Page 13: Guidelines for Canadian Drinking Water Quality: Guideline Technical Document – Tetrachloroethylene

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12.0 References

Abrahamsson, K., Ekdahl, A., Collen, J. and Pedersen, M. (1995). Marine algae—A source of trichloroethylene and perchloroethylene. Limnol. Oceanogr., 40(7): 1321-1326.

Adams, J.Q. and Clark, R.M. (1991). Evaluating the costs of packed-tower aeration and GAC for controlling selected organics. J. Am. Water Works Assoc., 83(1): 49-57.

Ahlborg, G. (1990). Pregnancy outcome among women working in laundries and dry-cleaning shops using tetrachloroethylene. Am. J. Ind. Med., 17(5): 567-575.

Aieta, M.E., Reagan, K.M., Lang, J.S., McReynolds, L. and Kang, J.W. (1988). Advanced oxidation processes for treating groundwater contaminated with TCE and PCE: pilot-scale evaluations. J. Am. Water Works Assoc., 80(5): 57-63.

Aitio, A., Pekari, K. and Jarvisalo, J. (1984). Skin absorption as a source of error in biological monitoring. Scand. J. Work Environ. Health, 10(5): 317-320.

Alberta Environment (2007). Personal communication from Karu Chinniah.

Allen, J.W., Collins, B.W. and Evansky, P.A. (1994). Spermatid micronucleus analyses of trichloroethylene and chloral hydrate effects in mice. Mutat. Res., 323(1-2): 81-88.

Altmann, L., Bottger, A. and Wiegand, H. (1990). Neurophysiological and psychophysical measurements reveal effects of acute low-level organic solvent exposure in humans. Int. Arch. Occup. Environ. Health, 62(7): 493-499.

Altmann, L., Wiegand, H., Böttger, A., Elstermeier, F. and Winneke, G. (1992). Neurobehavioural and neurophysiological outcomes of acute repeated perchloroethylene exposure. Appl. Psychol., 41(3): 269-279.

Altmann, L., Neuhann, H.F., Kramer, U., Witten, J. and Jermann, E. (1995). Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposure measured in neighborhoods of dry cleaning shops. Environ. Res., 69(2): 83-89.

Anders, M.W., Lash, L., Dekant, W., Elfarra, A.A. and Dohn, D.R. (1988). Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. Crit. Rev. Toxicol., 18(4): 311-341.

Andersen, A., Barlow, L., Engeland, A., Kjaerheim, K., Lynge, E. and Pukkala, E. (1999). Work-related cancer in the Nordic countries. Scand. J. Work Environ. Health, 25(Suppl. 2): 1-116.

Andrys, C., Hanovcova, I., Chylkova, V., Tejral, J., Eminger, S. and Prochazkova, J. (1997). Immunological monitoring of dry-cleaning shop workers—exposure to tetrachloroethylene. Cent. Eur. J. Public Health, 5(3): 136-142.

Anttila, A., Pukkala, E., Sallmen, M., Hernberg, S. and Hemminki, K. (1995). Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Occup. Environ. Med., 37(7): 797-806.

APHA, AWWA and WEF (2005). Standard methods for the examination of water and wastewater, 21st edition. American Public Health Association, American Water Works Association and Water Environment Federation, Washington, DC.

Aranyi, C., O'Shea, W.J., Graham, J.A. and Miller, F.J. (1986). The effects of inhalation of organic chemical air contaminants on murine lung host defenses. Fundam. Appl. Toxicol., 6(4): 713-720.

Aschengrau, A., Ozonoff, D., Paulu, C., Coogan, P., Vezina, R., Heeren, T. and Zhang, Y. (1993). Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts. Arch. Environ. Health, 48(5): 284-292.

Aschengrau, A., Paulu, C. and Ozonoff, D. (1998). Tetrachloroethylene-contaminated drinking water and the risk of breast cancer. Environ. Health Perspect., 106(Suppl. 4): 947-953.

Aschengrau, A., Rogers, S. and Ozonoff, D. (2003). Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environ. Health Perspect., 111(2): 167-173.

Aschengrau, A., Weinberg, J., Rogers, S., Gallagher, L., Winter, M., Vieira, V., Webster, T. and Ozonoff, D. (2008). Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes. Environ. Health Perspect., 116(6): 814-820.

Aschengrau, A., Weinberg, J.M., Gallagher, L.G., Winter, M.R., Vieira, V.M., Webster, T.F. and Ozonoff, D.M. (2009a). Exposure to tetrachloroethylene-contaminated drinking water and the risk of pregnancy loss. Water Qual. Expo. Health, 1: 23-34.

Aschengrau, A., Weinberg, J.M., Janulewicz, P.A., Gallagher, L.G., Winter, M.R., Vieira, V.M., Webster, T.F. and Ozonoff, D.M. (2009b). Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study. Environ. Health, 8(1): 1-16.

Aschengrau, A., Weinberg, J.M., Janulewicz, P.A., Romano, M.E., Gallagher, L.G., Winter, M.R., Martin, B.R., Vieira, V.M., Webster, T.F., White, R.F. and Ozonoff, D.M. (2011). Affinity for risky behaviors following prenatal and early childhood exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environ. Health, 10(1): 1-13.

Aschengrau, A., Weinberg, J.M., Janulewicz, P.A., Romano, M.E., Gallagher, L.G., Winter, M.R., Martin, B.R., Vieira, V.M., Webster, T.F., White, R.F. and Ozonoff, D.M. (2012). Occurrence of mental illness following prenatal and early childhood exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environ. Health, 11(1): 1-12.

ASTM (1999). Standard test method for measurement of purgeable organic compounds in water by capillary column gas chromatography/mass spectrometry. In: Annual book of ASTM standards. American Society for Testing and Materials, West Conshohocken, Pennsylvania, pp. 863-917.

ATSDR (1997). Toxicological profile for tetrachloroethylene. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia.

Austin, E.W., Okita, J.R., Okita, R.T., Larson, J.L. and Bull, R.J. (1995). Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation. Toxicology, 97(1-3): 59-69.

Austin, E.W., Parrish, J.M., Kinder, D.H. and Bull, R.J. (1996). Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids. Fundam. Appl. Toxicol., 31(1): 77-82.

AWWA (1991). Existing VOC treatment installations; design, operation and cost. Report of the Organics Contaminant Control Committee. Water Quality Division, American Water Works Association, Denver, Colorado (Report No. 0033986).

Bagnell, P.C. and Ellenberger, H.A. (1977). Obstructive jaundice due to a chlorinated hydrocarbon in breast milk. Can. Med. Assoc. J., 117(9): 1047-1048.

Bale, A.S., Adams, T.L., Bushnell, P.J., Shafer, T.J. and Boyes, W.K. (2005a). Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats. Pharmacol. Biochem. Behav., 82(4): 635-645.

Bale, A.S., Meacham, C.A., Benignus, V.A., Bushnell, P.J. and Shafer, T.J. (2005b). Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. Toxicol. Appl. Pharmacol., 205(1): 77-88.

Bale, A.S., Barone, S., Scott, C.S. and Cooper, G.S. (2011). A review of potential neurotoxic mechanisms among three chlorinated organic solvents. Toxicol. Appl. Pharmacol., 255(1): 113-126.

Band, P.R., Le, N.D., Fang, R., Deschamps, M., Gallagher, R.P. and Yang, P. (2000). Identification of occupational cancer risks in British Columbia. A population-based case-control study of 995 incident breast cancer cases by menopausal status, controlling for confounding factors. J. Occup. Environ. Med., 42(3): 284-310.

Bandman, A.L., et al. (1990). [Hazardous substances: halogenated hydrocarbons.] Chimia, 456 (Russian). [cited in CCOHS, 2012].

Barrio-Lage, G., Parsons, F.Z., Nassar, R.S. and Lorenzo, P.A. (1986). Sequential dehalogenation of chlorinated ethenes. Environ. Sci. Technol., 20: 96-99.

Bartsch, H., Malaveille, C., Barbin, A. and Planche, G. (1979). Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases. Arch. Toxicol., 41(4): 249-277.

Beland, F.A. (1999). NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0) administered by gavage to F344/N rats and B6C3F1 mice. Toxic. Rep. Ser., 59: 1-66, A1-E7.

Beliles, R.P. (2002). Concordance across species in the reproductive and developmental toxicity of tetrachloroethylene. Toxicol. Ind. Health, 18(2): 91-106.

Beliles, R.P., Brusick, D.J. and Mecler, F.J. (1980). Teratogenic-mutagenic risk of workplace contaminants: trichloroethylene, perchloroethylene, and carbon disulfide. National Institute for Occupational Safety and Health, Cincinnati, OH (NIOSH 210-77-0047).

Benignus, V.A., Boyes, W.K., Geller, A.M. and Bushnell, P.J. (2009). Long-term perchloroethylene exposure: a meta-analysis of neurobehavioral deficits in occupationally and residentially exposed groups. J. Toxicol. Environ. Health A, 72(13): 824-831.

Benoit, F.M., Davidson, W.R., Lovett, A.M., Nacson, S. and Ngo, A. (1985). Breath analysis by API/MS—Human exposure to volatile organic solvents. Int. Arch. Occup. Environ. Health, 55(2): 113-120.

Bergamaschi, E., Mutti, A., Bocchi, M.C., Alinovi, R., Olivetti, G., Ghiggeri, G.M. and Franchini, I. (1992). Rat model of perchloroethylene-induced renal dysfunctions. Environ. Res., 59(2): 427-439.

Bhunya, S.P. and Behera, B.C. (1987). Relative genotoxicity of trichloroacetic acid (TCA) as revealed by different cytogenetic assays: bone marrow chromosome aberration, micronucleus and sperm-head abnormality in the mouse. Mutat. Res., 188(3): 215-221.

Bignami, M., Conti, G., Conti, L., Crebelli, R., Misuraca, F., Puglia, A.M., Randazzo, R., Sciandrello, G. and Carere, A. (1980). Mutagenicity of halogenated aliphatic hydrocarbons in Salmonella typhimurium, Streptomyces coelicolor and Aspergillus nidulans. Chem. Biol. Interact., 30(1): 9-23.

Birner, G., Rutkowska, A. and Dekant, W. (1996). N-Acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure. Drug Metab. Dispos., 24(1): 41-48.

Blair, A., Petralia, S.A. and Stewart, P.A. (2003). Extended mortality follow-up of a cohort of dry cleaners. Ann. Epidemiol., 13(1): 50-56.

Bogen, K.T., Colston, B.W., Jr. and Machicao, L.K. (1992). Dermal absorption of dilute aqueous chloroform, trichloroethylene, and tetrachloroethylene in hairless guinea pigs. Fundam. Appl. Toxicol., 18(1): 30-39.

Bois, F.Y., Gelman, A., Jiang, J., Maszle, D.R., Zeise, L. and Alexeef, G. (1996). Population toxicokinetics of tetrachloroethylene. Arch. Toxicol., 70(6): 347-355.

Bouwer, E.J., Rittmann, B.E. and McCarty, P.L. (1981). Anaerobic degradation of halogenated 1- and 2-carbon organic compounds. Environ. Sci. Technol., 15(5): 596-599.

Bove, F.J., Fulcomer, M.C., Klotz, J.B., Esmart, J., Dufficy, E.M. and Savrin, J.E. (1995). Public drinking water contamination and birth outcomes. Am. J. Epidemiol., 141(9): 850-862.

Bradley, P.M. (2000). Microbial degradation of chloroethenes in groundwater systems. Hydrogeol. J., 8(1): 104-111.

Briving, C., Jacobson, I., Hamberger, A., Kjellstrand, P., Haglid, K.G. and Rosengren, L.E. (1986). Chronic effects of perchloroethylene and trichloroethylene on the gerbil brain amino acids and glutathione. Neurotoxicology, 7(1): 101-108.

Brodkin, C.A., Daniell, W., Checkoway, H., Echeverria, D., Johnson, J., Wang, K., Sohaey, R., Green, D., Redlich, C. and Gretch, D. (1995). Hepatic ultrasonic changes in workers exposed to perchloroethylene. Occup. Environ. Med., 52(10): 679-685.
Bromhead, J. (1997). Permeation of benzene, trichloroethene and tetrachloroethene through plastic pipes. An assessment for the Drinking Water Inspectorate. Literature search strategy devised by M.M. Wilson. LGC (Teddington) Ltd. Queens road, Teddington, Middlesex. TW110LY

Brown, D.P., Kaplan, S.D. and Samuel, D. (1987). Retrospective cohort mortality study of dry cleaner workers using perchloroethylene. J. Occup. Med., 29(6): 535-541.

Brownson, R.C., Alavanja, M.C. and Chang, J.C. (1993). Occupational risk factors for lung cancer among nonsmoking women: a case-control study in Missouri (United States). Cancer Causes Control, 4(5): 449-454.

Buben, J.A. and O'Flaherty, E.J. (1985). Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. Toxicol. Appl. Pharmacol., 78(1): 105-122.

Bushnell, P.J., Shafer, T.J., Bale, A.S., Boyes, W.K., Simmons, J.E., Eklund, C. and Jackson, T.L. (2005). Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry. Environ. Toxicol. Pharmacol., 19(3): 607-614.

Byczkowski, J.Z. and Fisher, J.W. (1994). Lactational transfer of tetrachloroethylene in rats. Risk Anal., 14(3): 339-349.

Cai, S.X., Huang, M.Y., Chen, Z., Liu, Y.T., Jin, C., Watanabe, T., Nakatsuka, H., Seiji, K., Inoue, O. and Ikeda, M. (1991). Subjective symptom increase among dry-cleaning workers exposed to tetrachloroethylene vapor. Ind. Health, 29(3): 111-121.

Caldwell, D.J. (1999). Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: a case study using alkyl phthalates. Regul. Toxicol. Pharmacol., 30(1): 45-53.

Callahan, M.A., Slimak, M.W., Gabel, N.W., May, I.P., Fowler, C.F., Freed, J.R., Jennings, P., Durfee, R.L., Whitmore, F.C., Maestri, B., Mabey, W.R., Holt, B.R. and Gould, C. (1979). Water-related environmental fate of 129 priority pollutants. Vol. II. Halogenated aliphatic hydrocarbons, halogenated ethers, monocyclic aromatics, phthalate esters, polycyclic aromatic hydrocarbons, nitrosamines, and miscellaneous compounds. Office of Water Planning and Standards, Office of Water and Waste Management, U.S. Environmental Protection Agency, Washington, DC (EPA-440/4-79-029b).

Calvert, G.M., Ruder, A.M. and Petersen, M.R. (2011). Mortality and end-stage renal disease incidence among dry cleaning workers. Occup. Environ. Med., 68(10): 709-716.

Cano, M.I. and Pollán, M. (2001). Non-Hodgkin's lymphomas and occupation in Sweden. Int. Arch. Occup. Environ. Health, 74(6): 443-449.

CAREX Canada (2010). Carcinogen profile: tetrachloroethylene (PERC). CAREX Canada, Vancouver, British Columbia.

Carney, E.W., Thorsrud, B.A., Dugard, P.H. and Zablotny, C.L. (2006). Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene. Birth Defects Res. B Dev. Reprod. Toxicol., 77(5): 405-412.

Carter, J.H., Carter, H.W. and DeAngelo, A.B. (1995). Biochemical, pathologic and morphometric alterations induced in male B6C3F1 mouse liver by short-term exposure to dichloroacetic acid. Toxicol. Lett., 81(1): 55-71.

Castro, K. and Zander, A. (1995). Membrane air stripping: effects of pretreatment. J. Am. Water Works Assoc., 87(3): 50-61.

Cavalleri, A., Gobba, F., Paltrinieri, M., Fantuzzi, G., Righi, E. and Aggazzotti, G. (1994). Perchloroethylene exposure can induce colour vision loss. Neurosci. Lett., 179(1-2): 162-166.

CCME (1999). Canadian soil quality guidelines for the protection of environmental and human health: tetrachloroethylene (1997). In: Canadian environmental quality guidelines. Canadian Council of Ministers of the Environment, Winnipeg, Manitoba.

CCOHS (2012). Registry of Toxic Effects of Chemical Substances (RTECS). Canadian Centre for Occupational Safety and Health, Hamilton, Ontario

Cearfoss, J. and Hassoun, E. (2012). The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice. J. Biochem. Mol. Toxicol., 26(4): 147-154.

Cederberg, H., Henriksson, J. and Binderup, M.L. (2010). DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of tetrachloroethylene. Mutagenesis, 25(2): 133-138.

Chang, L.W., Daniel, F.B. and DeAngelo, A.B. (1992). Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes. Environ. Mol. Mutagen., 20(4): 277-288.

Chen, H.H., Chan, M.H. and Fu, S.H. (2002). Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies. Toxicology, 170(3): 201-209.

Chiu, W.A. and Ginsberg, G.L. (2011). Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans. Toxicol. Appl. Pharmacol., 253(3): 203-234.

Chiu, W.A., Micallef, S., Monster, A.C. and Bois, F.Y. (2007). Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: empirical results and comparisons with previous studies. Toxicol. Sci., 95(1): 23-36.

Choi, Y.H., Kim, N., Seo, Y.S., Choi, S.J., Yang, J.O., Lee, E.Y., Hong, S.Y. and Lee, H.S. (2003). ARF requiring hemodialysis after accidental perchloroethylene ingestion. Am. J. Kidney Dis., 41(3): E11.

Chowdhury, Z., Summers, S., Westerhoff, G., Leto, B., Nowack, K. and Corwin, C. (2013). Activated carbon: solutions for improving water quality. American Water Works Association, Denver, Colorado.

Chrobak, R.S., Kelleher, D.L. and Suffet, I.H. (1985). Full scale GAC adsorption performance compared to pilot plant predictions. Proceedings of the Am. Water Works Assoc. Annual Conference, pp. 1115-1150.

Clewell, H.J., Gentry, P.R., Kester, J.E. and Andersen, M.E. (2005). Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene. Crit. Rev. Toxicol., 35(5): 413-433.

Cohn, P., Klotz, J., Bove, F., Berkowitz, M. and Fagliano, J. (1994). Drinking water contamination and the incidence of leukemia and non-Hodgkin's lymphoma. Environ. Health Perspect., 102(6): 556-561.

Connor, T.H., Theiss, J.C., Hanna, H.A., Monteith, D.K. and Matney, T.S. (1985). Genotoxicity of organic chemicals frequently found in the air of mobile homes. Toxicol. Lett., 25(1): 33-40.

Cooper, W.J., Meacham, D.E., Nickelsen, M.G., Lin, K., Ford, D.B., Kurucz, C.N. and Waite, T.D. (1993). The removal of tri- (TCE) and tetrachloroethylene (PCE) from aqueous solution using high energy electrons. J. Air Waste Manage. Assoc., 43(10): 1358-1366.

Corton, J.C. (2010). Mode of action analysis and human relevance of liver tumors induced by PPARα activation. In: Cancer risk assessment: chemical carcinogenesis, hazard evaluation, and risk quantification. Hsu, C.H. and Stedeford, T. (eds.). John Wiley & Sons, Hoboken, New Jersey, pp. 439-481.

Costa, C., Barbaro, M., Catania, S., Silvari, V. and Germano, M.P. (2004). Cytotoxicity evaluation after coexposure to perchloroethylene and selected peroxidant drugs in rat hepatocytes. Toxicol. In Vitro, 18(1): 37-44.

Costas, K., Knorr, R.S. and Condon, S.K. (2002). A case-control study of childhood leukemia in Woburn, Massachusetts: the relationship between leukemia incidence and exposure to public drinking water. Sci. Total Environ., 300(1-3): 23-35.

Couffin, N., Cabassud, C. and Lahoussine-Turcaud, V. (1998). A new process to remove halogenated VOCs for drinking water production: vacuum membrane distillation. Desalination, 117(1-3): 233-245.

Covington, T.R., Gentry, P.R., Van Landingham, C.B., Andersen, M.E., Kester, J.E. and Clewell, H.J. (2007). The use of Markov Chain Monte Carlo uncertainty analysis to support a public health goal for perchloroethylene. Regul. Toxicol. Pharmacol., 47(1): 1-18.

CPI (2004). CPI product profile for perchloroethylene (tetrachloroethylene). Camford Information Services Inc., Toronto, Ontario.

Crittenden, J.C., Cortright, R.D., Rick, B., Tang, S. and Perram, D. (1988). Using GAC to remove VOCs from air-stripper off-gas. J. Am. Water Works Assoc., 80(5): 73-84.

Crittenden, J.C., Trussell, R.R., Hand, D.W., Howe, K.J. and Tchobanoglous, G. (2005). Water treatment: principles and design, 2nd edition. John Wiley & Sons.

Cummings, B.S., Zangar, R.C., Novak, R.F. and Lash, L.H. (1999). Cellular distribution of cytochromes P-450 in the rat kidney. Drug Metab. Dispos., 27(4): 542-548.

Cummings, B.S., Lasker, J.M. and Lash, L.H. (2000). Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J. Pharmacol. Exp. Ther., 293(2): 677-685.

Cummins, M.D. and Westrick, J.J. (1990). Chapter 13. Treatment technologies and costs for removing volatile organic compounds from water: aeration. In: Significance and treatment of volatile organic compounds in water supplies. Ram, N.M., Christman, R.F. and Cantor, K.P. (eds.). Lewis Publishers, Boca Raton, Florida, pp. 261-312.

Cutler, J.J., Parker, G.S., Rosen, S., Prenney, B., Healey, R. and Caldwell, G.G. (1986). Childhood leukemia in Woburn, Massachusetts. Public Health Rep., 101(2): 201-205.

Daft, J.L. (1988). Rapid determination of fumigant and industrial chemical residues in food. J. Assoc. Off. Anal. Chem., 71(4): 748-760. As cited in: Government of Canada (1993).

Dallas, C.E., Muralidhara, S., Chen, X.M., Ramanathan, R., Varkonyi, P., Gallo, J.M. and Bruckner, J.V. (1994). Use of a physiologically based model to predict systemic uptake and respiratory elimination of perchloroethylene. Toxicol. Appl. Pharmacol., 128: 60-68.

Daniel, J.W. (1963). The metabolism of 36Cl-labelled trichloroethylene and tetrachloroethylene in the rat. Biochem. Pharmacol., 12(8): 795-802.

Dann, T. and Wang, D. (1992). Measurement of volatile organic compounds in Canada 1987-1990. Conservation and Protection, Environmental Technology Centre, Environment Canada, Ottawa, Ontario. As cited in: Government of Canada (1993).

DeAngelo, A.B., Daniel, F.B., Most, B.M. and Olson, G.R. (1997). Failure of monochloroacetic acid and trichloroacetic acid administered in the drinking water to produce liver cancer in male F344/N rats. J. Toxicol. Environ. Health, 52(5): 425-445.

DeAngelo, A.B., Daniel, F.B., Wong, D.M. and George, M.H. (2008). The induction of hepatocellular neoplasia by trichloroacetic acid administered in the drinking water of the male B6C3F1 mouse. J. Toxicol. Environ. Health A, 71(16): 1056-1068.

Degrassi, F. and Tanzarella, C. (1988). Immunofluorescent staining of kinetochores in micronuclei: a new assay for the detection of aneuploidy. Mutat. Res., 203(5): 339-345.

Dekant, W., Vamvakas, S., Berthold, K., Schmidt, S., Wild, D. and Henschler, D. (1986). Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem. Biol. Interact., 60(1): 31-45.

Delfino, R.J., Gong, H., Jr., Linn, W.S., Pellizzari, E.D. and Hu, Y. (2003a). Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environ. Health Perspect., 111(4): 647-656.

Delfino, R.J., Gong, H., Linn, W.S., Hu, Y. and Pellizzari, E.D. (2003b). Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air. J. Expo. Anal. Environ. Epidemiol., 13(5): 348-363.

DeMarini, D.M., Perry, E. and Shelton, M.L. (1994). Dichloroacetic acid and related compounds: induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100. Mutagenesis, 9(5): 429-437.

de Raat, K. (2003). The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and the Dutch Expert Committee on Occupational Standards. 133. Tetrachloroethylene (PER). National Institute for Working Life, Stockholm, Sweden, pp. 1-110 (Arbete och Hälsa 14).

Doherty, A.T., Ellard, S., Parry, E.M. and Parry, J.M. (1996). An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis, 11(3): 247-274.

Dosemeci, M., Cocco, P. and Chow, W. (1999). Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons. Am. J. Ind. Med., 36(1): 54-59.

Doyle, P., Roman, E., Beral, V. and Brookes, M. (1997). Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene. Occup. Environ. Med., 54(12): 848-853.

Dreessen, B., Westphal, G., Bünger, J., Hallier, E. and Müller, M. (2003). Mutagenicity of the glutathione and cysteine S-conjugates of the haloalkenes 1,1,2-trichloro-3,3,3-trifluoro-1-propene and trichlorofluoroethene in the Ames test in comparison with the tetrachloroethene-analogues. Mutat. Res., 539(1-2): 157-166.

Ducom, G. and Cabassud, C. (1999). Interests and limitations of nanofiltration for the removal of volatile organic compounds in drinking water production. Desalination, 124(1-3): 115-123.

Dybing, F. and Dybing, O. (1946). The toxic effect of tetrachloromethane and tetrachloroethylene in oily solution. Acta Pharmacol., 2: 223-226. As cited in de Raat (2003).

Dyksen, J.E. (2005). Chapter 5. Aeration and air stripping. In: Water treatment plant design, 4th edition. Baruth, E.E. (ed.). McGraw Hill, pp. 5.1-5.23.

Dyksen, J.E., Hess, A.F. and Hiltebrand, D.J. (1984). Interpreting packed column pilot test data for VOC removal. Proceedings of the 1984 Am. Water Works Assoc. Annual Conference, June, 1984, pp. 645-664.

Dyksen, J.E., Ford, R., Raman, K., Schaefer, J.K., Fung, L., Schwartz, B. and Barnes, M. (1992). In-line ozone and hydrogen peroxide treatment for removal of organic chemicals. American Water Works Association Research Foundation, Denver, Colorado.

Dyksen, J.E., Racsko, R.F. and Cline, G.C. (1995). Operating experiences at VOC treatment facilities. Proceedings of the 1995 Annual Am. Water Works Assoc. Conference, June, 1995, pp. 659-684.

Dzombak, D.A., Roy, B.R. and Fang, H.J. (1993). Air stripper design and costing computer program. J. Am. Water Works Assoc., 85(10): 63-72.

Ebrahim, A.S., Babakrishnan, K. and Sakthisekaran, D. (1996). Perchloroethylene-induced alterations in glucose metabolism and their prevention by 2-deoxy-D-glucose and vitamin E in mice. J. Appl. Toxicol., 16(4): 339-348.

Ebrahim, A.S., Babu, E., Thirunavukkarasu, C. and Sakthisekaran, D. (2001). Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases. Drug Chem. Toxicol., 24(4): 429-437.

ECETOC (1999). Tetrachloroethylene CAS no. 127-18-4. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium (Joint Assessment of Commodity Chemicals No. 39).

Echeverria, D., White, R.F. and Sampaio, C. (1995). A behavioral evaluation of PCE exposure in patients and dry cleaners: a possible relationship between clinical and preclinical effects. J. Occup. Environ. Med., 37(6): 667-680.

Emara, A.M., Abo El-Noor, M.M., Hassan, N.A. and Wagih, A.A. (2010). Immunotoxicity and hematotoxicity induced by tetrachloroethylene in Egyptian dry cleaning workers. Inhal. Toxicol., 22(2): 117-124.

Emmert, B., Bünger, J., Keuch, K., Müller, M., Emmert, S., Hallier, E. and Westphal, G.A. (2006). Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5. Toxicology, 228(1): 66-76.

Entz, R.C. and Diachenko, G.W. (1988). Residues of volatile halocarbons in margarines. Food Addit. Contam., 5(3): 267-276.

Environment Canada (2011). PERC regulations: Tetrachloroethylene (PERC) (Use in Dry Cleaning and Reporting Requirements) Regulations. Available at: www.ec.gc.ca/regs-tetra/default.asp?lang=en&n=997C37FF-1

Environment Canada (2014). National Pollutant Release Inventory online data search - facility reported data. Available at: http://ec.gc.ca/inrp-npri/donnees-data/index.cfm?lang=En

Eskenazi, B., Fenster, L., Hudes, M., Wyrobek, A.J., Katz, D.F., Gerson, J. and Rempel, D.M. (1991). A study of the effect of perchloroethylene exposure on the reproductive outcomes of wives of dry-cleaning workers. Am. J. Ind. Med., 20(5): 593-600.

European Commission (2005). Tetrachloroethylene. Part I—Environment. Summary risk assessment report. Institute for Health and Consumer Protection, Ispra (Special Publication I.05.104).

Feige, J.N., Gelman, L., Michalik, L., Desvergne, B. and Wahli, W. (2006). From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog. Lipid Res., 45(2): 120-159.

Fernandez, J., Guberan, E. and Caperos, J. (1976). Experimental human exposures to tetrachloroethylene vapor and elimination in breath after inhalation. Am. Ind. Hyg. Assoc. J., 37(3): 143-150.

Ferroni, C., Selis, L., Mutti, A., Folli, D., Bergamaschi, E. and Franchini, I. (1992). Neurobehavioral and neuroendocrine effects of occupational exposure to perchloroethylene. Neurotoxicology, 13(1): 243-248.

Fidaleo, M. (2009). Human health risk assessment for peroxisome proliferators: more than 30 years of research. Exp. Toxicol. Pathol., 61(3): 215-221.

Fisher, J., Lumpkin, M., Boyd, J., Mahle, D., Bruckner, J.V. and El-Masri, H.A. (2004). PBPK modeling of the metabolic interactions of carbon tetrachloride and tetrachloroethylene in B6C3F1 mice. Environ. Toxicol. Pharmacol., 16(1-2): 93-105.

Fisher, J.W., Whittaker, T.A., Taylor, D.H., Clewell, H.J., III and Andersen, M.E. (1989). Physiologically based pharmacokinetic modelling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol. Appl. Pharmacol., 99(3): 395-414.

Fogel, M.M., Taddeo, A.R. and Fogel, S. (1986). Biodegradation of chlorinated ethenes by a methane-utilizing mixed culture. Appl. Environ. Microbiol., 51(4): 720-724.

Forand, S.P., Lewis-Michl, E.L. and Gomez, M.I. (2012). Adverse birth outcomes and maternal exposure to trichloroethylene and tetrachloroethylene through soil vapor intrusion in New York State. Environ. Health Perspect., 120(4): 616-621.

Franchini, I., Cavatorta, A., Falzoi, M., Lucertini, S. and Mutti, A. (1983). Early indicators of renal damage in workers exposed to organic solvents. Int. Arch. Occup. Environ. Health, 52(1): 1-9.

Frantz, S.W. and Watanabe, P.G. (1983). Tetrachloroethylene: balance and tissue distribution in male Sprague-Dawley rats by drinking-water administration. Toxicol. Appl. Pharmacol., 69(1): 66-72.

Fredriksson, A., Danielsson, B.R. and Eriksson, P. (1993). Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates. Toxicol. Lett., 66(1): 13-19.

Freedman, D.L. and Gossett, J.M. (1989). Biological reductive dechlorination of tetrachloroethylene and trichloroethylene to ethylene under methanogenic conditions. Appl. Environ. Microbiol., 55(9): 2144-2151.

Fronk, C.A. (1987). Destruction of volatile organic contaminants in drinking water by ozone treatment. Ozone Sci. Eng., 9(3): 265-288.

Furnus, C.C., Ulrich, M.A., Terrors, M.C. and Dulout, F.N. (1990). The induction of aneuploidy in cultured Chinese hamster cells by propionaldehyde and chloral hydrate. Mutagenesis, 5(4): 323-326.

Fuscoe, J.C., Afshari, A.J., George, M.H., DeAngelo, A.B., Tice, R.R., Salmon, T. and Allen, J.W. (1996). In vivo genotoxicity of dichloroacetic acid: evaluation with the mouse peripheral blood micronucleus assay and the single cell gel assay. Environ. Mol. Mutagen., 27(1): 1-9.

Gallagher, L.G., Vieira, V.M., Ozonoff, D., Webster, T.F. and Aschengrau, A. (2011). Risk of breast cancer following exposure to tetrachloroethylene-contaminated drinking water in Cape Cod, Massachusetts: reanalysis of a case-control study using a modified exposure assessment. Environ. Health, 10: 47-47.

Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B.H., Resnick, M.A., Anderson, B. and Zeiger, E. (1987). Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutagen., 10(Suppl. 10): 1-175.

Garabrant, D.H., Lacey, J.V., Laing, T.J., Gillespie, B.W., Mayes, M.D., Cooper, B.C. and Schottenfeld, D. (2003). Scleroderma and solvent exposure among women. Am. J. Epidemiol., 157(6): 493-500.

Garnier, R., Bédouin, J., Pépin, G. and Gaillard, Y. (1996). Coin-operated dry cleaning machines may be responsible for acute tetrachloroethylene poisoning: report of 26 cases including one death. J. Toxicol. Clin. Toxicol., 34(2): 191-197.

Ge, R., Yang, S., Kramer, P.M., Tao, L. and Pereira, M.A. (2001). The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. J. Biochem. Mol. Toxicol., 15(2): 100-106.

Gearhart, J.M., Mahle, D.A., Greene, R.J., Seckel, C.S., Flemming, C.D., Fisher, J.W. and Clewell, H.J. (1993). Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol. Lett., 68(1-2): 131-144.

Gennari, P., Naldi, M., Motta, R., Nucci, M.C., Giacomini, C., Violante, F.S. and Raffi, G.B. (1992). Gamma-glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene. Am. J. Ind. Med., 21(5): 661-671.

Getz, K.D., Janulewicz, P.A., Rowe, S., Weinberg, J.M., Winter, M.R., Martin, B.R., Vieira, V.M., White, R.F. and Aschengrau, A. (2012). Prenatal and early childhood exposure to tetrachloroethylene and adult vision. Environ. Health Perspect., 120(9): 1327-1332.

Ghantous, H., Danielsson, B.R.G., Dencker, L., Gorczak, J. and Vesterberg, O. (1986). Trichloroacetic acid accumulates in murine amniotic fluid after tri- and tetrachloroethylene inhalation. Acta Pharmacol. Toxicol., 58(2): 105-114.

Giller, S., Le Curieux, F., Erb, F. and Marzin, D. (1997). Comparative genotoxicity of halogenated acetic acids found in drinking water. Mutagenesis, 12(5): 321-328.

Glaza, E. C and Park, J.K. (1992). Permeation of organic contaminants through gasket pipe joins. JAWWA 87 (7):92-100

Glaze, W. and Kang, J.W. (1988). Advanced oxidation processes for treating groundwater contaminated with TCE and PCE: laboratory study. J. Am. Water Works Assoc., 80(5): 57-63.

Gobba, F., Righi, E., Fantuzzi, G., Predieri, G., Cavazzuti, L. and Aggazzotti, G. (1998). Two-year evolution of perchloroethylene-induced color-vision loss. Arch. Environ. Health, 53(3): 196-198.

Gold, L.S., De Roos, A.J., Waters, M. and Stewart, P. (2008). Systematic literature review of uses and levels of occupational exposure to tetrachloroethylene. J. Occup. Environ. Hyg., 5(12): 807-839.

Golder Associates (1989). Interim report on supplementary hydrogeological investigations. Golder Associates Ltd., Vancouver, British Columbia. As cited in: Government of Canada (1993).

Goldman, J.A. (1996). Connective tissue disease in people exposed to organic chemical solvents: systemic sclerosis (scleroderma) in dry cleaning plant and aircraft industry workers. J. Clin. Rheumatol., 2(4): 185-190.

Goldsworthy, T.L. and Popp, J.A. (1987). Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity. Toxicol. Appl. Pharmacol., 88(2): 225-233.

Goldsworthy, T.L., Lyght, O., Burnett, V.L. and Popp, J.A. (1988). Potential role of alpha-2µ-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane. Toxicol. Appl. Pharmacol., 96(2): 367-379.

Goodfellow, F. Ouki, S. K. and Murray, V. (2002). Permeation of organic chemicals through plastic water-supply pipes. JCIWEM 2002; 16; p. 85

Gossett, J.M. (1987). Measurement of Henry's Law constants for C1 and C2 chlorinated hydrocarbons. Environ. Sci. Technol., 21(2): 202-208.

Government of Canada (1993). Priority Substances List assessment report: tetrachloroethylene. Environment Canada and Health Canada, Ottawa, Ontario.

Gralewicz, S. and Dyzma, M. (2005). Organic solvents and the dopaminergic system. Int. J. Occup. Med. Environ. Health, 18(2): 103-113.

Green, T. and Odum, J. (1985). Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes. Chem. Biol. Interact., 54(1): 15-31.

Green, T., Odum, J., Nash, J.A. and Foster, J.R. (1990). Perchloroethylene-induced rat kidney tumors: an investigation of the mechanisms involved and their relevance to humans. Toxicol. Appl. Pharmacol., 103(1): 77-89.

Greim, H., Bonse, G., Radwan, Z., Reichert, D. and Henschler, D. (1975). Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation. Biochem. Pharmacol., 24(21): 2013-2017.

Guariglia, S.R., Jenkins, E.C., Jr., Chadman, K.K. and Wen, G.Y. (2011). Chlorination byproducts induce gender specific autistic-like behaviors in CD-1 mice. Neurotoxicology, 32(5): 545-553.

Guberan, E. and Fernandez, J. (1974). Control of industrial exposure to tetrachloroethylene by measuring alveolar concentrations: theoretical approach using a mathematical model. Br. J. Ind. Med., 31(2): 159-167.

Guha, N., Loomis, D., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Baan, R., Mattock, H. and Straif, K., on behalf of the International Agency for Research on Cancer Monograph Working Group (2012). Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites. Lancet Oncol., 13(12): 1192-1193.

Guyton, K.Z., Chiu, W.A., Bateson, T.F., Jinot, J., Scott, C.S., Brown, R.C. and Caldwell, J.C. (2009). A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. Environ. Health Perspect., 117(11): 1664-1672.

Hand, D.W., Crittenden, J.C., Gehin, J.L. and Lykins, B.W.J. (1986). Design and evaluation of an air-stripping tower for removing VOCs from groundwater. J. Am. Water Works Assoc., 78(9): 87-97.

Hand, D.W., Crittenden, J.C., Miller, J.M. and Gehin, J.L. (1988). Performance of air stripping and granular activated carbon for synthetic organic chemical and volatile organic chemical removal from groundwater. Drinking Water Research Division, U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA 600/J-88/053).

Hardin, B.D., Bond, G.P., Sikov, M.R., Andrew, F.D., Beliles, R.P. and Niemeier, R.W. (1981). Testing of selected workplace chemicals for teratogenic potential. Scand. J. Work Environ. Health, 7(Suppl. 4): 66-75.

Harrington-Brock, K., Doerr, C.L. and Moore, M.M. (1998). Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK+/−-3.7.2C mouse lymphoma cells. Mutat. Res., 413(3): 265-276.

Hartmann, A. and Speit, G. (1995). Genotoxic effects of chemicals in the single cell gel (SCG) test with human blood cells in relation to the induction of sister-chromatid exchanges (SCE). Mutat. Res. Lett., 346(1): 49-56.

Hassoun, E.A. and Al-Dieri, A. (2012). Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice. Food Chem. Toxicol., 50(3-4): 701-706.

Hassoun, E.A. and Cearfoss, J. (2011). Dichloroacetate- and trichloroacetate-induced modulation of superoxide dismutase, catalase, and glutathione peroxidase activities and glutathione level in the livers of mice after subacute and subchronic exposures. Toxicol. Environ. Chem., 93(2): 332-344.

Hassoun, E.A. and Dey, S. (2008). Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure. J. Biochem. Mol. Toxicol., 22(1): 27-34.

Hassoun, E.A., Cearfoss, J. and Spildener, J. (2010). Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure. J. Appl. Toxicol., 30(5): 450-456.

Haworth, S., Lawlor, T. and Mortelmans, K. (1983). Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen., 5(Suppl. 1): 3-142.

Hayes, J.R., Condie, L.W., Jr. and Borzelleca, J.F. (1986). The subchronic toxicity of tetrachloroethylene (perchloroethylene) administered in the drinking water of rats. Fundam. Appl. Toxicol., 7(1): 119-125.

Health and Welfare Canada (1993). Chapter 4. Treatment options for specific contaminants. In: Water treatment principles and applications: a manual for the production of drinking water. Canadian Water and Wastewater Association, Ottawa, Ontario, p. 221.

Health Canada (1994). Human health risk assessment for priority substances. Minister of Supply and Services Canada, Ottawa, Ontario.

Health Canada (2007). Personal communication from Kristina Taracha, First Nations and Inuit Health Branch.

Health Canada (2010a). Regina Indoor Air Quality Study (2007): data summary for volatile organic compound sampling. Health Canada, Ottawa, Ontario (H128-1/10-617E-PDF).

Health Canada (2010b). Windsor Exposure Assessment Study (2005-2006): data summary for volatile organic compound sampling. Health Canada, Ottawa, Ontario (H128-1/10-618E-PDF).

Health Canada (2012). Halifax Indoor Air Quality Study (2009): volatile organic compounds (VOC) data summary. Health Canada, Ottawa, Ontario (H129-19/2012E-PDF).

Health Canada (2013). Tetrachloroethylene: extended analysis of dose-response assessment options. Internal report. Health Canada, Ottawa, Ontario (available upon request).

Heikes, D.L. (1987). Purge and trap method for determination of volatile halocarbons and carbon disulfide in table-ready foods. J. Assoc. Off. Anal. Chem., 70(2): 215-226.

Hemminki, K., Franssila, E. and Vainio, H. (1980). Spontaneous abortions among female chemical workers in Finland. Int. Arch. Occup. Environ. Health, 45(2): 123-126.

Hinnen, U., Schmid-Grendelmeier, P., Müller, E. and Elsner, P. (1995). Exposure to solvents in scleroderma: disseminated circumscribed scleroderma (morphea) in a painter exposed to perchloroethylene. Schweiz. Med. Wochenschr., 125(50): 2433-2437.

Hirvonen, A., Tuhkanen, T. and Kalliokoski, P. (1996a). Formation of chlorinated acetic acids during UV/H2O2-oxidation of ground water contaminated with chlorinated ethylenes. Chemosphere, 32(6): 1091-1102.

Hirvonen, A., Tuhkanen, T. and Kalliokoski, P. (1996b). Treatment of TCE- and PCE- contaminated groundwater using UV/H2O2 and O3/H2O2 oxidation processes. Water Sci. Technol., 33(6): 67-73.

Hirvonen, A., Tuhkanen, T., Ettala, M., Korhonen, S. and Kalliokoski, P. (1998). Evaluation of a field-scale UV/H2O2-oxidation system for the purification of groundwater contaminated with PCE. Environ. Technol., 19(8): 821-828.

Honma, T., Sudo, A., Miyagawa, M., Sato, M. and Hasegawa, H. (1980). Effects of exposure to trichloroethylene and tetrachloroethylene on the contents of acetylcholine, dopamine, norepinephrine and serotonin in rat brain. Ind. Health, 18(4): 171-178.

HSDB (2007). Tetrachloroethylene. Hazardous Substances Data Bank, National Library of Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland. Available at: http://toxnet.nlm.nih.gov.

IARC (1995). Dry cleaning, some chlorinated solvents and other industrial chemicals. International Agency for Research on Cancer, Lyon, France (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 63).

IARC (2014). Trichloroethylene, tetrachloroethylene, and some chlorinated agents. International Agency for Research on Cancer, Lyon, France (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 106).

Ikbal, M., Tastekin, A., Dogan, H., Pirim, I. and Ors, R. (2004). The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate. Mutat. Res., 564(2): 159-164.

Ikeda, M. (1977). Metabolism of trichloroethylene and tetrachloroethylene in human subjects. Environ. Health Perspect., 21: 239-245.

Ikeda, M. and Imanura, T. (1973). Biological half-life of trichloroethylene and tetrachloroethylene in human subjects. Int. Arch. Arbeitsmed., 31(3): 209-224.

Ikeda, M., Koizumi, A., Watanabe, T., Endo, A. and Sato, K. (1980). Cytogenetic and cytokinetic investigations on lymphocytes from workers occupationally exposed to tetrachloroethylene. Toxicol. Lett., 5(3-4): 251-256.

Infante-Rivard, C., Siemiatycki, J., Lakhani, R. and Nadon, L. (2005). Maternal exposure to occupational solvents and childhood leukemia. Environ. Health Perspect., 113(6): 787-792.

International Trade Centre (2014). Trade Map. Database available at: www.trademap.org/Index.aspx

IPCS (1984). Tetrachloroethylene. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Environmental Health Criteria 31).

IPCS (2007). Part 1: IPCS framework for analysing the relevance of a cancer mode of action for humans and case-studies. Part 2: IPCS framework for analysing the relevance of a non-cancer mode of action for humans. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Harmonization Project No. 4).

Iregren, A., Andersson, M. and Nylén, P. (2002). Color vision and occupational chemical exposures: I. An overview of tests and effects. Neurotoxicology, 23(6): 719-733.

Ishmael, J. and Dugard, P.H. (2006). A review of perchloroethylene and rat mononuclear cell leukemia. Regul. Toxicol. Pharmacol., 45(2): 178-184.

Ito, Y., Yamanoshita, O., Asaeda, N., Tagawa, Y., Lee, C.H., Aoyama, T., Ichihara, G., Furuhashi, K., Kamijima, M., Gonzalez, F.J. and Nakajima, T. (2007). Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. J. Occup. Health., 49(3): 172-182.

Jang, J.Y. and Droz, P.O. (1997). Ethnic differences in biological monitoring of several organic solvents. II. A simulation study with a physiologically based pharmacokinetic model. Int. Arch. Occup. Environ. Health, 70(1): 41-50.

Janulewicz, P.A., White, R.F., Winter, M.R., Weinberg, J.M., Gallagher, L.E., Vieira, V., Webster, T.F. and Aschengrau, A. (2008). Risk of learning and behavioral disorders following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol. Teratol., 30(3): 175-185.

Janulewicz, P.A., White, R.F., Martin, B.M., Winter, M.R., Weinberg, J.M., Vieira, V. and Aschengrau, A. (2012). Adult neuropsychological performance following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol. Teratol., 34(3): 350-359.

Ji, J. and Hemminki, K. (2005). Occupation and upper aerodigestive tract cancers: a follow-up study in Sweden. J. Occup. Environ. Med., 47(8): 785-795.

Ji, J., Granström, C. and Hemminki, K. (2005). Occupational risk factors for kidney cancer: a cohort study in Sweden. World J. Urol., 23(4): 271-278.

JISA (1993). Carcinogenicity study of tetrachloroethylene by inhalation in rats and mice. Japan Industrial Safety Association, Kanagawa (Data No. 3-1).

Jonker, D., Woutersen, R.A. and Feron, V.J. (1996). Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. Food Chem. Toxicol., 34(11-12): 1075-1082.

Kaiser, K.L.E. and Comba, M.E. (1986). Volatile halocarbon contaminant survey of the St. Clair River. Water Pollut. Res. J. Can., 21(3): 323-331.

Kargalioglu, Y., McMillan, B.J., Minear, R.A. and Plewa, M.J. (2002). Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimurium. Teratog. Carcinog. Mutagen., 22(2): 113-128.

Karimi, A.A., Redman, J.A., Glaze, W.H. and Stolarik, G.F. (1997). Evaluating an AOP for TCE and PCE removal. J. Am. Water Works Assoc., 89(8): 41-53.

Karlsson, J.E., Rosengren, L.E., Kjellstrand, P. and Haglid, K.G. (1987). Effects of low-dose inhalation of three chlorinated aliphatic organic solvents on deoxyribonucleic acid in gerbil brain. Scand. J. Work Environ. Health, 13(5): 453-458.

Kezic, S., Monster, A.C., van de Gevel, I.A., Kruse, J., Opdam, J.J. and Verberk, M.M. (2001). Dermal absorption of neat liquid solvents on brief exposures in volunteers. Am. Ind. Hyg. Assoc. J., 62(1): 12-18.

Kim, C.H. (2010). Homeostatic and pathogenic extramedullary hematopoiesis. J. Blood Med., 1: 13-19.

Kjellstrand, P., Holmquist, B., Kanje, M., Alm, P., Romare, S., Jonsson, I., Mansson, L. and Bjerkemo, M. (1984). Perchloroethylene: effects on body and organ weights and plasma butyrylcholinesterase activity in mice. Acta Pharmacol. Toxicol. (Copenh.), 54(5): 414-424.

Kjellstrand, P., Holmquist, B. and Jonsson, I. (1985). Effects of organic solvents on motor activity in mice. Toxicology, 35(1): 35-46.

Klaassen, C.D. and Plaa, G.L. (1966). Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicol. Appl. Pharmacol., 9(1): 139-151.

Klaassen, C.D. and Plaa, G.L. (1967). Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs. Toxicol. Appl. Pharmacol., 10(1): 119-131.

Klaunig, J.E., Babich, M.A., Baetcke, K.P., Cook, J.C., Corton, J.C., David, R.M., DeLuca, J.G., Lai, D.Y., McKee, R.H., Peters, J.M., Roberts, R.A. and Fenner-Crisp, P.A. (2003). PPARα agonist-induced rodent tumors: modes of action and human relevance. Crit. Rev. Toxicol., 33(6): 655-780.

Kline, S.A., McCoy, E.C., Rosenkranz, H.S. and Van Duuren, B.L. (1982). Mutagenicity of chloralkene epoxides in bacterial systems. Mutat. Res., 101(2): 115-125.

Kobayashi, S., Hutcheon, D.E. and Regan, J. (1982). Cardiopulmonary toxicity of tetrachloroethylene. J. Toxicol. Environ. Health, 10(1): 23-30.

Koppel, C., Arndt, I., Arndt, U. and Koeppe, P. (1985). Acute tetrachloroethylene poisoning—blood elimination kinetics during hyperventilation therapy. J. Toxicol. Clin. Toxicol., 23(2-3): 103-115.

Kringstad, K.P., Ljungquist, P.O., De Sousa, F. and Stromberg, L.M. (1981). Identification and mutagenic properties of some chlorinated aliphatic compounds in the spent liquor from kraft pulp chlorination. Environ. Sci. Technol., 15(5): 562-566.

Krishnan, K. and Carrier, R. (2008). Approaches for evaluating the relevance of multiroute exposures in establishing guideline values for drinking water contaminants. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 26(3): 300-316.

Kyrklund, T. and Haglid, K. (1991). Brain lipid composition in guinea pigs after intrauterine exposure to perchloroethylene. Pharmacol. Toxicol., 68(2): 146-148.

Kyrklund, T., Alling, C., Kjellstrand, P. and Haglid, K.G. (1984). Chronic effects of perchloroethylene on the composition of lipid and acyl groups in cerebral cortex and hippocampus of the gerbil. Toxicol. Lett., 22(3): 343-349.

Kyrklund, T., Kjellstrand, P. and Haglid, K.G. (1987). Lipid composition and fatty acid pattern of the gerbil brain after exposure to perchloroethylene. Arch. Toxicol., 60(5): 397-400.

Kyrklund, T., Kjellstrand, P. and Haglid, K.G. (1988). Effects of exposure to freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipid and fatty-acid composition of rat cerebral cortex. Scand. J. Work Environ. Health, 14(2): 91-94.

Kyrklund, T., Kjellstrand, P. and Haglid, K.G. (1990). Long-term exposure of rats to perchloroethylene, with and without a post-exposure solvent-free recovery period: effects on brain lipids. Toxicol. Lett., 52(3): 279-285.

Kyyronen, P., Taskinen, H., Lindbohm, M.L., Hemminki, K. and Heinonen, O.P. (1989). Spontaneous abortion and congenital malformations among women exposed to tetrachloride or tetrachloroethylene in dry cleaning. J. Epidemiol. Community Health, 43(4): 346-351.

Lacey, J.V., Jr., Garabrant, D.H., Laing, T.J., Gillespie, B.W., Mayes, M.D., Cooper, B.C. and Schottenfeld, D. (1999). Petroleum distillate solvents as risk factors for undifferentiated connective tissue disease (UCTD). Am. J. Epidemiol., 149(8): 761-770.

Lagakos, S.W., Wessen, B.J. and Zelen, M. (1986). An analysis of contaminated well water and health effects in Woburn, Massachusetts. J. Am. Statist. Assoc., 81(395): 583-596.

Larson, C.D., Love, O.T., Jr., Reynolds, G., III, McCallie, S.W., Moser, R.H. and Calabrese, E.J. (1983). Tetrachloroethylene leached from lined asbestos-cement pipe into drinking water. J. Am. Water Works Assoc., 75(4): 184-190.

Larson, J.L. and Bull, R.J. (1992). Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol., 115(2): 268-277.

Lash, L.H. and Parker, J.C. (2001). Hepatic and renal toxicities associated with perchloroethylene. Pharmacol. Rev., 53(2): 177-208.

Lash, L.H., Qian, W., Putt, D.A., Desai, K., Elfarra, A.A., Sicuri, A.R. and Parker, J.C. (1998). Glutathione conjugation of perchloroethylene in rats and mice in vitro: sex-, species-, and tissue-dependent differences. Toxicol. Appl. Pharmacol., 150(1): 49-57.

Lash, L.H., Putt, D.A., Huang, P., Hueni, S.E. and Parker, J.C. (2007). Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione. Toxicology, 235(1-2): 11-26.

Laughter, A.R., Dunn, C.S., Swanson, C.L., Howroyd, P., Cattley, R.C. and Corton, J.C. (2004). Role of the peroxisome proliferator-activated receptor alpha (PPARα) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. Toxicology, 203(1-3): 83-98.

Lauwerys, R., Herbrand, J., Buchet, J.P., Bernard, A. and Gaussin, J. (1983). Health surveillance of workers exposed to tetrachloroethylene in dry-cleaning shops. Int. Arch. Occup. Environ. Health, 52(1): 69-77.

Leavitt, S.A., DeAngelo, A.B., George, M.H. and Ross, J.A. (1997). Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver. Carcinogenesis, 18(11): 2101-2106.

Lee, L.J., Chung, C., Ma, Y., Wang, G., Chen, P., Hwang, Y. and Wang, J. (2003). Increased mortality odds ratio of male liver cancer in a community contaminated by chlorinated hydrocarbons in groundwater. Occup. Environ. Med., 60(5): 364-369.

Lehmann, I., Rehwagen, M., Diez, U., Seiffart, A., Rolle-Kampczyk, U., Richter, M., Wetzig, H., Borte, M. and Herbarth, O. (2001). Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study. Int. J. Hyg. Environ. Health, 204(4): 211-221.

Lehmann, I., Thoelke, A., Rehwagen, M., Rolle-Kampczyk, U., Schlink, U., Schulz, R., Borte, M., Diez, U. and Herbarth, O. (2002). The influence of maternal exposure to volatile organic compounds on the cytokine secretion profile of neonatal T cells. Environ. Toxicol., 17(3): 203-210.

Leonardos, G., Kendall, D. and Barnard, N. (1969). Odor threshold determination of 53 odorant chemicals. J. Air Pollut. Control Assoc., 19(2): 91-95.

Levine, B., Fierro, M.F., Goza, S.W. and Valentour, J.C. (1981). A tetrachloroethylene fatality. J. Forensic Sci., 26(1): 206-209.

Lillford, L., Beevers, C., Bowen, D. and Kirkland, D. (2010). Re: DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of tetrachloroethylene (Mutagenesis, 25, 133-138, 2010). Mutagenesis, 25(4): 427-428.

Lindbohm, M.L., Taskinen, H., Sallmen, M. and Hemminki, K. (1990). Spontaneous abortions among women exposed to organic solvents. Am. J. Ind. Med., 17(4): 449-463.

Lipski, C. and Cote, P. (1990). Use of pervaporation for removal of organic contaminants from water. Environ. Prog., 9: 254.

Love, O.T. and Eilers, R.G. (1982). Treatment of drinking water containing trichloroethylene and related industrial solvents. J. Am. Water Works Assoc., 74(8): 413-425.

Love, T.O., Miltner, R.J., Eilers, R.G. and and Fronk-Leist, C.A. (1983). Treatment of volatile organic compounds in drinking water. Municipal Environmental Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, Ohio.

Lovell, D. (2010). Is tetrachloroethylene genotoxic or not? Mutagenesis, 25(5): 443-446.

Lukaszewski, T. (1979). Acute tetrachloroethylene fatality. Clin. Toxicol., 15(4): 411-415.

Lykins, B.W.J. and Clark, R.M. (1994). US drinking water regulations: treatment technologies and cost. Drinking Water Research Division, U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA-600/J-94/381).

Lykins, B.W.J., Clark, R.M. and Fronk, C.A. (1988). Reverse osmosis for removing synthetic organics from drinking water: a cost and performance evaluation. Proceedings of the 1988 Am. Water Works Assoc. Annual Conference, Orlando, Florida, pp. 1433-1457.

Lynch, A.M. and Parry, J.M. (1993). The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens. Mutat. Res., 287(1): 71-86.

Lynge, E. and Thygesen, L. (1990). Primary liver cancer among women in laundry and dry-cleaning work in Denmark. Scand. J. Work Environ. Health, 16(2): 108-112.

Lynge, E., Carstensen, B. and Andersen, O. (1995). Primary liver cancer and renal cell carcinoma in laundry and dry-cleaning workers in Denmark. Scand. J. Work Environ. Health, 21(4): 293-295.

Lynge, E., Andersen, A., Rylander, L., Tinnerberg, H., Lindbohm, M., Pukkala, E., Romundstad, P., Jensen, P., Clausen, L.B. and Johansen, K. (2006). Cancer in persons working in dry cleaning in the Nordic countries. Environ. Health Perspect., 114(2): 213-219.

Maître, A., Hours, M., Bonneterre, V., Arnaud, J., Arslan, M.T., Carpentier, P., Bergeret, A. and de Gaudemaris, R. (2004). Systemic sclerosis and occupational risk factors: role of solvents and cleaning products. J. Rheumatol., 31(12): 2395-2401.

Mallin, K. (1990). Investigation of a bladder cancer cluster in northwestern Illinois. Am. J. Epidemiol., 132(Suppl. 1): S96-S106.

Mandel, J.S., McLaughlin, J.K., Schlehofer, B., Mellemgaard, A., Helmert, U., Lindblad, P., McCredie, M. and Adami, H.O. (1995). International renal-cell cancer study. IV. Occupation. Int. J. Cancer, 61(5): 601-605.

Marrazzini, A., Betti, C., Bernacchi, F., Barrai, I. and Barale, R. (1994). Micronucleus test and metaphase analyses in mice exposed to known and suspected spindle poisons. Mutagenesis, 9(6): 505-515.

Marsalek, J. (1986). Municipal sources of selected trace organics in Sarnia. Water Pollut. Res. J. Can., 21(3): 422-432.

Mather, G.G., Exon, J.H. and Koller, L.D. (1990). Subchronic 90 day toxicity of dichloroacetic and trichloroacetic acid in rats. Toxicology, 64(1): 71-80.

Matsushima, T., Hayashi, M., Matsuoka, A., Ishidate, M., Jr., Miura, K.F., Shimizu, H., Suzuki, Y., Morimoto, K., Ogura, H., Mure, K., Koshi, K. and Sofuni, T. (1999). Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis, 14(6): 569-580.

Mattsson, J.L., Albee, R.R., Yano, B.L., Bradley, G. and Spencer, P.J. (1998). Neurotoxicologic examination of rats exposed to 1,1,2,2-tetrachloroethylene (perchloroethylene) vapor for 13 weeks. Neurotoxicol. Teratol., 20(1): 83-98.

Mazzullo, M., Grilli, S., Lattanzi, G., Prodi, G., Turina, M.P. and Colacci, A. (1987). Evidence of DNA binding activity of perchloroethylene. Res. Commun. Chem. Pathol. Pharmacol., 58(2): 215-235.

McCredie, M. and Stewart, J.H. (1993). Risk factors for kidney cancer in New South Wales. IV. Occupation. Br. J. Ind. Med., 50(4): 349-354.

McDonald, G.J. and Wertz, W.E. (2007). PCE, TCE, and TCA vapors in subslab soil gas and indoor air: a case study in upstate New York. Ground Water Monit. R., 27(4): 86-92.

McDougal, J.N., Jepson, G.W., Clewell, H.J.I., Gargas, M.L. and Andersen, M.E. (1990). Dermal absorption of organic chemical vapors in rats and humans. Fundam. Appl. Toxicol., 14(2): 299-308.

McKinnon, R.J. and Dyksen, J.E. (1984). Removing organics from groundwater through aeration plus GAC. J. Am. Water Works Assoc., 76(5): 42-47.

Mester, B., Nieters, A., Deeg, E., Elsner, G., Becker, N. and Seidler, A. (2006). Occupation and malignant lymphoma: a population based case control study in Germany. Occup. Environ. Med., 63(1): 17-26.

Miligi, L., Costantini, A.S., Benvenuti, A., Kriebel, D., Bolejack, V., Tumino, R., Ramazzotti, V., Rodella, S., Stagnaro, E., Crosignani, P., Amadori, D., Mirabelli, D., Sommani, L., Belletti, I., Troschel, L., Romeo, L., Miceli, G., Tozzi, G.A., Mendico, I. and Vineis, P. (2006). Occupational exposure to solvents and the risk of lymphomas. Epidemiology, 17(5): 552-561.

Miller, B.M. and Adler, I.D. (1992). Aneuploidy induction in mouse spermatocytes. Mutagenesis, 7(1): 69-76.

Miller, L.J. and Uhler, A.D. (1988). Volatile halocarbons in butter: elevated tetrachloroethylene levels in samples obtained in close proximity to dry-cleaning establishments. Bull. Environ. Contam. Toxicol., 41(3): 469-474.

Milman, H.A., Story, D.L., Riccio, E.S., Sivak, A., Tu, A.S., Williams, G.M., Tong, C. and Tyson, C.A. (1988). Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes. Ann. N. Y. Acad. Sci., 534: 521-530.

Ministère du Développement durable, de l'Environnement et des Parcs du Québec (2007). Personal communication from Caroline Robert.

Moloney, W.C. and King, V.P. (1973). Reduction of leukemia incidence following splenectomy in the rat. Cancer Res., 33(3): 573-574.

Monster, A.C. (1979). Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene. Int. Arch. Occup. Environ. Health, 42(3-4): 311-317.

Monster, A.C., Regouin Peeters, W., Van Schijndel, A. and Van der Tuin, J. (1983). Biological monitoring of occupational exposure to tetrachloroethene. Scand. J. Work Environ. Health, 9(3): 273-281.

Moriya, M., Ohta, T., Watanabe, K., Miyazawa, T., Kato, K. and Shirasu, Y. (1983). Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat. Res., 116(3-4): 185-216.

Morton, W. and Marjanovic, D. (1984). Leukemia incidence by occupation in the Portland-Vancouver metropolitan area. Am. J. Ind. Med., 6(3): 185-205.

Moser, V.C., Cheek, B.M. and MacPhail, R.C. (1995). A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity. J. Toxicol. Environ. Health, 45(2): 173-210.

Motohashi, Y., Miyazaki, Y. and Takano, T. (1993). Assessment of behavioral effects of tetrachloroethylene using a set of time-series analyses. Neurotoxicol. Teratol., 15(1): 3-10.

Mufson, E.J., Counts, S.E., Perez, S.E. and Ginsberg, S.D. (2008). Cholinergic system during the progression of Alzheimer's disease: therapeutic implications. Expert Rev. Neurother., 8(11): 1703-1718.

Munz, C., Walther, J.L., Baldauf, G., Boller, M. and Bland, R. (1990). Evaluating layered upflow carbon adsorption for the removal of trace organic contaminants. J. Am. Water Works Assoc., 82(3): 63-76.

Murakami, K. and Horikawa, K. (1995). The induction of micronuclei in mice hepatocytes and reticulocytes by tetrachloroethylene. Chemosphere, 31(7): 3733-3739.

Mutti, A., Alinovi, R., Bergamaschi, E., Biagini, C., Cavazzini, S., Franchini, I., Lauwerys, R.R., Bernard, A.M., Roels, H., Gelpi, E., Rosello, J., Ramis, I., Price, R.G., Taylor, S.A., De Broe, M., Nuyts, G.D., Stolte, H., Fels, L.M. and Herbort, C. (1992). Nephropathies and exposure to perchloroethylene in dry-cleaners. Lancet, 340(8813): 189-193.

Nagata, Y. (2003). Measurement of odor threshold by triangle odor bag method. In: Odor Measurement Review. Office of Odor, Noise and Vibration, Environmental Management Bureau, Ministry of the Environment, Government of Japan, pp. 118-127.

Najm, N.I., Snoeyink, V.L., Lykins, B.W., Jr. and Adams, J.Q. (1991). Using powdered activated carbon: a critical review. J. Am. Water Works Assoc., 83(1): 65-75.

Nakatsuka, H., Watanabe, T., Takeuchi, Y., Hisanaga, N., Shibata, E., Suzuki, H., Huang, M.Y., Chen, Z., Qu, Q.S. and Ikeda, M. (1992). Absence of blue-yellow color vision loss among workers exposed to toluene or tetrachloroethylene, mostly at levels below occupational exposure limits. Int. Arch. Occup. Environ. Health, 64(2): 113-117.

Narotsky, M.G. and Kavlock, R.J. (1995). A multidisciplinary approach to toxicological screening: II. Developmental toxicity. J. Toxicol. Environ. Health, 45(2): 145-171.

Natarajan, A.T., Duivenvoorden, W.C.M., Meijers, M. and Zwanenburg, T.S.B. (1993). Induction of mitotic aneuploidy using Chinese hamster primary embryonic cells. Test results of 10 chemicals. Mutat. Res., 287(1): 47-56.

NCI (1977). Bioassay of tetrachloroethylene for possible carcinogenicity. Natl. Cancer. Inst. Carcinog. Tech. Rep. Ser., 13: 1-83.

Nelson, B.K., Taylor, B.J., Setzer, J.V. and Hornung, R.W. (1980). Behavioral teratology of perchloroethylene in rats. J. Environ. Pathol. Toxicol., 3(1-2): 233-250.

Nelson, G.M., Swank, A.E., Brooks, L.R., Bailey, K.C. and George, S.E. (2001). Metabolism, microflora effects, and genotoxicity in haloacetic acid-treated cultures of rat cecal microbiota. Toxicol. Sci., 60(2): 232-241.

Nelson, M.A. and Bull, R.J. (1988). Induction of strand breaks in DNA by trichloroethylene and metabolites in rat and mouse liver in vivo. Toxicol. Appl. Pharmacol., 94(1): 45-54.

Nelson, M.A., Lansing, A.J., Sanchez, I.M., Bull, R.J. and Springer, D.L. (1989). Dichloroacetic acid and trichloroacetic acid-induced DNA strand breaks are independent of peroxisome proliferation. Toxicology, 58(3): 239-248.

NEMI (1995). Method summary ASTM D5790. National Environmental Methods Index. Available at: http://web1.er.usgs.gov/nemi/method_summary.jsp?param_method_id=5455

Nesslany, F. and Marzin, D. (1999). A micromethod for the in vitro micronucleus assay. Mutagenesis, 14(4): 403-410.

Nestmann, E.R., Chu, I., Kowbel, D.J. and Matula, T.I. (1980). Short-lived mutagen in Salmonella produced by reaction of trichloroacetic acid and dimethyl sulphoxide. Can. J. Genet. Cytol., 22(1): 35-40.

New Brunswick Department of Health (2007). Personal communication from Karen White.

NHMRC and NRMMC (2011). National water quality management strategy. National Health and Medical Research Council, National Resource Management Ministerial Council, Commonwealth of Australia, Canberra (Australian Drinking Water Guidelines Paper 6).

Ni, Y.C., Wong, T.Y., Kadlubar, F.F. and Fu, P.P. (1994). Hepatic metabolism of chloral hydrate to free radical(s) and induction of lipid peroxidation. Biochem. Biophys. Res. Commun., 204(2): 937-943.

Nong, A. (2013). Physiologically-based pharmacokinetic (PBPK) modeling of tetrachloroethylene (PERC) exposure in drinking water. Computational Toxicology Laboratory, Exposure and Biomonitoring Division, Environmental Health Science Research Bureau, Health Canada, Ottawa, Ontario.

NSF/ANSI (2011). Standard 53—drinking water treatment units—health effects. Section 7.2.4. NSF International and American National Standards Institute, pp. 39-49.

NSF/ANSI (2012). Standard 58—reverse osmosis drinking water treatment systems. Section 7.1.1. NSF International and American National Standards Institute, pp. 28-38.

NTP (1986). NTP toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CAS no. 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, pp. 1-197 (NTP Technical Report Series 311).

NTP (2007). NTP report on the toxicology studies of dichloroacetic acid (CAS no. 79-43-6) in genetically modified (FVB tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies). National Toxicology Program, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, pp. 1-168 (NTP Genetically Modified Model Report 11).

Nutley, E.V., Tcheong, A.C., Allen, J.W., Collins, B.W., Ma, M., Lowe, X.R., Bishop, J.B., Moore, D.H., II and Wyrobek, A.J. (1996). Micronuclei induced in round spermatids of mice after stem-cell treatment with chloral hydrate: evaluations with centromeric DNA probes and kinetochore antibodies. Environ. Mol. Mutagen., 28(2): 80-89.

New York State Department of Health (2010). Tetrachloroethylene (perc) exposure and visual contrast sensitivity (VCS) test performance in adults and children residing in buildings with or without a dry cleaner. Bureau of Toxic Substance Assessment, Center for Environmental Health, Troy, New York.

Odum, J., Green, T., Foster, J.R. and Hext, P.M. (1988). The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol., 92(1): 103-112.

OEHHA (2001). Public health goal for tetrachloroethylene in drinking water. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California.

Ohtsuki, T., Sato, K., Koizumi, A., Kumai, M. and Ikeda, M. (1983). Limited capacity of humans to metabolize tetrachloroethylene. Int. Arch. Occup. Environ. Health, 51(4): 381-390.

Olsen, J., Hemminki, K., Ahlborg, G., Bjerkedal, T., Kyyronen, P., Taskinen, H., Lindbohm, M., Heinonen, O.P., Brandt, L., Kolstad, H., Halvorsen, B.A. and Egenaes, J. (1990). Low birthweight, congenital malformations, and spontaneous abortions among dry-cleaning workers in Scandinavia. Scand. J. Work Environ. Health, 16(3): 163-168.

OMEE (1994). Ontario typical range of chemical parameters in soil, vegetation, moss bags and snow. Version 1.0a. Phytotoxicity Section, Standards Development Branch, Ontario Ministry of Environment and Energy, Toronto, Ontario.

OMOE (1987). Municipal-industrial strategy for abatement. St. Clair River MISA pilot-site investigation. Preliminary report. Appendix 2. Ontario Ministry of the Environment, Toronto, Ontario. As cited in: CCME (1999).

OMOE (2007). Personal communication from Satish Deshpande, Ontario Ministry of the Environment.

Otson, R., Fellin, P. and Whitmore, R. (1992). A national pilot study on occurrence of airborne VOCs in residences. Proc. EPA/A & WMA Symposium on Measurement of Toxic and Related Air Pollutants, May, 1992, Durham, North Carolina. As cited in: Government of Canada (1993).

Parrish, J.M., Austin, E.W., Stevens, D.K., Kinder, D.H. and Bull, R.J. (1996). Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. Toxicology, 110(1-3): 103-111.

Parry, J.M., Parry, E.M., Warr, T., Lynch, A. and James, S. (1990). The detection of aneugens using yeasts and cultured mammalian cells. Prog. Clin. Biol. Res., 340 B: 247-266.

Paulu, C., Aschengrau, A. and Ozonoff, D. (1999). Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Environ. Health Perspect., 107(4): 265-271.

Pegg, D.G., Zempel, J.A., Braun, W.H. and Watanabe, P.G. (1979). Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats. Toxicol. Appl. Pharmacol., 51(3): 465-474.

Pereira, M.A., Kramer, P.M., Conran, P.B. and Tao, L. (2001). Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. Carcinogenesis, 22(9): 1511-1519.

Pereira, M.A., Wang, W., Kramer, P.M. and Tao, L. (2004). Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice. Toxicol. Sci., 77(2): 243-248.

Perrin, M.C., Opler, M.G., Harlap, S., Harkavy-Friedman, J., Kleinhaus, K., Nahon, D., Fennig, S., Susser, E.S. and Malaspina, D. (2007). Tetrachloroethylene exposure and risk of schizophrenia: offspring of dry cleaners in a population birth cohort, preliminary findings. Schizophr. Res., 90(1-3): 251-254.

Philip, B.K., Mumtaz, M.M., Latendresse, J.R. and Mehendale, H.M. (2007). Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology, 232(1-2): 1-14.

Plewa, M.J., Kargalioglu, Y., Vankerk, D., Minear, R.A. and Wagner, E.D. (2002). Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products. Environ. Mol. Mutagen., 40(2): 134-142.

Pohlabeln, H., Boffetta, P., Ahrens, W., Merletti, F., Agudo, A., Benhamou, E., Benhamou, S., Brüske-Hohlfeld, I., Ferro, G., Fortes, C., Kreuzer, M., Mendes, A., Nyberg, F., Pershagen, G., Saracci, R., Schmid, G., Siemiatycki, J., Simonato, L., Whitley, E., Wichmann, H., Winck, C., Zambon, P. and Jöckel, K. (2000). Occupational risks for lung cancer among nonsmokers. Epidemiology, 11(5): 532-538.

Potter, C.L., Chang, L.W., DeAngelo, A.B. and Daniel, F.B. (1996). Effects of four trihalomethanes on DNA strand breaks, renal hyaline droplet formation and serum testosterone in male F-344 rats. Cancer Lett., 106(2): 235-242.

Poulsen, M.M. and Kueper, B.H. (1992). A field experiment to study the behavior of tetrachloroethylene in unsaturated porous media. Environ. Sci. Technol., 26(5): 889-895.

Pozzani, U.C., Weil, C.S. and Carpenter, C.P. (1959). The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am. Ind. Hyg. Assoc. J., 20: 364-369. As cited in de Raat (2003).

Pukkala, E., Martinsen, J.I., Lynge, E., Gunnarsdottir, H.K., Sparén, P., Tryggvadottir, L., Weiderpass, E. and Kjaerheim, K. (2009). Occupation and cancer—follow-up of 15 million people in five Nordic countries. Acta Oncol., 48(5): 646-790.

Qiu, J., Chien, Y., Bruckner, J.V. and Fisher, J.W. (2010). Bayesian analysis of a physiologically based pharmacokinetic model for perchloroethylene in humans. J. Toxicol. Environ. Health A, 73(1): 74-91.

Ramsey, J.C. and Andersen, M.E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol., 73(1): 159-175.

Rao, H.V. and Brown, D.R. (1993). A physiologically based pharmacokinetic assessment of tetrachloroethylene in groundwater for a bathing and showering determination. Risk Anal., 13(1): 37-49.

Rapson, W.H., Nazar, M.A. and Butsky, V.V. (1980). Mutagenicity produced by aqueous chlorination of organic compounds. Bull. Environ. Contam. Toxicol., 24(4): 590-596.

Reichert, D., Neudecker, T., Spengler, U. and Henschler, D. (1983). Mutagenicity of dichloroacetylene and its degradation products trichloroacetyl chloride, trichloroacryloyl chloride and hexachlorobutadiene. Mutat. Res., 117(1-2): 21-29.

Reijnen, G.K., Van der Laan, J. and Van Paassen, J.A.M. (1985). Removal of chlorinated hydrocarbons by air stripping. Water Supply, 3(1): 219-226.

Reitz, R.H., Gargas, M.L., Mendrala, A.L. and Schumann, A.M. (1996). In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans. Toxicol. Appl. Pharmacol., 136(2): 289-306.

Riihimaki, V. and Pfaffli, P. (1978). Percutaneous absorption of solvent vapors in man. Scand. J. Work Environ. Health, 4(1): 73-85.

Ritter, L., Totman, C., Krishnan, K., Carrier, R., Vézina, A. and Morisset, V. (2007). Deriving uncertainty factors for threshold chemical contaminants in drinking water. J. Toxicol. Environ. Health B, 10(7): 527-557.

Robeck, G.G. and Love, O.T.J. (1983). Removal of volatile organic contaminants from groundwater. Drinking Water Research Division, Municipal Environmental Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA-600/D-83-011).

Roldan-Arjona, T., Garcia-Pedrajas, M.D., Luque-Romero, F.L., Hera, C. and Pueyo, C. (1991). An association between mutagenicity of the ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. Mutagenesis, 6(3): 199-205.

Rosengren, L.E., Kjellstrand, P. and Haglid, K.G. (1986). Tetrachloroethylene: levels of DNA and S-100 in the gerbil CNS after chronic exposure. Neurobehav. Toxicol. Teratol., 8(2): 201-206.

Russo, A. and Levis, A.G. (1992). Further evidence for the aneuploidogenic properties of chelating agents: induction of micronuclei in mouse male germ cells by EDTA. Environ. Mol. Mutagen., 19(2): 125-131.

Russo, A., Stocco, A. and Majone, F. (1992). Identification of kinetochore-containing (CREST+) micronuclei in mouse bone marrow erythrocytes. Mutagenesis, 7(3): 195-197.

Saland, G. (1967). Accidental exposure to perchloroethylene. N. Y. State J. Med., 67(17): 2359-2361.

Saskatchewan Environment (2007). Personal communication from Sam Ferris.

Savolainen, H., Pfäffli, P., Tengen, M. and Vainio, H. (1977). Biochemical and behavioural effects of inhalation exposure to tetrachlorethylene and dichloromethane. J. Neuropathol. Exp. Neurol., 36(6): 941-949.

Sbrana, I., Di Sibio, A., Lomi, A. and Scarcelli, V. (1993). C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. Mutat. Res. Fundam. Mol. Mech. Mutagen., 287(1): 57-70.

SCC (2011). Accredited certification bodies. Standards Council of Canada, Ottawa, Ontario (www.scc.ca/en).

Schlehofer, B., Heuer, C., Blettner, M., Niehoff, D. and Wahrendorf, J. (1995). Occupation, smoking and demographic factors, and renal cell carcinoma in Germany. Int. J. Epidemiol., 24(1): 51-57.

Schreiber, J.S., Hudnell, H.K., Geller, A.M., House, D.E., Aldous, K.M., Force, M.S., Langguth, K., Prohonic, E.J. and Parker, J.C. (2002). Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ. Health Perspect., 110(7): 655-664.

Schumann, A.M., Quast, J.F. and Watanabe, P.G. (1980). The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity. Toxicol. Appl. Pharmacol., 55(2): 207-219.

Schwarzenbach, R.P., Molnar-Kubica, E., Giger, W. and Wakeham, S.G. (1979). Distribution, residence time, and fluxes of tetrachloroethylene and 1,4-dichlorobenzene in Lake Zurich, Switzerland. Environ. Sci. Technol., 13(11): 1367-1373.

Schwetz, B.A., Leong, K.J. and Gehring, P.J. (1975). The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats. Toxicol. Appl. Pharmacol., 32(1): 84-96.

Schwille, F. (1988). Dense chlorinated solvents in porous and fractured media: model experiments. Lewis Publishers, Chelsea, MI.

Seeber, A. (1989). Neurobehavioral toxicity of long-term exposure to tetrachloroethylene. Neurotoxicol. Teratol., 11(6): 579-583.

Seelbach, A., Fissler, B. and Madle, S. (1993). Further evaluation of a modified micronucleus assay with V79 cells for detection of aneugenic effects. Mutat. Res., 303(4): 163-169.

Seidler, A., Möhner, M., Berger, J., Mester, B., Deeg, E., Elsner, G., Nieters, A. and Becker, N. (2007). Solvent exposure and malignant lymphoma: a population-based case-control study in Germany. J. Occup. Med. Toxicol., 2: 2.

Seiji, K., Inoue, O., Jin, C., Liu, Y.T., Cai, S.X., Ohashi, M., Watanabe, T., Nakatsuka, H., Kawai, T. and Ikeda, M. (1989). Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism. Am. J. Ind. Med., 16(6): 675-684.

Seiji, K., Jin, C., Watanabe, T., Nakatsuka, H. and Ikeda, M. (1990). Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits. Int. Arch. Occup. Environ. Health, 62(2): 171-176.

Seip, H.M., Alstad, J. and Carlberg, G.E. (1986). Measurement of mobility of organic compounds in soils. Sci. Total Environ., 50: 87-101.

Seldén, A.I. and Ahlborg, G., Jr. (2011). Cancer morbidity in Swedish dry-cleaners and laundry workers: historically prospective cohort study. Int. Arch. Occup. Environ. Health, 84(4): 435-443.

Semmens, M.J., Qin, R. and Zander, A. (1989). Using microporous hollow-fiber membrane to separate VOCs from water. J. Am. Water Works Assoc., 81(4): 162-167.

Seo, M., Kobayashi, R., Okamura, T., Ikeda, K., Satoh, M., Inagaki, N., Nagai, H. and Nagase, H. (2012). Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice. J. Toxicol. Sci., 37(2): 439-445.

Shafer, T.J., Bushnell, P.J., Benignus, V.A. and Woodward, J.J. (2005). Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. J. Pharmacol. Exp. Ther., 315(3): 1109-1118.

Shimada, T., Swanson, A.F., Leber, P. and Williams, G.M. (1985). Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions. Cell Biol. Toxicol., 1(3): 159-179.

Shirasu, Y., Moriya, M., Kato, K., Furuhashi, A. and Kada, T. (1976). Mutagenicity screening of pesticides in the microbial system. Mutat. Res., 40(1): 19-30.

Shu, X., Stewart, P., Wen, W., Han, D., Potter, J.D., Buckley, J.D., Heineman, E. and Robison, L.L. (1999). Parental occupational exposure to hydrocarbons and risk of acute lymphocytic leukemia in offspring. Cancer Epidemiol. Biomarkers Prevent., 8(9): 783-791.

Singley, E., Beaudet, B. and Ervin, A. (1979). Use of powdered activated carbon for removal of specific organic compounds. Proceedings of Seminar on Controlling Organics in Drinking Water; Am. Water Works Assoc. Annual Conference, San Francisco, California.

Smith, E.M., Miller, E.R., Woolson, R.F. and Brown, C.K. (1985). Bladder cancer risk among laundry workers, dry cleaners, and others in chemically-related occupations. J. Occup. Med., 27(4): 295-297.

Smyth, H.F., Jr., Weil, C.S., West, J.S. and Carpenter, C.P. (1969). An exploration of joint toxic action: twenty-seven industrial chemicals intubated in rats in all possible pairs. Toxicol. Appl. Pharmacol., 14(2): 340-347. As cited in: Government of Canada (1993).

Snoeyink, V.L. (1990). Chapter 13. Adsorption of organic compounds. In: Water quality and treatment, 4th edition. American Water Works Association, Denver, Colorado, pp. 781-875.

Snyder, R.D., Pullman, J., Carter, J.H., Carter, H.W. and DeAngelo, A.B. (1995). In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes. Cancer Res., 55(17): 3702-3705.

Sofuni, T., Hayashi, M., Matsuoka, A., Sawada, M., Hatanaka, M. and Ishidate, M., Jr. (1985). Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mammalian cells. Bull. Natl. Inst. Hyg. Sci., 103: 64-75.

Solet, D. and Robins, T.G. (1991). Renal function in dry cleaning workers exposed to perchloroethylene. Am. J. Ind. Med., 20(5): 601-614.

Speth, T.F. (1990). Chapter 12. Removal of volatile organic compounds from drinking water by adsorption. In: Significance and treatment of volatile organic compounds in water supplies. Ram, N.M., Christman, R.F. and Cantor, K.P. (eds.). Lewis Publishers, Chelsea, Michigan, pp. 229-257.

Spirtas, R., Stewart, P.A., Lee, J.S., Marano, D.E., Forbes, C.D., Grauman, D.J., Pettigrew, H.M., Blair, A., Hoover, R.N. and Cohen, J.L. (1991). Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. Br. J. Ind. Med., 48(8): 515-530.

Stefanski, S.A., Elwell, M.R. and Stromberg, P.C. (1990). Spleen, lymph nodes and thymus. In: Pathology of the Fischer rat: reference and atlas. Boorman, G.A. (ed.). Academic Press, San Diego, California, pp. 369-393.

Stenzel, M.H. and Sen Gupta, U. (1985). Treatment of contaminated groundwaters with granular activated carbon and air stripping. J. Air Pollut. Control Assoc., 35(12): 1304-1309. Stewart, R.D. (1969). Acute tetrachloroethylene intoxication. J. Am. Med. Assoc., 208(8): 1490-1492.

Stewart, R.D. and Dodd, H.C. (1964). Absorption of carbon tetrachloride, trichloroethylene, tetrachloroethylene, methylene chloride, and 1,1,1-trichloroethane through the human skin. Am. Ind. Hyg. Assoc. J., 25: 439-446.

Stewart, R.D., Gay, H.H., Erley, D.S., Hake, C.L. and Schaffer, A.W. (1961). Human exposure to tetrachloroethylene vapor. Arch. Environ. Health, 2: 516-522. Stewart, R.D., Baretta, E.D., Dodd, H.C. and Torkelson, T.R. (1970). Experimental human exposure to tetrachloroethylene. Arch. Environ. Health, 20(2): 225-229.

Stewart, R.D., Hake, C.L., Wu, A., Kalbfleisch, J., Newton, P.E., Marlow, S.K. and Vucicevic-Salama, M. (1977). Effects of perchloroethylene/drug interaction on behavior and neurological function. Allen-Bradley Medical Sciences Laboratory, Medical College of Wisconsin, Milwaukee, Wisconsin.

Stewart, R.D., Hake, C.L., Forster, H.V., Lebrun, A.J., Peterson, J.E. and Wu, A. (1981). Tetrachloroethylene: development of a biologic standard for the industrial worker by breath analysis. Department of Environmental Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin (NTIS PB82152166).

Storm, J.E. and Mazor, K.A. (2004). Update of residential tetrachloroethylene exposure and decreases in visual contrast sensitivity. Environ. Health Perspect., 112(15): A862-4; author reply A864-5.

Storm, J.E., Mazor, K.A., Aldous, K.M., Blount, B.C., Brodie, S.E. and Serle, J.B. (2011). Visual contrast sensitivity in children exposed to tetrachloroethylene. Arch. Environ. Occup. Health, 66(3): 166-177.

Story, D.L., Meierhenry, E.F., Tyson, C.A. and Milman, H.A. (1986). Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital. Toxicol. Ind. Health, 2(4): 351-362.

Stromberg, P.C. and Vogtsberger, L.M. (1983). Pathology of the mononuclear cell leukemia of Fischer rats. I. Morphologic studies. Vet. Pathol., 20(6): 698-708.

Stromberg, P.C., Grants, I.S., Kociba, G.J., Krakowka, G.S. and Mezza, L.E. (1990). Serial syngeneic transplantation of large granular lymphocyte leukemia in F344 rats. Vet. Pathol., 27(6): 404-410.

Sweeney, L.M., Kirman, C.R., Gargas, M.L. and Dugard, P.H. (2009). Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice. Toxicology, 260(1-3): 77-83.

Szakmáry, E., Ungváry, G. and Tátrai, E. (1997). The offspring-damaging effect of tetrachloroethylene in rats, mice and rabbits. J. Occup. Environ. Med., 3: 31-39.

Tanios, M.A., El Gamal, H., Rosenberg, B.J. and Hassoun, P.M. (2004). Can we still miss tetrachloroethylene-induced lung disease? The emperor returns in new clothes. Respiration, 71(6): 642-645.

Tao, L., Yang, S., Xie, M., Kramer, P.M. and Pereira, M.A. (2000). Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-jun and c-myc protooncogenes in mouse liver: prevention by methionine. Toxicol. Sci., 54(2): 399-407.

Tao, L., Li, Y., Kramer, P.M., Wang, W. and Pereira, M.A. (2004). Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Toxicology, 196(1-2): 127-136.

Taylor, J., Chen, S.S., Mulford, L.A. and Norris, D. (2000). Flat sheet, bench and pilot testing for pesticide removal using reverse osmosis. American Water Works Association Research Foundation and American Water Works Association, Denver, Colorado (90808).

Thomas, J., Haseman, J.K., Goodman, J.I., Ward, J.M., Loughran, T.P., Jr., and Spencer, P.J. (2007). A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicol. Sci., 99(1): 3-19.

Tinston, D.J. (1995). Perchloroethylene: multigeneration inhalation study in the rat. Zeneca Central Toxicology Laboratory, Cheshire, United Kingdom (CTL/P/4097).

Topudurti, K. (1993). Technology evaluation report: Perox-pure chemical oxidation technology.

Risk Reduction Engineering Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA/540/AR-93/501).

Topudurti, K., Wojciechowski, M., Anagnostopoulos, S. and Eilers, R. (1998). Field evaluation of a photocatalytic oxidation technology. Water Sci. Technol., 38(7): 117-125.

Toraason, M., Clark, J., Dankovic, D., Mathias, P., Skaggs, S., Walker, C. and Werren, D. (1999). Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene. Toxicology, 138(1): 43-53.

Toraason, M., Butler, M.A., Ruder, A., Forrester, C., Taylor, L., Ashley, D.L., Mathias, P., Marlow, K.L., Cheever, K.L., Krieg, E. and Wey, H. (2003). Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners. Mutat. Res., 539(1-2): 9-18.

Travier, N., Gridley, G., De Roos, A.J., Plato, N., Moradi, T. and Boffetta, P. (2002). Cancer incidence of dry cleaning, laundry and ironing workers in Sweden. Scand. J. Work Environ. Health, 28(5): 341-348.

Trevisan, A., Maccà, I., Rui, F., Carrieri, M., Bartolucci, G.B. and Manno, M. (2000). Kidney and liver biomarkers in female dry-cleaning workers exposed to perchloroethylene. Biomarkers, 5(6): 399-409.

Tsuruta, H. (1975). Percutaneous absorption of organic solvents. I. Comparative study of the in vivo percutaneous absorption of chlorinated solvents in mice. Ind. Health, 13(4): 227-236.

Tsuruta, H. (1977). Percutaneous absorption of organic solvents. II. A method for measuring the penetration rate of chlorinated solvents through excised rat skin. Ind. Health, 15(3-4): 131-139.

Tsuruta, H. (1989). Skin absorption of organic solvent vapors in nude mice in vivo. Ind. Health, 27(2): 37-47.

Umezu, T., Yonemoto, J., Soma, Y. and Miura, T. (1997). Behavioral effects of trichloroethylene and tetrachloroethylene in mice. Pharmacol. Biochem. Behav., 58(3): 665-671.

Uragami, T., Yamada, H. and Miyata, T. (2001). Removal of dilute volatile organic compounds in water through graft copolymer membranes consisting of poly(alkylmethacrylate) and poly(dimethylsiloxane) by pervaporation and their membrane morphology. J. Membr. Sci., 187(1-2): 255-269.

U.S. EPA (1984). Technologies and costs for the removal of volatile organic chemicals from potable water supplies. Prepared by Environmental Science and Engineering, Inc. for the Office of Drinking Water, U.S. Environmental Protection Agency, Washington, DC (ESE 84-912-0300).

U.S. EPA (1990). Technologies and costs for the removal of synthetic organic chemicals from potable water supplies. Criteria Standards Division, Office of Drinking Water, U.S. Environmental Protection Agency, Washington, DC (PB91-143438).

U.S. EPA (1991a). Technologies for upgrading existing or designing new drinking water treatment facilities. Office of Drinking Water, Center for Environmental Research Information, U.S. Environmental Protection Agency, Cincinnati, Ohio.

U.S. EPA (1991b). National primary drinking water regulations—synthetic organic chemicals and inorganic chemicals; final rule. Fed. Regist., 56(30): 3526.

U.S. EPA (1995). Methods for the determination of organic compounds in drinking water—supplement III. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC (EPA/600/R-95/131).

U.S. EPA (1998). Small system compliance technology list for the non-microbial contaminants regulated before 1996. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-R-98-002).

U.S. EPA (2002). National primary drinking water regulations; organic chemicals, sampling and analytical requirements. Code of Federal Regulations, Title 40, Vol. 19, Part 141, Paragraph 141.24, p. 363.

U.S. EPA (2009). Development of estimated quantitation levels for the second six-year review of national primary drinking water regulations. Office of Water, U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA 815-B-09-005).

U.S. EPA (2010). National primary drinking water regulations; announcement of the results of EPA's review of existing drinking water standards and request for public comment notices. Federal Register, Vol. 75, No. 59, pp. 15500-15572.

U.S. EPA (2011a). Benchmark dose software (BMDS) version 2.2 R67 [build: 12/08/2011]. U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2011b). Basic questions and answers for the drinking water strategy contaminant groups effort. U.S. Environmental Protection Agency, Washington, DC. Available at: http://water.epa.gov/lawsregs/rulesregs/sdwa/dwstrategy/upload/FactSheet_DrinkingWaterStrategy_VOCs.pdf

U.S. EPA (2012a). Technical factsheet on: Tetrachloroethylene. U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/ogwdw/pdfs/factsheets/voc/tech/tetrachl.pdf

U.S. EPA (2012b). Toxicological review of tetrachloroethylene (perchloroethylene) (CAS no. 127-18-4) in support of summary information on the Integrated Risk Information System (IRIS). U.S. Environmental Protection Agency, Washington, DC (EPA/635/R-08/011F).

U.S. EPA (2012c). EPA's vapor intrusion database: evaluation and characterization of attenuation factors for chlorinated volatile organic compounds and residential buildings. Office of Solid Waste and Emergency Response, U.S. Environmental Protection Agency, Washington, DC (EPA 530-R-10-002).

U.S. EPA (2012d). Petroleum hydrocarbons and chlorinated hydrocarbons differ in their potential for vapor intrusion. Office of Underground Storage Tanks, U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2012e). 2012 edition of the drinking water standards and health advisories. Office of Water, U.S. Enivronmental Protection Agency, Washington, DC (EPA 822-S-12-001).

Vagnarelli, P., De Sario, A. and De Carli, L. (1990). Aneuploidy induced by chloral hydrate detected in human lymphocytes with the Y97 probe. Mutagenesis, 5(6): 591-592.

Valencia, R., Mason, J.M., Woodruff, R.C. and Zimmering, S. (1985). Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen., 7(3): 325-348.

Vamvakas, S., Dekant, W., Berthold, K., Schmidt, S., Wild, D. and Henshler, D. (1987). Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. Biochem. Pharmacol., 36(17): 2741-2748.

Vamvakas, S., Herkenhoff, M., Dekant, W. and Henschler, D. (1989a). Mutagenicity of tetrachloroethene in the Ames test—metabolic activation by conjugation with glutathione. J. Biochem. Toxicol., 4(1): 21-27.

Vamvakas, S., Dekant, W. and Henschler, D. (1989b). Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes. Mutat. Res., 222(4): 329-335.

Vartianinen, T., Pukkala, E., Rienoja, T., Strandman, T. and Kaksonen, K. (1993). Population exposure to tri- and tetrachloroethene and cancer risk: two cases of drinking water pollution. Chemosphere, 27(7): 1171-1181.

Vaughan, T.L., Stewart, P.A., Davis, S. and Thomas, D.B. (1997). Work in dry cleaning and the incidence of cancer of the oral cavity, larynx, and oesophagus. Occup. Environ. Med., 54(9): 692-695.

Verplanke, A.J., Leummens, M.H. and Herber, R.F. (1999). Occupational exposure to tetrachloroethene and its effects on the kidneys. J. Occup. Environ. Med., 41(1): 11-16.

Vieira, V., Aschengrau, A. and Ozonoff, D. (2005). Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: using a dose model to assess exposure in a case-control study. Environ. Health, 4(1): 3-3.

Völkel, W., Friedewald, M., Lederer, E., Pähler, A., Parker, J. and Dekant, W. (1998). Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation. Toxicol. Appl. Pharmacol., 153(1): 20-27.

Vyskocil, A., Emminger, S., Tejral, J., Fiala, Z., Ettlerova, E. and Cermanova, A. (1990). Study on kidney function in female workers exposed to perchlorethylene. Hum. Exp. Toxicol., 9(6): 377-380.

Wakeham, S.G., Davis, A.C., Witt, R.T., Tripp, B.W. and Frew, N.M. (1980). Tetrachloroethylene contamination of drinking water by vinyl-coated asbestos-cement pipe. Bull. Environ. Contam. Toxicol., 25(1): 639-645.

Wakeham, S.G., Davis, A.C. and Karas, J.L. (1983). Mesocosm experiments to determine the fate and persistence of volatile organic compounds in coastal seawater. Environ. Sci. Technol., 17(10): 611-617.

Wallace, L.A., Pellizzari, E.D., Hartwell, T.D., Davis, V., Michael, L.C. and Whitmore, R.W. (1989). The influence of personal activities on exposure to volatile organic compounds. Environ. Res., 50(1): 37-55.

Walles, S.A.S. (1986). Induction of single-strand breaks in DNA of mice by trichloroethylene and tetrachloroethylene. Toxicol. Lett., 31(1): 31-35.

Wang, J.L., Chen, W.L., Tsai, S.Y., Sung, P.Y. and Huang, R.N. (2001). An in vitro model for evaluation of vaporous toxicity of trichloroethylene and tetrachloroethylene to CHO-K1 cells. Chem. Biol. Interact., 137(2): 139-154.

Wang, S., Karlsson, J.E., Kyrklund, T. and Haglid, K. (1993). Perchloroethylene-induced reduction in glial and neuronal cell marker proteins in rat brain. Pharmacol. Toxicol., 72(4-5): 273-278.

Warner, J., Hughes, T. and Claxton, L. (1988). Mutagenicity of 16 volatile organic chemicals in a vaporization technique with Salmonella typhimurium TA100. Environ. Mol. Mutagen., 11(Suppl, 11): 111-112.

Warr, T.J., Parry, E.M. and Parry, J.M. (1993). A comparison of two in vitro mammalian cell cytogenetic assays for the detection of mitotic aneuploidy using 10 known or suspected aneugens. Mutat. Res., 287(1): 29-46.

Warren, D.A., Reigle, T.G., Muralidhara, S. and Dallas, C.E. (1996). Schedule-controlled operant behavior of rats following oral administration of perchloroethylene: time course and relationship to blood and brain solvent levels. J. Toxicol. Environ. Health, 47(4): 345-362.

Waskell, L. (1978). A study of the mutagenicity of anesthetics and their metabolites. Mutat. Res., 57(2): 141-153.

Watanabe, K., Sasaki, T. and Kawakami, K. (1998). Comparisons of chemically-induced mutation among four bacterial strains, Salmonella typhimurium TA102 and TA2638, and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101: collaborative study III and evaluation of the usefulness of these strains. Mutat. Res., 416(3): 169-181.

Wenzel, D.G. and Gibson, R.D. (1951). A study of the toxicity and anthelmintic activity of n-butylidene chloride. J. Pharm. Pharmacol., 3(1): 169-176. As cited in: Government of Canada (1993).

White, I.N.H., Razvi, N., Gibbs, A.H., Davies, A.M., Manno, M., Zaccaro, C., Matteis, F.D., Pähler, A. and Dekant, W. (2001). Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells. Toxicol. Lett., 124(1-3): 129-138.

WHO (2000). Tetrachloroethylene. In: Air quality guidelines for Europe, 2nd edition. World Health Organization Regional Office for Europe, Copenhagen, Denmark, pp. 109-111.

WHO (2003). Tetrachloroethene in drinking-water: background document for development of WHO guidelines for drinking-water quality. World Health Organization, Geneva, Switzerland (WHO/SDE/WSH/03.04/23).

WHO (2011). Chapter 8. Chemical aspects. In: Guidelines for drinking-water quality, 4th edition. World Health Organization, Geneva, Switzerland.

Wilson, J.T., Enfield, C.G. and Dunlap, W.J. (1981). Transport and fate of selected organic pollutants in a sandy soil. J. Environ. Qual., 10(4): 501-506.

Windham, G.C., Shusterman, D., Swan, S.H., Fenster, L. and Eskenazi, B. (1991). Exposure to organic solvents and adverse pregnancy outcome. Am. J. Ind. Med., 20(2): 241-259.

Withey, R.J. and Hall, J.W. (1975). The joint toxic action of perchloroethylene with benzene or toluene in rats. Toxicology, 4(1): 5-15. As cited in: Government of Canada (1993).

Yang, Q., Ito, S. and Gonzalez, F.J. (2007). Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis, 28(6): 1171-1177.

Yllner, S. (1961). Urinary metabolites of 14C-tetrachloroethylene in mice. Nature, 191(4790): 820.

Yoshida, M., Lee, B.D. and Hosomi, M. (2000). Decomposition of aqueous tetrachloroethylene by Fenton oxidation treatment. Water Sci. Technol., 42(1-2): 203-208.

Zander, A.K., Semmens, M.J. and Narbaitz, R.M. (1989). Removing VOCs by membrane stripping. J. Am. Water Works Assoc., 87(11): 76-81.

Zeff, J.D. (1991). Full-scale ultraviolet-oxidation system for removing tetrachloroethylene from a drinking water well site in South Gate, California. Proceedings of the Am. Water Works Assoc. Annual Conference, January, 1991, pp. 463-477.

Zheng, T., Cantor, K.P., Zhang, Y. and Lynch, C.F. (2002). Occupation and bladder cancer: a population-based, case-control study in Iowa. J. Occup. Environ. Med., 44(7): 685-691.

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