List of alternative rheology modifiers for use in the production of hand sanitizers

Many ingredients can be considered as replacements for a rheology modifier used in a clear gel (e.g. a hydroalcoholic gel hand sanitizer). The list below contains examples of replacement rheology modifiers which can be used to form a clear or slightly hazed gel (please verify with each supplier); other ingredients may also be commercially available:

Carbomer/Carboxypolymethylene/Polyacrylic acid

Chemical substance: Carboxypolymethylene

  • Carbomer 940
  • Acritamer 940
  • Lingel 940
  • Tego Carbomer
  • TC-Carbomer 390
  • TC-Carbomer 640
  • Flogel FG 1000
  • BASF Rheocare C Plus
Carbomer 940

Chemical substance: Carbomer 940

  • Carbopol 940
  • Ashland 940
  • iGel 940
Carbomer 981

Chemical substance: Carbomer 981

  • Carbopol 981
  • Ashland 981
Carbomer 980

Chemical substance: Carbomer 980

  • Carbopol 980
  • Ashland 980
Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Chemical substance: Acrylates/C10-30 Alkyl Acrylate Crosspolymer

  • Carbopol 1382
  • Carbopol ETD2020
  • Ultrez 20
  • Ultrez 21
  • AQUPEC SER W-150C
  • iGel S9
  • Ultrathix 20
  • Ultrathix 21
Ammonium Acryloyldimethyltaurate/VP Copolymer

Chemical substance: Ammonium Acryloyldimethyltaurate/VP Copolymer

  • Aristoflex AVC
Hypromellose/Cellulose, 2-hydroxypropyl methyl ether/Cellulose hydroxypropyl methyl ether/Carbohydrate gum/Hydroxypropylmethylcellulose/Hydroxypropyl Methylcellulose

Chemical substance: Hypromellose/Cellulose, 2-hydroxypropyl methyl ether/Cellulose hydroxypropyl methyl ether/Carbohydrate gum/Hydroxypropylmethylcellulose/Hydroxypropyl Methylcellulose

  • Benecel E4M
  • Benecel E10M
  • Benecel K100M
Acrylic Acid/VP Crosspolymer

Chemical substance: Acrylic Acid/VP Crosspolymer

  • Ultrathix P-100
Silicic acid, lithium magnesium sodium salt/Lithium magnesium sodium silicate/Silicic acid, Lithium magnesium sodium salt

Chemical substance: Silicic acid, lithium magnesium sodium salt/Lithium magnesium sodium silicate/Silicic acid, Lithium magnesium sodium salt

  • Laponite-RD
Hydroxypropylcellulose/Cellulose, 2-hydroxypropyl ether/Hyprolose

Chemical substance: Hydroxypropylcellulose/Cellulose, 2-hydroxypropyl ether/Hyprolose

  • Klucel H CS
  • Klucel H Pharm
Acrylates Copolymer

Chemical substance: Acrylates Copolymer

  • Carbopol Aqua SF-1
  • BASF Rheocare TTA
  • Rheostyl UP
Polyquaternium-37

Chemical substance: Polyquaternium-37

  • BASF Cosmedia Ultragel 300
Polyquaternium-10

Chemical substance: Polyquaternium-10

  • Celquat SC-230M

Recent technologies can also be considered:

Microcrystalline cellulose

Chemical substance: Microcrystalline cellulose

  • Celluforce NCC

If product transparency is not a requirement for a given application, other alternatives could be considered, including:

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Chemical substance: Acrylates/C10-30 Alkyl Acrylate Crosspolymer

  • Pemulen TR1
  • Pemulen TR2
  • Pemulen EZ-4U
Polyquaternium-37 and Dicaprylyl Carbonate and Lauryl Glucoside

Chemical substance: Polyquaternium-37 and Dicaprylyl Carbonate and Lauryl Glucoside

  • BASF Cosmedia Triple C
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Chemical substance: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

  • Sepinov EMT 10
Polyacrylate-13 and Polyisobutene and Polysorbate 20

Chemical substance: Polyacrylate-13 and Polyisobutene and Polysorbate 20

  • Sepiplus 400
Acrylamide ̸Sodium Acryloyldimethyl Taurate Copolymer ̸Isohexadecane ̸Polysorbate 80

Chemical substance: Acrylamide ̸Sodium Acryloyldimethyl Taurate Copolymer ̸Isohexadecane ̸Polysorbate 80

  • Simulgel 600
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer

Chemical substance: Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer

  • Aristoflex HMB
  • Carbopol SMART 1000

Notes

This content was prepared and reviewed jointly by Health Canada and the Natural Research Council of Canada, with collaboration from Dr. Ripoll, Ph.D., Professor, DESS (Specialized Graduate Diploma) in cosmetology at UQAC and Chair of Quebec Chapter, Society of Cosmetic Chemists.

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