Certain substances on the Domestic Substances List used primarily as pharmaceuticals
| CAS RN | Common Pharmaceutical Name | Canada Gazette Notice | Final Screening Assessment | Conclusion on Section 64 criteria |
|---|---|---|---|---|
| 50-06-6 | Phenobarbital | HTML | HTML | Does not meet |
| 50-18-0 | Cyclophosphamide | |||
| 55-86-7 | Mechlorethamine | |||
| 55-98-1 | Busulfan | |||
| 56-75-7 | Chloramphenicol | |||
| 57-41-0 | Phenytoin | |||
| 68-22-4 | Norethindrone | |||
| 71-58-9 | Medroxyprogesterone | |||
| 81-81-2 | Warfarin | |||
| 126-07-8 | Griseofulvin | |||
| 148-82-3 | Melphalan | |||
| 154-93-8 | Carmustine | |||
| 305-03-3 | Chlorambucil | |||
| 443-48-1 | Metronidazole | |||
| 446-86-6 | Azathioprine | |||
| 604-75-1 | Oxazepam | |||
| 7481-89-2 | Zalcitabine | |||
| 13010-47-4 | Lomustine | |||
| 18883-66-4 | Streptozocin | |||
| 20830-81-3 | Daunorubicin | |||
| 29767-20-2 | Teniposide | |||
| 30516-87-1 | Zidovudine | |||
| 51264-14-3 | Amsacrine | |||
| 10540-29-1 | Tamoxifen | HTML | HTML | |
| 23214-92-8 | Doxorubicin | HTML | HTML | |
| 33419-42-0 | Etoposide | HTML | HTML | |
| 59865-13-3 | Cyclosporin A | HTML | HTML | |
| 63798-73-2 | Cyclosporin E |
| Date | Substances Affected | Activity |
|---|---|---|
| February 21, 2015 | All 28 substances | Publication of the final screening assessments in the Canada Gazette Part I: Vol. 149, No. 8 - February 21, 2015. |
| March 22, 2014 | All 28 substances | Publication of the draft screening assessments in the Canada Gazette, Part I: Vol. 148, No. 12 - March 22, 2014 and start of 60-day public comment period, ending May 21, 2014. |
Background
The substances were flagged during the categorization process as high hazard by Health Canada based on classifications for carcinogenicity or developmental toxicity, and/or as priorities by Environment Canada based on concerns regarding persistence, bioaccumulation and inherent toxicity to non-human organisms.
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