Page 10: Guidelines for Canadian Drinking Water Quality: Guideline Technical Document –
Enteric Protozoa: Giardia and Cryptosporidium

11.0 References

Aboytes, A., Di Giovanni, G.D., Abrams, F.A., Rheinecker, C., McElroy, W., Shaw, N. and LeChevallier, M.W. (2004). Detection of infectious Cryptosporidium in filtered drinking water. J. Am. Water Works Assoc., 96:88-98.

Abrahamsen, M.S., Templeton, T.J., Enomoto, S., Abrahante, J.E., Zhu, G., Lancto, C.A., Deng, M., Liu, C., Widmer, G., Tzipori, S., Buck, G.A., Xu, P., Bankier, A.T., Dear, P.H., Konfortov, B.A., Spriggs, H.F., Iyer, L., Anantharaman, V., Aravind, L. and Kapur, V. (2004). Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science, 304(5669):441-445.

Adam, R.D. (1991). The biology of Giardia spp. Microbiol. Rev., 55:706-732.

Adam, R.D. (2001). Biology of Giardia lamblia. Clin. Microbiol. Rev. 14(3):447-475.

Alpert, G.L., Bell, M., Kirkpatrick, C.E., Budinick, L.D., Campos, J.M., Friedman, H.M. and Plotkin, S.A. (1986). Outbreak of cryptosporidiosis in a day care center. Pediatrics, 77:152-157.

Amar, C.F., Dear, P.H., Pedraza-Díaz, S., Looker, N., Linnane, E. and McLauchlin, J. (2002). Sensitive PCR-restriction fragment length polymorphism assay for detection and genotyping of Giardia duodenalis in human feces. J. Clin. Microbiol., 40(2):446-452.

Amburgey, J.E., Amirtharajah, A., York, M.T., Brouckaert, B. M., Spivey, N. C. and Arrowood, M.J. (2005). Comparison of conventional and biological filter performance for Cryptosporidium and microsphere removal. J. Am. Water Works Assoc., 97(12): 77-91.

Aramini, J.J., Stephen, C., Dubey, J.P., Engelstoft, C., Schwantje, H. and Ribble, C.S. (1999). Potential contamination of drinking water with Toxoplasma gondii oocysts. Epidemiol. Infect., 122(2):305-315.

Armson, A., Thompson, R.C. and Reynoldson, J.A. (2003). A review of chemotherapeutic approaches to the treatment of cryptosporidiosis. Expert Rev. Anti-Infect. Ther., 1(2):297-305.

Armstrong, T.W. and Haas, C.N. (2008). Legionnaires' disease: evaluation of a quantitative microbial risk assessment model. J. Water Health, 6(2):149-166.

Assavasilavasukul, P., Harrington, G.W., Lau., B.L.T., Hoffman, R.M. and Borchardt, M.A. (2008). Effect of pathogen load on pathogen removal by conventional treatment. American Water Works Association Research Foundation and American Water Works Association. Denver, Colorado.

Atherholt,T.B., LeChevallier, M.W., Norton, W.D., and Rosen, J.S. (1998). Effect of rainfall on Giardia and Cryptosporidium. J. Am. Water Works Assoc., 90:66-80.

Awad-El-Kariem, F.M. (1999). Does Cryptosporidium parvum have a clonal population structure? Parasitol. Today, 15(12):502-504.

AWWA (1988). Roundtable: Cryptosporidium. American Water Works Association J. Am. Water Works Assoc., 80:14-28.

AWWA (1991). Guidance manual for compliance with the filtration and disinfection requirements for public water systems using surface water sources. American Water Works Association, Denver, Colorado.

AWWA (2011). Water quality and treatment: a handbook of community water supplies. 6th edition. J.K. Edzwald (ed.). McGraw-Hill, New York, New York.

Baeza, C. and Ducoste, J. (2004). A non-biological surrogate for sequential disinfection processes. Water Res., 38(14-15):3400-3410.

BCCDC (1996). Outbreak of cryptosporidiosis associated with municipal drinking water: Cranbrook, British Columbia, June. British Columbia Centre for Disease Control. B.C. Health Dis. Surveill., 5(10):93-103.

Belosevic, M. and Faubert, G.M. (1983). Giardia muris: correlation between oral dosage, course of infection, and trophozoite distribution in the mouse small intestine. Exp. Parasitol., 56:352-365.

Belosevic, M., Faubert, G.M., Guy, R., MacLean, J.D., Law, C. and Croll, N.A. (1983). Giardia lamblia infections in Mongolian gerbils: an animal model. J. Infect. Dis., 147:222-226.

Belosevic, M., Guy, R.A., Taghi-Kilani, R., Neumann, N.F., Gyurek, L.L., Liyanage, L.R., Millard, P.J. and Finch, G.R. (1997). Nucleic acid stains as indicators of Cryptosporidium parvum oocyst viability. Int. J. Parasitol., 27(7):787-798.

Belosevic, M., Craik, S.A., Stafford, J.L., Neumann, N.F., Kruithof, J. and Smith, D.W. (2001). Studies on the resistance/reactivation of Giardia muris cysts and Cryptosporidium parvum oocysts exposed to medium-pressure ultraviolet radiation. FEMS Microbiol. Lett., 204(1):197-203.

Bennett, J.W., Gauci, M.R., Le Moenic, S., Schaefer, F.W. III, and Lindquist, H.D. (1999). A comparison of enumeration techniques for Cryptosporidium parvum oocysts. J. Parasitol., 85(6):1165-1168.

Berrilli, F., Di Cave, D., De Liberato, C., Franco, A., Scaramozzino, P. and Orecchia, P. (2004). Genotype characterisation of Giardia duodenalis isolates from domestic and farm animals by SSU-rRNA gene sequencing. Vet. Parasitol., 122(3):193-199.

Bertrand, I., Gantzer, C., Chesnot, T. and Schwartzbrod, J. (2004). Improved specificity for Giardia lamblia cyst quantification in wastewater by development of a real-time PCR method. J. Microbiol. Methods, 57(1):41-53.

Betancourt, W.Q. and Rose, J.B. (2004). Drinking water treatment processes for removal of Cryptosporidium and Giardia. Vet. Parasitol., 126(1-2):219-234.

Bingham, A.K., Jarroll, E.L., Jr. and Meyer, E.A. (1979). Giardia sp.: physical factors of excystation in vitro, and excystation vs. eosin exclusion as determinants of viability. Exp. Parasitol., 47:284-291.

Black, E.K., Finch, G.R., Taghi-Kilani, R. and Belosevic, M. (1996). Comparison of assays for Cryptosporidium parvum oocysts viability after chemical disinfection. FEMS Microbiol. Lett., 135:187-189.

Boreham, P.F., Upcroft, J.A. and Upcroft, P. (1990). Changing approaches to the study of Giardia epidemiology: 1681-2000. Int. J. Parasitol., 20(4):479-487.

Boulter-Bitzer, J.I., Lee, H. and Trevors, J.T. (2007). Molecular targets for detection and immunotherapy in Cryptosporidium parvum. Biotechnol. Adv., 25(1):13-44.

Bowie, W.R., King, A.S., Werker, D.H., Isaac-Renton, J.L., Bell, A., Eng, S.B. and Marion, S.A. (1997). Outbreak of toxoplasmosis associated with municipal drinking water. The B.C. Toxoplasma Investigation Team. Lancet, 350(9072):173-177.

Bukhari, Z., McCuin, R.M., Fricker, C.R. and Clancy, J.L. (1998). Immunomagnetic separation of Cryptosporidium parvum from source water samples of various turbidities. Appl. Environ. Microbiol., 64(11):4495-4499.

Bukhari, Z., Hargy, T.M., Bolton, J.R., Dussert, B. and Clancy, J.L. (1999). Medium-pressure UV for oocyst inactivation. J. Am. Water Works Assoc., 91(3):86-94.

Bukhari, Z., Marshall, M.M., Korich, D.G., Fricker, C.R., Smith, H.V., Rosen, J. and Clancy, J.L. (2000). Comparison of Cryptosporidium parvum viability and infectivity assays following ozone treatment of oocysts. Appl. Environ. Microbiol., 66(7):2972-2980.

Cacciò, S.M. and Pozio, E. (2006). Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis. Expert Rev. Anti-Infect. Ther., 4(3):429-443.

Cacciò, S., Homan, W., Camilli, R., Traldi, G., Kortbeek, T. and Pozio, E. (2000). A microsatellite marker reveals population heterogeneity within human and animal genotypes of Cryptosporidium parvum. Parasitology, 120(Pt. 3):237-244.

Cacciò, S.M., De Giacomo, M. and Pozio, E. (2002). Sequence analysis of the beta-giardin gene and development of a polymerase chain reaction-restriction fragment length polymorphism assay to genotype Giardia duodenalis cysts from human faecal samples. Int. J. Parasitol., 32(8):1023-1030.

Campbell, A.T. and Wallis, P. (2002). The effect of UV irradiation on human-derived Giardia lamblia cysts. Water Res., 36(4):963-969.

Campbell, A.T., Robertson, L.J. and Smith, H.V. (1992). Viability of Cryptosporidium parvum oocysts: correlation of in vitro excystation with inclusion or exclusion of fluorogenic vital dyes. Appl. Environ. Microbiol., 58:3488-3493.

Caprioli, A., Gentile, G., Baldassari, L., Bisicchia, R., Romoli, E. and Donelli, G. (1989). Cryptosporidium as a common cause of childhood diarrhoea in Italy. Epidemiol. Infect., 102:537-540.

CCME (2004). From source to tap: guidance on the multi-barrier approach to safe drinking water. Canadian Council of Ministers of the Environment Winnipeg, Manitoba.

CDC (2004). Surveillance for waterborne-disease outbreaks associated with drinking water--United States, 2001-2002. United States Centers for Disease Control and Prevention MMWR Morb. Mortal. Wkly. Rep., 53(SS08):23-45.

Chalmers, R.M., Elwin, K., Reilly, W.J., Irvine, H., Thomas, A.L. and Hunter, P.R. (2002). Cryptosporidium in farmed animals: the detection of a novel isolate in sheep. Int. J. Parasitol., 32:21-26.

Chappell, C.L., Okhuysen, P.C., Sterling, C.R., Wang, C., Jakubowski, W. and DuPont, H.L. (1999). Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobulin G. Am. J. Trop. Med. Hyg., 60(1):157-164.

Chappell, C.L., Okhuysen, P.C., Langer-Curry, R., Widmer, G., Akiyoshi, D.E., Tanriverdi, S. and Tzipori, S. (2006). Cryptosporidium hominis: experimental challenge of healthy adults. Am. J. Trop. Med. Hyg., 75(5):851-857.

Chauret, C., Armstrong, N., Fisher, J., Sharma, R., Springthorpe, S. and Sattar, S. (1995). Correlating Cryptosporidium and Giardia with microbial indicators. J. Am. Water Works Assoc., 87(11): 76-84.  

Chauret, C.P., Radziminski, C.Z., Lepuil, M., Creason, R. and Andrews, R.C. (2001). Chlorine dioxide inactivation of Cryptosporidium parvum oocysts and bacterial spore indicators. Appl. Environ. Microbiol., 67(7):2993-3001.

Chesnot, T. and Schwartzbrod, J. (2004). Quantitative and qualitative comparison of density-based purification methods for detection of Cryptosporidium oocysts in turbid environmental matrices. J. Microbiol. Methods, 58(3):375-386.

Christensen, J. and Linden, K. (2002). New findings regarding the impacts of suspended particles on UV disinfection of drinking water. In: Proceedings of the Annual Conference of the American Water Works Association, New Orleans, LA, June 16-20. American Water Works Association, Denver, Colorado.

Clancy, J.L., Hargy, T.M., Marshall, M.M. and Dyksen, J.E. (1998). UV light inactivation of Cryptosporidium oocysts. J. Am. Water Works Assoc., 90(9):92-102.

Clancy Environmental Consultants, Inc. (1996). Performance evaluation of Canadian laboratories--recovery and enumeration of Giardia cysts and Cryptosporidium oocysts from water samples. A report submitted to Health Canada by Clancy Environmental Consultants, Inc., St. Albans, Vermont.

Coulliette, A.D., Huffman, D.E., Slifko, T.R. and Rose, J.B. (2006). Cryptosporidium parvum: treatment effects and the rate of decline in oocyst infectivity. J. Parasitol., 92(1):58-62.

Crabb, J.H. (1998). Antibody-based immunotherapy of cryptosporidiosis. Adv. Parasitol., 40:121-149.

Craik, S.A., Finch, G.R., Bolton, J.R. and Belosevic, M. (2000). Inactivation of Giardia muris cysts using medium-pressure radiation in filtered drinking water. Water Res., 34(18):4325-4332.

Craik, S.A., Weldon, D., Finch, G.R., Bolton, J.R. and Belosevic, M. (2001). Inactivation of Cryptosporidium parvum oocysts using medium- and low-pressure ultraviolet radiation. Water Res., 35(6):1387-1398.

Craun, G.F. (1979). Waterborne outbreaks of giardiasis. In: Waterborne transmission of giardiasis. W. Jakubowski and J.C. Hoff (eds.). U.S. Environmental Protection Agency, Cincinnati, OH. pp. 127-149 (EPA 600/9-79-001).

Craun, G.F. (1986). Waterborne giardiasis in the United States 1965-1984. Lancet, 328 (8505):513-514.

Craun, G. F., Berger, P.S., and Calderon, R. L. (1997). Coliform bacteria and waterborne disease outbreaks. J. Am. Water Works Assoc., 89 (3):96-104.

Craun, G.F., Hubbs, S.A., Frost, F., Calderon, R.L. and Via, S.H. (1998). Waterborne outbreaks of cryptosporidiosis. J. Am. Water Works Assoc., 90:81-91.

Craun, G.F., Brunkard, J.M., Yoder, J.S., Roberts, V.A., Carpenter, J., Wade, T., Calderon, R.L., Roberts, J.M., Beach, M.J. and Roy, S.L. (2010). Causes of outbreaks associated with drinking water in the United States from 1971 to 2006. Clin Microbiol Rev., 23(3):507-528.

Craun, M.F., Craun, G.F., Calderon, R.L. and Beach, M.J. (2006). Waterborne outbreaks reported in the United States. J. Water Health, 4(Suppl. 2):19-30.

Current, W. (1986). Cryptosporidiosis. J. Am. Vet. Med. Assoc., 187:1334-1338.

Davies, C.M., Altavilla, N., Krogh, M., Ferguson, C.M., Deere, D.A. and Ashbolt, N.J. (2005). Environmental inactivation of Cryptosporidium oocysts in catchment soils. J. Appl. Microbiol., 98(2):308-317.

Davies, R.B. and Hibler, C.P. (1979). Animal reservoirs and cross-species transmission of Giardia. In: Waterborne transmission of giardiasis. W. Jakubowski and J.C. Hoff (eds.). U.S. Environmental Protection Agency, Cincinnati, Ohio. pp. 104-126 (EPA 600/9-79-001).

Dechesne, M. and Soyeux, E. (2007). Assessment of source water pathogen contamination. J. Water Health, 5(Suppl. 1):39-50.

Deere, D., Vesey, G., Milner, M., Williams, K., Ashbolt, N. and Veal, D. (1998). Rapid method for fluorescent in situ ribosomal RNA labelling of Cryptosporidium parvum. J. Appl. Microbiol., 85(5):807-818.

Deere, D., Stevens, M., Davison, A., Helm, G. and Dufour, A. (2001). Management strategies. In: Water quality--Guidelines, standards for health: assessment of risk and risk management for water-related infectious disease. L. Fewtrell and J. Bartram (eds.). IWA Publishing, London, United Kingdom, on behalf of the World Health Organization, Geneva, Switzerland.

Delaunay, A., Gargala, G., Li, X., Favennec, L. and Ballet, J.J. (2000). Quantitative flow cytometric evaluation of maximal Cryptosporidium parvum oocyst infectivity in a neonate mouse model. Appl. Environ. Microbiol., 66(10):4315-4317.

DeLoyde, J.L., Anderson, W.B., Cleary, S.A., Ndiongue, S., LeCraw, R.A., Galan, M. and Huck, P.M. (2006). Removal of Cryptosporidium oocysts and Giardia cysts by pilot-scale multi-stage slow sand filtration. In: Recent progress in slow sand and alternative biofiltration processes. Gimbel, R., Graham,  N.J.D.and Collins, M.R. (eds.). IWA Publishing, Cornwall, United Kingdom.

Deng, M.Q., Cliver, D.O. and Mariam, T.W. (1997). Immunomagnetic capture PCR to detect viable Cryptosporidium parvum oocysts from environmental samples. Appl. Environ. Microbiol., 63(8):3134-3138.

Deng, M.Q., Lam, K.M. and Cliver, D.O. (2000). Immunomagnetic separation of Cryptosporidium parvum oocysts using MACS MicroBeads and high gradient separation columns. J. Microbiol. Methods, 40(1):11-17.

denHollander, N., Riley, D. and Befus, D. (1988). Immunology of giardiasis. Parasitol. Today, 4:124-131.

deRegnier, D.P., Cole, L., Schupp, D.G. and Erlandsen, S.L. (1989). Viability of Giardia cysts suspended in lake, river, and tap water. Appl. Environ. Microbiol., 55:1223-1229.

Diallo, M.B., Anceno, A.J., Tawatsupa, B., Houpt, E.R., Wangsuphachart, V. and Shipin, O.V. (2008). Infection risk assessment of diarrhea-related pathogens in a tropical canal network. Sci. Total Environ., 407(1):223-232.

Diamond, L.P., Harlow, D.R. and Cunnick, C.C. (1978). A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans. R. Soc. Trop. Med. Hyg., 72:431-432.

DiGiorgio, C.L., Gonzalez, D.A. and Huitt, C.C. (2002). Cryptosporidium and Giardia recoveries in natural waters by using Environmental Protection Agency Method 1623. Appl. Environ. Microbiol., 68(12):5952-5955.

Di Giovanni, G.D., Hashemi, F.H., Shaw, N.J., Abrams, F.A., LeChevallier, M.W. and Abbaszadegan, M. (1999). Detection of infectious Cryptosporidium parvum oocysts in surface and filter backwash water samples by immunomagnetic separation and integrated cell culture-PCR. Appl. Environ. Microbiol., 65(8):3427-3432.

Dillingham, R.A., Lima, A.A. and Guerrant, R.L. (2002). Cryptosporidiosis: epidemiology and impact. Microbes Infect., 4(10):1059-1066.

Dorner, S.M., Anderson, W.B., Gaulin, T., Candon, H.L., Slawson, R.M., Payment, P. and Huck, P.M. (2007). Pathogen and indicator variability in a heavily impacted watershed. J. Water Health, 5(2): 241-257.

Dorsch, M.R. and Veal, D.A. (2001). Oligonucleotide probes for specific detection of Giardia lamblia cysts by fluorescent in situ hybridization. J. Appl. Microbiol., 90(5):836-842.

Douglas, I. (2009). Using quantitative microbial risk assessment (QMRA) to optimize drinking water treatment. In: Proceedings of the AWWA Water Quality Technology Conference & Exposition, Seattle, WA, November 16-18, 2009. American Water Works Association, Denver, Colorado.

Drescher, A.C., Greene, D.M. and Gadgil, A.J. (2001). Cryptosporidium inactivation by low-pressure UV in a water disinfection device. J. Environ. Health, 64(3):31-35.

Driedger, A., Staub, E., Pinkernell, U., Mariñas, B., Köster, W. and Von Gunten, U. (2001). Inactivation of Bacillus subtilis spores and formation of bromate during ozonation. Water Res., 35(12):2950-2960.

Dubey, J.P. (1998). Toxoplasma gondii oocyst survival under defined temperatures. J. Parasitol., 84(4):862-865.

DuPont, H.L., Chappell, C.L., Sterling, C.R., Okhuysen, P.C., Rose, J.B. and Jakubowski, W. (1995). The infectivity of Cryptosporidium parvum in healthy volunteers. N. Engl. J. Med., 332:855-859.

Eberhard, M.L., Ortega, Y.R., Hanes, D.E., Nace, E.K., Do, R.Q., Robl, M.G., Won, K.Y., Gavidia, C., Sass, N.L., Mansfield, K., Gozalo, A., Griffiths, J., Gilman, R., Sterling, C.R. and Arrowood, M.J. (2000). Attempts to establish experimental Cyclospora cayetanensis infection in laboratory animals. J. Parasitol., 86(3):577-582.

Edberg, S.C., Rice, E.W., Karlin, R.J. and Allen, M.J. (2000). Escherichia coli: the best biological drinking water indicator for public health protection. J. Appl. Microbiol., 88:106S-116S.

Egyed, Z., Sréter, T., Széll, Z. and Varga, I. (2003). Characterization of Cryptosporidium spp.--recent developments and future needs. Vet. Parasitol., 111(2-3):103-104.

Eligio-García, L., Cortes-Campos, A. and Jiménez-Cardoso, E. (2005). Genotype of Giardia intestinalis isolates from children and dogs and its relationship to host origin. Parasitol. Res., 97(1):1-6.

Emelko, M. B. and Huck, P. M. (2004). Microspheres as surrogates for Cryptosporidium filtration. J. Am. Water Works Assoc., 96(3): 94-105.

Emelko, M.B., Huck, P. M, and Douglas, I.P. (2003). Cryptosporidium and microsphere removal during late in-cycle filtration. J. Am. Water Works Assoc., 95(5):173-182.

Emelko, M.B., Huck, P.M., and Coffey, B.M. (2005). A review of Cryptosporidium removal by granular media filtration. J. Am. Water Works Assoc., 95(12):101-115.

Enriquez, F.J. and Riggs, M.W. (1998). Role of immunoglobulin A monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection. Infect. Immunol., 66(9):4469-4473.

EPCOR (2005). Edmonton water performance report. EPCOR Water Services Inc., Edmonton, Alberta.

Erlandsen, S.L. and Bemrick, W.J. (1988). Waterborne giardiasis: sources of Giardia cysts and evidence pertaining to their implication in human infection. In: Advances in Giardia research. P.M. Wallis and B.R. Hammond (eds.). University of Calgary Press, Calgary, Alberta. pp. 227-236.

Erlandsen, S.L., Sherlock, L.A., Januschka, M., Schupp, D.G., Schaefer, F.W., III, Jakubowski, W. and Bemrick, W.J. (1988). Cross-species transmission of Giardia spp.: inoculation of beavers and muskrats with cysts of human, beaver, mouse and muskrat origin. Appl. Environ. Microbiol., 54:2777-2785.

Farthing, M.J.G. (1989). Giardiasis as a disease. In: Giardia from molecules to disease. R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery (eds.). CAB International, Cambridge, United Kingdom. pp. 15-37.

Farthing, M.J.G. (1992). Giardia comes of age: progress in epidemiology, immunology and chemotherapy. J. Antimicrob. Chemother., 30(5):563-566.

Farthing, M.J. (2000). Clinical aspects of human cryptosporidiosis. Contrib. Microbiol., 6:50-74.

Fayer, R. (2004). Cryptosporidium: a water-borne zoonotic parasite. Vet. Parasitol., 126(1-2):37.

Fayer, R. and Xiao, L. (2008). Cryptosporidium and cryptosporidiosis. 2nd edition. CRC Press, Boca Raton, Florida.

Fayer, R., Morgan, U. and Upton, S.J. (2000). Epidemiology of Cryptosporidium: transmission, detection and identification. Int. J. Parasitol., 30(12-13):1305-1322.

Fayer, R., Santín, M. and Trout, J.M. (2008). Cryptosporidium ryanae n. sp. (Apicomplexa: Cryptosporidiidae) in cattle (Bos taurus). Vet. Parasitol., 156(3-4):191-198.

Feng, Y.Y., Ong, S.L., Hu, J.Y., Song, L.F., Tan, X.L. and Ng, W.J. (2003). Effect of particles on the recovery of Cryptosporidium oocysts from source water samples of various turbidities. Appl. Environ. Microbiol., 69(4):1898-1903.

Feng, Y., Alderisio, K.A., Yang, W., Blancero, L.A., Kuhne, W.G., Nadareski, C.A., Reid, M. and Xiao, L. (2007). Cryptosporidium genotypes in wildlife from a New York watershed. Appl Environ Microbiol., 73(20):6475-6483.

Ferguson, C., Kaucner, C., Krogh, M., Deere, D. and Warnecke, M. (2004). Comparison of methods for the concentration of Cryptosporidium oocysts and Giardia cysts from raw waters. Can. J. Microbiol., 50(9):675-682.

Filice, F.P. (1952). Studies on the cytology and life history of a Giardia from a laboratory rat. Univ. Calif. Publ. Zool., 57:53-146.

Finch, G.R., Daniels, C.W., Black, E.K., Schaefer, F.W., III, and Belosevic, M. (1993). Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice. Appl. Environ. Microbiol., 59:3661-3665.

Finch, G.R., Black, E.K., Gyürék, L.L. and Belosevic, M. (1994). Ozone disinfection of Giardia and Cryptosporidium. American Water Works Association Research Foundation and American Water Works Association, Denver, Colorado.

Finch, G.R., Gyürék, L., Liyanage, L.R.J. and Belosevic, M. (1997). Effect of various disinfection methods on the inactivation of Cryptosporidium. American Water Works Association Research Foundation, Denver, Colorado. 66 pp.

Fontaine, M. and Guillot, E. (2003). An immunomagnetic separation-real-time PCR method for quantification of Cryptosporidium parvum in water samples. J. Microbiol. Methods, 54(1):29-36.

Fox, L.M. and Saravolatz, L.D. (2005). Nitazoxanide: a new thiazolide antiparasitic agent. Clin. Infect. Dis., 40(8):1173-1180.

Freire-Santos, F., Oteiza-Lopez, A.M., Vergara-Castiblanco, C.A. and Ares-Mazas, E. (2000). Study of the combined influence of environmental factors on viability of Cryptosporidium parvum oocysts in water evaluated by fluorogenic vital dyes and excystation techniques. Vet. Parasitol., 89(4):253-259.

Fricker, C. and Clancy, J. (1998). Crypto's protocol prospects. Water Qual. Int., May/June:11-15.

Gale, P. (1996). Developments in microbiological risk assessment models for drinking water--a short review. J. Appl. Bacteriol., 81:403-410.

Gammie, L., Goatcher, L. and Fok, N. (2000). A Giardia/Cryptosporidium near miss? In: Proceedings of the 8th National Conference on Drinking Water, Quebec City, Quebec, October 28-30, 1998. Canadian Water and Wastewater Association, Ottawa, Ontario.

Gaut, S., Robertson, L.,Gjerde, B., Dagestad, A., and Brattli, B. (2008). Occurrence of Cryptosporidium oocysts and Giardia cysts in Norwegian groundwater wells in bedrock. J Water Health, 6(3):383-388.

Gillin, F.D. and Diamond, L.S. (1980). Entamoeba histolytica and Entamoeba invadens: effects of temperature and oxygen tension on growth and survival. Exp. Parasitol., 49(3):328-338.

Girouard, D., Gallant, J., Akiyoshi, D.E., Nunnari, J. and Tzipori, S. (2006). Failure to propagate Cryptosporidium spp. in cell-free culture. J. Parasitol., 92(2):399-400.

Gobet, P. and Toze, S. (2001). Relevance of Cryptosporidium parvum hsp70 mRNA amplification as a tool to discriminate between viable and dead oocysts. J. Parasitol., 87(1):226-229.

Goh, S., Reacher, M., Casemore, D.P., Verlander, N.Q., Charlett, A., Chalmers, R.M., Knowles, M., Pennington, A., Williams, J., Osborn, K. and Richards, S. (2005). Sporadic cryptosporidiosis decline after membrane filtration of public water supplies, England, 1996-2002. Emerg. Infect. Dis., 11(2):251-259.

Gold, D., Stein, B. and Tzipori, S. (2001). The utilization of sodium taurocholate in excystation of Cryptosporidium parvum and infection of tissue culture. J. Parasitol., 87(5):997-1000.

Graczyk, T.K., Cranfield, M.R., Fayer, R. and Anderson, M.S. (1996). Viability and infectivity of Cryptosporidium parvum oocysts are retained upon intestinal passage through a refractory avian host. Appl. Environ. Microbiol., 62:3234-3237.

Graczyk, T.K., Fayer, R., Trout, J.M., Lewis, E.J., Farley, C.A., Sulaiman, I. and Lal, A.A. (1998). Giardia sp. cysts and infectious Cryptosporidium parvum oocysts in the feces of migratory Canada geese (Branta canadensis). Appl. Environ. Microbiol., 64:2736-2738.

Graczyk, T.K., Majewska, A.C. and Schwab, K.J. (2008). The role of birds in dissemination of human waterborne enteropathogens. Trends Parasitol., 24(2):55-59.

Greinert, J., Furtado, D., Smith, J., Monte Barardi, C. and Simões, C. (2004). Detection of Cryptosporidium oocysts and Giardia cysts in swimming pool filter backwash water concentrates by flocculation and immunomagnetic separation. Int. J. Environ. Health Res.,14(6):395-404.

Griffin, D.W., Gibson, C.J. III, Lipp, E.K., Riley, K., Paul, J.H. III, and Rose, J.B. (1999). Detection of viral pathogens by reverse transcriptase PCR and of microbial indicators by standard methods in the canals of the Florida Keys. Appl. Environ. Microbiol., 65(9):4118-4125.

Grow, A.E., Wood, L.L., Claycomb, J.L. and Thompson, P.A. (2003). New biochip technology for label-free detection of pathogens and their toxins. J. Microbiol. Methods, 53(2):221-233.

Gupta, M. and Haas, C.N. (2004). The Milwaukee Cryptosporidium outbreak: assessment of incubation time and daily attack rate. J. Water Health, 2(2):59-69.

Guy, R.A., Payment, P., Krull, U.J. and Horgen, P.A. (2003). Real-time PCR for quantification of Giardia and Cryptosporidium in environmental water samples and sewage. Appl. Environ. Microbiol., 69(9):5178-5185.

Guyot, K., Follet-Dumoulin, A., Lelievre, E., Sarfati, C., Rabodonirina, M., Nevez, G., Cailliez, J.C., Camus, D. and Dei-Cas, E. (2001). Molecular characterization of Cryptosporidium isolates obtained from humans in France. J. Clin. Microbiol., 39:3472-3480.

Haas, C.N., Rose, J.B. and Gerba, C.P. (1999). Quantitative microbial risk assessment. John Wiley, New York, New York.

Hallier-Soulier, S. and Guillot, E. (2000). Detection of cryptosporidia and Cryptosporidium parvum oocysts in environmental water samples by immunomagnetic separation-polymerase chain reaction. J. Appl. Microbiol., 89(1):5-10.

Hallier-Soulier, S. and Guillot, E. (2003). An immunomagnetic separation-reverse transcription polymerase chain reaction (IMS-RT-PCR) test for sensitive and rapid detection of viable waterborne Cryptosporidium parvum. Environ. Microbiol., 5(7):592-598.

Hancock, C.M., Rose, J.B., and Callahan, M. (1998). Prevalence of Cryptosporidium and Giardia in US groundwaters. J. Am. Water Works Assoc., 90(3):58-61.

Havelaar, A. and Melse, J.M. (2003). Quantifying public health risk in the WHO Guidelines for drinking-water quality: a burden of disease approach. Rijkinstituut voor Volskgezondheid en Milieu, Bilthoven, Netherlands (RIVM Report 734301022).

Health and Welfare Canada (1981). Tapwater consumption in Canada. Environmental Health Directorate, Health Protection Branch, Department of National Health and Welfare, Ottawa, Ontario.

Health and Welfare Canada (1993). Water treatment principles and applications: a manual for the production of drinking water. Canadian Water and Wastewater Association, Ottawa, Ontario.

Health Canada (2003). Arthritis in Canada. An ongoing challenge. Health Canada, Ottawa, Ontario (Catalogue No. H39-4/14-2003E).

Health Canada (2006a). Guidelines for Canadian drinking water quality: Guideline technical document-- Escherichia coli. Water Quality and Health Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.

Health Canada (2006b). Guidelines for Canadian drinking water quality: Guideline technical document--Total coliforms. Water Quality and Health Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.

Health Canada (2008). Guidelines for Canadian drinking water quality: Guideline technical document -- Chlorite and chlorate. Water Quality and Health Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.

Health Canada (2012a). Guidelines for Canadian recreational water quality, Third edition. Water, Air and Climate Change Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario. (Catalogue No H129-15/2012E).

Health Canada (2012b). Guidelines for Canadian drinking water quality: Guideline technical document --Turbidity. Water, Air and Climate Change Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.

Hewlett, E.L., Andrews, J.S., Ruffier, J. and Schaefer, F.W., III (1982). Experimental infection of mongrel dogs with Giardia lamblia cysts and cultured trophozoites. J. Infect. Dis., 145:89-93.

Heyworth, M.F. (1988). Immunology of Giardia infections. In: Advances in Giardia research. P.M. Wallis and B.R. Hammond (eds.). University of Calgary Press, Calgary, Alberta. pp. 45-48.

Hibler, C.P., Hancock, C.M., Perger, L.M., Wegrzyn, J.G. and Swabby, K.D. (1987). Inactivation of Giardia cysts with chlorine at 0.5 to 5.0°C. American Water Works Association, Denver, Colorado. 39 pp. (Technical Research Series).

Hijjawi, N.S., Meloni, B.P., Morgan, U.M. and Thompson, R.C. (2001). Complete development and long-term maintenance of Cryptosporidium parvum human and cattle genotypes in cell culture. Int. J. Parasitol., 31(10):1048-1055.

Hijjawi, N.S., Meloni, B.P., Ryan, U.M., Olson, M.E. and Thompson, R.C. (2002). Successful in vitro cultivation of Cryptosporidium andersoni: evidence for the existence of novel extracellular stages in the life cycle and implications for the classification of Cryptosporidium. Int. J. Parasitol., 32(14):1719-1726.

Hijjawi, N.S., Meloni, B.P., Ng'anzo, M., Ryan, U.M., Olson, M.E., Cox, P.T., Monis, P.T. and Thompson, R.C. (2004). Complete development of Cryptosporidium parvum in host cell-free culture. Int. J. Parasitol., 34(7):769-777.

Hijnen, W.A., Beerendonk, E., Smeets, P. and Medema, G.J. (2004a). Elimination of microorganisms by drinking water treatment processes--a review. 1st edition. Kiwa N.V. Water Research, The Hague, Netherlands.

Hijnen, W.A., Schijven, J.F., Bonné, P., Visser, A. and Medema G.J. (2004b). Elimination of viruses, bacteria and protozoan oocysts by slow sand filtration. Water Sci. Technol., 50(1):147-154.

Hoff, J.C. (1986). Inactivation of microbial agents by chemical disinfectants. U.S. Environmental Protection Agency, Cincinnati, OH (Report No. EPA/600/S286/067).

Homan, W.L. and Mank, T.G. (2001). Human giardiasis: genotype linked differences in clinical symptomatology. Int. J. Parasitol., 31(8):822-826.

Hoque, M.E., Hope, V.T., Scragg, R. and Kjellstrom, T. (2003). Children at risk of giardiasis in Auckland: a case-control analysis. Epidemiol. Infect., 131(1):655-662.

Hörman, A., Rimhanen-Finne, R., Maunula, L., von Bonsdorff, C., Torvela, N., Heikinheimo, A. and Hänninen, M.
(2004). Campylobacter spp., Giardia spp., Cryptosporidium spp., noroviruses, and indicator organisms in surface
water in southwestern Finland, 2000-2001. Appl. Environ. Microbiol., 70(1): 87-95.

Hrudey, S.E. and Hrudey, E.L. (2004). Safe drinking water: lessons from recent outbreaks in affluent nations. IWA Publishing, London, United Kingdom. 486 pp.

Hsu, B.M. and Huang, C. (2001). Performances of the immunomagnetic separation method for Cryptosporidium in water under various operation conditions. Biotechnol. Prog., 17(6):1114-1118.

Hsu, B.M., Wu, N.M., Jang, H.D., Shih, F.C., Wan, M.T. and Kung, C.M. (2005). Using the flow cytometry to quantify the Giardia cysts and Cryptosporidium oocysts in water samples. Environ. Monit. Assess., 104(1-3):155-162.

Hu, J., Feng, Y., Ong, S.L., Ng, W.J., Song, L., Tan, X. and Chu, X. (2004). Improvement of recoveries for the determination of protozoa Cryptosporidium and Giardia in water using Method 1623. J. Microbiol. Methods, 58(3):321-325.

Huck, P.M., Emelko, M.B., Coffey, B.M., Maurizio, D. and O'Melia, C. (2001). Filter operation effects on pathogen passage. American Water Works Association Research Foundation, Denver, Colorado (Report No. 90874).

Huck, P.M., Coffey, B.M., Emelko, M.B., Maurizio, D.D., Slawson, R.M., Anderson, W.B., Van Den Oever, J., Douglas, I.P. and O'Melia, C.R. (2002). Effects of filter operation on Cryptosporidium removal. J. Am. Water Works Assoc., 94(6):97-111.

Hunter, P.R. and Nichols, G. (2002). Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients. Clin. Microbiol. Rev., 15(1):145-154.

Hunter, P.R. and Thompson, R.C. (2005). The zoonotic transmission of Giardia and Cryptosporidium. Int. J. Parasitol., 35(11-12):1181-1190.

Ireland Environmental Protection Agency (1995). Water treatment manuals--Filtration. Ardcavan, Wexford, Ireland.

Isaac-Renton, J.L., Cordeiro, C., Sarafis, K. and Shahriari, H. (1993). Characterization of Giardia duodenalis isolates from a waterborne outbreak. J. Infect. Dis., 167:431-440.

Isaac-Renton, J.L., Lewis, L.F., Ong, C.S. and Nulsen, M.F. (1994). A second community outbreak of waterborne giardiasis in Canada and serological investigation of patients. Trans. R. Soc. Trop. Med. Hyg., 88(4):395-399.

Isaac-Renton, J., Moorehead, W. and Ross, A. (1996). Longitudinal studies of Giardia contamination in two community drinking water supplies: cyst levels, parasite viability and health impact. Appl. Environ. Microbiol., 62:47-54.

Isaac-Renton, J., Bowie, W.R., King, A., Irwin, G.S., Ong, C.S., Fung, C.P., Shokeir, M.O. and Dubey, J.P. (1998). Detection of Toxoplasma gondii oocysts in drinking water. Appl. Environ. Microbiol., 64(6):2278-2280.

Iturriaga, R., Zhang, S., Sonek, G.J. and Stibbs, H. (2001). Detection of respiratory enzyme activity in Giardia cysts and Cryptosporidium oocysts using redox dyes and immunofluorescence techniques. J. Microbiol. Methods, 46(1):19-28.

Jacangelo, J.G., Adham, S.A. and Laîné, J.M. (1995). Mechanism of Cryptosporidium, Giardia, and MS2 virus removal by microfiltration and ultrafiltration. J. Am. Water Works Assoc., 87(9):107-121.

Jaidi, K., Barbeau, B., Carrière, A., Desjardins, R. and Prévost, M. (2009). Including operational data in QMRA model: development and impact of model inputs. J. Water Health, 7(1):77-95.

Jakubowski, W. (1994). Personal communication. U.S. Environmental Protection Agency, Cincinnati, Ohio.

Janoff, E.N. and Reller, L.B. (1987). Cryptosporidium species, a protean protozoan. J. Clin. Microbiol., 25:967-975.

Jenkins, M.B., Anguish, L.J., Bowman, D.D., Walker, M.J. and Ghiorse, W.C. (1997). Assessment of a dye permeability assay for determination of inactivation rates of Cryptosporidium parvum oocysts. Appl. Environ. Microbiol., 63:3844-3850.

Jirků, M., Valigurová, A., Koudela, B., Krízek, J., Modrý, D. and Slapeta J. (2008). New species of Cryptosporidium Tyzzer, 1907 (Apicomplexa) from amphibian host: morphology, biology and phylogeny. Folia Parasitol (Praha), 55(2):81-94.

Joachim, A. (2004). Human cryptosporidiosis: an update with special emphasis on the situation in Europe. J. Vet. Med. B Infect. Dis. Vet. Public Health, 51(6):251-259.

Joachim, A., Eckert, E., Petry, F., Bialek, R. and Daugschies, A. (2003). Comparison of viability assays for Cryptosporidium parvum oocysts after disinfection. Vet. Parasitol., 111(1):47-57.

Johnson, A.M., Linden, K., Ciociola, K.M., De Leon, R., Widmer, G. and Rochelle, P.A. (2005). UV inactivation of Cryptosporidium hominis as measured in cell culture. Appl. Environ. Microbiol., 71(5):2800-2802.

Juranek, D.D. (1995). Cryptosporidiosis: sources of infection and guidelines for prevention. Clin. Infect. Dis., 21(Suppl.):S57-S61.

Karanis, P., Kourenti, C. and Smith, H. (2007). Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt. J. Water Health, 5(1):1-38.

Karasudani, T., Aoki, S., Takeuchi, J., Okuyama, M., Oseto, M., Matsuura, S., Asai, T. and Inouye, H. (2001). Sensitive detection of Cryptosporidium oocysts in environmental water samples by reverse transcription-PCR. Jpn. J. Infect. Dis., 54(3):122-124.

Kato, S. and Bowman, D.D. (2002). Using flow cytometry to determine the viability of Cryptosporidium parvum oocysts extracted from spiked environmental samples in chambers. Parasitol. Res., 88(4):326-331.

Kaucner, C. and Stinear, T. (1998). Sensitive and rapid detection of viable Giardia cysts and Cryptosporidium parvum oocysts in large-volume water samples with wound fiberglass cartridge filters and reverse transcription-PCR. Appl. Environ. Microbiol., 64(5):1743-1749.

Keegan, A.R., Fanok, S., Monis, P.T. and Saint, C.P. (2003). Cell culture-Taqman PCR assay for evaluation of Cryptosporidium parvum disinfection. Appl. Environ. Microbiol., 69(5):2505-2511.

Kirner, J.C., Littler, J.D. and Angelo, L.A. (1978). A waterborne outbreak of giardiasis in Camas, Washington. J. Am. Water Works Assoc., 70:35-40.

Korich, D.G., Mead, J.R., Madore, M.S., Sinclair, N.A. and Sterling, C.R. (1990). Effects of ozone, chlorine dioxide, chlorine, and monochloramine on Cryptosporidium parvum oocyst viability. Appl. Environ. Microbiol., 56(5):1423-1428.

Korich, D.G., Marshall, M.M., Smith, H.V., O'Grady, J., Bukhari, Z., Fricker, C.R., Rosen, J.P. and Clancy, J.L. (2000). Inter-laboratory comparison of the CD-1 neonatal mouse logistic dose-response model for Cryptosporidium parvum oocysts. J. Eukaryot. Microbiol., 47(3):294-298.

Kostrzynska, M., Sankey, M., Haack, E., Power, C., Aldom, J.E., Chagla, A.H., Unger, S., Palmateer, G., Lee, H., Trevors, J.T. and De Grandis, S.A. (1999). Three sample preparation protocols for polymerase chain reaction based detection of Cryptosporidium parvum in environmental samples. J. Microbiol. Methods, 35(1):65-71.

Krasner, S.W., Weinberg, H.S., Richardson, S.D., Salvador, J.P., Chinne, R., Sclimenti, M.J., Onstad, G.D. and Thruston, A.D. (2006). Occurrence of a new generation of disinfection byproducts. Environ. Sci. Technol., 40:7175-7185.

Kucik, C.J., Martin, G.L. and Sortor, B.V. (2004). Common intestinal parasites. Am. Fam. Physician, 69(5):1161-1168.

Kuhn, R.C., Rock, C.M. and Oshima, K.H. (2002). Effects of pH and magnetic material on immunomagnetic separation of Cryptosporidium oocysts from concentrated water samples. Appl. Environ. Microbiol., 68(4):2066-2070.

Larson, M.A. and Mariñas, B.J. (2003). Inactivation of Bacillus subtilis spores with ozone and monochloramine.Water Res., 37(4):833-844.

Lean, I.S., McDonald, V. and Pollok, R.C. (2002). The role of cytokines in the pathogenesis of Cryptosporidium infection. Curr. Opin. Infect. Dis., 15(3):229-234.

Learmonth, J.J., Ionas, G., Ebbett, K.A. and Kwan, E.S. (2004). Genetic characterization and transmission cycles of Cryptosporidium species isolated from humans in New Zealand. Appl. Environ. Microbiol., 70:3973-3978.

LeChevallier, M.W. and Au, K.K. (2004). Water treatment and pathogen control: process efficiency in achieving safe drinking water. IWA Publishing, London, United Kingdom, on behalf of the World Health Organization.

LeChevallier, M.W., Norton, W.D. and Lee, R.G. (1991a). Occurrence of Giardia and Cryptosporidium spp. in surface water supplies. Appl. Environ. Microbiol., 57:2610-2616.

LeChevallier, M.W., Norton, W.D. and Lee, R.G. (1991b). Occurrence of Giardia and Cryptosporidium spp. in filtered drinking water supplies. Appl. Environ. Microbiol., 57:2617-2621.

LeChevallier, M.W., Norton, W.D., Siegel, J.E. and Abbaszadegan, M. (1995). Evaluation of the immunofluorescence procedure for detection of Giardia cysts and Cryptosporidium oocysts in water. Appl. Environ. Microbiol., 61:690-697.

LeChevallier, M.W., Di Giovanni, G.D., Clancy, J.L., Bukhari, Z., Bukhari, S., Rosen, J.S., Sobrinho, J. and Frey, M.M. (2003). Comparison of Method 1623 and cell culture-PCR for detection of Cryptosporidium spp. in source waters. Appl. Environ. Microbiol., 69(2):971-979.

Lemos, V., Graczyk, T.K., Alves, M., Lobo, M.L., Sousa, M.C., Antunes, F. and Matos, O. (2005). Identification and determination of the viability of Giardia lamblia cysts and Cryptosporidium parvum and Cryptosporidium hominis oocysts in human fecal and water supply samples by fluorescent in situ hybridization (FISH) and monoclonal antibodies. Parasitol. Res., 98(1):48-53.

Lengerich, E.J., Addiss, D.G. and Juranek, D.D. (1994). Severe giardiasis in the United States. Clin. Infect. Dis., 18:760-763.

Lepesteur, M., Blasdall, S. and Ashbolt, N.J. (2003). Particle dispersion for further Cryptosporidium and Giardia detection by flow cytometry. Lett. Appl. Microbiol., 37(3):218-229.

Li, X., Atwill, E.R., Dunbar, L.A. and Tate, K.W. (2010). Effect of daily temperature fluctuation during the cool season on the infectivity of Cryptosporidium parvum. Appl Environ Microbiol., 76(4):989-993.

Limor, J.R., Lal, A.A. and Xiao, L. (2002). Detection and differentiation of Cryptosporidium parasites that are pathogenic for humans by real-time PCR. J. Clin. Microbiol., 40(7):2335-2338.

Lin, S.D. (1985). Giardia lamblia and water supply. J. Am. Water Works Assoc., 77:40-47.

Linden, K.G., Shin, G. and Sobsey, M.D. (2001). Comparative effectiveness of UV wavelengths for the inactivation of Cryptosporidium parvum oocysts in water. Water Sci. Technol., 43(12):171-174.

Linden, K.G., Shin, G.A., Faubert, G., Cairns, W. and Sobsey, M.D. (2002). UV disinfection of Giardia lamblia cysts in water. Environ. Sci. Technol., 36(11):2519-2522.

Lindquist, H.D., Ware, M., Stetler, R.E., Wymer, L. and Schaefer, F.W., III ( 2001). A comparison of four fluorescent antibody-based methods for purifying, detecting, and confirming Cryptosporidium parvum in surface waters. J. Parasitol., 87(5):1124-1131.

Lippy, E.C. (1981). Waterborne disease: occurrence is on the upswing. J. Am. Water Works Assoc., 73:57-62.

Lopez, C.E., Dykes, A.C., Juranek, D.D., Sinclair, S.P., Conn, J.M., Christie, R.W., Lippy, E.C., Schultz, M.G. and Mires, M.H. (1980). Waterborne giardiasis: a community-wide outbreak of disease and a high rate of asymptomatic infection. Am. J. Epidemiol., 112:495-507.

Lowery, C.J., Moore, J.E., Millar, B.C., Burke, D.P., McCorry, K.A., Crothers, E. and Dooley, J.S. (2000). Detection and speciation of Cryptosporidium spp. in environmental water samples by immunomagnetic separation, PCR and endonuclease restriction. J. Med. Microbiol., 49(9):779-785.

Lowery, C.J., Nugent, P., Moore, J.E., Millar, B.C., Xiru, X. and Dooley, J.S. (2001a). PCR-IMS detection and molecular typing of Cryptosporidium parvum recovered from a recreational river source and an associated mussel (Mytilus edulis) bed in Northern Ireland. Epidemiol. Infect., 127(3):545-553.

Lowery, C.J., Moore, J.E., Millar, B.C., McCorry, K.A., Xu, J., Rooney, P.J. and Dooley, J.S. (2001b). Occurrence and molecular genotyping of Cryptosporidium spp. in surface waters in Northern Ireland. J. Appl. Microbiol., 91(5):774-779.

Ma, P., Kaufman, D.L., Helmick, C.G., D'Souza, A.J. and Navin, T.R. (1985). Cryptosporidiosis in tourists returning from the Caribbean. N. Engl. J. Med., 312:647-648.

MacDonald, L.M., Sargent, K., Armson, A., Thompson, R.C. and Reynoldson, J.A. (2002). The development of a real-time quantitative-PCR method for characterisation of a Cryptosporidium parvum in vitro culturing system and assessment of drug efficacy. Mol. Biochem. Parasitol., 121(2):279-282.

Macler, B.A. and Regli, S. (1993). Use of microbial risk assessment in setting US drinking water standards. Int. J. Food Microbiol., 18(4):245-256.

Mamane-Gravetz, H. and Linden, K.G. (2004). Impact of particle aggregated microbes on UV disinfection. Presented at the AWWA Water Quality Technology Conference, San Antonio, Texas, November 14-18.  American Water Works Association, Denver, Colorado.

Mara, D.D., Sleigh, P.A., Blumenthal, U.J. and Carr, R.M. (2007). Health risks in wastewater irrigation: comparing estimates from quantitative microbial risk analyses and epidemiological studies. J. Water Health, 5(1):39-50.

Marshall, M.M., Naumovitz, D., Ortega, Y. and Sterling, C.R. (1997). Waterborne protozoan pathogens. Clin. Microbiol. Rev., 10(1):67-85.

Masago, Y., Oguma, K., Katayama, H., Hirata, T. and Ohgaki, S. (2004). Cryptosporidium monitoring system at a water treatment plant, based on waterborne risk assessment. Water Sci. Technol., 50(1):293-299.

Matsue, T., Fujino, T., Kajima, J. and Tsuji, M. (2001). Infectivity and oocyst excretion patterns of Cryptosporidium muris in slightly infected mice. J. Vet. Med. Sci., 63(3):319-320.

Maya, C., Beltran, N., Jimenez, B. and Bonilla, P. (2003). Evaluation of the UV disinfection process in bacteria and amphizoic amoeba inactivation. Water Sci. Technol. Water Supply, 3(4):285-291.

McCuin, R.M. and Clancy, J.L. (2003). Modifications to United States Environmental Protection Agency Methods 1622 and 1623 for detection of Cryptosporidium oocysts and Giardia cysts in water. Appl. Environ. Microbiol., 69(1):267-274.

McCuin, R.M., Bukhari, Z., Sobrinho, J. and Clancy, J.L. (2001). Recovery of Cryptosporidium oocysts and Giardia cysts from source water concentrates using immunomagnetic separation. J. Microbiol. Methods, 45(2):69-76.

McDonald, V., Smith, R., Robinson, H. and Bancroft, G. (2000). Host immune responses against Cryptosporidium. Contrib. Microbiol., 6:75-91.

McLauchlin, J., Amar, C., Pedraza-Diaz, S. and Nichols, G.L. (2000). Molecular epidemiological analysis of Cryptosporidium spp. in the United Kingdom: results of genotyping Cryptosporidium spp. in 1,705 fecal samples from humans and 105 fecal samples from livestock animals. J. Clin. Microbiol., 38(11):3984-3990.

McTigue, N.E., LeChevallier, M., Arora, H. and Clancy, J. (1998). National assessment of particle removal by filtration. American Water Works Association Research Foundation and American Water Works Association, Denver, Colorado.

Medema, G.J., Bahar, M. and Schets, F.M. (1997). Survival of Cryptosporidium parvum, Escherichia coli, faecal enterococci and Clostridium perfringens in river water: influence of temperature and autochthonous microorganisms. Water Sci. Technol., 35(11-12):249-252.

Medema, G.J., Shaw, S., Waite, M., Snozzi, M., Morreau, A. and Grabow, W. (2003). Catchment characterisation and source water quality. In: Assessing microbial safety of drinking water: improving approaches and methods. A. Dufour, M. Snozzi, W. Koster, J. Bartram, E. Ronchi and L. Fewtrell (eds.). World Health Organization, Geneva, Switzerland. pp. 111-158.

Medema, G., Loret, J.-F., Stenström, T.-A. and Ashbolt, N. (eds.). (2006). Quantitative microbial risk assessment in the water safety plan. April 2006. European Union MicroRisk Project. Report for the European Commission under the Fifth Framework Programme, Theme 4: Energy, environment and sustainable development.

Meisel, J.L., Perera, D.R., Meligro, C. and Robin, C.E. (1976). Overwhelming watery diarrhoea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology, 70:1156-1160.

Mercado, R., Buck, G.A., Manque, P.A. and Ozaki, L.S. (2007). Cryptosporidium hominis infection of the human respiratory tract. Emerg. Infect. Dis., 13(3):462-464.

Messner, M.J., Chappell, C.L. and Okhuysen, P.C. (2001). Risk assessment for Cryptosporidium: a hierarchical Bayesian analysis of human dose response data. Water Res., 35:3934-3940.

Metro Vancouver (2009). The Greater Vancouver Water District quality control annual report 2009, Volume 1.

MOE (2006). Procedure for disinfection of drinking water in Ontario. As adopted by reference by Ontario Regulation 170/03 under the Safe Drinking Water Act. Ontario Ministry of the Environment Toronto, Ontario (PIBS 4448e01).

Mofidi, A.A., Meyer, E.A., Wallis, P.M., Chou, C.I., Meyer, B.P., Ramalingam, S. and Coffey, B.M. (2002). The effect of UV light on the inactivation of Giardia lamblia and Giardia muris cysts as determined by animal infectivity assay (P-2951-01). Water Res., 36(8):2098-2108.

Mølbak, K., Højlyng, N., Gottschau, A., Sá, J.C.C., Ingholt, L., da Silva, A.P.J. and Aaby, P. (1993). Cryptosporidiosisin infancy and childhood mortality in Guinea Bissau, West Africa. Br. Med. J., 307:417-420.

Mons, M.N., van der Wielen, J.M.L., Blokker, E.J.M., Sinclair, M.I., Hulshof, K.F.A.M., Dangendorf, F., Hunter, P.R. and Medema, G.J. (2007). Estimation of the consumption of cold tap water for microbiological risk assessment: an overview of studies and statistical analysis of data. J. Water Health, 5(Suppl. 1):151-170.

Moore, A.C., Herwaldt, B.L., Craun, G.F., Calderon, R.L., Highsmith, A.K. and Juranek, D.D. (1993). Surveillance for waterborne disease outbreaks--United States, 1991-1992. MMWR Morbid. Mortal. Wkly. Rep., 42:1-35.

Moorehead, W., Guasparini, R., Donovan, C., Mathias, R., Cottle, R. and Baytalan, G. (1990). Giardiasis outbreak from a chlorinated community water supply. Can. J. Public Health, 81:358-362.

Morgan, U.M., Constantine, C.C., Forbes, D.A. and Thompson, R.C. (1997). Differentiation between human and animal isolates of Cryptosporidium parvum using rDNA sequencing and direct PCR analysis. J. Parasitol., 83(5):825-830.

Morgan-Ryan, U.M., Fall, A., Ward, L.A., Hijjawi, N., Sulaiman, I., Fayer, R., Thompson, R.C., Olson, M., Lal, A. and Xiao, L. (2002). Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens. J. Eukaryot. Microbiol., 49(6):433-440.

Moss, D.M. and Arrowood, M.J. (2001). Quantification of Cryptosporidium parvum oocysts in mouse fecal specimens using immunomagnetic particles and two-color flow cytometry. J. Parasitol., 87(2):406-412.

Moulton-Hancock, C., Rose, J.B., Vasconcelos, G.J., Harris, S.I. and Sturbaum, G.D. (2000). Giardia and Cryptosporidium occurrence in groundwater. J. Am. Water Works Assoc., 92(9):117-123.

Murray, C.J.L. and Lopez, A.D. (eds.) (1996a). The global burden of disease: a comprehensive assessment of mortality and disability from disease, injury and risk factors in 1990 and projected to 2020. Harvard University Press, Cambridge, MA (Global Burden of Disease and Injury Series, Vol. 1).

Murray, C. and Lopez, A. (1996b). Global health statistics. Harvard School of Public Health, Cambridge, MA (Global Burden of Disease and Injury Series, Vol. 2).

MWH (2005). Water treatment principles and design. 2nd edition. John Wiley & Sons, New York, New York.

Nash, T.E. (1994). Immunology: the role of the parasite. In: Giardia from molecules to disease. R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery (eds.). CAB International, Cambridge, UK. pp. 139-154.

Nash, T.E., Herrington, D.A., Losonsky, G.A. and Levine, M.M. (1987). Experimental human infections with Giardia lamblia. J. Infect. Dis., 156:974-984.

Navin, T.R. and Juranek, D.D. (1984). Cryptosporidiosis: clinical, epidemiologic and parasitological review. Rev. Infect. Dis., 6:313-327.

Neumann, N.F., Gyurek, L.L., Finch, G.R. and Belosevic, M. (2000a). Intact Cryptosporidium parvum oocysts isolated after in vitro excystation are infectious to neonatal mice. FEMS Microbiol. Lett., 183:331-336.

Neumann, N.F., Gyurek, L.L., Gammie, L., Finch, G.R. and Belosevic, M. (2000b). Comparison of animal infectivity and nucleic acid staining for assessment of Cryptosporidium parvum viability in water. Appl. Environ. Microbiol., 66(1):406-412.

Nieminski, E.C. and Bellamy, W.D. (2000). Application of surrogate measures to improve treatment plant performance. American Water Works Association Research Foundation and American Water Works Association, Denver, CO.

Nieminski, E.C. and Ongerth, J.E. (1995). Removing Giardia and Cryptosporidium by conventional treatment and direct filtration. J. Am. Water Works Assoc., 87(9):96-106.

Nieminski, E.C., Schaefer, F.W., III, and Ongerth, J.E. (1995). Comparison of two methods for detection of Giardia cysts and Cryptosporidium oocysts in water. Appl. Environ. Microbiol., 61(5):1714-1719.

Nime, F.A., Burek, J.D., Page, D.L., Holscher, M.A. and Yardley, J.H. (1976). Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology, 70(4):592-598.

Nimri, L.F. and Batchoun, R. (1994). Prevalence of Cryptosporidium species in elementary school children. J. Clin. Microbiol., 32:1040-1042.

Noordeen, F., Horadagoda, N.U., Faizal, A.C., Rajapakse, R.P., Razak, M.A. and Arulkanthan, A. (2002). Infectivity of Cryptosporidium parvum isolated from asymptomatic adult goats to mice and goat kids. Vet. Parasitol., 103(3):217-225.

NRMMC-EPHC (2006). Australian guidelines for water recycling: managing health and environmental risks (Phase 1). Natural Resource Management Ministerial Council, Environment Protection and Heritage Council, Australian Health Ministers Conference, Adelaide, Australia.

Nwachuku, N., Craun, G.F. and Calderon, R.L. (2002). How effective is the TCR in assessing outbreak vulnerability? J. Am. Water Works Assoc., 94(9):88-96.

Ochiai, Y., Takada, C. and Hosaka, M. (2005). Detection and discrimination of Cryptosporidium parvum and C. hominis in water samples by immunomagnetic separation-PCR. Appl. Environ. Microbiol., 71(2):898-903.

O'Donoghue, P.J. (1995). Cryptosporidium and cryptosporidiosis in man and animals. Int. J. Parasitol., 25:139-195.

O'Handley, R.M. and Olson, M.E. (2006). Giardiasis and cryptosporidiosis in ruminants. Vet. Clin. North Am. Food Anim. Pract., 22(3):623-643.

O'Handley, R.M., Cockwill, C., McAllister, T.A., Jelinski, M., Morck, D.W. and Olson, M.E. (1999). Duration of naturally acquired giardiasis and cryptosporidiosis in dairy calves and their association with diarrhea. J. Am. Vet. Med. Assoc., 214(3):391-396.

Okhuysen, P.C. and Chappell, C.L. (2002). Cryptosporidium virulence determinants--are we there yet? Int. J. Parasitol., 32:517-525.

Okhuysen, P.C., Chappell, C.L., Serling, C.R., Jakubowski, W. and DuPont, H.L. (1998). Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum. Infect. Immunol., 66:441-443.

Okhuysen, P.C., Chappell, C.L., Crabb, J.H., Sterling, C.R. and DuPont, H.L. (1999). Virulence of three distinct Cryptosporidium parvum isolates for healthy adults. J. Infect. Dis., 180:1275-1281.

Okhuysen, P.C., Rich, S.M., Chappell, C.L., Grimes, K.A., Widmer, G., Feng, X. and Tzipori, S. (2002). Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout mice. J. Infect. Dis., 185(9):1320-1325.

Okhuysen, P.C., Rogers, G.A., Crisanti, A., Spano, F., Huang, D.B., Chappell, C.L. and Tzipori, S. (2004). Antibody response of healthy adults to recombinant thrombospondin-related adhesive protein of Cryptosporidium 1 after experimental exposure to Cryptosporidium oocysts. Clin. Diagn. Lab. Immunol., 11(2):235-238.

Olson, M.E., Morck, D.W. and Ceri, H. (1994). Vaccination against Giardia in domestic kittens. In: Giardia from molecules to disease. R.C.A. Thompson, J.A. Reynoldson and A.J. Lymbery (eds.). CAB International, Cambridge, UK. pp. 366-367.

Olson, M.E., Thorlakson, C.L., Deselliers, L., Worck, D.W. and McAllister, T.A. (1997). Giardia and Cryptosporidium in Canadian farm animals. Vet. Parasitol., 68:375-381.

Olson, M.E., O'Handley, R.M., Ralston, B.J., McAllister, T.A. and Thompson, R.C. (2004). Update on Cryptosporidium and Giardia infections in cattle. Trends Parasitol., 20(4):185-191.

Ong, C., Moorehead, W., Ross, A. and Isaac-Renton, J. (1996). Studies of Giardia spp. and Cryptosporidium spp. in two adjacent watersheds. Appl. Environ. Microbiol., 62:2798-2805.

Ong, C.S.L., Pearce, M., Eisler, D., Goh, S.H., King, A.S., Bowie, W.R., Isaac-Renton, J.L. and Beard, C.B. (1997). An outbreak of cryptosporidiosis in southeastern British Columbia, Canada. In: Proceedings of the 1997 International Symposium on Waterborne Cryptosporidium, March 2-5, 1997, Newport Beach, CA. C.R. Fricker and J.L. Clancy (eds.). American Water Works Association, Denver, Colorado.

Ong, C.S., Eisler, D.L., Goh, S.H., Tomblin, J., Awad-El-Kariem, F.M., Beard, C.B., Xiao, L., Sulaiman, I., Lal, A., Fyfe, M., King, A., Bowie, W.R. and Isaac-Renton, J.L. (1999). Molecular epidemiology of cryptosporidiosis outbreaks and transmission in British Columbia, Canada. Am. J. Trop. Med. Hyg., 61(1):63-69.

Ong, C.S., Eisler, D.L., Alikhani, A., Fung, V.W., Tomblin, J., Bowie, W.R. and Isaac-Renton, J.L. (2002). Novel Cryptosporidium genotypes in sporadic cryptosporidiosis cases: first report of human infections with a cervine genotype. Emerg. Infect. Dis., 8(3):263-268.

Ongerth, J.E., Hunter, G.D. and DeWalle, F.B. (1995). Watershed use and Giardia cyst presence. Water Res., 29:1295-1299.

Oppenheimer, J., Gillogly, T., Stolarik, G. and Ward, R. (2002). Comparing the efficiency of low and medium pressure UV light for inactivating Giardia muris and Cryptosporidium parvum in waters with low and high levels of turbidity. In: Proceedings of the Annual Conference and Exhibition of the American Water Works Association, New Orleans, LA, June 16-20. American Water Works Association, Denver, Colorado.

Parker, D.Y., Leonard, M.J., Barber, P., Bonic, G., Jones, W. and Leavell, K.L. (1999). Microfiltration treatment of filter backwash recycle water from a drinking water treatment facility. In: Proceedings of the AWWA Water Quality Technology Conference. American Water Works Association, Denver, Colorado.

Passantino, L., Malley, J., Knudson, M., Ward, R. and Kim, J. (2004). Effect of low turbidity and algae on UV disinfection performance. J. Am. Water Works Assoc., 96:128-137.

Patania, N.L, Jacangelo, J.G., Cummings, L., Wilczak, A., Riley, K., and Oppenheimer, J. (1995). Optimization of filtration for cyst removal. American Water Works Association Research Foundation and American Water Works Association. Denver, Colorado.

Payment, P. and Franco, E. (1993). Clostridium perfringens and somatic coliphages as indicators of the efficiency of drinking water treatment for viruses and protozoan cysts. Appl. Environ. Microbiol., 59:2418-2424.

Payment, P. and Pintar, K. (2006). Waterborne pathogens: a critical assessment of methods, results and data analysis. Rev. Sci. Eau, 19(3):233-245.

Payment, P., Siemiatycki, J., Richardson, L., Renaud, G., Franco, E. and Prévost, M. (1997). A prospective epidemiological study of gastrointestinal health effects due to the consumption of drinking water. Int. J. Environ. Health Res., 7:5-31.

Payment, P., Berte, A., Prévost, M., Ménard, B. and Barbeau, B. (2000). Occurrence of pathogenic microorganisms in the Saint Lawrence River (Canada) and comparison of health risks for populations using it as their source of drinking water. Can. J. Microbiol., 46(6):565-576.

Peng, M.M., Xiao, L., Freeman, A.R., Arrowood, M.J., Escalante, A.A., Weltman, A.C., Ong, C.S.L., MacKenzie, W.R., Lal, A.A. and Beard, C.B. (1997). Genetic polymorphism among Cryptosporidium parvum isolates: evidence of two distinct human transmission cycles. Emerg. Infect. Dis., 3(4):567-573.

Pett, B., Smith, F. and Stendahl, D. (1993). Cryptosporidiosis outbreak from an operations point of view. Kitchener-Waterloo, Ontario, Spring 1993. In: Proceedings of the AWWA Water Quality Technology Conference, Miami, FL. American Water Works Association, Denver, Colorado. pp. 1739-1766.

PHAC (2007). Notifiable disease incidence by year, 1989-2004. Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario.

Pieniazek, N.J., Bornay-Llinares, F.J., Slemenda, S.B., da Silva, A.J., Moura, I.N., Arrowood, M.J., Ditrich, O. and Addiss, D.G. (1999). New Cryptosporidium genotypes in HIV-infected persons. Emerg. Infect. Dis., 5(3):444-449.

Pokorny, N.J., Weir, S.C., Carreno, R.A., Trevors, J.T. and Lee, H. (2002). Influence of temperature on Cryptosporidium parvum oocyst infectivity in river water samples as detected by tissue culture assay. J Parasitol., 88(3):641-643.

Pollok, R.C., McDonald, V., Kelly, P. and Farthing, M.J. (2003). The role of Cryptosporidium parvum-derived phospholipase in intestinal epithelial cell invasion. Parasitol. Res., 90(3):181-186.

Pond, K., Rueedi, J. and Pedley, S. (2004). MicroRisk literature review Pathogens in drinking water sources. Centre for Public and Environmental Health, University of Surrey, Guildford, Surrey, UK.

Power, M.L. and Ryan, U.M. (2008). A new species of Cryptosporidium (Apicomplexa: Cryptosporidiidae) from eastern grey kangaroos (Macropus giganteus). J Parasitol., 94(5):1114-1117.

Priest, J.W., Bern, C., Xiao, L., Roberts, J.M., Kwon, J.P., Lescano, A.G., Checkley, W., Cabrera, L., Moss, D.M., Arrowood, M.J., Sterling, C.R., Gilman, R.H. and Lammie, P.J. (2006). Longitudinal analysis of Cryptosporidium species-specific immunoglobulin G antibody responses in Peruvian children. Clin. Vaccine Immunol., 13(1):123-131.

Quah, J.X., Ambu, S., Lim, Y.A., Mahdy, M.A. and Mak, J.W. (2011). Molecular identification of Cryptosporidium parvum from avian hosts. Parasitology, 138(5):573-577.

Quintero-Betancourt, W., Peele, E.R. and Rose, J.B. (2002). Cryptosporidium parvum and Cyclospora cayetanensis: a review of laboratory methods for detection of these waterborne parasites. J. Microbiol. Methods, 49(3):209-224.

Quintero-Betancourt, W., Gennaccaro, A.L., Scott, T.M. and Rose, J.B. (2003). Assessment of methods for detection of infectious Cryptosporidium oocysts and Giardia cysts in reclaimed effluents. Appl. Environ. Microbiol., 69(9):5380-5388.

Ralston, B.J., McAllister, T.A. and Olson, M.E. (2003). Prevalence and infection pattern of naturally acquired giardiasis and cryptosporidiosis in range beef calves and their dams. Vet. Parasitol., 14(2):113-122.

Ramirez, N.E. and Sreevatsan, S. (2006). Development of a sensitive detection system for Cryptosporidium in environmental samples. Vet. Parasitol., 136(3-4):201-213.

Read, C., Walters, J., Robertson, I.D. and Thompson, R.C. (2002). Correlation between genotype of Giardia duodenalis and diarrhoea. Int. J. Parasitol., 32(2):229-231.

Read, C.M., Monis, P.T. and Thompson, R.C. (2004). Discrimination of all genotypes of Giardia duodenalis at the glutamate dehydrogenase locus using PCR-RFLP. Infect. Genet. Evol., 4(2):125-130.

Regli, S., Rose, J.B., Haas, C.N. and Gerba, C.P. (1991). Modeling the risk from Giardia and viruses in drinking water. J. Am. Water Works Assoc., 83(11):76-84.

Rendtorff, R.C. (1978). The experimental transmission of Giardia lamblia among volunteer subjects. In: Waterborne transmission of giardiasis. W. Jakubowski and J.C. Hoff (eds.). U.S. Environmental Protection Agency, Cincinnati, OH. pp. 64-81 (EPA 600/9-79-001).

Reynolds, D.T., Slade, R.B., Sykes, N.J., Jonas, A. and Fricker, C.R. (1999). Detection of Cryptosporidium oocysts in water: techniques for generating precise recovery data. J. Appl. Microbiol., 87(6):804-813.

Rice, E.W. and Schaefer, F.W., III (1981). Improved in vitro excystation procedure for Giardia lamblia cysts. J. Clin. Microbiol., 14:709-710.

Riggs, M.W. (2002). Recent advances in cryptosporidiosis: the immune response. Microbes Infect., 4(10):1067-1080.

Rimhanen-Finne, R., Ronkainen, P. and Hanninen, M.L. (2001). Simultaneous detection of Cryptosporidium parvum and Giardia in sewage sludge by IC-PCR. J. Appl. Microbiol., 91(6):1030-1035.

Rimhanen-Finne, R., Horman, A., Ronkainen, P. and Hanninen, M.L. (2002). An IC-PCR method for detection of Cryptosporidium and Giardia in natural surface waters in Finland. J. Microbiol. Methods, 50(3):299-303.

Roach, P.D., Olson, M.E., Whitley, G. and Wallis, P.M. (1993). Waterborne Giardia cysts and Cryptosporidium oocysts in the Yukon, Canada. Appl. Environ. Microbiol., 59:67-73.

Robertson, B., Sinclair, M.I., Forbes, A.B., Veitch, M., Kirk, M., Cunliffe, D., Willis, J. and Fairley, C.K. (2002). Case-control studies of sporadic cryptosporidiosis in Melbourne and Adelaide, Australia. Epidemiol. Infect., 128(3):419-431.

Robertson, L.J., Campbell, A.T. and Smith, H.V. (1992). Survival of Cryptosporidium parvum oocysts under various environmental pressures. Appl. Environ. Microbiol., 58:3494-3500.

Robertson, L.J., Campbell, A.T. and Smith, H.V. (1998). Viability of Cryptosporidium parvum oocysts: assessment by the dye permeability assay. Appl. Environ. Microbiol., 64(9):3544-3545.

Robertson, L.J., Hermansen, L., Gjerde, B.K., Strand, E., Alvsvåg, J.O. and Langeland, N. (2006). Application of genotyping during an extensive outbreak of waterborne giardiasis in Bergen, Norway, during autumn and winter 2004. Appl. Environ. Microbiol., 72(3):2212-2217.

Rochelle, P.A., Ferguson, D.M., Handojo, T.J., De Leon, R., Stewart, M.H. and Wolfe, R.L. (1997). An assay combining cell culture with reverse transcriptase PCR to detect and determine the infectivity of waterborne Cryptosporidium parvum. Appl. Environ. Microbiol., 63:2029-2037.

Rochelle, P.A., De Leon, R., Johnson, A., Stewart, M.H. and Wolfe, R.L. (1999). Evaluation of immunomagnetic separation for recovery of infectious Cryptosporidium parvum oocysts from environmental samples. Appl. Environ. Microbiol., 65(2):841-845.

Rochelle, P.A., Marshall, M.M., Mead, J.R., Johnson, A.M., Korich, D.G., Rosen, J.S. and De Leon, R. (2002). Comparison of in vitro cell culture and a mouse assay for measuring infectivity of Cryptosporidium parvum. Appl. Environ. Microbiol., 68(8):3809-3817.

Rochelle, P.A., Mofidi, A.A., Marshall, M.M., Upton, S.J., Montelone, B., Woods, K. and Di Giovanni, G. (2005). An investigation of UV disinfection and repair in Cryptosporidium parvum. AWWA Research Foundation Report. American Water Works Association Research Foundation, Denver, Colorado.

Rosales, M.J., Cordón, G.P., Moreno, M.S. and Sánchez, C.M. (2005). Extracellular like-gregarine stages of Cryptosporidium parvum. Acta Trop., 95(1):74-78.

Rose, J.B. and Gerba, C.P. (1991). Use of risk assessment for development of microbial standards. Water Sci. Technol., 24:29-34.

Rose, J.B., Darbin, H. and Gerba, C.P. (1988). Correlations of the protozoa, Cryptosporidium and Giardia, with water quality variables in a watershed. Water Sci. Technol., 20(11/12):271-276.

Rose, J.B, Gerba, C.P., and Jakubowski, W. (1991). Survey of potable water supplies for Cryptosporidium and Giardia. Environ. Sci. Technol., 25(8):1393-1400.

Rose, J.B., Lisle, J.T. and LeChevallier, M. (1997). Waterborne cryptosporidiosis: incidence, outbreaks and treatment strategies. In: Cryptosporidium and cryptosporidiosis. R. Fayer (ed.). CRC Press, Boca Raton, Florida. pp. 93-109.

Roy, S.L., DeLong, S.M., Stenzel, S.A., Shiferaw, B., Roberts, J.M., Khalakdina, A., Marcus, R., Segler, S.D., Shah, D.D., Thomas, S., Vugia, D.J., Zansky, S.M., Dietz, V. and Bea, M.J. (2004). Risk factors for sporadic cryptosporidiosis among immunocompetent persons in the United States from 1999 to 2001. J. Clin. Microbiol., 42(7):2944-2951.

Ryan, U., Xiao, L., Read, C., Zhou, L., Lal, A.A. and Pavlasek, I. (2003). Identification of novel Cryptosporidium genotypes from the Czech Republic. Appl. Environ. Microbiol., 69:4302-4307.

Ryan, U.M., Bath, C., Robertson, I., Read, C., Elliot, A., McInnes, L., Traub, R. and Besier, B. (2005a). Sheep may not be an important zoonotic reservoir for Cryptosporidium and Giardia parasites. Appl. Environ. Microbiol., 71(9):4992-4997.

Ryan, U., Read, C., Hawkins, P., Warnecke, M., Swanson, P., Griffith, M., Deere, D., Cunningham, M. and Cox, P. (2005b). Genotypes of Cryptosporidium from Sydney water catchment areas. J. Appl. Microbiol., 98(5):1221-1229.

Ryan, U.M., Power, M. and Xiao, L. (2008). Cryptosporidium fayeri n. sp. (Apicomplexa: Cryptosporidiidae) from the red kangaroo (Macropus rufus). J. Eukaryot. Microbiol., 55(1):22-26.

Sartory, D.P., Parton, A., Parton, A.C., Roberts, J. and Bergmann, K. (1998). Recovery of Cryptosporidium oocysts from small and large volume water samples using a compressed foam filter system. Lett. Appl. Microbiol., 27(6):318-322.

Schaefer, D.A., Auerbach-Dixon, B.A. and Riggs, M.W. (2000). Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis. Infect. Immunol., 68(5):2608-2616.

Schets, F.M., Engels, G.B., During, M. and de Roda Husman, A.M. (2005). Detection of infectious Cryptosporidium oocysts by cell culture immunofluorescence assay: applicability to environmental samples. Appl. Environ. Microbiol., 71(11):6793-6798.

Schuler, P.F. and Ghosh, M.M. (1990). Diatomaceous earth filtration of cysts and other particulates using chemical additives. J. Am. Water Works Assoc. (2):67-75.

Schuler, P. and Ghosh, M. (1991). Slow sand filtration of cysts and other particulates. In: Proceedings of the 1991 Annual Conference of the American Water Works Association. American Water Works Association, Denver, Colorado.

Schuster, C.J., Ellis, A.G., Robertson, W.J., Charron, D.F., Aramini, J.J., Marshall, B.J. and Medeiros, D.T. (2005). Infectious disease outbreaks related to drinking water in Canada, 1974-2001. Can. J. Public Health, 96(4):254-258.

Shin, G.A., Linden, K.G., Arrowood, M.J. and Sobsey, M.D. (2001). Low-pressure UV inactivation and DNA repair potential of Cryptosporidium parvum oocysts. Appl. Environ. Microbiol., 67(7):3029-3032.

Shukla, R., Giraldo, P., Kraliz, A., Finnigan, M. and Sanchez, A.L. (2006). Cryptosporidium spp. and other zoonotic enteric parasites in a sample of domestic dogs and cats in the Niagara region of Ontario. Can. Vet. J., 47(12):1179-1184.

Slifko, T.R., Friedman, D., Rose, J.B. and Jakubowski, W. (1997). An in vitro method for detecting infectious Cryptosporidium oocysts with cell culture. Appl. Environ. Microbiol., 63:3669-3675.

Slifko, T.R., Huffman, D.E., Dussert, B., Owens, J.H., Jakubowski, W., Haas, C.N. and Rose, J.B. (2002). Comparison of tissue culture and animal models for assessment of Cryptosporidium parvum infection. Exp. Parasitol., 101(2-3):97-106.

Sluter, S.D., Tzipori, S. and Widmer, G. (1997). Parameters affecting polymerase chain reaction detection of waterborne Cryptosporidium parvum oocysts. Appl. Microbiol. Biotechnol., 48(3):325-330.

Smeets, P., Rietveld, L., Hijnen, W., Medema, G. and Stenström, T.A. (2006). Efficacy of water treatment processes. Prepared for the MicroRisk project.

Smeets, P.W., Dullemont, Y.J., Van Gelder, P.H., Van Dijk, J.C. and Medema, G.J. (2008). Improved methods for modelling drinking water treatment in quantitative microbial risk assessment; a case study of Campylobacter reduction by filtration and ozonation. J. Water Health, 6(3):301-314.

Smith, A., Reacher, M., Smerdon, W., Adak, G.K., Nichols, G. and Chalmers, R.M. (2006). Outbreaks of waterborne infectious intestinal disease in England and Wales, 1992-2003. Epidemiol Infect., 134(6):1141-1149.

Smith, H.V. and Rose, J.B. (1990). Waterborne cryptosporidiosis. Parasitol. Today, 6:8-12.

Smith, H.V., Parker, J.F.W., Bukhari, Z., Campbell, D.M., Benton, C., Booth, N. and McCreadie, A. (1993). Significance of small numbers of Cryptosporidium sp. oocysts in water. Lancet, 342(8866):312-313.

Smith, H.V., Cacciò, S.M., Cook, N., Nichols, R.A. and Tait, A. (2007). Cryptosporidium and Giardia as foodborne zoonoses. Vet. Parasitol., 149(1-2):29-40.

Smith, J.J., Gunasekera, T.S., Barardi, C.R., Veal, D. and Vesey, G. (2004). Determination of Cryptosporidium parvum oocyst viability by fluorescence in situ hybridization using a ribosomal RNA-directed probe. J. Appl. Microbiol., 96(2):409-417.

Soave, R. (1996). Cyclospora: an overview. Clin. Infect. Dis., 23(3):429-435.

Spano, F., Putignani, L., Naitza, S., Puri, C., Wright, S. and Crisanti, A. (1998a). Molecular cloning and expression analysis of a Cryptosporidium parvum gene encoding a new member of the thrombospondin family. Mol. Biochem. Parasitol., 92(1):147-162.

Spano, F., Putignani, L., Crisanti, A., Sallicandro, P., Morgan, U.M., Le Blancq, S.M., Tchack, L., Tzipori, S. and Widmer, G. (1998b). Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins. J. Clin. Microbiol., 36(11):3255-3259.

Staatscourant (2001). Dutch Drinking Water Decree. Dutch Government Gazette, January 9, 2001.

Stachan, R. and Kunstýr, I. (1983). Minimal infectious doses and prepatent periods in Giardia muris, Spironucleus muris and Trichomonas muris. Zentralbl. Bakteriol. Hyg. A, 256:249-256.

Stantic-Pavlinic, M., Xiao, L., Glaberman, S., Lal, A.A., Orazen, T., Rataj-Verglez, A., Logar, J. and Berce, I. (2003). Cryptosporidiosis associated with animal contacts. Wien. Klin. Wochenschr., 115(34):125-127.

States, S., Scheuring, M., Buzza, E., Evans, R. and Movahead, B. (1999). Removal of Cryptosporidium by membrane filtration. In: Proceedings of the AWWA Water Quality Technology Conference. American Water Works Association, Denver, Colorado.

Stehr-Green, J.K., McCaig, L., Remsen, H.M., Rains, C.S., Fox, M. and Juranek, D.D. (1987). Shedding of oocysts in immunocompetent individuals infected with Cryptosporidium. Am. J. Trop. Med. Hyg., 36:338-342.

Stevens, M.N., Ashbolt, N.J. and Cunliffe, D. (2001). Microbial indicators of drinking water quality--A NHMRC discussion paper. National Health and Medical Research Council, Canberra, Australia.

Stinear, T., Matusan, A., Hines, K. and Sandery, M. (1996). Detection of a single viable Cryptosporidium parvum oocyst in environmental water concentrates by reverse transcription-PCR. Appl. Environ. Microbiol., 62(9):3385-3390.

Straub, T.M., Daly, D.S., Wunshel, S., Rochelle, P.A., DeLeon, R. and Chandler, D.P. (2002). Genotyping Cryptosporidium parvum with an hsp70 single-nucleotide polymorphism microarray. Appl. Environ. Microbiol., 68(4):1817-1826.

Stuart, J.M., Orr, H.J., Warburton, F.G., Jeyakanth, S., Pugh, C., Morris, I., Sarangi, J. and Nichols, G. (2003). Risk factors for sporadic giardiasis: a case-control study in southwestern England. Emerg. Infect. Dis., 9(2):229-233.

Sturbaum, G.D., Klonicki, P.T., Marshall, M.M., Jost, B.H., Clay, B.L. and Sterling, C.R. (2002). Immunomagnetic separation (IMS)-fluorescent antibody detection and IMS-PCR detection of seeded Cryptosporidium parvum oocysts in natural waters and their limitations. Appl. Environ. Microbiol., 68(6):2991-2996.

Sulaiman, I.M., Xiao, L., Yang, C., Escalante, L., Moore, A., Beard, C.B., Arrowood, M.J. and Lal, A.A. (1998). Differentiating human from animal isolates of Cryptosporidium parvum. Emerg. Infect. Dis., 4(4):681-685.

Sunderland, D., Graczyk, T.K., Tamang, L. and Breysse, P.N. (2007). Impact of bathers on levels of Cryptosporidium parvum oocysts and Giardia lamblia cysts in recreational beach waters. Water Res., 41:3483- 3489.

Taguchi, T., Shinozaki, Y., Takeyama, H., Haraguchi, S., Yoshino, M., Kaneko, M., Ishimori, Y. and Matsunaga, T. (2006). Direct counting of Cryptosporidium parvum oocysts using fluorescence in situ hybridization on a membrane filter. J. Microbiol. Methods, 67(2):373-380.

Takashima, Y., Xuan, X., Kimata, I., Iseki, M., Kodama, Y., Nagane, N., Nagasawa, H., Matsumoto, Y., Mikami, T. and Otsuka, H. (2003). Recombinant bovine herpesvirus-1 expressing p23 protein of Cryptosporidium parvum induces neutralizing antibodies in rabbits. J. Parasitol., 89(2):276-282.

Tang, G., Adu-Sarkodie, K., Kim, D., Kim, J.H., Teefy, S., Shukairy, H.M. and Mariñas, B.J. (2005). Modeling Cryptosporidium parvum oocyst inactivation and bromate formation in a full-scale ozone contactor. Environ. Sci. Technol., 39(23):9343-9350.

Taylor, J.S. and Weisner, M. (1999). Membranes. In: Water quality and treatment: a handbook of community water supplies. 5th edition. R.D. Letterman (ed.). McGraw Hill, New York, NY. pp. 11-1-11-71.

Templeton, M.R., Andrews, R.C. and Hofmann, R. (2005). Inactivation of particle-associated viral surrogates by ultraviolet light. Water Res., 39(15):3487-3500.

Teunis, P.F., Rutjes, S.A., Westrell, T. and de Roda Husman, A.M. (2009). Characterization of drinking water treatment for virus risk assessment. Water Res., 43(2):395-404.

Thompson, R.C. (2004). The zoonotic significance and molecular epidemiology of Giardia and giardiasis. Vet Parasitol., 126(1-2):15-35.

Thompson, R.C. and Monis, P.T. (2004). Variation in Giardia: implications for taxonomy and epidemiology. Adv. Parasitol., 58:69-137.

Thompson, R.C., Palmer, C.S. and O'Handley, R. (2008). The public health and clinical significance of Giardia and Cryptosporidium in domestic animals. Vet. J., 177(1):18-25.

Traub, R.J., Monis, P.T., Robertson, I., Irwin, P., Mencke, N. and Thompson, R.C. (2004). Epidemiological and molecular evidence supports the zoonotic transmission of Giardia among humans and dogs living in the same community. Parasitology, 128(Pt. 3):253-262.

Traub, R.J., Robertson, I.D., Irwin, P.J., Mencke, N. and Thompson, R.C. (2005). Canine gastrointestinal parasitic zoonoses in India. Trends Parasitol., 21(1):42-48.

Tyzzer, E.E. (1907). A sporozoan found in the peptic glands of the common mouse. Proc. Soc. Exp. Biol. Med., 5:12-13.

Tyzzer, E.E. (1912). Cryptosporidium parvum (sp. nov.): a coccidian found in the small intestine of the common mouse. Arch. Protistenk., 26:394-418.

Tzipori, S. (1983). Cryptosporidiosis in animals and humans. Microbiol. Rev., 47:84-96.

Tzipori, S. and Ward, H. (2002). Cryptosporidiosis: biology, pathogenesis and disease. Microbes Infect., 4(10):1047-1058.

Umejiego, N.N., Li, C., Riera, T., Hedstrom, L. and Striepen, B. (2004). Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J. Biol. Chem., 279(39):40320-40327.

Ungar, B.L.P. (1994). Cryptosporidium and cryptosporidiosis. In: Textbook of AIDS medicine. S. Broder, D. Bolognesi and T.C. Merigan, Jr. (eds.). Williams and Wilkins, Baltimore, Maryland. Chapter 21.

Upton, S.J. and Current, W.L. (1985). The species of Cryptosporidium (Apicomplexa: Cryptosporidiidae). J. Parasitol., 71:624-629.

U.S. EPA (1989). Part V, Environmental Protection Agency, 40 CFR Parts 141 and 142. National Primary Drinking Water Regulations: Filtration; disinfection; turbidity; Giardia lamblia; viruses; Legionella, and heterotrophic bacteria; Final rule. Fed. Regist., 54:27485-27541.

U.S. EPA (1991). Guidance manual for compliance with filtration and disinfection requirements for public water systems using surface water sources. U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2003). LT1ESTWR disinfection profiling and benchmarking technical guidance manual. Office of Water, U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2005). Method 1623: Cryptosporidium and Giardia in water by filtration/IMS/FA. Office of Water, Office of Science and Technology, Engineering and Analysis Division, U.S. Environmental Protection Agency, Washington, DC (EPA 821-R-01-025).

U.S. EPA (2006a). National Primary Drinking Water Regulations: Long Term 2 Enhanced Surface Water Treatment; final rule. Fed. Regist., 71(3):678-671; 782-783.

U.S. EPA (2006b). 40 CFR Parts 9, 141 and 142. National Primary Drinking Water Regulations: Ground Water Rule. Final rule. Fed. Regist., 71.

U.S. EPA (2006c). Ultraviolet disinfection guidance manual. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-R-06-007).

Van Dyke, M.I., Morton, V., Anderson, W.B., Isaac-Renton, J.L. and Huck, P. (2006). The occurrence of selected bacterial and protozoan pathogens in the Grand River watershed. In: Proceedings of the 12th National Conference on Drinking Water, Saint John, New Brunswick, April 1-4, 2006. Canadian Water and Wastewater Association, Ottawa, Ontario.

Verhille, S., Hofmann, R., Chauret, C. and Andrews, R. (2003). Indigenous bacterial spores as indicators of Cryptosporidium inactivation using chlorine dioxide. J Water Health, 1(2):91-100.

Vesey, G., Griffiths, K.R., Gauci, M.R., Deere, D., Williams, K.L. and Veal, D.A. (1997). Simple and rapid measurement of Cryptosporidium excystation using flow cytometry. Int. J. Parasitol., 27(11):1353-1359.

Vesey, G., Ashbolt, N., Fricker, E.J., Deere, D., Williams, K.L., Veal, D.A. and Dorsch, M. (1998). The use of a ribosomal RNA targeted oligonucleotide probe for fluorescent labelling of viable Cryptosporidium parvum oocysts. J. Appl. Microbiol., 85(3):429-440.

Wallis, P.M., Isaac-Renton, J.L., Erlandsen, S.L. and Olson, M.E. (1995). Risk assessment for waterborne giardiasis and cryptosporidiosis in Canada. Unpublished report to Health Canada.

Wallis, P.M., Erlandsen, S.L., Isaac-Renton, J.L., Olson, M.E., Robertson, W.J. and van Keulen, H. (1996). Prevalence of Giardia cysts and Cryptosporidium oocysts and characterization of Giardia spp. isolated from drinking water in Canada. Appl. Environ. Microbiol., 62(8):2789-2797.

Wallis, P.M., Primrose, B. and Robertson, W.J. (1998). Outbreak of waterborne giardiasis caused by sewage contamination of drinking water. Environ. Health Rev., 42(2):44-51.

Wang, Z., Vora, G.J. and Stenger, D.A. (2004). Detection and genotyping of Entamoeba histolytica, Entamoeba dispar, Giardia lamblia, and Cryptosporidium parvum by oligonucleotide microarray. J. Clin. Microbiol., 42(7):3262-3271.

Ward, P.I., Deplazes, P., Regli, W., Rinder, H. and Mathis, A. (2002). Detection of eight Cryptosporidium genotypes in surface and waste waters in Europe. Parasitology, 124(Pt. 4):359-368.

Weir, S.C., Pokorny, N.J., Carreno, R.A., Trevors, J.T. and Lee, H. (2001). Improving the rate of infectivity of Cryptosporidium parvum oocysts in cell culture using centrifugation. J. Parasitol., 87(6):1502-1504.

Welker, R., Porter, R., Pett, W.B., Provart, M.R. and Schwartz, K.T. (1994). Cryptosporidiosis outbreak in Kitchener-Waterloo: identification, assessment and future prevention. In: Proceedings of the Sixth National Conference on Drinking Water, Victoria, B.C., October 16-18, 1994. W. Robertson, T. Kauri and S. Irwin (eds.). American Water Works Association, Denver, Colorado.

Westrell, T., Andersson, Y. and Stenström, T.A. (2006). Drinking water consumption patterns in Sweden. J. Water Health, 4(4):511-522.

WHO (1996). The world health report 1996 - Fighting disease, fostering development. Brussels, Belgium. World Health Organization.

WHO  (2011). Guidelines for drinking-water quality. 4th edition. World Health Organization. Geneva, Switzerland.

Widmer, G. (1998). Genetic heterogeneity and PCR detection of Cryptosporidium parvum. Adv. Parasitol., 40:223-239.

Widmer, G., Tzipori, S., Fichtenbaum, C.J. and Griffiths, J.K. (1998). Genotypic and phenotypic characterization of Cryptosporidium parvum isolates from people with AIDS. J. Infect. Dis., 178(3):834-840.

Wiesner, J. and Seeber, F. (2005). The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs. Expert Opin. Ther. Targets, 9:23-44.

Wolfe, M.S. (1984). Symptomatology, diagnosis and treatment. In: Giardia and giardiasis: biology, pathogenesis and epidemiology. S.L. Erlandsen and E.A. Meyer (eds.). Plenum Press, New York, New York. pp. 147-161.

Wong, P.H. and Ong, C.S. (2006). Molecular characterization of the Cryptosporidium cervine genotype. Parasitology, 133(Pt. 6):693-700.

Wu, J., Long, S.C., Das, D. and Dorner, S.M. (2011). Are microbial indicators and pathogens correlated? A statistical analysis of 40 years of research. J. Water Health, 9(2):265-278.

Wyatt, C.R., Lindahl, S., Austin, K., Kapil, S. and Branch, J. (2005). Response of T lymphocytes from previously infected calves to recombinant Cryptosporidium parvum P23 vaccine antigen. J. Parasitol., 91(5):1239-1242.

Xiao, L. and Fayer, R. (2008). Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission. Int. J. Parasitol., 38(11):1239-1255.

Xiao, L. and Lal, A. (2002). Molecular detection and differentiation of Cryptosporidium oocysts in water: the challenge and promise. In: Proceedings of the AWWA Water Quality Technology Conference, Seattle, Washington. American Water Works Association, Denver, Colorado.

Xiao, L., Bern, C., Limor, J., Sulaiman, I., Roberts, J., Checkley, W., Cabrera, L., Gilman, R.H. and Lal, A.A. (2001). Identification of 5 types of Cryptosporidium parasites in children in Lima, Peru. J. Infect. Dis., 183(3):492-497.

Xiao, L., Fayer, R., Ryan, U. and Upton, S.J. (2004). Cryptosporidium taxonomy: recent advances and implications for public health. Clin. Microbiol. Rev., 17(1):72-97.

Xu, P., Widmer, G., Wang, Y., Ozaki, L.S., Alves, J.M., Serrano, M.G., Puiu, D., Manque, P., Akiyoshi, D., Mackey, A.J., Pearson, W.R., Dear, P.H., Bankier, A.T., Peterson, D.L., Abrahamsen, M.S., Kapur, V., Tzipori, S. and Buck, G.A. (2004). The genome of Cryptosporidium hominis. Nature, 431(7012):1107-1112.

Yagita, K., Izumiyama, S., Tachibana, H., Masuda, G., Iseki, M., Furuya, K., Kameoka, Y., Kuroki, T., Itagaki, T. and Endo, T. (2001). Molecular characterization of Cryptosporidium isolates obtained from human and bovine infections in Japan. Parasitol. Res., 87:950-955.

Yakub, G.P. and Stadterman-Knauer, K.L. (2000). Evaluation of immunomagnetic separation for recovery of Cryptosporidium parvum and Giardia duodenalis from high-iron matrices. Appl. Environ. Microbiol., 66(8):3628-3631.

Zu, S.-X., Zhu, S.-Y. and Li, J.-F. (1992). Human cryptosporidiosis in China. Trans. R. Soc. Trop. Med. Hyg., 86:639-640.

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