Rapid screening of substances with limited general population exposure
Official Title: Rapid screening of substances with limited general population exposure
Environment and Climate Change Canada Health Canada
December 2018
Cat. No.: En14-344/2018E-PDF
ISBN: 978-0-660-28455-2
Synopsis
On the basis of available information, 171 substances for which potential for direct exposure to humans was not anticipated were identified and were therefore considered to be candidates for a rapid screening approach. These 171 substances met categorization criteria under subsection 73(1) of CEPA or were considered a priority because of other human health or ecological concerns.
For this rapid screening analysis, the approach for the human health component has been updated from past rapid screening approaches to incorporate elements of Health Canada’s threshold of toxicological concern (TTC)-based approach. Rather than a volume cut-off based on the commercial status of the substances, a two-fold approach was used to determine exposure for the general population of Canada. The initial screening was based on the potential for direct exposure as outlined in previous rapid screening publications. If no direct exposure was identified, rather than using a volume cut-off based on quantities of the substance in commerce, as in most previous rapid screening approaches, the potential for indirect human exposure from environmental media (e.g., air, water, or soil) was determined using an approach based on Health Canada’s TTC approach.
On the basis of this approach, both direct and indirect exposure to the general population of Canada is expected to be negligible for 99 of the 171 substances. Direct and/or indirect exposure potential was identified for the remaining 72 substances, and as a result, these substances will undergo further assessment to evaluate risk to human health.
The ecological risks of 89 of the 99 substances identified in this rapid screening assessment as having negligible exposure to the general population were characterized using the ecological risk classification of organic substances (ERC). The ERC is a risk-based approach that employs multiple metrics for assessing both hazard and exposure on the basis of weighted consideration of various lines of evidence to determine risk classification. Hazard profiles based primarily on metrics regarding mode of toxic action, chemical reactivity, food web-derived internal toxicity thresholds, bioavailability, and chemical and biological activity are established. Metrics considered in the exposure profiles include potential emission rate, overall persistence, and long-range transport potential. A risk matrix is used to assign a low, moderate or high level of potential concern for substances on the basis of their hazard and exposure profiles. Three of the 99 substances have previously been determined not to be of ecological concern through rapid screening evaluations. The ecological risks of seven of the 99 substances remain to be evaluated. As a result of these approaches, 88 of the 99 substances were identified as being of moderate or low ecological concern.
When the results of the human health exposure analysis and the ERC are considered together, 88 of the 99 substances for which human exposure is considered to be negligible were identified as not being of concern to human health or the environment. The remaining 11 substances, although considered to be of low concern to human health, require further assessment because of potential ecological concerns. The results supporting low risk to human health for these 11 substances may form the basis, in conjunction with other relevant information that becomes available after publication of this document, for conclusions made under section 68 or 74 of CEPA at a later time.
Considering all available lines of evidence presented in this screening assessment, there is low risk of harm to the environment from the 88 substances listed in Appendix B. It is concluded that these 88 substances do not meet the criteria under paragraphs 64(a) or (b) of CEPA as they are not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity or that constitute or may constitute a danger to the environment on which life depends.
On the basis of the information presented in this screening assessment, it is concluded that these 88 substances do not meet the criteria under paragraph 64(c) of CEPA as they are not entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health.
Therefore, it is concluded that the 88 substances identified in Appendix B do not meet any of the criteria set out in section 64 of CEPA.
1. Introduction
On the basis of available information, 171 substances for which potential for direct exposures to humans was not anticipated were identified and were therefore considered to be candidates for a rapid screening approach. Substances that met the above criteria, but that are currently being addressed under other assessment activities, were not included in this rapid screening. The 171 substances met categorization criteria under subsection 73(1) of CEPA or were considered a priority on the basis of other human health or ecological concerns (ECCC, HC [modified 2017]). Unlike most previous rapid screening assessments (e.g., Environment Canada, Health Canada 2014; ECCC, HC 2016), the substances selected as candidates for this initiative were not limited to those reported to be in commerce in Canada at less than or equal to 1000 kg/year; potential for direct human exposure to the substance was the determining factor for consideration.
Seven substances from the Confidential Domestic Substances List (CDSL) were included as a part of the 171 substances in this rapid screening approach. Pursuant to paragraphs 3 to 7 of the Masked Name Regulations, a confidential accession number is given to a substance whose identity has been reported as confidential. The identity of the seven substances has been masked in this rapid screening in accordance with sections 88 and 113 of CEPA. Assessments and conclusions pertaining to some of the substances in this rapid screening may be subsequently updated as part of future assessments if the substance is found to be part of a larger class or moiety.
The approach used to determine exposures for the general population of Canada was two-fold. The initial screening was based on the potential for direct exposure using a process consistent with that of previous rapid screenings. Substances reported as having commercial activity in Canada were evaluated on the basis of their presence in several “streams” (e.g., food, non-prescription drugs, natural health products, cosmetics, and other products available to consumers). If no direct exposures were identified, rather than using a volume cut-off based on quantities of the substance in commerce, as in previous rapid screening approaches, the potential for indirect human exposure from environmental media (e.g., air, water, or soil) was determined using an approach based on Health Canada’s threshold of toxicological concern (TTC) approach. Potential releases to the environment were modelled using information on manufacturing and import quantities provided in response to notices regarding commercial activity in Canada collected via mandatory surveys under section 71 of CEPA. For the general population, estimated intakes of less than or equal to 2.5 ng/kg bw/day were considered to be negligible. For the purposes of this assessment, this value is based on the lowest human TTC value for a chemical, below which there is a low probability of risk to human health.
The ecological risks of the majority of substances in this rapid screening were characterized using the ecological risk classification of organic substances (ERC) approach (ECCC 2016a). The ERC describes the hazard of a substance using key metrics including mode of toxic action, chemical reactivity, food web-derived internal toxicity thresholds, bioavailability, and chemical and biological activity. It considers the possible exposure of organisms in the aquatic and terrestrial environments on the basis of such factors as potential emission rates, overall persistence and long-range transport potential in air. The various lines of evidence are combined to identify substances warranting further evaluation of their potential to cause harm to the environment or as having a low likelihood of causing harm to the environment.
This rapid screening was prepared by staff in the CEPA Risk Assessment Program at Health Canada and Environment and Climate Change Canada and incorporates input from other programs within these departments. The ERC document was subject to an external peer-review and a 60-day public comment period. While external comments were taken into consideration, the final content and outcome of the screening assessment remain the responsibility of Environment and Climate Change Canada and Health Canada.
This rapid screening focuses on scientific information critical to determining whether substances meet the criteria as set out in section 64 of CEPA and incorporates a weight-of-evidence approach and precaution.Footnote 1 The rapid screening presents the critical information and considerations on which the conclusions are based.
2. Approach
2.1 Overall approach for evaluation of exposure to the general population
The human health component of this rapid screening approach is illustrated in Figure 1. It consists of multiple steps that address the potential for exposure to a substance.
Figure 1. Overview of approach for evaluation of indirect and direct exposures to the general population
Figure 1 illustrates the human health component of this rapid screening approach. The potential for direct exposure of a candidate substance is evaluated as the first step. If potential for direct exposure to the general population is identified, the substance requires further assessment and is subsequently removed from further consideration in the rapid screening approach. If potential for direct exposure is not identified, an additional step to evaluate the potential for indirect exposure to the general population is conducted. The results of this second step determine whether or not the substance requires further assessment or can be considered to represent a negligible risk for exposure to the general population.
The approach used in this rapid screening is similar to that of previous rapid screenings (e.g., Environment Canada, Health Canada 2014; ECCC, HC 2016). However, in most previous rapid screening approaches, the candidate substances were typically identified on the basis of their low potential for indirect exposure at the outset (i.e., reported quantities in Canadian commerce not exceeding 1000 kg/year). The scope of those screening assessments was therefore limited to evaluation of the potential for direct exposure. The scope of this rapid screening was broadened and updated to reflect and utilize elements of the TTC approach. For example, if no direct exposure was identified, rather than using a volume cut-off based on quantities of the substance in commerce, as in previous rapid screening approaches, the potential for indirect human exposure from environmental media (e.g., air, water, or soil) was determined using an approach based on the TTC approach.
2.2 Process for evaluating the potential for direct exposure of the general population
In this rapid screening, the term “direct exposure” refers to a substance that is available to Canadians for their use either directly or as part of a mixture, product, or manufactured item. In this context, direct use does not include exposures from chemical products used by workers in an industrial or workplace setting. A user is considered to be anyone from the general population who has access to a product that is advertised, imported, or sold in Canada (including those marketed and sold online in Canada). Considerations for determination of direct exposure potential are described below and outlined in Figure 2.
Figure 2. Considerations for the determination of potential for direct exposure to the general population
Figure 2 illustrates the process for determining the potential for direct exposure of the general population of Canada. In some cases, the process requires two steps for direct use determination. To determine if a substance is used or present in a product used by Canadians, numerous sources of both domestic and international use and product information were consulted, including but not limited to:
Domestic
- Information from a mandatory section 71 survey under CEPA - Notice with respect to selected substances identified as priority for action (Canada 2006)
- Information from a mandatory section 71 survey under CEPA - Phase One of the Domestic Substances List (DSL) Inventory Update (DSL IU) (Canada 2009)
- Information from a mandatory section 71 survey under CEPA - Phase Two of the DSL IU (Canada 2012)
- Health Canada’s Lists of Permitted Food Additives (Health Canada [modified 2016])
- Health Canada’s Natural Health Products Ingredients Database (NHPID 2016)
- Health Canada’s Licensed Natural Health Products Database (LNHPD 2016)
- Health Canada’s Drug Product Database (DPD 2016)
- Pest Management Regulatory Agency’s Product Information Database (PMRA 2016)
- Pest Management Regulatory Agency’s List of Formulants (PMRA 2010)
- List of Pharmaceuticals sold in Canada (Health Canada 2011 & 2012) (IMS 2013)
- Notifications submitted under the Cosmetic Regulations to Health Canada
- Notifications submitted under the Food and Drugs Act to Health Canada
International
- United States Environmental Protection Agency’s (US EPA) Chemical and Product Categories Database (CPCat 2016)
- Everything Added to Food in the United States Database (EAFUS 2011)
- United States Food and Drug Administration’s Food Additive Status List (US FDA 2013)
- United States Food and Drug Administration’s List of Indirect Additives used in Food Contact Substances (US FDA 2011)
- European Commission’s Food Additive Database (EU 2014a)
- European Commission’s Food Flavourings Database (EU 2014b)
- European Commission’s Cosmetic Ingredient Database (COSING 2014)
- Household Products Database (HPD 2016)
- Hazardous Substances Data Bank (HSDB c1993-2008)
- Danish Surveys on Chemicals in Consumer Products - various (Denmark 2016)
- Material safety data sheets (MSDS) - various internet sources
- National and international assessments and databases
If there is identified or expected use of a candidate substance, or if the substance is found in a product used by Canadians, a subsequent step is required to determine the potential for direct exposure from use of the product. The following considerations were used to determine potential for direct exposure:
1. Substances for which direct exposures of the general population are not expected include, but are not limited to, those used only:
- as intermediates in the manufacturing process;
- for commercial or industrial use; or
- for research purposes.
2. Substances with potential for direct exposure of the general population include those that are present, either intentionally or unintentionally, in products or manufactured items that are commonly used by Canadians. These include, but are not limited to, substances used in:
- products intended for use by children, and manufactured items such as plastic or wooden toys;
- cosmetics, non-prescription drugs and natural health products;
- commercial paints and inks;
- commercial adhesives;
- hobby activities or do-it-yourself products;
- clothing, fabric and other textiles, including bedding and furniture;
- cleaning products; and
- food additives and packaging.
3. Information on the potential of the substance to migrate from products is also considered, including the type of product that the substance is present in, the substance’s functional use in that product, as well as the substance’s physical-chemical properties. For example, direct exposure would not be expected to occur for a substance used as a curing agent in a polymer as the substance would be reacted into the stable matrices of the cured polymer and would therefore not typically be available for migration. If this information is not known for a substance, it is assumed that the substance may be migrating out of the final product, which may lead to direct exposure for users.
If there is no evidence for use of a substance in a product used by Canadians, the substance is determined to have a low potential for direct exposure, and its potential for indirect exposure is then considered.
2.3 Process for evaluating the potential for indirect exposure of the general population
In most previous rapid screenings (e.g., Environment Canada, Health Canada 2014; ECCC, HC 2016), the cut-off for inclusion of a candidate substance was based on reported quantities in commerce in Canada that were less than or equal to 1000 kg/year per substance. However, for this rapid screening, no quantity cut-off value was used, and the scope of this rapid screening was broadened and updated to reflect and utilize elements of the TTC approach. For example, if no direct exposure was identified, rather than using a volume cut-off based on quantities of the substance in commerce, as in previous rapid screening approaches, the potential for indirect human exposure from environmental media (e.g., air, water, or soil) was determined using an approach consistent with that reported in Health Canada’s Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances (Health Canada 2016). As a result, some substances included in this rapid screening approach may result in some level of indirect exposure from environmental media. The general scheme for evaluating the potential for indirect exposure of the general population in Canada is shown in Figure 3.
Figure 3. Considerations for the determination of potential for indirect exposure to the general population
Figure 3 illustrates the process for determining the potential for indirect exposure of the general population. The initial step for candidate substances in this rapid screening approach considers the total volumes reported in Canadian commerce via mandatory surveys. This was based on information provided in response to notices regarding commercial activity in Canada collected from both Phase One and Phase Two of the DSL IU (Canada 2009, Canada 2012) and a survey conducted in 2006 (Canada 2006) under section 71 of CEPA.
As with most previous rapid screening approaches, substances reported at less than or equal to 1000 kg/year were considered to represent a low potential for exposure of the general population via indirect sources (Environment Canada, Health Canada 2014; ECCC, HC 2016). For substances that were reported at volumes greater than 1000 kg/year, an additional step was undertaken to determine the estimated intake rates from indirect exposure. This evaluation step was adopted from the approach described in Health Canada 2016.
Briefly, the approach relied on empirical or modelled physical-chemical properties and environmental degradation half-lives of substances obtained using EPI Suite (EPI Suite 2012). Data and results obtained from EPI Suite, along with Canadian manufacturing and import data (Canada 2006, Canada 2009, Canada 2012), were then entered into the environmental fugacity model, ChemCAN (ChemCAN 2003) to estimate environmental concentrations for each substance. As a conservative approach, emission volumes modelled in ChemCAN were based on the total volumes reported to be manufactured and imported in Canada (i.e., assuming 100% of the substance manufactured or imported into Canada is released to the environment).
As required, modelling was refined by considering wastewater treatment (WWT) removal rates estimated using SimpleTreat (Struijs et al. 1991) and the STP model in EPI Suite (EPI Suite 2012). The lower of the two removal rates generated by the two models for a substance was applied to reduce the initial emission volume used for the ChemCAN modelling.
If a substance was not a suitable candidate for fugacity modelling because of its physical-chemical properties (e.g., vapour pressure less than 10-7 Pa or water solubility less than 1 ng/L), theoretical environmental intake estimates were generated. See Health Canada 2016 for a detailed discussion regarding the assessment of indirect exposure for substances not amenable to fugacity modelling.
The estimated environmental concentrations were used to derive human intake values to estimate indirect exposure of the general population to each substance on the basis of Canadian exposure factors (Health Canada 1998). Empirical Canadian monitoring or emissions release data were used, when available, provided the empirically-based predicted environmental concentrations exceeded the environmental concentration estimates derived from in-commerce quantities.
The approach used to estimate indirect exposure is considered conservative as it assumes (1) an emission factor of 100%, (2) a worst-case mode-of-entry into the environment, and (3) all releases as occurring in only one region of Canada. For the purposes of this assessment, human exposure is considered to be negligible for all substances having predicted indirect exposures of 2.5 ng/kg bw/d or less.Footnote 2
2.4 Ecological approach
The ecological risks of the majority of substances in this rapid screening were characterized using the ERC approach (ECCC 2016a). The ERC is a risk-based approach that considers multiple metrics for assessing both hazard and exposure, with weighted consideration of multiple lines of evidence for determining risk classification. The various lines of evidence are combined to discriminate between substances of lower or higher potency and lower or higher potential for exposure in various media. This approach reduces the overall uncertainty with risk characterization compared to an approach that relies on a single metric in a single medium (e.g., LC50) for characterization. Since several substances are UVCB (unknown or variable composition, complex reaction products, or biological materials) substances and could not be suitably represented by a single chemical structure, a manual judgement-based approach to classification was used. The following paragraphs in this section summarize the approach, which is described in detail in ECCC (2016a).
Data on physical-chemical properties, fate (chemical half-lives in various media and biota, partition coefficients, and fish bioconcentration), acute fish ecotoxicity, and chemical import or manufacture volume in Canada were collected from scientific literature, from available empirical databases (e.g., OECD QSAR Toolbox), and from responses to surveys under section 71 of CEPA or were generated using selected quantitative structure-activity relationship (QSAR) or mass-balance fate and bioaccumulation models. These data were used as inputs to other mass-balance models or to complete the substance hazard and exposure profiles.
Hazard profiles based primarily on metrics regarding mode of toxic action, chemical reactivity, food web-derived internal toxicity thresholds, bioavailability, and chemical and biological activity were established. Exposure profiles were also composed using multiple metrics including potential emission rate, overall persistence, and long-range transport potential. Hazard and exposure profiles were compared to decision criteria in order to classify the hazard and exposure potentials for each organic substance as low, moderate, or high. Additional rules were applied (e.g., classification consistency, margin of exposure) to refine the preliminary classifications of hazard or exposure. However, in the case of the UVCBs, hazard and exposure could not be fully profiled because of the lack of a representative structure to estimate needed properties and the lack of empirical data for these properties. Therefore, manual classification of hazard and exposure was performed through examination of the UVCB constituents and information obtained from section 71 surveys under CEPA and decisions were based on consideration of similar substances and application of expert judgement.
A risk matrix was used to assign a low, moderate or high classification of potential risk for each substance on the basis of its hazard and exposure classifications. ERC classifications of potential risk were verified using a two-step approach. The first step adjusted the risk classification outcomes from moderate or high to low for substances that had a low estimated rate of emission to water after wastewater treatment, representing a low potential for exposure. The second step reviewed low risk potential classification outcomes using relatively conservative, local-scale (i.e., in the area immediately surrounding a point-source of discharge) risk scenarios designed to be protective of the environment to determine whether the classification of potential risk should be increased.
3. Rapid screening results
3.1 Assessment of the potential to cause harm to human health
Figure 4 illustrates the results of the evaluation of direct and indirect exposure of the general population for the candidate substances, with an accompanying number of substances associated with each step of the process.
Figure 4. Results of the evaluation of direct and indirect exposure to the general population
As a result of this exposure characterization, 68 of the 171 substances were identified as having the potential to result in direct exposure of the general population, and so further assessment of these substances is required. Four of the remaining 103 substances had predicted indirect exposure estimates higher than the TTC value (i.e., 2.5 ng/kg bw/day). Therefore, 72 substances in total will undergo further human health assessment in future publications (see Appendix A).
On the basis of the evaluation of both direct and indirect exposure conducted as part of this rapid screening approach, exposure of the general population was considered to be negligible for the remaining 99 substances.
3.2 Assessment of the potential to cause ecological harm
The ecological risks of 89 of the 99 substances that were determined to have negligible exposure to the general population in this rapid screening were characterized using the ERC approach. Three additional substances were previously determined not to be of ecological concern through rapid screening evaluations (Environment Canada, Health Canada 2014; ECCC, HC 2016). As a result of this approach, 88 substances were identified as being of moderate or low ecological concern. The critical data and considerations used to create substance-specific profiles and classifications associated with ecological hazard, exposure and risk, as well as identification of potential need for tracking of future use patterns, are presented in ECCC (2016b).
A summary of the hazard, exposure and risk classifications can be found in Appendix B.
3.3 Determination of substances of low concern for human health and the environment
Figure 5 illustrates the combined results of the assessment to cause harm to human health, as determined via the potential for direct and indirect exposure of the general population, and the assessment to cause ecological harm, as determined via the ERC approach.
Figure 5. Determining substances of low concern for human health and ecological risk
From the subset of 99 substances for which exposure of the general population was considered to be negligible, 88 substances were also identified as having low potential to pose ecological risk (ECCC 2016b) (see Appendix B). The remaining 11 substances were found to be of low concern to human health, but were identified as requiring further assessment because of potential ecological concerns (see Appendix C). The results supporting low risk to human health for these 11 substances may form the basis, in conjunction with other relevant information that becomes available after publication of this document, for conclusions made under section 68 or 74 of CEPA at a later time.
Although the above-mentioned 88 substances were determined to be of low risk for the environment and human health, several of these substances are associated with health and/or possible ecological effects of concern because of inherent hazard (see Appendix D). Substances associated with health effects of concern were identified on the basis of classifications assigned by other national or international agencies for carcinogenicity, genotoxicity, developmental toxicity or reproductive toxicity. While use patterns and quantities dictate that these substances are not currently of concern, given the associated human health effects, there may be a concern for human health if use patterns were to change or quantities were to increase.
Substances associated with ecological effects of concern include those that are potential DNA and/or RNA binders, potential endocrine disrupting chemicals which target estrogen receptor signalling, possible substitutes for a substance in a high concern ERC group, moderate concern substances not associated with a high concern ERC group, substances having greater potential for local-scale exposures, or substances having high hazard but low current exposure according to ERC results. The potential effects and how they may manifest in the environment were not further investigated due to the low overall exposure to these substances.
4. Summary of uncertainties
It is recognized that the conclusions resulting from the use of this rapid screening approach have associated uncertainties. However, the use of a wide range of filters (e.g., the domestic and international sources listed in Section 2.2) and conservative exposure scenarios gives confidence that the substances identified as not requiring further assessment are unlikely to be of concern.
Modelled data for physical-chemical properties, environmental degradation half-lives, wastewater treatment removal rates, and environmental concentrations were used in the estimation of indirect exposure when empirical data was unavailable. Despite uncertainty associated with modelled data, the assumptions and inputs used to estimate indirect exposure are likely to lead to an overestimation. The uncertainties associated with determining the potential for indirect exposure of the general population are outlined in Health Canada’s Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances (Health Canada 2016).
The ERC uses a weighted approach to minimize the potential for both over- and under- classification of hazard, exposure and subsequent risk. The balanced approaches for dealing with uncertainties are described in greater detail in ECCC 2016a.
5. Conclusion
On the basis of the information presented in this screening assessment, it is concluded that the 88 substances identified in Appendix B are not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity, that constitute or may constitute a danger to the environment on which life depends, or that constitute or may constitute a danger in Canada to human life or health.
Therefore, it is concluded that the 88 substances identified in Appendix B do not meet any of the criteria set out in section 64 of CEPA.
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Appendices
CAS RN |
Chemical Name |
Potential exposure identified |
57-97-6 |
Benz[a]anthracene, 7,12-dimethyl- |
Direct |
59-50-7 |
Phenol, 4-chloro-3-methyl- |
Direct |
61-82-5 |
1H-1,2,4-Triazol-3-amine |
Direct |
68-26-8 |
Retinol |
Direct |
75-05-8 |
Acetonitrile |
Indirect |
75-18-3 |
Methane, thiobis- |
Direct |
77-09-8 |
1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)- |
Direct |
81-15-2 |
Benzene, 1-(1,1-dimethylethyl)-3,5-dimethyl-2,4,6-trinitro- |
Direct |
86-30-6 |
Benzenamine, N-nitroso-N-phenyl- |
Direct |
88-19-7 |
Benzenesulfonamide, 2-methyl- |
Direct |
95-55-6 |
Phenol, 2-amino- |
Direct |
101-84-8 |
Benzene, 1,1’-oxybis- |
Direct |
101-96-2 |
1,4-Benzenediamine, N,N’-bis(1-methylpropyl)- |
Direct |
106-92-3 |
Oxirane, [(2-propenyloxy)methyl]- |
Direct |
110-85-0 |
Piperazine |
Direct |
111-82-0 |
Dodecanoic acid, methyl ester |
Direct |
112-05-0 |
Nonanoic acid |
Direct |
112-69-6 |
1-Hexadecanamine, N,N-dimethyl- |
Direct |
120-78-5 |
Benzothiazole, 2,2’-dithiobis- |
Indirect |
123-77-3 |
Diazenedicarboxamide |
Direct |
124-40-3 |
Methanamine, N-methyl- |
Direct |
132-27-4 |
[1,1’-Biphenyl]-2-ol, sodium salt |
Direct |
136-60-7 |
Benzoic acid, butyl ester |
Direct |
137-26-8 |
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl- |
Direct |
2390-60-5 |
Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, chloride |
Direct |
2492-26-4 |
2(3H)-Benzothiazolethione, sodium salt |
Direct |
3147-75-9 |
Phenol, 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)- |
Direct |
4193-55-9 |
Benzenesulfonic acid, 2,2’-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxyethyl)amino]-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium salt |
Direct |
4572-09-2 |
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, compd. with (2,5-dioxo-4-imidazolidinyl)urea (1:1) |
Direct |
6408-72-6 |
9,10-Anthracenedione, 1,4-diamino-2,3-diphenoxy- |
Direct |
7778-54-3a |
Hypochlorous acid, calcium salt |
Direct |
7789-38-0a |
Bromic acid, sodium salt |
Direct |
8005-03-6 |
C.I. Acid Black 2 |
Direct |
8008-57-9 |
Oils, orange, sweet |
Direct |
9007-13-0 |
Resin acids and Rosin acids, calcium salts |
Direct |
10038-98-9a |
Germane, tetrachloro- |
Indirect |
11103-57-4 |
Vitamin A |
Direct |
12136-45-7a |
Potassium oxide (K2O) |
Direct |
15647-08-2 |
Phosphorous acid, 2-ethylhexyl diphenyl ester |
Direct |
16090-02-1 |
Benzenesulfonic acid, 2,2’-(1,2-ethenediyl)bis[5-[[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium salt |
Direct |
25155-23-1 |
Phenol, dimethyl-, phosphate (3:1) |
Direct |
25167-32-2 |
Benzenesulfonic acid, oxybis[dodecyl-, disodium salt |
Direct |
26264-05-1 |
Benzenesulfonic acid, dodecyl-, compd. with 2-propanamine (1:1) |
Direct |
26694-69-9 |
Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate |
Direct |
28519-02-0 |
Benzenesulfonic acid, dodecyl(sulfophenoxy)-, disodium salt |
Direct |
37310-83-1 |
9-Octadecen-1-ol, (Z)-, phosphate |
Direct |
57855-77-3 |
Naphthalenesulfonic acid, dinonyl-, calcium salt |
Direct |
58713-21-6 |
1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, hydrochloride |
Direct |
61788-44-1 |
Phenol, styrenated |
Direct |
61790-44-1 |
Fatty acids, tall-oil, potassium salts |
Direct |
61791-34-2 |
Onium compounds, morpholinium, 4-ethyl-4-soya alkyl, Et sulfates |
Direct |
68122-86-1 |
Imidazolium compounds, 4,5-dihydro-1-methyl-2-nortallow alkyl-1-(2-tallow amidoethyl), Me sulfates |
Direct |
68153-35-5 |
Ethanaminium, 2-amino-N-(2-aminoethyl)-N-(2-hydroxyethyl)-N-methyl-, N,N’-ditallow acyl derivs., Me sulfates (salts) |
Direct |
68186-14-1 |
Resin acids and Rosin acids, Me esters |
Direct |
68308-67-8 |
Quaternary ammonium compounds, ethyldimethylsoya alkyl, Et sulfates |
Direct |
68391-01-5 |
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides |
Direct |
68411-30-3 |
Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts |
Direct |
68442-97-7 |
1H-Imidazole-1-ethanamine, 4,5-dihydro-, 2-nortall-oil alkyl derivs. |
Indirect |
68476-03-9 |
Fatty acids, montan-wax |
Direct |
68511-50-2 |
1-Propene, 2-methyl-, sulfurized |
Direct |
68584-24-7 |
Benzenesulfonic acid, C10-16-alkyl derivs., compds. with 2-propanamine |
Direct |
68649-12-7 |
1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated |
Direct |
68909-20-6 |
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica |
Direct |
68937-41-7 |
Phenol, isopropylated, phosphate (3:1) |
Direct |
68966-38-1 |
1H-Imidazole-1-ethanol, 4,5-dihydro-2-isoheptadecyl- |
Direct |
68990-53-4 |
Glycerides, C14-22 mono- |
Direct |
70321-86-7 |
Phenol, 2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)- |
Direct |
71011-26-2 |
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides, compds. with hectorite |
Direct |
72391-24-3 |
Benzenesulfonic acid, [[(chloroacetyl)amino]methyl][4-[[4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-1-anthracenyl]amino]phenoxy]methyl-, monosodium salt |
Direct |
92113-31-0 |
Collagens, hydrolyzates |
Direct |
111174-63-1 |
Protein hydrolyzates, leather, reaction products with isostearoyl chloride |
Direct |
120547-52-6 |
Oxirane, mono[(C12-13-alkyloxy)methyl] derivs. |
Direct |
CAS RN/ Confidential Ascension Number |
Chemical Name |
ERC hazard |
ERC exposure |
ERC risk |
74-88-4 |
Methane, iodo- |
high |
low |
lowa |
78-21-7 |
Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate |
moderate |
low |
low |
90-93-7 |
Methanone, bis[4-(diethylamino)phenyl]- |
high |
low |
lowa |
91-66-7b |
Benzenamine, N,N-diethyl- |
low |
low |
low |
95-54-5 |
1,2-Benzenediamine |
high |
low |
lowa |
98-88-4 |
Benzoyl chloride |
moderate |
low |
low |
100-00-5b |
Benzene, 1-chloro-4-nitro- |
low |
low |
low |
101-90-6b |
Oxirane, 2,2’-[1,3-phenylenebis(oxymethylene)]bis- |
moderate |
low |
low |
112-90-3 |
9-Octadecen-1-amine, (Z)- |
high |
low |
lowa |
118-96-7 |
Benzene, 2-methyl-1,3,5-trinitro- |
moderate |
moderate |
moderate |
121-14-2b |
Benzene, 1-methyl-2,4-dinitro- |
moderate |
moderate |
moderate |
126-99-8b |
1,3-Butadiene, 2-chloro- |
low |
low |
low |
134-09-8 |
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoate |
low |
low |
low |
271-89-6b |
Benzofuran |
low |
low |
low |
556-52-5b |
Oxiranemethanol |
low |
low |
low |
630-20-6b |
Ethane, 1,1,1,2-tetrachloro- |
low |
low |
low |
632-99-5b |
Benzenamine, 4-[(4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methyl-, monohydrochloride |
low |
low |
low |
647-42-7 |
1-Octanol, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro- |
low |
low |
low |
1533-45-5 |
Benzoxazole, 2,2’-(1,2-ethenediyldi-4,1-phenylene)bis- |
high |
low |
lowa |
2387-03-3 |
1-Naphthalenecarboxaldehyde, 2-hydroxy-, [(2-hydroxy-1-naphthalenyl)methylene]hydrazone |
high |
low |
lowa |
2422-91-5 |
Benzene, 1,1’,1’’-methylidynetris[4-isocyanato- |
high |
low |
lowa |
2475-45-8b |
9,10-Anthracenedione, 1,4,5,8-tetraamino- |
high |
low |
lowa |
2478-20-8 |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-(2,4-dimethylphenyl)- |
low |
low |
low |
3426-43-5 |
Benzenesulfonic acid, 2,2’-(1,2-ethenediyl)bis[5-[[4-methoxy-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium salt |
high |
low |
lowa |
4035-89-6 |
Imidodicarbonic diamide, N,N’,2-tris(6-isocyanatohexyl)- |
high |
low |
lowa |
4051-63-2 |
[1,1’-Bianthracene]-9,9’,10,10’-tetrone, 4,4’-diamino- |
high |
low |
lowa |
4151-51-3 |
Phenol, 4-isocyanato-, phosphorothioate (3:1) (ester) |
high |
low |
lowa |
4378-61-4 |
Dibenzo[def,mno]chrysene-6,12-dione, 4,10-dibromo- |
low |
low |
low |
5521-31-3b |
Anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetrone, 2,9-dimethyl- |
moderate |
moderate |
moderate |
5718-26-3 |
1H-Indole-5-carboxylic acid, 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-2,3-dihydro-1,3,3-trimethyl-, methyl ester |
high |
low |
lowa |
7576-65-0 |
1H-Indene-1,3(2H)-dione, 2-(3-hydroxy-2-quinolinyl)- |
moderate |
low |
low |
7789-36-8 |
Bromic acid, magnesium salt, hexahydrate |
|
|
lowc |
8021-39-4 |
Creosote, wood |
low |
low |
low |
12068-03-0 |
Benzenesulfonic acid, methyl-, sodium salt |
low |
low |
low |
13676-91-0 |
9,10-Anthracenedione, 1,8-bis(phenylthio)- |
high |
low |
lowa |
13680-35-8 |
Benzenamine, 4,4’-methylenebis[2,6-diethyl- |
low |
low |
low |
16294-75-0 |
14H-Anthra[2,1,9-mna]thioxanthen-14-one |
low |
low |
low |
18917-89-0b |
Magnesium, bis(2-hydroxybenzoato-O1,O2)-, (T-4)- |
|
|
lowd |
19286-75-0 |
9,10-Anthracenedione, 1-hydroxy-4-(phenylamino)- |
high |
low |
lowa |
21564-17-0 |
Thiocyanic acid, (2-benzothiazolylthio)methyl ester |
high |
low |
lowa |
24448-20-2 |
2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) ester |
moderate |
low |
low |
25428-43-7 |
3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-pentenyl)-, (R,R)-(±)- |
low |
low |
low |
25638-17-9b |
Naphthalenesulfonic acid, butyl-, sodium salt |
low |
low |
lowa |
26446-73-1 |
Phosphoric acid, bis(methylphenyl) phenyl ester |
moderate |
low |
lowa |
28768-32-3 |
Oxiranemethanamine, N,N’-(methylenedi-4,1-phenylene)bis[N-(oxiranylmethyl)- |
high |
low |
lowa |
31135-57-6 |
1H-Benzimidazolesulfonic acid, 2-heptadecyl-1-[(sulfophenyl)methyl]-, disodium salt |
high |
low |
lowa |
33204-76-1 |
Cyclotetrasiloxane, 2,2,4,6,6,8-hexamethyl-4,8-diphenyl-, cis- |
low |
low |
low |
43048-08-4 |
2-Propenoic acid, 2-methyl-, (octahydro-4,7-methano-1H-indene-5,?-diyl)bis(methylene) ester |
moderate |
low |
low |
53980-88-4 |
2-Cyclohexene-1-octanoic acid, 5(or 6)-carboxy-4-hexyl- |
moderate |
low |
low |
61789-85-3b |
Sulfonic acids, petroleum |
high |
low |
lowa |
62973-79-9 |
Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, molybdatesilicate |
high |
low |
lowa |
63022-09-3 |
Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, molybdatephosphate |
high |
low |
lowa |
66072-38-6 |
Oxirane, 2,2’,2’’-[methylidynetris(phenyleneoxymethylene)]tris- |
high |
low |
lowa |
66241-11-0b |
C.I. Leuco Sulphur Black 1 |
moderate |
moderate |
moderate |
68310-07-6 |
Xanthylium, 3,6-bis(ethylamino)-9-[2-(methoxycarbonyl)phenyl]-2,7-dimethyl-, molybdatephosphate |
low |
low |
low |
68409-66-5 |
Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, molybdatephosphate |
high |
low |
lowa |
68442-82-0b |
Calcium, carbonate dimethylhexanoate complexes |
low |
low |
lowe |
68478-81-9b |
9-Octadecenoic acid (Z)-, reaction products with 3-(dodecenyl)dihydro-2,5-furandione and triethylenetetramine |
low |
low |
low |
68527-01-5 |
Alkenes, C12-30 α-, bromo chloro |
high |
low |
moderatef |
68527-02-6b |
Alkenes, C12-24, chloro |
high |
low |
moderatef |
68604-99-9 |
Fatty acids, C18-unsatd., phosphates |
high |
low |
lowa |
68647-55-2 |
Fatty acids, tall-oil, esters with triethanolamine |
low |
low |
low |
68814-02-8 |
Ethanaminium, N-[4-[bis[4-(diethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, molybdatephosphate |
high |
low |
lowa |
68890-99-3 |
Benzene, mono-C10-16-alkyl derivs. |
low |
low |
low |
68909-77-3 |
Ethanol, 2,2’-oxybis-, reaction products with ammonia, morpholine derivs. Residues |
low |
high |
low |
68952-35-2b |
Tar acids, cresylic, Ph phosphates |
moderate |
low |
low |
68953-80-0b |
Benzene, mixed with toluene, dealkylation product |
low |
high |
low |
68987-42-8 |
Benzene, ethylenated, residues |
low |
low |
low |
70833-37-3
|
Nickel, bis(3-amino-4,5,6,7-tetrachloro-1H-isoindol-1-one oximato-N²,o1)- |
|
|
lowd |
71011-25-1 |
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides, compds. with bentonite and bis(hydrogenated tallow alkyl)dimethylammonium chlorides |
high |
low |
lowa |
71820-35-4 |
Fatty acids, tall-oil, low-boiling, reaction products with 1-piperazineethanamine |
low |
low |
low |
75627-12-2 |
Xanthylium, 3,6-bis(ethylamino)-9-[2-(methoxycarbonyl)phenyl]-2,7-dimethyl-, molybdatesilicate |
high |
low |
moderate |
80083-40-5 |
Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, molybdatetungstatesilicate |
high |
low |
lowa |
80939-62-4 |
Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates |
low |
low |
low |
90367-27-4 |
Ethanol, 2,2’-[[3-[(2-hydroxyethyl)amino]propyl]imino]bis-, N-tallow alkyl derivs. |
low |
low |
low |
90459-62-4 |
Octadecanoic acid, reaction products with diethylenetriamine, di-Me sulfate-quaternized |
high |
low |
lowa |
91081-53-7 |
Rosin, reaction products with formaldehyde |
high |
low |
lowa |
102082-92-8 |
Xanthylium, 3,6-bis(diethylamino)-9-[2-(methoxycarbonyl)phenyl]-, molybdatesilicate |
high |
low |
lowa |
106276-80-6 |
Benzoic acid, 2,3,4,5-tetrachloro-6-cyano-, methyl ester, reaction products with p-phenylenediamine and sodium methoxide |
high |
low |
moderate |
111174-61-9 |
Alcohols, C8-16, reaction products with phosphorus oxide (P2O5), compds. with 2-ethyl-1-hexanamine |
high |
low |
lowa |
115340-80-2 |
1-Propanaminium, 3-amino-N-ethyl-N,N-dimethyl-, N-wheat-oil acyl derivs., Et sulfates |
high |
low |
lowa |
129828-23-5 |
Fatty acids, tall-oil, reaction products with Bu phenylmethyl phthalate, 2-(dimethylamino)ethanol, morpholine and overbased calcium petroleum sulfonates |
low |
low |
low |
CDSL#10685-2 |
Substituted dimercaptodithiazole |
high |
low |
moderate |
CDSL#10703-2 |
Substituted alkylphenol, calcium salt |
high |
low |
moderate |
CDSL#11053-1 |
Fatty acids compounded with ethylenediamine |
low |
low |
low |
CDSL#11555-8 |
Fatty acids, reaction products with maleic anhydride and triethanolamine |
low |
low |
low |
CDSL#11556-0 |
Fatty acids, reaction products with maleic anhydride |
low |
low |
low |
CDSL#11557-1 |
Fatty acids, reaction products with maleic anhydride and oleylamine |
low |
low |
low |
aThe risk classification outcome for this substance was adjusted to low risk on the basis of its low potential for exposure.
bThis substance was not identified under subsection 73(1) of CEPA but was included in this assessment as it was considered a priority because of other human health or ecological concerns.
cLow ecological concern as a result of the rapid screening of substances identified from phase one of the Domestic Substances List inventory update.
dLow ecological concern as a result of rapid screening of substances identified from phase two of the Domestic Substances List inventory update.
eSubstance was run through ERC following publication of the science approach document.
fOn the basis of additional evaluation, the ERC classification of ecological risk of the substance decreased following publication of the science approach document.
CAS RN/ Confidential Ascension Number |
Chemical Name |
5470-11-1a |
Hydroxylamine, hydrochloride |
8050-28-0 |
Rosin, maleated |
8052-10-6 |
Tall-oil rosin |
25619-56-1 |
Naphthalenesulfonic acid, dinonyl-, barium salt |
61789-87-5 |
Sulfonic acids, petroleum, magnesium salts |
61790-48-5 |
Sulfonic acids, petroleum, barium salts |
65652-41-7 |
Phosphoric acid, bis[(1,1-dimethylethyl)phenyl] phenyl ester |
68188-19-2a |
Paraffin waxes and Hydrocarbon waxes, chloro, chlorosulfonated |
68425-61-6 |
Naphthalenesulfonic acid, bis(1-methylethyl)-, compd. with cyclohexanamine (1:1) |
72854-22-9a |
Paraffin waxes and Hydrocarbon waxes, chloro, sulfonated, ammonium salts |
CDSL#11105-8 |
Phosphorothioic acid, dialkyl ester, alkylamine salt |
aEcological risk of substance to be evaluated
CAS |
Chemical Name |
Health/Possible Ecological effect(s) of concern |
74-88-4 |
Methane, iodo- |
Human Healtha, Ecologicalb |
78-21-7 |
Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate |
Ecologicalc |
90-93-7 |
Methanone, bis[4-(diethylamino)phenyl]- |
Ecologicalb |
95-54-5 |
1,2-Benzenediamine |
Human Healtha, Ecologicalb |
98-88-4 |
Benzoyl chloride |
Human Healtha Ecologicald |
100-00-5 |
Benzene, 1-chloro-4-nitro- |
Human Healtha |
101-90-6 |
Oxirane, 2,2’-[1,3-phenylenebis(oxymethylene)]bis- |
Human Healtha, Ecologicald |
112-90-3 |
9-Octadecen-1-amine, (Z)- |
Ecologicalb |
118-96-7 |
Benzene, 2-methyl-1,3,5-trinitro- |
Human Healtha, Ecologicale |
121-14-2 |
Benzene, 1-methyl-2,4-dinitro- |
Human Healtha, Ecologicale |
126-99-8 |
1,3-Butadiene, 2-chloro- |
Human Healtha |
134-09-8 |
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoate |
Ecologicalf |
271-89-6 |
Benzofuran |
Human Healtha |
556-52-5 |
Oxiranemethanol |
Human Healtha |
630-20-6 |
Ethane, 1,1,1,2-tetrachloro- |
Human Healtha |
632-99-5 |
Benzenamine, 4-[(4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methyl-, monohydrochloride |
Human Healtha, Ecologicalf |
1533-45-5 |
Benzoxazole, 2,2’-(1,2-ethenediyldi-4,1-phenylene)bis- |
Ecologicalb |
2387-03-3 |
1-Naphthalenecarboxaldehyde, 2-hydroxy-, [(2-hydroxy-1-naphthalenyl)methylene]hydrazone |
Ecologicalb |
2422-91-5 |
Benzene, 1,1’,1’’-methylidynetris[4-isocyanato- |
Ecologicalb |
2475-45-8 |
9,10-Anthracenedione, 1,4,5,8-tetraamino- |
Human Healtha, Ecologicalb |
2478-20-8 |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-(2,4-dimethylphenyl)- |
Ecologicalf |
3426-43-5 |
Benzenesulfonic acid, 2,2’-(1,2-ethenediyl)bis[5-[[4-methoxy-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium salt |
Ecologicalb |
4035-89-6 |
Imidodicarbonic diamide, N,N’,2-tris(6-isocyanatohexyl)- |
Ecologicalb |
4051-63-2 |
[1,1’-Bianthracene]-9,9’,10,10’-tetrone, 4,4’-diamino- |
Ecologicalb |
4151-51-3 |
Phenol, 4-isocyanato-, phosphorothioate (3:1) (ester) |
Ecologicalb |
5521-31-3 |
Anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetrone, 2,9-dimethyl- |
Ecologicale |
5718-26-3 |
1H-Indole-5-carboxylic acid, 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-2,3-dihydro-1,3,3-trimethyl-, methyl ester |
Ecologicalb |
13676-91-0 |
9,10-Anthracenedione, 1,8-bis(phenylthio)- |
Ecologicalb |
19286-75-0 |
9,10-Anthracenedione, 1-hydroxy-4-(phenylamino)- |
Ecologicalb |
21564-17-0 |
Thiocyanic acid, (2-benzothiazolylthio)methyl ester |
Ecologicalb |
25638-17-9 |
Naphthalenesulfonic acid, butyl-, sodium salt |
Ecologicalc |
26446-73-1 |
Phosphoric acid, bis(methylphenyl) phenyl ester |
Ecologicalc |
28768-32-3 |
Oxiranemethanamine, N,N’-(methylenedi-4,1-phenylene)bis[N-(oxiranylmethyl)- |
Ecologicalb |
31135-57-6 |
1H-Benzimidazolesulfonic acid, 2-heptadecyl-1-[(sulfophenyl)methyl]-, disodium salt |
Ecologicalb |
53980-88-4 |
2-Cyclohexene-1-octanoic acid, 5(or 6)-carboxy-4-hexyl- |
Ecologicalg |
61789-85-3 |
Sulfonic acids, petroleum |
Ecologicalb |
62973-79-9 |
Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, molybdatesilicate |
Ecologicalb |
63022-09-3 |
Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, molybdatephosphate |
Ecologicalb |
66072-38-6 |
Oxirane, 2,2’,2’’-[methylidynetris(phenyleneoxymethylene)]tris- |
Ecologicalb |
66241-11-0 |
C.I. Leuco Sulphur Black 1 |
Ecologicale |
68409-66-5 |
Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, molybdatephosphate |
Ecologicalb |
68604-99-9 |
Fatty acids, C18-unsatd., phosphates |
Ecologicalb |
68814-02-8 |
Ethanaminium, N-[4-[bis[4-(diethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, molybdatephosphate |
Ecologicalb |
68890-99-3 |
Benzene, mono-C10-16-alkyl derivs. |
Ecologicalc |
68953-80-0 |
Benzene, mixed with toluene, dealkylation product |
Human Healtha, |
71011-25-1 |
Quaternary ammonium compounds, benzyl(hydrogenated tallow alkyl)dimethyl, chlorides, compds. with bentonite and bis(hydrogenated tallow alkyl)dimethylammonium chlorides |
Ecologicalb |
75627-12-2 |
Xanthylium, 3,6-bis(ethylamino)-9-[2-(methoxycarbonyl)phenyl]-2,7-dimethyl-, molybdatesilicate |
Ecologicale |
80083-40-5 |
Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, molybdatetungstatesilicate |
Ecologicalb |
80939-62-4 |
Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates |
Ecologicalc |
90367-27-4 |
Ethanol, 2,2’-[[3-[(2-hydroxyethyl)amino]propyl]imino]bis-, N-tallow alkyl derivs. |
Ecologicalc |
90459-62-4 |
Octadecanoic acid, reaction products with diethylenetriamine, di-Me sulfate-quaternized |
Ecologicalb |
91081-53-7 |
Rosin, reaction products with formaldehyde |
Ecologicalb |
102082-92-8 |
Xanthylium, 3,6-bis(diethylamino)-9-[2-(methoxycarbonyl)phenyl]-, molybdatesilicate |
Ecologicalb |
106276-80-6 |
Benzoic acid, 2,3,4,5-tetrachloro-6-cyano-, methyl ester, reaction products with p-phenylenediamine and sodium methoxide |
Ecologicale |
111174-61-9 |
Alcohols, C8-16, reaction products with phosphorus oxide (P2O5), compds. with 2-ethyl-1-hexanamine |
Ecologicalb |
115340-80-2 |
1-Propanaminium, 3-amino-N-ethyl-N,N-dimethyl-, N-wheat-oil acyl derivs., Et sulfates |
Ecologicalb |
CDSL#10685-2 |
Substituted dimercaptodithiazole |
Ecologicale |
aHigh health hazard was identified on the basis of classifications by other national or international agencies for carcinogenicity, genotoxicity, developmental toxicity or reproductive toxicity.
bERC classified this substance as potentially having a high potency. The potential effects and how they may manifest in the environment were not further investigated due to the low ecological exposure of this substance.
cERC classified this substance as having low potential for risk on the basis of current use patterns; however, it is structurally similar to substances having a higher potential for risk. The potential effects and how they may manifest in the environment were not further investigated due to the low ecological exposure of this substance..
dStructural alerts from the OECD toolbox identified this substance as potentially being a DNA and/or protein binder. The potential effects and how they may manifest in the environment were not further investigated due to the low ecological exposure of this substance.
eERC classified this substance as having a moderate potential for risk; however, its chemical group was not prioritized for assessment at this time.
fStructural alerts from the OECD toolbox identified this substance as potentially being an endocrine receptor binder. The potential effects and how they may manifest in the environment were not further investigated due to the low ecological exposure of this substance. .
gERC classified this substance as having low potential for risk on the basis of current use patterns; however, greater potential for local-scale exposure was identified.
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