Certain substances on the Domestic Substances List used primarily as pharmaceuticals

Final Screening Assessments of 28 Substances Used Primarily as Pharmaceuticals
CAS RN Common Pharmaceutical Name Canada Gazette Notice Final Screening Assessment Conclusion on Section 64 criteria
50-06-6 Phenobarbital  HTML  HTML Does not meet
50-18-0 Cyclophosphamide
55-86-7 Mechlorethamine
55-98-1 Busulfan
56-75-7 Chloramphenicol
57-41-0 Phenytoin
68-22-4 Norethindrone
71-58-9 Medroxyprogesterone
81-81-2 Warfarin
126-07-8 Griseofulvin
148-82-3 Melphalan
154-93-8 Carmustine
305-03-3 Chlorambucil
443-48-1 Metronidazole
446-86-6 Azathioprine
604-75-1 Oxazepam
7481-89-2 Zalcitabine
13010-47-4 Lomustine
18883-66-4 Streptozocin
20830-81-3 Daunorubicin
29767-20-2 Teniposide
30516-87-1 Zidovudine
51264-14-3 Amsacrine
10540-29-1 Tamoxifen  HTML  HTML
23214-92-8 Doxorubicin  HTML  HTML
33419-42-0 Etoposide  HTML  HTML
59865-13-3 Cyclosporin A  HTML  HTML
63798-73-2 Cyclosporin E
Date Substances Affected Activity
February 21, 2015 All 28 substances Publication of the final screening assessments in the Canada Gazette Part I: Vol. 149, No. 8 - February 21, 2015.
March 22, 2014 All 28 substances Publication of the draft screening assessments in the Canada Gazette, Part I: Vol. 148, No. 12 - March 22, 2014 and start of 60-day public comment period, ending May 21, 2014.


The substances were flagged during the categorization process as high hazard by Health Canada based on classifications for carcinogenicity or developmental toxicity, and/or as priorities by Environment Canada based on concerns regarding persistence, bioaccumulation and inherent toxicity to non-human organisms.

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