Guidelines for Canadian Drinking Water Quality: Guideline Technical Document – Dimethoate

The theoretical maximum daily intake of dimethoate from food is 0.46 mg/d, based on the residue tolerance limits set by the Food Directorate of the Department of National Health and Welfare.^{Footnote 11} Based on market basket surveys in the United States, the actual average daily intake of dimethoate by adults has been estimated to be 0.008 µg/kg bw.^{Footnote 12} Dimethoate was found in 358 of 6391 U.S. domestic food samples analysed; 96% of the samples had levels at or below 2 ppm.^{Footnote 13}

Analytical Methods and Treatment Technology

The concentration of dimethoate in water may be determined by extracting into dichloromethane, drying the extract and redissolving it in hexane, and analysing by gas-liquid chromatography with flame photometric detection (phosphorus mode; detection limit 0.5 µg/L).,^{Footnote 9},^{Footnote 10}

No information on the effectiveness of current treatment technologies in removing dimethoate from drinking water was identified.

Health Effects

Dimethoate is readily absorbed from the gastrointestinal tract; 76 to 100% of an orally administered dose (quantity unspecified) was excreted in the urine of human volunteers within 24 hours.^{Footnote 14} In rats, about 60% of an administered dose (quantity unspecified) was excreted in the urine and expired air in 24 hours.^{Footnote 15} The principal metabolite of dimethoate is the thiocarboxy derivative.^{Footnote 16} Based on comparisons of the rate of degradation in liver specimens from humans and other species and acute toxicity data in animals, the oral LD₅₀ for humans is predicted to be about 30 mg/kg.,^{Footnote 16}

Dimethoate is a cholinesterase inhibitor. Thirty-six male and female human volunteers were administered oral doses of dimethoate of 5, 15, 30, 45 and 60 mg/d for periods of 14 to 57 days. There were no significant effects on cholinesterase levels in 12 persons ingesting 5 mg/d for 28 days or in nine persons ingesting 15 mg/d for 39 days. There was a decrease in whole blood cholinesterase activity by day 20 in the eight volunteers receiving 30 mg/d, which persisted until the end of the study. This depression occurred earlier and to a somewhat greater degree in the higher dose groups. The no-observed-adverse-effect level (NOAEL) was considered to be 15 mg/d, or 0.2 mg/kg bw per day.^{Footnote 17} In other studies in humans, no inhibition of cholinesterase activity was observed in two adults ingesting 9 and 18 mg/d for 21 days or in 20 adults ingesting 2.5 mg/d for four weeks.,^{Footnote 14}

The NOAEL for erythrocyte and plasma cholinesterase inhibition of dimethoate administered daily in the diet of dogs was 10 and 50 ppm, respectively, or 0.2 and 1.0 mg/kg bw per day.^{Footnote 18} In rats, the reported NOAEL for cholinesterase inhibition has been found to range from 1 ppm (about 0.05 mg/kg bw per day) to 32 ppm dimethoate in the diet.,^{Footnote 2}

On the basis of the results of an early study, the U.S. National Cancer Institute (NCI) concluded that dimethoate was not carcinogenic in Osborne-Mendel rats and B6C3F₁ mice.^{Footnote 19} However, recent histological examination and re-evaluation of the NCI and other studies indicate that dimethoate is oncogenic in two strains of rats and probably in mice. Benign and malignant neoplasms of the liver, endocrine organs and lymphatic system were observed as well as other toxic effects (atrophy of the testes, chronic renal disease and parathyroid hyperplasia).^{Footnote 20} Owing to inadequacies of the available studies, the International Agency for Research on Cancer (IARC) was unable to classify dimethoate with regard to its potential carcinogenicity.^{Footnote 21}

Dimethoate was mutagenic in a number of in vivo and in vitro short-term tests.,^{Footnote 6} In mice drinking water containing 60 ppm (9.5 to 10.5 mg/kg bw per day) dimethoate, there were adverse reproductive effects on mating success, survival of pups and growth of surviving pups; however, no teratogenic effects were observed.^{Footnote 22} Effects on foetal development were observed in cats and rats exposed to 12 mg/kg bw per day but not at 3 or 6 mg/kg bw per day in either species.^{Footnote 23},^{Footnote 24}

Rationale

In 1984, the Food and Agriculture Organization (FAO) and the World Health Organization (WHO),^{Footnote 6} withdrew their estimate of an acceptable daily intake (ADI) for dimethoate because of the incomplete data base. Until further experimental studies are completed, a temporary ADI has been established by WHO,^{Footnote 6} as follows:

where:

• 0.2 mg/kg bw per day is considered to be the NOAEL from studies in human volunteers,^{Footnote 17}
• 100 is the uncertainty factor.

Based on the above ADI, the maximum acceptable concentration (MAC) for dimethoate in drinking water is derived as follows:

where:

• 0.002 mg/kg bw per day is the temporary ADI established by the FAO/WHO
• 70 kg bw is the average body weight of an adult
• 0.20 is the proportion of daily intake of dimethoate allocated to drinking water
• 1.5 L/d is the average daily consumption of drinking water by an adult.

References