Summary of Public Comments Received on the Draft Screening Assessment for tamoxifen [Chemical Abstracts Service Registry Number (CAS RN) 10540-29-1]
One comment was received on the draft screening assessment for tamoxifen to be addressed as part of the Government of Canada’s Chemicals Management Plan categorization of substances on the Domestic Substance List.
| Comment | Response |
|---|---|
| The draft screening assessment does not include the most sensitive ecotoxicological endpoint determined in Supplement A of the following paper by Knacker T, Boettcher M, Rufli H, Frische T, Stolzenberg HC, Teigeler M, Zok S, Braunbeck T, Schäfers C (2010), Environmental effect assessment for sexual-endocrine disrupting chemicals – fish testing strategy. Integrated Environmental Assessment and Management, Vol 6 (4): 653-662. | The final screening assessment includes review of the Knakcker et al. (2010) study and related Supplement A. The final screening assessment incorporates a description of this study and most sensitive ecotoxicological value defined within the study. This value is selected as the critical toxicity value (CTV) and is used to derive the predicted no-effect concentration (PNEC). In the robust study summary this CTV was found to be reliable with satisfactory confidence. |