow alkylExposure
62638-00-0Cyclohexanebutanoic acid, lithium saltExposure
63182-07-0Benzenesulfonic acid, ethenyl-, lithium salt, polymer with diethenylbenzeneExposure
64601-11-2Hexanedioic acid, monomethyl ester, lithium saltExposure
64742-70-7Paraffin oils (petroleum), catalytic dewaxed heavyExposure
64742-71-8Paraffin oils (petroleum), catalytic dewaxed lightExposure
64754-95-6Castor oil, hydrogenated, lithium saltExposure
64755-02-8Fatty acids, tallow, lithium saltsExposure
65072-36-86-Benzothiazolesulfonic acid, 2-amino-, monolithium salt Exposure
65150-80-3C.I. Direct Yellow 11, lithium saltExposure
65232-89-5Vanadium hydroxide oxide phosphateExposure
65530-69-0Poly(difluoromethylene), α-[2-[(2-carboxyethyl)thio]ethyl]-ω-fluoro-, lithium saltExposure
66071-82-7Fatty acids, tallow, hydrogenated, lithium salts Exposure
66104-72-1Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[(4-hydroxyphenyl)azo]-, dilithium disodium salt Exposure
67762-41-8Alcohols, C10-16Exposure
67923-89-12,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-[[4'-[(1-hydroxy-4-sulfo-2-naphthalenyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-, trilithium saltExposure
68141-24-2Cyclohexanol, 3-(5,5-dimethyl-6-methylenebicyclo[2.2.1]hept-2-yl)-Exposure
68187-15-5C.I. Pigment Yellow 159Exposure
68412-21-5Neodecanoic acid, rare earth saltsExposure
68476-89-1Rare earth metals, silicides Exposure
68514-63-6Naphthenic acids, cerium(4++) saltsExposure
68516-14-3Rutile, neodymiumExposure
68584-06-5Benzene, diethenyl-, polymer with ethenylbenzene and ethenylethylbenzene, sulfonated, lithium saltsExposure
68585-82-0Yttrium oxide (Y2O3), europium-dopedExposure
68609-21-2Ethene, homopolymer, oxidized, lithium saltExposure
68611-42-7C.I. Pigment Yellow 162Exposure
68611-43-8C.I. Pigment Yellow 161Exposure
68649-48-9Paraffin waxes and Hydrocarbon waxes, oxidized, lithium saltsExposure
68783-36-8Fatty acids, C16-22, lithium saltsExposure
68783-37-9Fatty acids, C16-18, lithium saltsExposure
68784-83-8Yttrium oxide sulfide (Y2O2S), europium-dopedExposure
68815-49-6Lithium, 12-hydroxyoctadecanoate sebacate complexesExposure
68909-13-7Bastnaesite, calcined conc.Exposure
70248-09-8C.I. Pigment Brown 37Exposure
71550-22-62,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-, tetralithium saltExposure
72927-96-92-Anthracenesulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-[(2,4,6-trimethylphenyl)amino]-, monolithium saltExposure
75522-97-3Adenosine 5'-(hexahydrogen pentaphosphate), 5'<<FAR5'-ester with adenosine, trilithium saltExposure
75659-72-22,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-, monolithium trisodium saltExposure
75659-73-32,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-, dilithium disodium saltExposure
75673-18-62,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-[[4'-[(1-hydroxy-4-sulfo-2-naphthalenyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-, monolithium disodium saltExposure
75673-19-72,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-[[4'-[(1-hydroxy-4-sulfo-2-naphthalenyl)azo]-3,3'-dimethoxy[1,1'-biphenyl]-4-yl]azo]-, dilithium monosodium saltExposure
75673-34-61-Naphthalenesulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-hydroxy-, dilithium salt Exposure
75673-35-71-Naphthalenesulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-hydroxy-, monolithium monosodium saltExposure
75752-17-92,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-, trilithium monosodium salt Exposure
80146-13-0Copper, [29H,31H-phthalocyaninato(2-)-N²9,N³0,N³¹,N³²]-, aminosulfonyl sulfo derivs., ammonium lithium sodium salts Exposure
83221-38-9Benzenesulfonamide, 4-[[4-[[4-(2-hydroxybutoxy)-3-methylphenyl]azo]phenyl]amino]-3-nitro-N-(phenylsulfonyl)-, monolithium saltExposure
83221-68-52-Naphthalenesulfonic acid, 6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4-diaminophenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]phenyl]amino]-3-sulfophenyl]azo]-4-hydroxy-, trilithium saltExposure
83221-69-62-Naphthalenesulfonic acid, 6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4-diaminophenyl)azo]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]phenyl]amino]-3-sulfophenyl]azo]-4-hydroxy-, lithium sodium saltExposure
83221-72-12,7-Naphthalenedisulfonic acid, 4-amino-3,6-bis[[4-[(2,4-diaminophenyl)azo]phenyl]azo]-5-hydroxy-, lithium sodium saltExposure
83249-27-8Chromate(3-), bis[3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)]-, trilithiumExposure
83249-66-5Chromate(1-), bis[3-[[[5-[(2-chloro-4-nitrophenyl)azo]-2-hydroxyphenyl]methylene]amino]-4-hydroxybenzenesulfonamidato(2-)]-, lithiumExposure
83399-85-31,4-Benzenedisulfonic acid, 2-[[4-[[4-[[(2,3-dichloro-6-quinoxalinyl)carbonyl]amino]-5-sulfo-1-naphthalenyl]azo]-7-sulfo-1-naphthalenyl]azo]-, lithium sodium saltExposure
83400-10-61,5-Naphthalenedisulfonic acid, 2-[[8-[[(2,3-dichloro-6-quinoxalinyl)carbonyl]amino]-1-hydroxy-3,6-disulfo-2-naphthalenyl]azo]-, lithium sodium saltExposure
83400-11-71,7-Naphthalenedisulfonic acid, 4-(benzoylamino)-6-[[5-[[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]methyl]-1-sulfo-2-naphthalenyl]azo]-5-hydroxy-, lithium sodium saltExposure
83400-12-82,7-Naphthalenedisulfonic acid, 5-(benzoylamino)-3-[[5-[[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]methyl]-1-sulfo-2-naphthalenyl]azo]-4-hydroxy-, lithium sodium saltExposure
83732-89-2Chromate(1-), bis[4-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-3-hydroxy-N,N-dimethylbenzenesulfonamidato(2-)]-, lithiumExposure
83783-94-22,7-Naphthalenedisulfonic acid, 3,3'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)azo]]bis[5-amino-4-hydroxy-, lithium sodium salt, compd. with 2,2'-(methylimino)bis[ethanol]Exposure
83783-95-32-Naphthalenesulfonic acid, 3,3'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)azo]]bis[6-amino-4-hydroxy-, lithium sodium salt, compd. with 2,2'-(methylimino)bis[ethanol]Exposure
83783-96-42,7-Naphthalenedisulfonic acid, 5-amino-3-[[4-[2-[4-[(7-amino-1-hydroxy-3-sulfo-2-naphthalenyl)azo]-2-sulfophenyl]ethenyl]-3-sulfophenyl]azo]-4-hydroxy-, lithium sodium salt, compd. with 2,2'-(methylimino)bis[ethanol]Exposure
83783-99-7Benzoic acid, 3,3'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)azo]]bis[6-hydroxy-5-methyl-, lithium sodium salt, compd. with 2,2'-(methylimino)bis[ethanol]Exposure
83804-08-4Cobaltate(1-), bis[4-hydroxy-3-[(2-hydroxy-1-naphthalenyl)azo]-N-methylbenzenesulfonamidato(2-)]-, lithium Exposure
83804-10-8Chromate(1-), bis[4-[(2-chloro-4-nitrophenyl)azo]-2-[[(2-hydroxy-5-nitrophenyl)imino]methyl]phenolato(2-)]-, lithium Exposure
83804-11-9Chromate(1-), bis[4-hydroxy-3-[(2-hydroxy-1-naphthalenyl)azo]benzenesulfonamidato(2-)]-, lithium Exposure
83804-12-0Chromate(1-), [4-hydroxy-3-[(2-hydroxy-1-naphthalenyl)azo]benzenesulfonamidato(2-)][N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthalenyl]acetamidato(2-)]-, lithiumExposure
83804-13-1Chromate(1-), bis[N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthalenyl]acetamidato(2-)]-, lithium Exposure
84559-92-22,7-Naphthalenedisulfonic acid, 3,3'-[azoxybis[(2-methoxy-4,1-phenylene)azo]]bis[4,5-dihydroxy-, tetralithium salt Exposure
85136-25-02,7-Naphthalenedisulfonic acid,3,3'-[azoxybis[(2-methoxy-4,1-phenylene)azo]]bis[4,5-dihydroxy-, lithium sodium salt Exposure
85480-61-1Chromate(2-), [5-chloro-2-hydroxy-3-[(2-hydroxy-1-naphthalenyl)azo]benzenesulfonato(3-)][4-[(2-chloro-4-nitrophenyl)azo]-2-[[(2-hydroxy-5-nitrophenyl)imino]methyl]phenolato(2-)]-, lithium sodiumExposure
85480-62-2Chromate(2-), [1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphthalenolato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-1-naphthalenesulfonato(3-)]-, lithium sodiumExposure
85480-63-3Chromate(2-), [4-[(2-chloro-4-nitrophenyl)azo]-2-[[(2-hydroxy-5-nitrophenyl)imino]methyl]phenolato(2-)][2-hydroxy-3-[(2-hydroxy-1-naphthalenyl)azo]-5-nitrobenzenesulfonato(3-)]-, lithium sodiumExposure
85480-64-4Chromate(2-), [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)]-, lithium sodium Exposure
85480-69-9Cuprate(4-), [7-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]-4-hydroxy-3-[(2-hydroxy-4,7-disulfo-1-naphthalenyl)azo]-1,5-naphthalenedisulfonato(6-)]-, lithium potassium sodium Exposure
85828-74-6Chromate(2-), [4-[4,5-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulfonato(3-)][1-[[2-hydroxy-5-[(2-methoxyphenyl)azo]phenyl]azo]-2-naphthalenolato(2-)]-, lithium sodium Exposure
85828-75-7Chromate(2-), [3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)][N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthalenyl]acetamidato(2-)]-, lithium sodiumExposure
85828-76-8Chromate(2-), [3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)][1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphthalenolato(2-)]-, lithium sodiumExposure
85828-86-0Chromate(2-), [5-chloro-2-hydroxy-3-[(5-hydroxynaphth[2,1-d]-1,3-oxathiol-4-yl)azo]benzenesulfonic acid S,S-dioxidato(3-)][4-[(2,5-dichlorophenyl)azo]-2-[[(2-hydroxy-5-nitrophenyl)imino]methyl]phenolato(2-)]-, lithium sodiumExposure
85865-79-8Chromate(2-), [2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2)][2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodiumExposure
89415-87-22,4-Imidazolidinedione, 1,3-dichloro-5-ethyl-5-methylimidazolidine-2,4-dioneExposure
90294-38-5Chromate(2-), [3-[[[5-[(2-chloro-4-nitrophenyl)azo]-2-hydroxyphenyl]methylene]amino]-4-hydroxybenzenesulfonamidato(2-)][2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodiumExposure
90294-48-7Chromate(3-), bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodium Exposure
90341-63-2Cuprate(4-), [7-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]-3-[(2,8-dihydroxy-4,6-disulfo-1-naphthalenyl)azo]-4-hydroxy-1,5-naphthalenedisulfonato(6-)]-, lithium sodiumExposure
90341-64-3Cuprate(4-), [7-[(5-chloro-2-fluoro-6-methyl-4-pyrimidinyl)amino]-4-hydroxy-3-[(2-hydroxy-4,6-disulfo-1-naphthalenyl)azo]-1,5-naphthalenedisulfonato(6-)]-, lithium potassium sodiumExposure
90341-75-6Cuprate(8-), [µ-[[3,3'-(carbonyldiimino)bis[7-[(2,8-dihydroxy-3,6-disulfo-1-naphthalenyl)azo]-8-hydroxy-1,5-naphthalenedisulfonato]](12-)]]di-, lithium sodiumExposure
91081-19-5Resin acids and Rosin acids, cerium(3++) salts Exposure
91273-04-01H-1,2,4-Triazole-1-methanamine, N,N-bis(2-ethylhexyl)-Exposure
94317-64-3Phosphorothioic triamide, butyl-Exposure
96792-67-5Ethanone, 1-(hexahydrodimethyl-1H-benzindenyl)-Exposure
102082-94-02,7-Naphthalenedisulfonic acid, 4-amino-6-[[4-[[[4-[(2,4-diaminophenyl)azo]phenyl]amino]sulfonyl]phenyl]azo]-5-hydroxy-3-[(4-nitrophenyl)azo]-, lithium saltExposure
106028-58-42,7-Naphthalenedisulfonic acid, 6-amino-4-hydroxy-3-[[7-sulfo-4-[(4-sulfophenyl)azo]-1-naphtalenyl]azo]-, tetralithium saltExposure
106726-11-8Neodecanoic acid, neodynium(3+) saltExposure
106990-43-61,3,5-Triazine-2,4,6-triamine, N,N'''-[1,2-ethanediylbis[[[4,6-bis[butyl(1,2,2,6,6-pentamethyl-4-piperidinyl)amino]-1,3,5-triazin-2-yl]imino]-3,1-propenediyl]]bis[N',N''-dibutyl-N',N''-bis(1,2,2,6,6-pentamethyl-4-piperidinyl)-Exposure
108624-00-62,7-Naphthalenedisulfonic acid, 4-amino-6-[[5-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]-2-sulfophenyl]azo]-5-hydroxy-3-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-, lithium sodium salt Exposure
110152-63-1Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-[(4-hydroxyphenyl)azo]-, lithium sodium saltExposure
120962-01-8Lubricating greases, contg. glycerol-12-hydroxyoctadecanoic acid-lithium hydroxide reaction products Exposure
125302-03-62-Propenoic acid, 2-methyl-, lithium salt, polymer with 1-(1,1-dimethylethyl)-4-ethenylbenzeneExposure
125328-83-82H-1-Benzopyran-2-one, 4-methyl-7-(phosphonooxy)-, dilithium saltExposure
125328-86-12-Anthracenesulfonic acid, 1-amino-4-[[4-(1,1-dimethylethyl)phenyl]amino]-9,10-dihydro-9,10-dioxo-, monolithium salt Exposure
125352-04-7Cuprate(3-), [µ-[4-[[3,3'-dihydroxy-4'-[(2-hydroxy-6-sulfo-1-naphthalenyl)azo][1,1'-biphenyl]-4-yl]azo]-3-hydroxy-2,7-naphthalenedisulfonato(7-)]]di-, ammonium lithium sodium, compds. with diethanolamineExposure
125643-61-0Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, C7_9-branched alkyl estersExposure
126637-70-5Cuprate(4-), [µ-[[3,3'-[(3,3'-dihydroxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydroxy-2,7-naphthalenedisulfonato]](8-)]]di-, dilithium disodiumExposure
126990-35-0Cyclopentane, 1,1'-(dimethoxysilylene)bis-Exposure
127519-17-9Benzenepropanoic acid, 3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxy-, C7-9-branched and linear alkyl estersExposure
129811-21-8Rare earth metals, 2-ethylhexanoate naphthenate complexes Exposure
136210-30-5Aspartic acid N,N'-(methylenedi-4,1-cyclohexanediyl)bis-, tetraethyl esterExposure
136210-32-7DL-Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, tetraethyl esterExposure
163702-01-0Benzene, (1-methylethenyl)-, homopolymer, ar-(2-hydroxy-2-methyl-1-oxopropyl) derivs.Exposure
168253-59-6Aspartic acid, N,N'-(2-methyl-1,5-pentanediyl)bis-, tetraethyl esterExposure
192268-65-8Phosphorothioic acid, O,O,O-triphenyl esters, tert-Bu derivs.Exposure
474510-57-11-Propanone, 1,1'-(methylene-di-4,1-phenylene)bis[2-hydroxy-2-methyl-Exposure

a CAS RN: Chemical Abstracts Service Registry Number.

Appendix E. Substances identified for monitoring of international activity

CAS RNaSubstance name
50-00-0Formaldehyde
50-03-3Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)-
52-51-71,3-Propanediol, 2-bromo-2-nitro-
75-15-0Carbon disulfide
75-78-5Silane, dichlorodimethyl-
78-87-5Propane, 1,2-dichloro-
79-00-5Ethane, 1,1,2-trichloro-
84-74-21,2-Benzenedicarboxylic acid, dibutyl ester
85-68-71,2-Benzenedicarboxylic acid, butyl phenylmethyl ester
95-50-1Benzene, 1,2-dichloro-
96-33-32-Propenoic acid, methyl ester
96-49-11,3-Dioxolan-2-one
98-01-12-Furancarboxaldehyde
99-62-7Benzene, 1,3-bis(1-methylethyl)-
100-18-5Benzene, 1,4-bis(1-methylethyl)-
102-06-7Guanidine, N,N'-diphenyl-
103-23-1Hexanedioic acid, bis(2-ethylhexyl) ester
104-93-8Benzene, 1-methoxy-4-methyl-
105-59-9Ethanol, 2,2'-(methylimino)bis-
106-46-7Benzene, 1,4-dichloro-
108-05-4Acetic acid ethenyl ester
108-87-2Cyclohexane, methyl-
108-95-2Phenol
115-96-8Ethanol, 2-chloro-, phosphate (3:1)
116-25-62,4-Imidazolidinedione, 1-(hydroxymethyl)-5,5-dimethyl-
117-81-71,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester
120-93-42-Imidazolidinone
123-51-31-Butanol, 3-methyl-
126-11-41,3-Propanediol, 2-(hydroxymethyl)-2-nitro-
140-95-4Urea, N,N'-bis(hydroxymethyl)-
149-44-0Methanesulfinic acid, hydroxy-, monosodium salt
461-72-32,4-Imidazolidinedione
597-82-0Phosphorothioic acid, O,O,O-triphenyl ester
624-92-0Disulfide, dimethyl
754-12-11-Propene, 2,3,3,3-tetrafluoro
868-77-92-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester
994-05-8Butane, 2-methoxy-2-methyl-
999-97-3Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
1308-38-9Chromium oxide (Cr2O3)
1333-86-4Carbon black
1506-02-1Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-
1634-04-4Propane, 2-methoxy-2-methyl-
2162-74-5Benzenamine, N,N'-methanetetraylbis[2,6-bis(1-methylethyl)-
2386-87-07-Oxabicyclo[4.1.0]heptane-3-carboxylic acid, 7-oxabicyclo[4.1.0]hept-3-ylmethyl ester
2832-19-1Acetamide, 2-chloro-N-(hydroxymethyl)-
3081-01-41,4-Benzenediamine, N-(1,4-dimethylpentyl)-N'-phenyl-
3107-18-4Cyclohexanesulfonic acid, undecafluoro-, potassium salt
3302-10-1Hexanoic acid, 3,5,5-trimethyl-
3468-63-12-Naphthalenol, 1-[(2,4-dinitrophenyl)azo]-
3710-84-7Ethanamine, N-ethyl-N-hydroxy-
3720-97-62-Imidazolidinone, 4,5-dihydroxy-
3891-98-3Dodecane, 2,6,10-trimethyl-
4719-04-41,3,5-Triazine-1,3,5(2H,4H,6H)-triethanol
5026-74-4Oxiranemethanamine, N-[4-(oxiranylmethoxy)phenyl]-N-(oxiranylmethyl)-
5395-50-6Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetrakis(hydroxymethyl)-
6440-58-02,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
7440-36-0Antimony
7631-95-0Molybdate (MoO4²-), disodium, (T-4)-
7722-64-7Permanganic acid (HMnO4), potassium salt (1:1)
7758-19-2Chlorous acid, sodium salt
9003-36-5Formaldehyde, polymer with (chloromethyl)oxirane and phenol
10028-22-5Sulfuric acid, iron(3++) salt (3:2)
10254-57-6Carbamodithioic acid, dibutyl-, methylene ester
14548-60-8Methanol, (phenylmethoxy)-
16228-00-52,4-Imidazolidinedione, 3-(hydroxymethyl)-5,5-dimethyl-
17928-28-8Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]-
18127-01-0Benzenepropanal, 4-(1,1-dimethylethyl)-
18172-67-3Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-, (1S)-
21145-77-7Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-
25321-09-9Benzene, bis(1-methylethyl)-
25584-83-22-Propenoic acid, monoester with 1,2-propanediol
27107-89-78-Oxa-3,5-dithia-4-stannatetradecanoic acid, 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-, 2-ethylhexyl ester
27813-02-12-Propenoic acid, 2-methyl-, monoester with 1,2-propanediol
28299-41-4Benzene, 1,1'-oxybis[methyl-
28472-97-1Nonanedioic acid, diisodecyl ester
29420-49-31-Butanesulfonic acid, 1,1,2,2,3,3,4,4,4-nonafluoro-, potassium salt
30007-47-71,3-Dioxane, 5-bromo-5-nitro-
31394-54-4Isoheptane
32388-55-9Ethanone, 1-(2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl)-, [3R-(3α,3aβ,7β,8aα)]-
32492-61-8Poly(oxy-1,2-ethanediyl), α,α'-[(1-methylethylidene)di-4,1-phenylene]bis[ω-hydroxy-
34375-28-5Ethanol, 2-(hydroxymethylamino)-
36483-57-51-Propanol, 2,2-dimethyl-, tribromo deriv.
36861-47-9Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-
39236-46-9Urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-
51200-87-4Oxazolidine, 4,4-dimethyl-
53306-54-01,2-Benzenedicarboxylic acid, bis(2-propylheptyl) ester
53988-10-62H-Benzimidazole-2-thione, 1,3-dihydro-4(or 5)-methyl-
57677-95-91-Octanol, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-, 1,1'-(hydrogen phosphate)
63500-71-02H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-
66204-44-2Oxazolidine, 3,3'-methylenebis[5-methyl-
67584-42-3Cyclohexanesulfonic acid, decafluoro(pentafluoroethyl)-, potassium salt
68479-98-1Benzenediamine, ar,ar-diethyl-ar-methyl-
68609-97-2Oxirane, mono[(C12-14-alkyloxy)methyl] derivs.
68938-03-4Octene, hydroformylation products, low-boiling
70356-09-11,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-
71617-10-22-Propenoic acid, 3-(4-methoxyphenyl)-, 3-methylbutyl ester
75980-60-8Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-
78491-02-8Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-
101357-15-7Benzenamine, reaction products with aniline hydrochloride and nitrobenzene
118832-72-7Acetic acid, [[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]thio]-, C10-14-isoalkyl esters
NAbCrumb Rubber (Substances in recycled crumb rubber used as infill material in synthetic turf)

a CAS RN: Chemical Abstracts Service Registry Number.

b Not applicable.

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