Page 13: Guidelines for Canadian Drinking Water Quality: Guideline Technical Document – Selenium

Part II. Science and Technical Considerations (continued)

12.0 References

Abdo, K.M. (1994). NTP technical report on toxicity studies of sodium selenate and sodium selenite (CAS Nos. 13410-01-0 and 10102-18-8) administered in drinking water to F344/N rats and B6C3F1 mice. National Toxicology Program, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina (NTP Toxicity Report Series No. 38; NIH Publication 94-3387). Available at: http://ntp.niehs.nih.gov/ntp/htdocs/ST_rpts/tox038.pdf

Abedelahi, A., Salehnia, M., Allameh, A.A. and Davoodi, D. (2010). Sodium selenite improves the in vitro follicular development by reducing the reactive oxygen species level and increasing the total antioxidant capacity and glutathione peroxide activity. Hum. Reprod., 25(4): 977-985.

Adams, W.J. and Johnson, H.E. (1977). Survey of the selenium content in the aquatic biota of western Lake Erie. J. Great Lakes Res., 3(1-2): 10-14.

Akbaraly, T.N., Arnaud, J., Rayman, M.P., Hininger-Favier, I., Roussel, A.M., Berr, C. and Fontbonne, A. (2010). Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study. Nutr. Metab. (Lond.), 7: 21.

Alanne, M., Kristiansson, K., Auro, K., Silander, K., Kuulasmaa, K., Peltonen, L., Salomaa, V. and Perola, M. (2007). Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts. Hum. Genet., 122(3): 355-365.

Allen, N.E., Appleby, P.N., Roddam, A.W., Tjonneland, A., Johnsen, N.F., Overvad, K., Boeing, H., Weikert, S., Kaaks, R., Linseisen, J., Trichopoulou, A., Misirli, G., Trichopoulos, D., Sacerdote, C., Grioni, S., Palli, D., Tumino, R., Bueno-de-Mesquita, H.B., Kiemeney, L.A., Barricarte, A., Larranaga, N., Sanchez, M.J., Agudo, A., Tormo, M.J., Rodriguez, L., Stattin, P., Hallmans, G., Bingham, S., Khaw, K.T., Slimani, N., Rinaldi, S., Boffetta, P., Riboli, E. and Key, T.J. (2008). Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am. J. Clin. Nutr., 88(6): 1567-1575.

Anderson, A.M. (1994). Multi-media monitoring of trace metals and pesticides in the Battle River 1989-1990. A joint publication of Environment Canada, Alberta Environmental Protection, Alberta Environmental Centre and Saskatchewan Environment and Resource Management (PPWP Report No. 146). Available at: http://environment.gov.ab.ca/info/library/7994.pdf

Anjaria, K.B. and Madhvanath, U. (1988). Genotoxicity of selenite in diploid yeast. Mutat. Res., 204(4): 605-614.

Ankerst, J. and Sjogren, H.O. (1982). Effect of selenium on the induction of breast fibroadenomas by adenovirus type 9 and 1,2-dimethylhydrazine-induced bowel carcinogenesis in rats. Int. J. Cancer, 29(6): 707-710.

Anundi, I., Stahl, A. and Hogberg, J. (1984). Effects of selenite on O2 consumption, glutathione oxidation and NADPH levels in isolated hepatocytes and the role of redox changes in selenite toxicity. Chem. Biol. Interact., 50(3): 277-288.

APHA, American Water Works Association and Water Environment Federation (1992). Standard methods for the examination of water and wastewater. 18th edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (1995). Standard methods for the examination of water and wastewater. 19th edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (2005). Standard methods for the examination of water and wastewater. 21st edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (2012). Standard methods for the examination of water and wastewater. 22nd edition. American Public Health Association, Washington, DC.

ASTM (1998). D3859-98 Standard test methods for selenium in water. ASTM International, West Conshohocken, Pennsylvania.

ASTM (2003). D3859-98 Standard test methods for selenium in water. ASTM International, West Conshohocken, Pennsylvania.

ASTM (2008). D3859-98 standard test methods for selenium in water. ASTM International, West Conshohocken, Pennsylvania.

ATSDR (2003). Toxicological profile for selenium. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia. Available at: www.atsdr.cdc.gov/toxprofiles/tp92.pdf

Barger, J.L., Kayo, T., Pugh, T.D., Vann, J.A., Power, R., Dawson, K., Weindruch, R. and Prolla, T.A. (2012). Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes Nutr., 7(2): 155-165.

Beilstein, M.A. and Whanger, P.D. (1988). Glutathione peroxidase activity and chemical forms of selenium in tissues of rats given selenite or selenomethionine. J. Inorg. Biochem., 33(1): 31-46.

Bergman, K., Cekan, E., Slanina, P., Gabrielsson, J. and Hellenäs, K.E. (1990). Effects of dietary sodium selenite supplementation on salicylate-induced embryo- and fetotoxicity in the rat. Toxicology, 61(2): 135-146.

Biswas, S., Talukder, G. and Sharma, A. (2000). Chromosome damage induced by selenium salts in human peripheral lymphocytes. Toxicol. In Vitro, 14(5): 405-408.

Blankenberg, S., Rupprecht, H.J., Bickel, C., Torzewski, M., Hafner, G., Tiret, L., Smieja, M., Cambien, F., Meyer, J. and Lackner, K.J. (2003). Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N. Engl. J. Med., 349(17): 1605-1613.

Bleiman, N. and Michael, Y. (2010). Selenium removal from drinking water by adsorption on chitosan-clay composites and oxides: batch and column tests. J. Hazard. Mater., 183: 590-595.

Bleys, J., Navas-Acien, A. and Guallar, E. (2007). Serum selenium and diabetes in U.S. adults. Diabetes Care, 30(4): 829-834.

Bleys, J., Navas-Acien, A. and Guallar, E. (2008). Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch. Intern. Med., 168(4): 404-410.

Blodgett, D.J. and Bevill, R.F. (1987). Acute selenium toxicosis in sheep. Vet. Hum. Toxicol., 29(3): 233-236.

Boegel, J.V. and Clifford, D.A. (1986). Selenium oxidation and removal by ion exchange. U.S. Environmental Protection Agency, Washington, DC (EPA/600/S2-86/031).

Boosalis, M.G. (2008). The role of selenium in chronic disease. Nutr. Clin. Pract., 23(2): 152-160.

Branco, V., Canário, J., Lu, J., Holmgren, A. and Carvalho, C. (2012). Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic. Biol. Med., 52(4): 781-793.

Nagpal, N.K. and Howell, K. (2001). Water quality guidelines for selenium. Water Protection Branch, Ministry of Environment, Victoria, British Columbia. Available at: www.env.gov.bc.ca/wat/wq/BCguidelines/selenium/report2c_v3-02.htm#P157_7492

Brookes, S.T., Whitely, E., Egger, M., Smith, G.D., Mulheran, P.A., Peters, T.J. (2004). Subgroup analyses in randomized trials: risks of subgroup-specific analyses; power and sample size for the interaction test. J Clin Epidemiol., 57:229-36.

Brozmanová, J., Mániková, D., Vlčková, V. and Chovanec, M. (2010). Selenium: a double-edged sword for defense and offence in cancer. Arch. Toxicol., 84(12): 919-938.

Bruhn, R.L., Stamer, W.D., Herrygers, L.A., Levine, J.M. and Noecker, R.J. (2009). Relationship between glaucoma and selenium levels in plasma and aqueous humour. Br. J. Ophthalmol., 93(9): 1155-1158.

Burk, R.F. (2002). Selenium, an antioxidant nutrient. Nutr. Clin. Care, 5(2): 75-79.

Burk, R.F., Norsworthy, B.K., Hill, K.E., Motley, A.K. and Byrne, D.W. (2006). Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol. Biomarkers Prev., 15(4): 804-810.

Butler, J.A., Whanger, P.D. and Patton, N.M. (1988). Effects of feeding selenium deficient diets to rhesus monkeys (Macaca mulatta). J. Am. Coll. Nutr., 7(1): 43-56.

Butler, J.A., Whanger, P.D., Kaneps, A.J. and Patton, N.M. (1990). Metabolism of selenite and selenomethionine in the rhesus monkey. J. Nutr., 120(7): 751-759.

Casey, R. and Siwik, P. (2000). Concentrations of selenium in surface water, sediment and fish from the McLeod, Pembina and Smoky rivers: results of surveys from fall 1998 to fall 1999. Interim report. Environmental Monitoring and Evaluation Branch, Alberta Environment, Edmonton, Alberta. Available at: http://environment.gov.ab.ca/info/library/5843.pdf

CCME (2009). Canadian soil quality guidelines. Selenium. Environmental and human health effects. Scientific criteria document. Canadian Council of Ministers of the Environment, Winnipeg, Manitoba. Available at: www.ccme.ca/assets/pdf/soqg_se_scd_1438.pdf

Chan, L., Receveur, O., Sharp, D., Schwartz, H., Ing, A. and Tikhonov, C. (2011). First Nations Food, Nutrition and Environment Study (FNFNES): results from British Columbia (2008/2009). University of Northern British Columbia, Prince George, British Columbia. Available at: www.fnfnes.ca/docs/BC%20Reports/FNFNES_Report_BC_FINAL_PRINT_v2.pdf

Chan, L., Receveur, O., Sharp, D., Schwartz, H., Ing, A., Fediuk, K., Black, A. and Tikhonov, C. (2012). First Nations Food, Nutrition and Environment Study (FNFNES): results from Manitoba (2010). University of Northern British Columbia, Prince George, British Columbia. Available at: www.fnfnes.ca/docs/MB%20Reports/FNFNES%20Regional%20Report%20-%20MB%20Final.pdf

Chen, X., Mikhail, S.S., Ding, Y.W., Yang, G., Bondoc, F. and Yang, C.S. (2000). Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Carcinogenesis, 21(8): 1531-1536.

Cheng, Y.Y. and Qian, P.C. (1990). The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. Biomed. Environ. Sci., 3: 422-428.

Civil, I.D. and McDonald, M.J. (1978). Acute selenium poisoning: case report. N. Z. Med. J., 87(612): 354-356.

Clark, L.C., Combs, G.F., Jr., Turnbull, B.W., Slate, E.H., Chalker, D.K., Chow, J., Davis, L.S., Glover, R.A., Graham, G.F., Gross, E.G., Krongrad, A., Lesher, J.L., Jr., Park, H.K., Sanders, B.B., Jr., Smith, C.L. and Taylor, J.R. (1996). Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA, 276(24): 1957-1963.

Clark, L.C., Dalkin, B., Krongrad, A., Combs, G.F., Jr., Turnbull, B.W., Slate, E.H., Witherington, R., Herlong, J.H., Janosko, E., Carpenter, D., Borosso, C., Falk, S. and Rounder, J. (1998). Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol., 81(5): 730-734.

Clark, R.F., Strukle, E., Williams, S.R. and Manoguerra, A.S. (1996). Selenium poisoning from a nutritional supplement. JAMA, 275(14): 1087-1088.

Clifford, D.A. (1999). Ion exchange and inorganic adsorption. Chapter 9 in: Water quality and treatment: a handbook of community water supplies. 5th edition. R.D. Letterman (ed.). American Water Works Assocation; McGraw-Hill, New York, New York.

Comstock, G.W., Alberg, A.J., Huang, H.Y., Wu, K., Burke, A.E., Hoffman, S.C., Norkus, E.P., Gross, M., Cutler, R.G., Morris, J.S., Spate, V.L. and Helzlsouer, K.J. (1997). The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol. Biomarkers Prev., 6(11): 907-916.

Cousin, A., Renson, M.A. and Rousselin, A. (2011). Une nouvelle voie d'élimination du sélénium dans les eaux potables. Essais réalisés pour le Siaep de la vallée de l'Aubetin. Tech. Sci. Meth., 5: 55-64.

CSA (2009). CSA B137 Series-09--Thermoplastic pressure piping compendium. Canadian Standards Association, Mississauga, Ontario.

CSA (2011a). ASME A112.18.1-2011/CSA B125.1-11--Plumbing supply fittings. Canadian Standards Association, Mississauga, Ontario.

CSA (2011b). CSA B125.3-11--Plumbing fittings. Canadian Standards Association, Mississauga, Ontario.

Cummins, L.M. and Kimura, E.T. (1971). Safety evaluation of selenium sulfide antidandruff shampoos. Toxicol. Appl. Pharmacol., 20(1): 89-96.

Cumming, L., Wang, L., Chen, A. (2007). Arsenic and antimony removal from drinking water by adsorptive media. U.S. EPA demonstration project at South Truckee Meadows General Improvement District, NV interim evaluation report. EPA /600/R-07/081

Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A., Dauchet, L., Galan, P. and Hercberg, S. (2006). Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am. J. Clin. Nutr., 84(2): 395-399.

Dabeka, R.W. (1994). Unpublished report on selenium and iodine levels in total diet samples. Food Research Division, Health Canada, Ottawa, Ontario [cited in CCME, 2009].

Dalla Puppa, L., Savaskan, N.E., Brauer, A.U., Behne, D. and Kyriakopoulos, A. (2007). The role of selenite on microglial migration. Ann. N. Y. Acad. Sci., 1096: 179-183.

Davis, C.D., Feng, Y., Hein, D.W. and Finley, J.W. (1999). The chemical form of selenium influences 3,2′-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon. J. Nutr., 129(1): 63-69.

Deagen, J.T.Butler, J.A.Beilstein, M.A.Whanger, P.D.  (1987). Effects of dietary selenite, selenocysteine, selenomethionine, on selenocysteine lyase and glutathione peroxidase activities and selenium levels in rat tissues. J. Nutr. 117: 91-98

DeMarco, J. (2005). Utility challenges. Presented at the U.S. Environmental Protection Agency's Lead and Copper Rule workshop: lead and plumbing fittings and fixtures, July 26-27, 2005.

Dennert, G., Zwahlen, M., Brinkman, M., Vinceti, M., Zeegers, M.P.A. and Horneber, M. (2011). Selenium for preventing cancer (review). Cochrane Database Syst. Rev., 5: CD005195. Available at: www.thecochranelibrary.com/details/file/1064571/CD005195.html

de Rosa, V., Erkekoğlu, P., Forestier, A., Favier, A., Hincal, F., Diamond, A.M., Douki, T. and Rachidi, W. (2012). Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells. Free Radic. Res., 46(2): 105-116.

Diwadkar-Navsariwala, V., Prins, G.S., Swanson, S.M., Birch, L.A., Ray, V.H., Hedayat, S., Lantvit, D.L. and Diamond, A.M. (2006). Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. Proc. Natl. Acad. Sci. U. S. A., 103(21): 8179-8184.

Dorea, J.G. (2002). Selenium and breast-feeding. Br. J. Nutr., 88: 443-461.

Drake, E.N. (2006). Cancer chemoprevention: selenium as a prooxidant, not an antioxidant. Med. Hypotheses, 67(2): 318-322.

Duffield, A.J., Thomson, C.D., Hill, K.E. and Williams, S. (1999). An estimation of selenium requirements for New Zealanders. Am. J. Clin. Nutr., 70(5): 896-903.

Duffield-Lillico, A.J., Reid, M.E., Turnbull, B.W., Combs, G.F., Jr., Slate, E.H., Fischbach, L.A., Marshall, J.R. and Clark, L.C. (2002). Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol. Biomarkers Prev., 11(7): 630-639.

Duffield-Lillico, A.J., Slate, E.H., Reid, M.E., Turnbull, B.W., Wilkins, P.A., Combs, G.F., Park, H.K., Gross, E.G., Graham, G.F., Stratton, M.S., Marshall, J.R. and Clark, L.C.; for the Nutritional Prevention of Cancer Study Group (2003). Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J. Natl. Cancer Inst., 95(19): 1477-1481.

EFSA Panel on Dietetic Products, Nutrition and Allergies (2000). Scientific Opinion of the Scientific Committee on Food on the tolerable upper intake level of selenium (expressed on 19 October). European Commission, Brussels, Belgium. (SCF/CS/NUT/UPPLEV/25 Final). Available at: http://ec.europa.eu/food/fs/sc/scf/out80g_en.pdf

EFSA Panel on Dietetic Products, Nutrition and Allergies (2006). Scientific Opinions: Selenium. In: Tolerable upper intake levels for vitamins and minerals. Scientific Committee on Food, European Food Safety Authority, Parma, Italy. Available at: www.efsa.europa.eu/en/ndatopics/docs/ndatolerableuil.pdf

EFSA Panel on Dietetic Products, Nutrition and Allergies (2010). Scientific Opinion on the substantiation of health claims related to selenium and maintenance of normal hair (ID 281), maintenance of normal nails (ID 281), protection against heavy metals (ID 383), maintenance of normal joints (ID 409), maintenance of normal thyroid function (ID 410, 1292), protection of DNA, proteins and lipids from oxidative damage (ID 410, 1292), and maintenance of the normal function of the immune system (ID 1750) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J., 8(10): 1727. Available at: www.efsa.europa.eu/en/efsajournal/doc/1727.pdf

Environment Canada (2012). Personal communication from C. Audette, National Air Pollution Surveillance Network.

Erkekoğlu, P., Rachidi, W., Yüzügüllü, O.G., Giray, B., Öztürk, M., Favier, A. and Hıncal, F. (2011). Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells--protection by selenium compounds. Food Chem. Toxicol., 49(7): 1565-1571.

Esaki, N., Nakamura, T., Tanaka, H. and Soda, K. (1982). Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine. Mammalian distribution and purification and properties of pig liver enzyme. J. Biol. Chem., 257(8): 4386-4391.

Expert Group on Vitamins and Minerals (2002). Revised review of selenium. Prepared by the Expert Group on Vitamins and Minerals Secretariat for consideration by the Expert Group on Vitamins and Minerals (EVM/99/17.REVISEDAUG2002). Available at: www.food.gov.uk/multimedia/pdfs/selenium.pdf

Expert Group on Vitamins and Minerals (2003). Safe upper levels for vitamins and minerals. Available at: http://cot.food.gov.uk/pdfs/vitmin2003.pdf

Fairweather-Tait, S.J., Collings, R. and Hurst, R. (2010). Selenium bioavailability: current knowledge and future research requirements. Am. J. Clin. Nutr., 91(5): 1484S-1491S.

Fairweather-Tait, S.J., Bao, Y., Broadley, M.R., Collings, R., Ford, D., Hesketh, J.E. and Hurst, R. (2011). Selenium in human health and disease. Antioxid. Redox Signal., 14(7): 1337-1383.

FDA (1984). Toxicity with superpotent selenium. FDA Drug Bulletin, 14:19.

Ferguson, L.R., Karunasinghe, N., Zhu, S. and Wang, A.H. (2012). Selenium and its role in the maintenance of genomic stability. Mutat. Res., 733(1-2): 100-110.

Ferm, V.H., Hanlon, D.P., Willhite, C.C., Choy, W.N. and Book, S.A. (1990). Embryotoxicity and dose-response relationships of selenium in hamsters. Reprod. Toxicol., 4(3): 183-190.

Fishbein, L. (1983). Environmental selenium and its significance. Fundam. Appl. Toxicol., 3: 411-419.

Flores-Mateo, G., Navas-Acien, A., Pastor-Barriuso, R. and Guallar, E. (2006). Selenium and coronary heart disease: a meta-analysis. Am. J. Clin. Nutr., 84(4): 762-773.

Folster, H.G., Wilson, D.B., Hanson, S. and Duran, R. (1980). Water treatment for small public supplies. Operation data-1979. San Jon and Alamogordo. Partial technical completion report. Project No. T-0009. New Mexico Water Resources Research Institute in cooperation with the Department of Chemical Engineering, New Mexico State University, Las Cruces, New Mexico.

Forceville, X. (2006). Seleno-enzymes and seleno-compounds: the two faces of selenium. Crit. Care, 10(6): 180.

Forceville, X., Laviolle, B., Annane, D., Vitoux, D., Bleichner, G., Korach, J.M., Cantais, E., Georges, H., Soubirou, J.L., Combes, A. and Bellissant, E. (2007). Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit. Care, 11(4): R73.

Fordyce, F.M., Zhang, G., Green, K. and Liu, X. (2000). Soil, grain and water chemistry and human selenium imbalances in Enshi District, Hubei Province, China. Appl. Geochem., 15: 117-132

Foster, L.H. and Sumar, S. (1997). Selenium in health and disease: a review. Crit. Rev. Food Sci. Nutr., 37(3): 211-228.

Francesconi, K.A. and Pannier, F. (2004). Selenium metabolites in urine: a critical overview of past work and current status. Clin. Chem., 50(12): 2240-2253.

Freemantle N. (2001). Interpreting the results of secondary end-points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic? BMJ., 322:989-91.

Gailer, J., George, G.N., Pickering, I.J., Prince, R.C., Younis, H.S. and Winzerling, J.J. (2002). Biliary excretion of [(GS)(2)AsSe]− after intravenous injection of rabbits with arsenite and selenate. Chem. Res. Toxicol., 15(11): 1466-1471.

Gasmi, A., Garnier, R., Galliot-Guilley, M., Gaudillat, C., Quartenoud, B., Buisine, A. and Djebbar, D. (1997). Acute selenium poisoning. Vet. Hum. Toxicol., 39(5): 304-308.

Geoghegan, M., McAuley, D., Eaton, S. and Powell-Tuck, J. (2006). Selenium in critical illness. Curr. Opin. Crit. Care, 12(2): 136-141.

Government of the Northwest Territories (2011). 2010 GNWT report on drinking water. Available at: www.maca.gov.nt.ca/resources/GNWT-report-on-drinking-water-2010.pdf

Griffiths, J.C., Matulka, R.A. and Power, R. (2006). Acute and subchronic toxicity studies on Sel-Plex®, a standardized, registered high-selenium yeast. Int. J. Toxicol., 25(6): 465-476.

Gromadzińska, J., Reszka, E., Bruzelius, K., Wąsowicz, W. and Åkesson, B. (2008). Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur. J. Nutr., 47: 29-50.

Guan, L., Han, B., Li, J., Li, Z., Huang, F., Yang, Y. and Xu, C. (2009). Exposure of human leukemia NB4 cells to increasing concentrations of selenite switches the signaling from pro-survival to pro-apoptosis. Ann. Hematol., 88(8): 733-742.

Gunter, S.A., Beck, P.A. and Phillips, J.M. (2003). Effects of supplementary selenium source on the performance and blood measurements in beef cows and their calves. J. Anim. Sci., 81(4): 856-864.

Hansen, J.C., Deutch, B. and Pedersen, H.S. (2004). Selenium status in Greenland Inuit. Contaminants in the Greenland environment: an update. Sci. Total Environ., 331(1-3): 207-214.

Harr, J.R., Bone, J.F., Tinsley, I.J., Weswig, P.H. and Yamamoto, R.S. (1967). Selenium toxicity in rats. II. Histopathology. In: Selenium in biomedicine. O.H. Muth (ed.). AVI, Westport, Connecticut. pp. 153-178.

Hawkes, W.C. and Turek, P.J. (2001). Effects of dietary selenium on sperm motility in healthy men. J. Androl., 22(5): 764-772.

Hawkes, W.C., Alkan, Z. and Wong, K. (2009). Selenium supplementation does not affect testicular selenium status or semen quality in North American men. J. Androl., 30(5): 525-533.

Hawkes, W.C., Keim, N.L., Richter, D.B., Gustafson, M.B., Gale, B., Mackey, B.E. and Bonnel, E.L. (2008). High-selenium yeast supplementation in free-living North American men: no effect on thyroid hormone metabolism or body composition. J. Trace Elem. Med. Biol., 22(2): 131-142.

Health Canada (1994). Canadian Environmental Protection Act. Human health risk assessment for priority substances. Minister of Supply and Services Canada, Ottawa, Ontario. Available at: www.hc-sc.gc.ca/ewh-semt/alt_formats/hecs-sesc/pdf/pubs/contaminants/approach/approach-eng.pdf

Health Canada (2007). Selenium. Natural Health Products Ingredients Database, Natural Health Products Directorate, Health Canada, Ottawa, Ontario. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=161&lang=eng

Health Canada (2010a). Report on human biomonitoring of environmental chemicals in Canada. Results of the Canadian Health Measures Survey Cycle 1 (2007-2009). Health Canada, Ottawa, Ontario. Available at: www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/chms-ecms/index-eng.php

Health Canada (2010b). Dietary reference intakes tables. Available at: www.hc-sc.gc.ca/fn-an/alt_formats/hpfb-dgpsa/pdf/nutrition/dri_tables-eng.pdf

Health Canada (2011). Average dietary intakes (µg/kg bw/day) of trace elements for Canadians in different age/sex groups for Total Diet Study. Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Ottawa, Ontario. Available at: www.hc-sc.gc.ca/fn-an/surveill/total-diet/index-eng.php

Health Canada (2012a). Personal communication from A.-M. Tugulea.

Health Canada (2012b). Review of post-1996 epidemiological studies on selenium and diabetes and amyotrophic lateral sclerosis (ALS). Report prepared by M. Camus, Population Studies Division, Health Canada.

Hoffman, J.L. (1977). Selenite toxicity, depletion of liver S-adenosylmethionine, and inactivation of methionine adenosyltransferase. Arch. Biochem. Biophys., 179(1): 136-140.

Hurst, R., Hooper, L., Norat, T., Lau, R., Aune, D., Greenwood, D.C., Vieira, R., Collings, R., Harvey, L.J., Sterne, J.A., Beynon, R., Savović, J. and Fairweather-Tait, S.J. (2012). Selenium and prostate cancer: systematic review and meta-analysis. Am. J. Clin. Nutr., 96(1): 111-122.

Huxstep, M. and Sorg, T. (1988). Reverse osmosis treatment to remove inorganic contaminants from drinking water; rule. U.S. Environmental Protection Agency, Washington, DC (EPA/600/S2-87/109).

IARC (1975). Some aziridines, N-, S- & O-mustards and selenium. International Agency for Research on Cancer, Lyon, France. pp. 245-260 (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 9. Available at: http://monographs.iarc.fr/ENG/Monographs/vol9/volume9.pdf

Institute of Medicine (2000). Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academy Press, Washington, DC. pp. 285-324.

Ip, C., Hayes, C., Budnick, R.M. and Ganther, H.E. (1991). Chemical form of selenium, critical metabolites, and cancer prevention. Cancer Res., 51(2): 595-600.

Ip, C., Thompson, H.J. and Ganther, H.E. (2000). Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Cancer Epidemiol. Biomarkers Prev., 9(1): 49-54.

IPCS (2006). Elemental speciation in human health risk assessment. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland. (Environmental Health Criteria 234). Available at: www.inchem.org/documents/ehc/ehc/ehc234.pdf

Jacangelo, J.G., Adham, S. and Laine, J.-M. (1997). Membrane filtration for microbial removal. American Water Works Association and AWWA Research Foundation, Denver, Colorado.

Jackson, M.I. and Combs, G.F., Jr. (2008). Selenium and anticarcinogenesis: underlying mechanisms. Curr. Opin. Clin. Nutr. Metab. Care, 11(6): 718-726.

Jacobs, M.M. (1980). Effects of selenium on chemical carcinogens. Prev. Med., 9(3): 362-367.

Jacobs, M. and Forst, C. (1981a). Toxicological effects of sodium selenite in Sprague-Dawley rats. J. Toxicol. Environ. Health, 8(4): 575-585.

Jacobs, M. and Forst, C. (1981b). Toxicological effects of sodium selenite in Swiss mice. J. Toxicol. Environ. Health, 8(4): 587-598.

Jaffe, W.G., Ruphael, M., Mondragon, M.C. and Cuevas, M.A. (1972). Clinical and biochemical study in school children of a seleniferous zone. Arch. Latinoam. Nutr., 22(4): 595-611.

Jariwalla, R.J., Gangapurkar, B. and Nakamura, D. (2009). Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium. Br. J. Nutr., 101(2): 182-189.

Johnson, C.C., Fordyce, F.M. and Rayman, M.P. (2010). Symposium on "Geographical and geological influences on nutrition": factors controlling the distribution of selenium in the environment and their impact on health and nutrition. Proc. Nutr. Soc., 69(1): 119-132.

Kandas, N.O., Randolph, C. and Bosland, M.C. (2009). Differential effects of selenium on benign and malignant prostate epithelial cells: stimulation of LNCaP cell growth by noncytotoxic, low selenite concentrations. Nutr. Cancer, 61(2): 251-264.

Kaur, P. and Bansal, M.P. (2005). Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice. Nutrition, 21(3): 351-357.

Kaur, P., Evje, L., Aschner, M. and Syversen, T. (2009). The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity. Toxicol. In Vitro, 23(3): 378-385.

Kaur, R. and Parshad, V.R. (1994). Effects of dietary selenium on differentiation, morphology and functions of spermatozoa of the house rat, Rattus rattus L. Mutat. Res., 309(1): 29-35.

Kaur, R., Sharma, S. and Rampal, S. (2003). Effect of sub-chronic selenium toxicosis on lipid peroxidation, glutathione redox cycle and antioxidant enzymes in calves. Vet. Hum. Toxicol., 45(4): 190-192.

Kaur, R., Rampal, S. and Sandhu, H.S. (2005). Clinical and haematological studies on experimentally induced selenosis in crossbred cow calves. Pakistan Vet. J., 25(3): 127-133.

Keck, A.S. and Finley, J.W. (2004). Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr. Cancer Ther., 3(1): 5-12.

Kemper, J.M., Westerhoff, P., Dotson, A. and Mitch, W.A. (2009). Nitrosamine, dimethylnitramine, and chloropicrin formation during strong base anion-exchange treatment. Environ. Sci. Technol., 43(2): 466-472.

Khalil, A.M. (1989). The induction of chromosome aberrations in human purified peripheral blood lymphocytes following in vitro exposure to selenium. Mutat. Res., 224(4): 503-506.

Khalil, A.M. and Maslat, A.O. (1990). Chromosome aberrations, sister-chromatid exchanges and cell-cycle kinetics in human peripheral blood lymphocytes exposed to organoselenium in vitro. Mutat. Res., 232(2): 227-232.

Kim, Y.S., Jhon, D.Y. and Lee, K.Y. (2004). Involvement of ROS and JNK1 in selenite-induced apoptosis in Chang liver cells. Exp. Mol. Med., 36(2): 157-164.

Kim, Y.Y. and Mahan, D.C. (2001). Comparative effects of high dietary levels of organic and inorganic selenium on selenium toxicity of growing-finishing pigs. J. Anim. Sci., 79(4): 942-948.

Kimoto, W.I., Doodley, C.J., Carre, J. and Fiddler, W. (1980). Role of strong ion exchange resin in nitrosamine formation in water. Water Res., 14: 869-876.

Kise, Y., Yoshimura, S., Akieda, K., Umezawa, K., Okada, K., Yoshitake, N., Shiramizu, H., Yamamoto, I. and Inokuchi, S. (2004). Acute oral selenium intoxication with ten times the lethal dose resulting in deep gastric ulcer. J. Emerg. Med., 26(2): 183-187.

Kitajima, T., Jigami, Y. and Chiba, Y. (2012). Cytotoxic mechanism of selenomethionine in yeast. J. Biol. Chem., 287(13): 10032-10038.

Klein, E.A. (2009). Selenium and vitamin E: interesting biology and dashed hope. J. Natl. Cancer Inst., 101(5): 283-285.

Klein, E.A., Lippman, S.M., Thompson, I.M., Goodman, P.J., Albanes, D., Taylor, P.R. and Coltman, C. (2003). The Selenium and Vitamin E Cancer Prevention Trial. World J. Urol., 21(1): 21-27.

Kljai, K. and Runje, R. (2001). Selenium and glycogen levels in diabetic patients. Biol. Trace Elem. Res., 83(3): 223-229.

Kohrle, J. and Gartner, R. (2009). Selenium and thyroid. Best Pract. Res. Clin. Endocrinol. Metab., 23(6): 815-827.

Koppel, C., Baudisch, H., Beyer, K.H., Kloppel, I. and Schneider, V. (1986). Fatal poisoning with selenium dioxide. J. Toxicol. Clin. Toxicol., 24(1): 21-35.

Kornhauser, C., Garcia-Ramirez, J.R., Wrobel, K., Pérez-Luque, E., Garay-Sevilla, M.E. and Wrobel, K. (2008). Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Primary Care Diabetes, 2(2): 81-85.

Kramer, G.F. and Ames, B.N. (1988). Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutat. Res., 201(1): 169-180.

Kreft, P. (1985). Removal of inorganic selenium from drinking water using activated alumina. In: Proceedings of the First Annual Environmental Symposium on Selenium in the Environment. California Agriculture Technology Institute, California State University, Fresno, California (Publication No. CAT1/860201).

Kremer, D., Ilgen, G. and Feldmann, J. (2005). GC-ICP-MS determination of dimethylselenide in human breath after ingestion of 77Se-enriched selenite: monitoring of in-vivo methylation of selenium. Anal. Bioanal Chem., 383(3): 509-515.

Krishnan, K. and Carrier, R. (2013). The use of exposure source allocation factor in the risk assessment of drinking-water contaminants. J. Toxicol. Environ. Health B Crit. Rev., 16(1): 39-51.

Kuan, W.-H., Lo, S.-L., Wang, M.K. and Lin, C.-F. (1998). Removal of Se (IV) and Se (VI) from water by aluminum-oxide coated sand. Water Res., 32(3): 915-923.

L'Abbé, M.R., Trick, K.D. and Koshy, A. (1996). The selenium content of Canadian infant formula and breast milk. J. Food Compos. Anal., 2: 119-126.

Laclaustra, M., Navas-Acien, A., Stranges, S., Ordovas, J.M. and Guallar, E. (2009). Serum selenium concentrations and hypertension in the US population. Circ. Cardiovasc. Qual. Outcomes, 2(4): 369-376.

Laclaustra, M., Navas-Acien, A., Stranges, S., Ordovas, J.M. and Guallar, E. (2010). Serum selenium and plasma lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis. 210:643-8.

Lane, H.W. and Medina, D. (1985). Mode of action of selenium inhibition of 7,12-dimethylbenz[a]anthracene-induced mouse mammary tumorigenesis. J. Natl. Cancer Inst., 75(4): 675-679.

Lawson, T. and Birt, D.F. (1983). Enhancement of the repair of carcinogen-induced DNA damage in the hamster pancreas by dietary selenium. Chem. Biol. Interact., 45(1): 95-104.

Leblanc, A., Lapointe, S., Beaudet, A., Côté, I., Dumas, P., Labrecque, F., Lamy, C., Larochelle, J., Lepage, L., Pelletier, F. and Weber, J.-P. (2004). Étude sur l'établissement de valeurs de référence d'éléments traces et de métaux dans le sang, le sérum et l'urine de la population de la grande région de Québec. Direction toxicologie humaine, Direction risques biologiques, environnementaux et occupationnels, Institut national de santé publique du Québec. Available at: www.inspq.qc.ca/pdf/publications/289-ValeursReferenceMetaux.pdf

Lemire, M., Fillion, M., Barbosa, F., Jr., Guimarães, J.R.D. and Mergler, D. (2010). Elevated levels of selenium in the typical diet of Amazonian riverside populations. Sci. Total Environ., 408(19): 4076-4084.

Lemire, M., Philibert, A., Fillion, M., Passos, C.J.S., Guimarães, J.R.D., Barbosa, F., Jr., and Mergler, D. (2012). No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon. Environ. Int., 40: 128-136.

Letavayová, L., Vlčková, V. and Brozmanová, J. (2006). Selenium: from cancer prevention to DNA damage. Toxicology, 227(1-2): 1-14.

Letavayová, L., Vlasáková, D., Spallholz, J.E., Brozmanová, J. and Chovanec, M. (2008). Toxicity and mutagenicity of selenium compounds in Saccharomyces cerevisiae. Mutat. Res., 638(1-2): 1-10.

Li, C. (1998). Removal of selenium from drinking water by manganese greensand filtration. A thesis submitted to the faculty graduate students and research in paprtial fulfilment of the requirements for the degree of master of applied science in environmental system. University of Regina.

Li, C. and Viraraghavan, T. (1998). Removal of selenium in drinking water by manganese greensand, iron oxide-coated sand and ion-exchange resin. In: Water resources and the urban environment-98. Proceedings of the 1998 National Conference on Environmental Engineering, Chicago, IL, June 7-10, 1998. T.E. Wilson (ed.). American Society of Civil Engineers, Reston, Virginia. pp. 356-361.

Li, G.X., Lee, H.J., Wang, Z., Hu, H., Liao, J.D., Watts, J.C., Combs, G.F., Jr., and Lu, J. (2008). Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite. Carcinogenesis, 29(5): 1005-1012.

Lippman, S.M., Klein, E.A., Goodman, P.J., Lucia, M.S., Thompson, I.M., Ford, L.G., Parnes, H.L., Minasian, L.M., Gaziano, J.M., Hartline, J.A., Parsons, J.K., Bearden, J.D., 3rd, Crawford, E.D., Goodman, G.E., Claudio, J., Winquist, E., Cook, E.D., Karp, D.D., Walther, P., Lieber, M.M., Kristal, A.R., Darke, A.K., Arnold, K.B., Ganz, P.A., Santella, R.M., Albanes, D., Taylor, P.R., Probstfield, J.L., Jagpal, T.J., Crowley, J.J., Meyskens, F.L., Jr., Baker, L.H. and Coltman, C.A., Jr. (2009). Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA, 301(1): 39-51.

Lo, L.W., Koropatnick, J. and Stich, H.F. (1978). The mutagenicity and cytotoxicity of selenite, "activated" selenite and selenate for normal and DNA repair-deficient human fibroblasts. Mutat. Res., 49(3): 305-312.

Lo, S.-L. and Chen, T.Y. (1997). Adsorption of Se (IV) and Se (VI) on iron-coated sand from water. Chemosphere, 35(5): 919-930.

Lofroth, G. and Ames, B.N. (1978). Mutagenicity of inorganic compounds in Salmonella typhimurium: arsenic, chromium, and selenium. Mutat. Res., 53: 65-66.

Lombeck, I., Menzel, H. and Frosch, D. (1987). Acute selenium poisoning of a 2-year-old child. Eur. J. Pediatr., 146(3): 308-312.

Longnecker, M.P., Taylor, P.R., Levander, O.A., Howe, M., Veillon, C., McAdam, P.A., Patterson, K.Y., Holden, J.M., Stampfer, M.J. and Morris, J.S. (1991). Selenium in diet, blood, and toenails in relation to human health in a seleniferous area. Am. J. Clin. Nutr., 53(5): 1288-1294.

Longtin, R. (2003). Selenium for prevention: eating your way to better DNA repair? J. Natl. Cancer Inst., 95(2): 98-100.

Lopez, P.L., Preston, R.L. and Pfander, W.H. (1969). Whole-body retention, tissue distribution and excretion of selenium-75 after oral and intravenous administration in lambs fed varying selenium intakes. J. Nutr., 97(1): 123-132.

Lovley, D.R. (1995). Bioremediation of organic and metal contaminants with dissimilatory reduction. J. Ind. Microbiol., 14: 85-93.

Maas, P., Patch, S. and Lagasse, M. (2002). Measurements of lead, bismuth and selenium discharge from water service valve and fittings manufactured from Sebiloy (EnviroBrass II) brass alloy. UNC-Asheville Environmental Quality Institute (Technical Report No. 02-105).

MacFarquhar, F., Broussard, D.L., Melstrom, P., Hutchinson, R., Wolkin, A., Martin, C., Burk, R.F., Dunn, J.R., Green, A.L., Hammond, R., Schaffner, W. and Jones, T.F. (2010). Acute selenium toxicity associated with a dietary supplement. Arch. Intern. Med., 170(3): 256-261.

Maneval, J., Klein, G. and Sincovic, J. (1985). Selenium removal from drinking water by ion exchange. U.S. Environmental Protection Agency, Washington, DC (EPA-600/S2-85-074).

Martin, R.F., Janghorbani, M. and Young, V.R. (1988). Kinetics of a single administration of 74Se-selenite by oral and intravenous routes in adult humans. J. Parenter. Enteral Nutr., 12(4): 351-355.

Matoba, R., Kimura, H., Uchima, E., Abe, T., Yamada, T., Mitsukuni, Y. and Shikata, I. (1986). An autopsy case of acute selenium (selenious acid) poisoning and selenium levels in human tissues. Forensic Sci. Int., 31(2): 87-92.

Mayne, S.T. (2003). Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J. Nutr., 133(3): 933S-940S.

McCarty, M.F. (1998). Selenium, calcium channel blockers, and cancer risk--the Yin and Yang of apoptosis? Med. Hypotheses, 50(5): 423-433.

McKeown, B. and Marinas, B. (1985). The chemistry of selenium in an aqueous environment. In: Proceedings of the First Annual Environmental Symposium on Selenium in the Environment. California Agriculture Technology Institute, California State University, Fresno, California (Publication No. CAT1/860201).

Mézes, M. and Balogh, K. (2009). Prooxidant mechanisms of selenium toxicity. Acta Biol. Szeged., 53(1): 15-18.

Miller, S., Walker, S.W., Arthur, J.R., Nicol, F., Pickard, K., Lewin, M.H., Howie, A.F. and Beckett, G.J. (2001). Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin. Sci., 100: 543-550.

Minami, H., Cai, W., Kusumoto, T., Nishikawa, K., Zang, Q., Inoue, S. and Atsuya, I. (2003). Isotope dilution analysis of selenite and selenate in natural water using microwave-induced nitrogen plasma mass spectrometry. Anal. Sci., 19: 1359-1363.

Ministère du Développement durable, de l'Environnement et des Parcs du Québec (2012). Personal communication from C. Robert and A. Bolduc.

Misra, S., Hamilton, C. and Niyogi, S. (2012). Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss). Toxicol. In Vitro, 26(4): 621-629.

Moon, H., Ko, W., Han, S.W., Kim, D., Hwang, Y., Park, H. and Kwon, I.K. (2012). Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem. Biophys. Res. Commun., 418(2): 247-253.

Morss, S.G. and Olcott, H.S. (1967). Absence of effect of tocopherol on acute oral toxicity of sodium selenite in the rat. Proc. Soc. Exp. Biol. Med., 124(2): 483-485.

Moxon, A.L. (ed.) (1937). Alkali disease, or selenium poisoning. South Dakota Agricultural Experiment Station, Brookings, SD. p. 91 (Bulletin 331).

Najm, I. and Trussell, R. (2001). NDMA formation in water and wastewater. J. Am. Water Works Assoc., 93(2): 92-99.

Nakamuro, K., Yoshikawa, K., Sayato, Y., Kurata, H. and Tonomura, M. (1976). Studies on selenium-related compounds. V. Cytogenetic effect and reactivity with DNA. Mutat. Res., 40: 177-184.

Nantel, A.J., Brown, M., Dery, P. and Lefebvre, M. (1985). Acute poisoning by selenious acid. Vet. Hum. Toxicol., 27(6): 531-533.

National Institutes of Health (2011). Dietary supplement fact sheet: selenium. Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland. Available at: http://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/

Natural Resources Canada (2010). Preliminary estimate of the mineral production of Canada, by province, 2010. Available at: http://mmsd.mms.nrcan.gc.ca/stat-stat/prod-prod/PDF/2010%20Mineral%20Production.pdf

Natural Resources Canada (2011). Preliminary estimate of the mineral production of Canada, by province, 2011. Available at:  http://mmsd.mms.nrcan.gc.ca/stat-stat/prod-prod/PDF/2011P%20Mineral%20Production.pdf

Navarro-Alarcón, M., López-G de la Serrana, H., Pérez-Valero, V. and López-Martı́nez, C. (1999). Serum and urine selenium concentrations as indicators of body status in patients with diabetes mellitus. Sci. Total Environ., 228(1): 79-85.

NCI and NTP (1980). Bioassay of selenium sulfide (gavage) for possible carcingenicity. CAS No. 7446-34-6. National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, Maryland. (NTP-80-17; NCI-CG-TR-194). Available at: http://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr194.pdf

Nelson, A.A., Fitzhugh, O.G. and Calvery, H.O. (1943). Liver tumors following cirrhosis caused by selenium in rats. Cancer Res., 3(4): 230-236.

New Brunswick Department of Health and Wellness (2012). Personal communication from K. Gould.

Newfoundland and Labrador Department of Environment and Conservation (2012). Personal communication from H. Khan and A. Tobin.

NHMRC and NRMMC (2011). Australian Drinking Water Guidelines Paper 6 National Water Quality Management Strategy. National Health and Medical Research Council, National Resource Management Ministerial Council, Commonwealth of Australia, Canberra, Australia. Available at: www.nhmrc.gov.au/_files_nhmrc/publications/attachments/eh52_aust_drinking_water_guidelines_update_120710_0.pdf

Nobunaga, T., Satoh, H. and Suzuki, T. (1979). Effects of sodium selenite on methylmercury embryotoxicity and teratogenicity in mice. Toxicol. Appl. Pharmacol., 47(1): 79-88.

Noda, M., Takano, T. and Sakurai, H. (1979). Mutagenic activity of selenium compounds. Mutat. Res., 66(2): 175-179.

Nogueira, C. and Rocha, J. (2011). Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds. Arch. Toxicol., 85(11): 1313-1359.

Norppa, H., Westermarck, T., Laasonen, M., Knuutila, L. and Knuutila, S. (1980a). Chromosomal effects of sodium selenite in vivo. I. Aberrations and sister chromatid exchanges in human lymphocytes. Hereditas, 93(1): 93-96.

Norppa, H., Westermarck, T., Oksanen, A., Rimaila-Parnanen, E. and Knuutila, S. (1980b). Chromosomal effects of sodium selenite in vivo. II. Aberrations in mouse bone marrow and primary spermatocytes. Hereditas, 93(1): 97-99.

Norppa, H., Westermarck, T. and Knuutila, S. (1980c). Chromosomal effects of sodium selenite in vivo. III. Aberrations and sister chromatid exchanges in Chinese hamster bone marrow. Hereditas, 93(1): 101-105.

Norton, R.L. and Hoffmann, P.R. (2011). Selenium and asthma. Mol. Aspects Med., 33(1): 98-106.

Nova Scotia Department of the Environment (2012). Personal communication from J. MacDonald and C. Mosher.

NRCC (2010). National Plumbing Code of Canada 2010. National Research Council of Canada, Ottawa, Ontario. Available at: www.nrc-cnrc.gc.ca/eng/services/irc/codes-centre.html

NSF/ANSI (1994) Standard 61: Drinking water system components--Health effects. NSF International and American National Standards Institute, Ann Arbor, Michigan. Draft. As cited in Twarog, 1995.

NSF/ANSI (2009a). Section 7.1.2. In: Standard 58: Reverse osmosis drinking water treatment systems. NSF International and American National Standards Institute, Ann Arbor, Michigan.

NSF/ANSI (2009b). Section 5. In: Standard 62: Drinking water distillation system. NSF International and American National Standards Institute, Ann Arbor, Michigan.

NSF/ANSI (2011a). Standard 61: Drinking water system components--Health effects. NSF International and American National Standards Institute, Ann Arbor, Michigan.

NSF/ANSI (2011b). Standard 53: Drinking water treatments units--Health effects. NSF International and American National Standards Institute, Ann Arbor, Michigan.

NTP (1996). Sodium selenate: short term reproductive and developmental toxicity study when administered to Sprague-Dawley rats in the drinking water. National Toxicology Program, National Institute of Health, U.S. Department of Health and Human Services, Research Triangle Park

North Carolina (NTIS PB 96 190 616). Available at: http://ntp.niehs.nih.gov/index.cfm?objectid=070EBC7E-AB05-DF93-4DE25D0266C01B5B

Nuttall, K.L. (2006). Evaluating selenium poisoning. Ann. Clin. Lab. Sci., 36(4): 409-420.

OEHHA (2010). Public Health Goal for selenium in drinking water. Prepared by Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Pesticide and Environmental Toxicology Branch. p. 219. Available at: http://oehha.ca.gov/water/phg/pdf/SeleniumPHG121010.pdf

Ontario Ministry of the Environment (2012). Personal communication from S. Deshpande and M. Hussain.

O'Toole, D. and Raisbeck, M.F. (1995). Pathology of experimentally induced chronic selenosis (alkali disease) in yearling cattle. J. Vet. Diagn. Invest., 7: 364-373.

O'Toole, D., Raisbeck, M., Case, J.C. and Whitson, T.D. (1996). Selenium-induced "blind staggers" and related myths. A commentary on the extent of historical livestock losses attributed to selenosis on western US rangelands. Vet. Pathol. Online, 33(1): 104-116.

Otten, J.J., Pitzi Hellwig, J. and Meyers, L.D. (eds.) (2006). Dietary reference intakes: the essential guide to nutrient requirements. Institute of Medicine, National Academies Press, Washington, DC.

Park, K., Rimm, E.B., Siscovick, D.S., Spiegelman, D., Manson, J.E., Morris, J.S., Hu, F.B. and Mozaffarian, D. (2012). Toenail selenium and incidence of type 2 diabetes in U.S. men and women. Diabetes Care, 35(7): 1544-1551.

Patterson, B. and Levander, O. (1997). Naturally occurring selenium compounds in cancer chemoprevention trials: a workshop summary. Cancer Epidemiol. Biomarkers Prev., 6(1): 63-69.

Pehrson, B., Ortman, K., Madjid, N. and Trafikowska, U. (1999). The influence of dietary selenium as selenium yeast or sodium selenite on the concentration of selenium in the milk of suckler cows and on the selenium status of their calves. J. Anim. Sci., 77(12): 3371-3376.

Peters, D.T. (1995). Bismuth-modified cast red brass to meet U.S. drinking water standards. In: Copper 95: Third International Conference, Santiago, Chile, November 26-29, 1995. Plenary lectures: Economics, applications and fabrication of copper. Vol. 1. pp. 301-322. Canadian Institute of Mining, Metallurgy and Petroleum, Montreal, Quebec.

Pickrell, J.A. and Oehme, F.W. (2002). Invited response to definition of hormesis (EJ Calabrese and LA Baldwin). Hum. Exp. Toxicol., 21(2): 107-109; discussion 113-114.

Pinto, A., Speckmann, B., Heisler, M., Sies, H. and Steinbrenner, H. (2011). Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds. J. Inorg. Biochem., 105(6): 812-820.

Plasterer, M.R., Bradshaw, W.S., Booth, G.M., Carter, M.W., Schuler, R.L. and Hardin, B.D. (1985). Developmental toxicity of nine selected compounds following prenatal exposure in the mouse: naphthalene, p-nitrophenol, sodium selenite, dimethyl phthalate, ethylenethiourea, and four glycol ether derivatives. J. Toxicol. Environ. Health, 15(1): 25-38.

Pletnikova, I.P. (1970). Biological effect and level of safety of selenium in its entry into the organism with drinking water. Gig. Sanit., 35(2): 14-19.

Podoll, K.L., Bernard, J.B., Ullrey, D.E., DeBar, S.R., Ku, P.K. and Magee, W.T. (1992). Dietary selenate versus selenite for cattle, sheep, and horses. J. Anim. Sci., 70:1965-1970.

Rajpathak, S., Rimm, E., Morris, J.S. and Hu, F. (2005). Toenail selenium and cardiovascular disease in men with diabetes. J. Am. Coll. Nutr., 24(4): 250-256.

Ramana, A. and Sengupta, A.K. (1992). Removing selenium (IV) and arsenic (V) oxyanions with tailored chelating polymers. Environ. Eng. 118(5): 755-775.

Ray, J.H. (1984). Sister-chromatid exchange induction by sodium selenite: reduced glutathione converts Na2SeO3 to its SCE-inducing form. Mutat. Res., 141(1): 49-53.

Ray, J.H. and Altenburg, L.C. (1982). Sister-chromatid exchange induction by sodium selenite: plasma protein-bound selenium is not the active SCE-inducing metabolite of Na2SeO3. Mutat. Res., 102(3): 285-296.

Rayman, M.P. (2008). Food-chain selenium and human health: emphasis on intake. Br. J. Nutr., 100(2): 254-268.

Rayman, M.P. (2012). Selenium and human health. Lancet, 379(9822): 1256-1268.

Rayman, M.P., Stranges, S., Griffin, B.A., Pastor-Barriuso, R. and Guallar, E. (2011). Effect of supplementation with high-selenium yeast on plasma lipids. A randomized trial. Ann. Intern. Med., 154(10): 656-665.

Redman, C., Scott, J.A., Baines, A.T., Basye, J.L., Clark, L.C., Calley, C., Roe, D., Payne, C.M. and Nelson, M.A. (1998). Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett., 125(1-2): 103-110.

Rees, K., Hartley, L., Day, C., Clarke, A. and Stranges, S. (2012). Selenium supplementation for the primary prevention of cardiovascular disease (protocol). Cochrane Database Syst. Rev., 2: CD009671.

Reid, M.E., Stratton, M.S., Lillico, A.J., Fakih, M., Natarajan, R., Clark, L.C. and Marshall, J.R. (2004). A report of high-dose selenium supplementation: response and toxicities. J. Trace Elem. Med. Biol., 18(1): 69-74.

Reid, M.E., Duffield-Lillico, A., Slate, E., Natarajan, N., Turnbull, B., Jacobs, E., Combs, G.F., Alberts, D.S., Clark, L.C. and Marshall, J.R. (2008). The nutritional prevention of cancer: 400 mcg per day selenium treatment. Nutr. Cancer, 60(2): 155-163.

Rosenfeld, I. and Beath, O.A. (1954). Effect of selenium on reproduction in rats. Proc. Soc. Exp. Biol. Med., 87(2): 295-297.

Rovira, M., Gimenez, J., Martinez, M., Martinez-Llado, X., de Pablo, J., Marti, V. and Duro, L. (2008). Sorption of selenium (IV) and selenium (VI) onto natural iron oxide: goethite and hematite. J. Hazard. Mater., 150(2): 279-284.

Sandvig, A., Boyd, G., Kirmeyer, G., Edwards, M., Triantafyllidou, S. and Murphy, B.M. (2007). Performance and metal release of non-leaded brass meters, components, and fittings. Published by IWA, London, UK, on behalf of the AWWA Research Foundation, Denver, Colorado (Project No. 3112).

Sandvig, A., Martel, K., Beggs, K., Murray, A, Grreiner, P., Kneen, G., McLellan, C., Bennet, D. and Terrell, J. (2012).  Is NSF 61 relevant for chloraminating utilities? Report #4243. Water Research Foundation. Denver, Colorado.

Sandy, T. and DiSante, P.E. (2010). Review of available technologies for the removal of selenium in drinking water. Prepared for North American Metals Council by CH2M HILL. Available at: www.namc.org/docs/00062756.PDF

Sanmartin, C., Plano, D. and Palop, J.A. (2008). Selenium compounds and apoptotic modulation: a new perspective in cancer therapy. Mini Rev. Med. Chem., 8: 1020-1031.

Saskatchewan Department of Environment and Resource Management (2012). Personal communication from S. Ferris.

Sayato, Y., Nakamuro, K. and Hasegawa, T. (1997). [Selenium methylation and toxicity mechanism of selenocystine.] Yakugaku Zasshi, 117(10-11): 665-672 (in Japanese).

Scarlato, E.A. and Higa, J. (1990). Selenium. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Poison Information Monograph 483). Available at: www.inchem.org/documents/pims/chemical/pim483.htm

SCC (2011). Directory of accredited product and service certification bodies. Standards Council of Canada, Ottawa, Ontario. Available at: www.scc.ca/en/programs-services/product-certification/directory-of-accredited-clients

Schellmann, B., Raithel, H.J. and Schaller, K.H. (1986). Acute fatal selenium poisoning. Toxicological and occupational medical aspects. Arch. Toxicol., 59(1): 61-63.

Schock, M.R. (2005). Distribution systems as reservoirs and reactors for inorganic contaminants. In: Distribution system water quality challenges in the 21st century: a strategic guide. American Water Works Association, Denver, Colorado.

Schock, M.R. and Lytle, D.A. (2011). Internal corrosion and deposition control. In: Water quality and treatment--a handbook of community water supplies. 6th edition. American Water Works Association and McGraw-Hill, New York, New York.

Schrauzer, G.N. (2000). Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J. Nutr., 130(7): 1653-1656.

Schrauzer, G.N., White, D.A. and Schneider, C.J. (1978). Selenium and cancer: effects of selenium and of the diet on the genesis of spontaneous mammary tumors in virgin inbred female C3H/St mice. Bioinorg. Chem., 8(5): 387-396.

Schroeder, H.A. and Mitchener, M. (1971a). Selenium and tellurium in mice. Arch. Environ. Health, 24: 66-71.

Schroeder, H.A. and Mitchener, M. (1971b). Toxic effects of trace elements on the reproduction of mice and rats. Arch. Environ. Health, 23: 102-106.

Schroeder, H.A. and Mitchener, M. (1972). Selenium and tellurium in rats: effects on growth, survival, and tumors. J. Nutr., 101: 1531-1540.

Shalini, S. and Bansal, M.P. (2007). Alterations in selenium status influences (sic) reproductive potential of male mice by modulation of transcription factor NFkappaB. Biometals, 20(1): 49-59.

Shalini, S. and Bansal, M.P. (2008). Dietary selenium deficiency as well as excess supplementation induces multiple defects in mouse epididymal spermatozoa: understanding the role of selenium in male fertility. Int. J. Androl., 31(4): 438-449.

Shamberger, R.J. (1981). Selenium in the environment. Sci. Total Environ., 17(1): 59-74.

Shearer, T.R. and Hadjimarkos, D.M. (1975). Geographic distribution of selenium in human milk. Arch. Environ. Health, 30(5): 230-233.

Shen, H., Yang, C., Liu, J. and Ong, C. (2000). Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells. Free Radic. Biol. Med., 28(7): 1115-1124.

Shi, Y., Wang, L., Chen, Y. and Xu, D. (2009). Research on removing selenium from raw water by using Fe/Se co-precipitation system. J. Water Supply Res. Technol.-Aqua, 58(1): 51-56.

Sorg, T.J. (1985). Selenium removal using the conventional coagulation or lime soda ash softening processes. In: Proceedings of the First Annual Environmental Symposium on Selenium in the Environment. California Agriculture Technology Institute, California State University, Fresno, California (Publication No. CAT1/860201).

Sorg, T.J. and Logsdon, G.S. (1978). Treatment technology to meet the interim primary drinking water regulations for inorganics: Part 2. J. Am. Water Works Assoc., 70(7): 379-393.

Sorg, T.J., Forbes, R.W. and Chambers, D.S. (1980). Removal of radium-226 from Sarasota County, Fla., drinking water by reverse osmosis. J. Am. Water Works Assoc., 74(4): 230-237.

Spallholz, J.E. (1997). Free radical generation by selenium compounds and their prooxidant toxicity. Biomed. Environ. Sci., 10(2-3): 260-270.

Spallholz, J.E. (2001). Selenium and the prevention of cancer. Part 2. Mechanisms for the carcinostatic activity of Se compounds. Bulletin of the Selenium-Tellurium Development Association, Grimbergen, Belgium. Available at: www.selenomethionine.com/SeMC2.pdf

Stapleton, S.R. (2000). Selenium: an insulin-mimetic. Cell. Mol. Life Sci., 57(13-14): 1874-1879.

Steinbrenner, H., Speckmann, B., Pinto, A., Sies, H. (2011). High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J. Clin. Biochem. Nutr., 48(1):40-45.

Stewart, M.S., Davis, R.L., Walsh, L.P. and Pence, B.C. (1997). Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Lett., 117(1): 35-40.

Stranges, S., Marshall, J.R., Trevisan, M., Natarajan, R., Donahue, R.P., Combs, G.F., Farinaro, E., Clark, L.C. and Reid, M.E. (2006). Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial. Am. J. Epidemiol., 163(8): 694-699.

Stranges, S., Marshall, J.R., Natarajan, R., Donahue, R.P., Trevisan, M., Combs, G.F., Cappuccio, F.P., Ceriello, A. and Reid, M.E. (2007). Effects of long-term selenium supplementation on the incidence of type 2 diabetes. Ann. Intern. Med., 147(4): 217-223.

Stranges, S., Navas-Acien, A., Rayman, M.P. and Guallar, E. (2010). Selenium status and cardiometabolic health: state of the evidence. Nutr. Metab. Cardiovasc. Dis., 20(10): 754-760.

Su, L., Wang, M., Yin, S., Wang, H., Chen, L., Sun, L. and Ruan, D. (2008). The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues. Ecotoxicol. Environ. Saf., 70(3): 483-489.

Sutter, M.E., Thomas, J.D., Brown, J. and Morgan, B. (2008). Selenium toxicity: a case of selenosis caused by a nutritional supplement. Ann. Intern. Med., 148(12): 970-971.

Suzuki, K.T. (2005). Metabolomics of selenium: Se metabolites based on speciation studies. J. Health Sci., 51(2): 107-114.

Suzuki, K.T., Kurasaki, K., Okazaki, N. and Ogra, Y. (2005). Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes. Toxicol. Appl. Pharmacol., 206(1): 1-8.

Suzuki, Y., Hashiura, Y., Matsumura, K., Matsukawa, T., Shinohara, A. and Furuta, N. (2010). Dynamic pathways of selenium metabolism and excretion in mice under different selenium nutritional statuses. Metallomics, 2(2): 126-132.

Swanson, C.A., Patterson, B.H., Levander, O.A., Veillon, C., Taylor, P.R., Helzlsouer, K., McAdam, P.A. and Zech, L.A. (1991). Human [74Se]selenomethionine metabolism: a kinetic model. Am. J. Clin. Nutr., 54(5): 917-926.

Taylor, J.S. and Wiesner, M. (1999). Membranes. In: Water quality and treatment--a handbook of community water supplies. 5th edition. R.D. Letterman (ed.). American Water Works Association and McGraw-Hill, Inc. New York, New York.

Thayer, K.A., Heindel, J.J., Bucher, J.R. and Gallo, M.A. (2012). Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ. Health Perspect., 120(6): 779-789.

Thiry, C., Ruttens, A., De Temmerman, L., Schneider, Y. and Pussemier, L. (2012). Current knowledge in species-related bioavailability of selenium in food. Food Chem., 130(4): 767-784.

Thompson, J.N., Erdody, P. and Smith, D.C. (1975). Selenium content of food consumed by Canadians. J. Nutr., 105(3): 274-277.

Thomson, C., Robinson, M., Campbell, D. and Rea, H. (1982). Effect of prolonged supplementation with daily supplements of selenomethionine and sodium selenite on glutathione peroxidase activity in blood of New Zealand residents. Am. J. Clin. Nutr., 36(1): 24-31.

Thomson, C.D., McLachlan, S.K., Grant, A.M., Paterson, E. and Lillico, A.J. (2005). The effect of selenium on thyroid status in a population with marginal selenium and iodine status. Br. J. Nutr., 94(6): 962-968.

Tinsley, I.J., Harr, J.R., Bone, J.F., Weswig, P.H. and Yamamoto, R.S. (1967). Selenium toxicity in rats. I. Growth and longevity. In: Selenium in biomedicine: a symposium. O.H. Muth (ed.). AVI, Westport, Connecticut. pp. 141-152.

Kitajima, T., Jigami, Y., Chiba, Y. (2012). Cytotoxic mechanism of selenomethionine in yeast. J. Biol. Chem. 287(13):10032-8.

Tiwary, A.K., Stegelmeier, B.L., Panter, K.E., James, L.F. and Hall, J.O. (2006). Comparative toxicosis of sodium selenite and selenomethionine in lambs. J. Vet. Diagn. Invest., 18(1): 61-70.

Triantafyllidou, S. and Edwards, M. (2006). Evaluation of the leaching potential of alternative brasses. Appendix B in: Performance and metal release of non-leaded brass meters, components and fittings. Published by IWA, London, United Kingdom, on behalf of the AWWA Research Foundation, Denver, Colorado.

Trussell, R.R., Trussell, A. and Kreft, P. (1980). Selenium removal from ground water using activated alumina. U.S. Environmental Protection Agency, Washington, DC (EPA 600/2-80-153).

Turner, R.J. and Finch, J.M. (1991). Selenium and the immune response. Proc. Nutr. Soc., 50(2): 275-285.

Twarog, D.L. (1995). Modified red brass with bismuth and selenium. AFS Research, American Foundrymen's Society, Inc., Des Plaines, Illinois.

U.S. EPA (1985). Technologies and cost for the removal of selenium from potable water supplies. Prepared by V.J. Ciccone & Associates, Inc., for the Science and Technology Branch, Criteria and Standards Division, Office of Drinking Water, U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (1989). National primary and secondary drinking water regulations. Fed. Regist., 54(97): 22062.

U.S. EPA (1990a). The drinking water criteria document on selenium. Criteria and Standards Division, U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (1990b). Technologies for upgrading existing or designing new drinking water treatment facilities. U.S. Environmental Protection Agency, Washington, DC (EPA/625/4-89/023).

U.S. EPA (1990c). Environmental pollution control alternatives: drinking water treatment for small communities. U.S. Environmental Protection Agency, Washington, DC (EPA/625/5-90/025).

U.S. EPA (1991a). Selenium and compounds (CASRN 7782-49-2). Integrated Risk Information System, U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/iris/subst/0472.htm

U.S. EPA (1991b). Selenium sulfide (CASRN 7446-34-6). Integrated Risk Information System, U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/iris/subst/0458.htm

U.S. EPA (1991c). National primary drinking water regulations--synthetic organic chemicals and inorganic chemicals; Monitoring for unregulated contaminants; National primary drinking water regulations implementation; National secondary drinking water regulations final rule. Fed. Regist., 56(20): 3526.

U.S. EPA (1994). Method for the determination of metals in environmental samples; Supplement I. U.S. Environmental Protection Agency, Washington, DC (EPA/600/R-94/111).

U.S. EPA (1998). Small system compliance technology list for the non-microbial contaminants regulated before 1996. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA/815/R-98/002).

U.S. EPA (2003). Method 200.5 Rev 4.2. Determination of trace elements in drinking water by axially viewed inductively coupled plasma-atomic emission spectrometry. U.S. Environmental Protection Agency, Washington, DC (EPA-600/R-094-115).

U.S. EPA (2006). Inorganic contaminant accumulation in potable water distribution system. Prepared by HDR Engineering Inc. for the U.S. Environmental Protection Agency, Washington, DC (Contract No. 68-C-02-042; Work Assignment No. 1-06).

U.S. EPA (2009). Analytical feasibility support document for the second six-year review of existing National Primary Drinking Water Regulations. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA/815/B-09/003).

U.S. EPA (2010). National primary drinking water regulations; announcement of the results of EPA's review of existing drinking water standards and request for public comment and/or information of related issues. Fed. Regist., 75(104): 30401-30402. Available at: www.gpo.gov/fdsys/pkg/FR-2010-06-01/pdf/2010-12915.pdf

U.S. EPA (2011). Analytical methods approved for drinking water compliance monitoring of inorganic contaminants. U.S. Environmental Protection Agency, Washington, DC. Available at: http://water.epa.gov/scitech/drinkingwater/labcert/upload/methods_inorganic.pdf

U.S. EPA (2012). Basic information about selenium in drinking water. U.S. Environmental Protection Agency, Washington, DC. Available at: http://water.epa.gov/drink/contaminants/basicinformation/selenium.cfm

Valdiglesias, V., Pásaro, E., Méndez, J. and Laffon, B. (2009). In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review. Arch. Toxicol., 84(5): 337-351.

Vinceti, M., Nacci, G., Rocchi, E., Cassinadri, T., Vivoli, R., Marchesi, C. and Bergomi, M. (2000). Mortality in a population with long-term exposure to inorganic selenium via drinking water. J. Clin. Epidemiol., 53(10): 1062-1068.

Vinceti, M., Bonvicini, F., Rothman, K.J., Vescovi, L. and Wang, F. (2010). The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study. Environ. Health, 9: 77.

Vinson, J.A. and Bose, P. (1981). Comparison of the bio-availability of trace elements in inorganic salts, amino acid chelates and yeast. In: Mineral elements '80. Proceedings. Part II. A Nordic symposium on soil-plant-animal-man interrelationships and implications to human health, Helsinki, Finland. pp. 615-621. Available at: http://nutriadvisor.sportron.com/content/en/pdf/clin_trials/study006.pdf

Wang, L., Bonorden, M.J.L., Li, G., Lee, H., Hu, H., Zhang, Y., Liao, J.D., Cleary, M.P. and Lu, J. (2009). Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. Cancer Prev. Res. (Phila.), 2(5): 484-495.

Wastney, M.E., Combs, G.F., Canfield, W.K., Taylor, P.R., Patterson, K.Y., Hill, A.D., Moler, J.E. and Patterson, B.H. (2011). A human model of selenium that integrates metabolism from selenite and selenomethionine. J. Nutr., 141(4): 708-717.

Water Research Foundation (2012). Project 4191: The performance of non-leaded brass materials (project update available at www.waterrf.org/search/Results.aspx?k=4191).

Waters, D.J., Shen, S., Cooley, D.M., Bostwick, D.G., Qian, J., Combs, G.F., Jr., Glickman, L.T., Oteham, C., Schlittler, D. and Morris, J.S. (2003). Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate. J. Natl. Cancer Inst., 95(3): 237-241.

Waters, D.J., Shen, S., Glickman, L.T., Cooley, D.M., Bostwick, D.G., Qian, J., Combs, G.F., Jr., and Morris, J.S. (2005). Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model. Carcinogenesis, 26(7): 1256-1262.

Whanger, P.D. (1989). Selenocompounds in plants and their effects on animals. In: Toxicantsof plant origin. Vol. III. Proteins and amino acids. P.R. Cheeke (ed.). CRC Press, Boca Raton, Florida. pp. 141-167.

Whanger, P.D. (2002). Selenocompounds in plants and animals and their biological significance. J. Am. Coll. Nutr., 21(3): 223-232.

Whiting, R.F., Wei, L. and Stich, H.F. (1980). Unscheduled DNA synthesis and chromosome aberrations induced by inorganic and organic selenium compounds in the presence of glutathione. Mutat. Res., 78(2): 159-169.

WHO (2011). Selenium in drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization, Geneva, Switzerland. Available at: www.who.int/water_sanitation_health/dwq/chemicals/selenium.pdf

WHO and FAO (2004). Selenium. Chapter 10 in: Vitamin and mineral requirements in human nutrition. 2nd edition. World Health Organization, Geneva, Switzerland; and Food and Agriculture Organization of the United Nations, Rome, Italy. pp. 194-216. Available at: http://whqlibdoc.who.int/publications/2004/9241546123.pdf

Willett, W.C., Polk, B.F., Morris, J.S., Stampfer, M.J., Pressel, S., Rosner, B., Taylor, J.O., Schneider, K. and Hames, C.G. (1983). Prediagnostic serum selenium and risk of cancer. Lancet, 2(8342): 130-134.

Willhite, C.C., Hawkes, W.C., Omaye, S.T., Choy, W.N., Cox, D.N. and Cukierski, M.J. (1992). Absorption, distribution and elimination of selenium as L-selenomethionine in non-human primates. Food Chem. Toxicol., 30(11): 903-913.

Woutersen, R.A., Appel, M.J. and Van Garderen-Hoetmer, A. (1999). Modulation of pancreatic carcinogenesis by antioxidants. Food Chem. Toxicol., 37(9-10): 981-984.

Wright, P. and Bell, M. (1966). Comparative metabolism of selenium and tellurium in sheep and swine. Am. J. Physiol., 211(1): 6-10.

Wycherly, B.J., Moak, M.A. and Christensen, M.J. (2004). High dietary intake of sodium selenite induces oxidative DNA damage in rat liver. Nutr. Cancer, 48(1): 78-83.

Xia, Y., Hill, K.E., Byrne, D.W., Xu, J. and Burk, R.F. (2005). Effectiveness of selenium supplements in a low-selenium area of China. Am. J. Clin. Nutr., 81(4): 829-834.

Yan, L. and DeMars, L.C. (2012). Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. Int. J. Cancer, 131(6): 1260-1266.

Yang, D.Y. (1984). Keshan disease--endemic myocardial disease. Zhonghua Nei Ke Za Zhi, 23(7): 445-447.

Yang, G. and Zhou, R. (1994). Further observations on the human maximum safe dietary selenium intake in a seleniferous area of China. J. Trace Elem. Electrolytes Health Dis., 8(3-4): 159-165.

Yang, G.Q., Wang, S.Z., Zhou, R.H. and Sun, S.Z. (1983). Endemic selenium intoxication of humans in China. Am. J. Clin. Nutr., 37(5): 872-881.

Yang, G., Zhou, R., Yin, S., Gu, L., Yan, B., Liu, Y., Liu, Y. and Li, X. (1989a). Studies of safe maximal daily dietary selenium intake in a seleniferous area in China. I. Selenium intake and tissue selenium levels of the inhabitants. J. Trace Elem. Electrolytes Health Dis., 3(2): 77-87.

Yang, G., Yin, S., Zhou, R., Gu, L., Yan, B., Liu, Y. and Liu, Y. (1989b). Studies of safe maximal daily dietary Se-intake in a seleniferous area in China. Part II: Relation between Se-intake and the manifestation of clinical signs and certain biochemical alterations in blood and urine. J. Trace Elem. Electrolytes Health Dis., 3(3): 123-130.

Yoon, S.O., Kim, M.M. and Chung, A.S. (2001). Inhibitory effect of selenite on invasion of HT1080 tumor cells. J. Biol. Chem., 276(23): 20085-20092.

Yu, R.A., Yang, C.F. and Chen, X.M. (2006). DNA damage, apoptosis and C-myc, C-fos, and C-jun overexpression induced by selenium in rat hepatocytes. Biomed. Environ. Sci., 19(3): 197-204.

Zachara, B.A., Pawluk, H., Korenkiewicz, J. and Skok, Ź. (2001). Selenium levels in kidney, liver and heart of newborns and infants. Early Hum. Dev., 63(2): 103-111.

Zeng, H., Uthus, E.O., Ross, S.A. and Davis, C.D. (2009). High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver. Biol. Trace Elem. Res., 131(1): 71-80.

Zhang, J. and Spallholz, J.E. (2011). Toxicity of selenium compounds and nano-selenium particles. In: Handbook of systems toxicology. D. Casciano and S.C. Sahu (eds.). John Wiley & Sons, West Sussex, United Kingdom. pp. 787-801.

Zhang, P. and Sparks, D. (1990). Kinetics of selenate and selenite adsorption/desorption at the geothite/water interface. Environ. Sci. Technol. 24 pp. 1848-1856

Zhong, W. and Oberley, T.D. (2001). Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Cancer Res., 61(19): 7071-7078.

Zhou, Y., Zhang, S., Liu, C. and Cai, Y. (2009). The protection of selenium on ROS mediated-apoptosis (sic) by mitochondria dysfunction in cadmium-induced LLC-PK1 cells. Toxicol. In Vitro, 23(2): 288-294.

Zingaro, R.A., Dufner, D.C., Murphy, A.P. and Moody, C.D. (1997). Reduction of oxoselenium by iron (II) hydroxide. Environ. Int., 23(3): 299-304.

Zouboulis, A.I. and Katsoyiannis, I.A. (2005). Recent advances in the bioremediation of arsenic-contaminated groundwater. Environ. Int., 31: 213-219.

Zwolak, I. and Zaporowska, H. (2012). Selenium interactions and toxicity: a review. Cell Biol. Toxicol., 28(1): 31-46.

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