Health Science Publications
In this section you will find summaries of research projects recently completed by scientists and researchers within Health Canada. The results of federal research, aimed at protecting the health of Canadians and their environments, will contribute to evidence-based decision making, programs and/or policy. This site will be periodically updated with information on the latest research coming out of the Department.
Acoustics
- Chronic noise exposure in the spontaneously hypertensive rat
- Prevalence of hearing loss among Canadians aged 20 to 79: Audiometric results from the 2012/2013 Canadian Health Measures Survey
- Prevalence of hearing loss among a representative sample of Canadian children and adolescents, 3 to 19 years of age
- Wind turbine sound pressure level calculations at dwellings
- Wind turbine sound power measurements
- Estimating annoyance to calculated wind turbine shadow flicker is improved when variables associated with wind turbine noise exposure are considered
- Personal and situational variables associated with wind turbine noise annoyance
- Exposure to wind turbine noise: Perceptual responses and reported health effects
- Self-reported and measured stress responses associated with exposure to wind turbine noise
- Effects of Wind Turbine Noise on Self-Reported and Objective Measures of Sleep
- An assessment of quality of life using the WHOQOL-BREF among participants living in the vicinity of wind turbines
- Self-Reported and Objectively Measured Health Indicators among a Sample of Canadians Living within the Vicinity of Industrial Wind Turbines: Social Survey and Sound Level Modelling Methodology
- MP3 Player Listening Sound Pressure Levels among 10 to 17 year old Students
Air
- Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology
- Risk assessment for cardiovascular and respiratory mortality due to air pollution and synoptic meteorology in 10 Canadian cities
- Ambient particulate air pollution and acute lower respiratory infections: A systematic review and implications for estimating the global burden of disease
- Association of weather and air pollution interactions on daily mortality in 12 Canadian cities
- A case-control study of medium-term exposure to ambient nitrogen dioxide pollution and hospitalization for stroke
- Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome
- Ambient ozone concentrations and the risk of perforated and non-perforated appendicitis: A multicity case-crossover study
- Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring
- Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: An investigation of personal and indoor air sources
- Presence of other allergic disease modifies the effect of early childhood traffic-related air pollution exposure on asthma prevalence
- Comparison of remote sensing and fixed-site monitoring approaches for examining air pollution and health in a national study population
- Estimates of global mortality attributable to particulate air pollution using satellite imagery
- Estimation of the Arctic aerosols from local and long-range transport using relationships between 210Pb and 212Pb atmospheric activity concentrations
- Impact of Humidity on Speciation and Bioaccessibility of Pb, Zn, Co and Se in House Dust
- Analysis of Selected Phthalates in Canadian Indoor Dust Collected Using Household Vacuum and Standardized Sampling Techniques
- Mice Exposed In Situ to Urban Air Pollution Exhibit Pulmonary Alterations in Gene Expression in the Lipid Droplet Synthesis Pathways
- The Air Quality Health Index as a Predictor of Emergency Department Visits for Ischemic Stroke in Edmonton, Alberta
- A Cohort Study of Intra-Urban Variations in Volatile Organic Compounds and Mortality, Toronto, Canada
- Acute Changes in Lung Function Associated with Proximity to a Steel Plant: A Randomized Study
- Acute Effects of Ambient Ozone on Mortality in Europe and North America: Results from the APHENA Study
- Application of the Deletion/Substitution/Addition Algorithm to Selecting Land Use Regression Models for Interpolating Air Pollution Measurements in California
- Associations between Ambient Air Pollution and Daily Mortality among Elderly Persons in Montreal, Quebec
- Changing Air Mass Frequencies in Canada: Potential Links and Implications for Human Health
- Comparison of Geostatistical Interpolation and Remote Sensing Techniques for Estimating Long-Term Exposure to Ambient PM2.5 Concentrations Across the Continental United States
- Canadian House Dust Study: Population-Based Concentrations, Loads and Loading Rates of Arsenic, Cadmium, Chromium, Copper, Nickel, Lead, and Zinc inside Urban Homes
- Exposure to Air Pollution near a Steel Plant and Effects on Cardiovascular Physiology: A Randomized Crossover Study
- Residential Indoor and Outdoor Coarse Particles and Associated Endotoxin Exposures
- Urinary Polycyclic Aromatic Hydrocarbons as a Biomarker of Exposure to PAHS in Air: A Pilot Study among Pregnant Women
- Traffic-Related Air Pollution and Acute Changes in Heart Rate Variability and Respiratory Function in Urban Cyclists
- Windsor, Ontario Exposure Assessment Study: Design and Methods Validation of Personal, Indoor and Outdoor Air Pollution Monitoring
- Back-Extrapolation of Estimates of Exposure from Current Land-Use Regression Model
- Evaluation of Land-Use Regression Models Used to Predict Air Quality Concentrations in an Urban Area
- Buoyancy-Corrected Gravimetric Analysis of Lightly Loaded Filters
- Concentration Distribution and Bioaccessibility of Trace Elements in Nano and Fine Urban Airborne Particulate Matter: Influence of Particle Size
- Hepatic mRNA, microRNA, and miR-34a-Target Responses in Mice after 28 Exposure to Doses of Benzo(a)pyrene that Elicit DNA Damage and Mutation
- Spatial Distribution of Polycyclic Aromatic Hydrocarbons (Pahs) in an Urban Environment
- Germline Mutation Rates in Mice Following in Utero Exposure to Diesel Exhaust Particles by Maternal Inhalation
- Physical-Chemical and Microbiological Characterization, and Mutagenic Activity of Airborne Pm Sampled in A Biomass-Fueled Electrical Production Facility
Biotechnology
Chemicals
- Effects of Chronic Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants on the Reproductive and Thyroid System in Adult Male Rats
- Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform
- Size distribution effects of cadmium tellurium quantum dots (CdS/CdTe) immunotoxicity on aquatic organisms
- Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan
- Simultaneous determination of thirteen organophosphate esters in settled indoor house dust and a comparison between two sampling techniques
- Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3- one and 2-methyl-4-isothiazolin-3-one biocide formulation in Sprague-Dawley rats
- Correction and comparability of phthalate metabolite measurements of Canadian biomonitoring studies
- Incorporating New Technologies into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework
- Nationally Representative Levels of Selected Volatile Organic Compounds in Canadian Residential Indoor Air: Population-Based Survey
- In Vitro Dermal Absorption of Di(2-ethylhexyl) adipate (DEHA) in a Roll-On Deodorant Using Human Skin
- Implementation of the indoor air component of cycle 2 of the Canadian Health Measures Survey
- In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA
- Predictors of indoor BTEX concentrations in Canadian residences
- Soil ingestion rate determination in a rural population of Alberta, Canada practicing a wilderness lifestyle
- Transformation of 2,2',4,4'-tetrabromodiphenyl ether under UV irradiation: Potential sources of the secondary pollutants
- The Association between Urinary Phthalates and Lung Function
- Applicability of a high-throughput shotgun plasma protein screening approach in understanding maternal biological pathways relevant to infant birth weight outcome
- Effects of Jatropha oil on rats following 28-day oral treatment
- Determination of isoflavones in rat serum using liquid chromatography-tandem mass spectrometry with a highly efficient core-shell column
- Measurements of selected brominated flame retardants in nursing women: Implications for human exposure
- Toxicogenomic outcomes predictive of forestomach carcinogenesis following exposure to benzo(a)pyrene: Relevance to human cancer risk
- Exposure to Free and Conjugated Forms of Bisphenol A and Triclosan among Pregnant Women in the MIREC Cohort
- Phthalate and Bisphenol A Exposure among Pregnant Women in Canada - Results from the MIREC Study
- Hexachloronorbornene-Based Flame Retardants in Humans: Levels in Maternal Serum and Milk
- Thyroid Hormone Response Element Half-Site Organization and its Effect on Thyroid Hormone Mediated Transcription
- Bromodeoxyuridine (BrdU) Treatment to Measure Hepatocellular Proliferation Does Not Mask Furan-Induced Gene Expression Changes in Mouse Liver
- Differential Expression of Long Noncoding RNAs in the Livers of Female B6C3F1 Mice Exposed to the Carcinogen Furan
- Hepatic mRNA, microRNA, and miR-34a-Target Responses in Mice After 28 Days Exposure to Doses of Benzo(a)pyrene that Elicit DNA Damage and Mutation
- Identification of Thyroid Hormone Receptor Binding Sites in Developing Mouse Cerebellum
- Determination of Selected Perfluorinated Compounds and Polyfluoroalkyl Phosphate Surfactants in Human Milk
- Effects of Lactational and/or In Utero Exposure to Environmental Contaminants on the Glucocorticoid Stress-Response and DNA Methylation of the Glucocorticoid Receptor Promoter in Male Rats
- Cohort Profile: The Maternal-Infant Research on Environmental Chemicals (MIREC) Research Platform
- Phthalates in Cosmetic and Personal Care Products: Concentrations and Possible Dermal Exposure
- Thyroid Hormone-Regulated Gene Expression in Juvenile Mouse Liver: Identification of Thyroid Response Elements Using Microarray Profiling and in Silico Analyses
- Simultaneous Measurement of Benzo[A]Pyrene-Induced Pig-A and Lacz Mutations, Micronuclei And DNA Adducts in Muta Mouse
- Barhl1 is directly Regulated by Thyroid Hormone in the Developing Cerebellum of Mice
- Pulmonary Gene and Microrna Expression Changes in Mice Exposed to Benzo(A)Pyrene by Oral Gavage
- Assessment of Subclinical, Toxicant-Induced Hepatic Gene Expression Profiles after Low-Dose, Short-Term Exposures in Mice
- Polychlorinated Biphenyls (PCBS) Contamination and Aryl Hydrocarbon Receptor (AHR) Agonist Activity of Omega-3 Polyunsaturated Fatty Acid Supplements: Implications for Daily Intake of Dioxins and PCBS
- A Survey of the Traditional Food Consumption that may Contribute to Enhanced Soil Ingestion in a Canadian First Nation Community
- A Soil Ingestion Pilot Study of a Population Following a Traditional Lifestyle Typical of Rural or Wilderness Areas
Nanotechnology
- In Vitro Immunotoxicology of Quantum Dots and Comparison with Dissolved Cadmium and Tellurium
- Cadmium telluride quantum dot nanoparticle cytotoxicity and effects on model immune responses to Pseudomonas aeruginosa
- Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells
- Comparison of toxicity of uncoated and coated silver nanoparticles
- Critical Experimental Parameters Related to the Cytotoxicity of Zinc Oxide Nanoparticles
- Synthesis and Physicochemical Characterization of Mesoporous Nanoparticles
- Nanosilver Cytotoxicity in Rainbow Trout (Oncorhynchus mykiss) Erythrocytes and Hepatocytes
- Carbon Black Nanoparticle Instillation Induces Sustained Inflammation and Genotoxicity in Mouse Lung and Liver
- Pulmonary Response to Surface-Coated Nanotitanium Dioxide Particles Includes Induction of Acute Phase Response Genes, Inflammatory Cascades, and Changes in Micrornas: A Toxicogenomic Study
- Poly(Ethylene Imine) Nanocarriers do not Induce Mutations nor Oxidative DNA Damage In Vitro in Mutamouse Fe1 Cells
- Mutation Spectrum in Fe1-Muta™ Mouse Lung Epithelial Cells Exposed to Nanoparticulate Carbon Black
Radiation
- Cardiovascular Changes in Atherosclerotic ApoE-Deficient Mice Exposed to Co60 (?) Radiation
- Counting 241Am in the BfS Human Skull Phantom on Contact - Evaluation in the Human Monitoring Laboratory
- Managing Children during a Radiological or Nuclear Emergency - Canadian Perspectives
- Evaluation of the Annual Canadian Biodosimetry Network Intercomparisons
- Health Canada investigates radiation levels in food and the potential health effects resulting from food consumption.
- Multi-Parameter Dose Estimations in Radiation Biodosimetry Using the Automated Cytokinesis-Block Micronucleus Assay with Imaging Flow Cytometry
- A Report on Radioactivity Measurements of Fish Samples from the West Coast of Canada
- Analysis of Chromosome Damage for Biodosimetry Using Imaging Flow Cytometry
- Radioxenon Detections in the CTBT International Monitoring System Likely Related to the Announced Nuclear Test in North Korea on February 12, 2013
- Source Term Estimation of Radioxenon Released from the Fukushima Dai-ichi Nuclear Reactors Using Measured Air Concentrations and Atmospheric Transport Modeling
- A Gamma-Gamma Coincidence/Anticoincidence Spectrometer for Low-Level Cosmogenic 22Na/7Be Activity Ratio Measurement
Radon
- Indoor Radon Characteristics in Canadian Arctic Regions
- Results of Simultaneous Radon and Thoron Measurements in 33 Metropolitan Areas of Canada
- An Update on Thoron Exposure in Canada with Simultaneous 222Rn and 220Rn Measurements in Fredericton and Halifax
- Assessment of Radon Equilibrium Factor from Distribution Parameters of Simultaneous Radon and Radon Progeny Measurements
- Radon Exhalation from Building Materials for Decorative Use
Tobacco
- In vitro exposure to cigarette smoke induces oxidative stress in follicular cells of F1 hybrid mice
- IL-1 Receptor Regulates microRNA-135b Expression in a Negative Feedback Mechanism during Cigarette Smoke-Induced Inflammation
- A Global Toxicogenomic Analysis Investigating the Mechanistic Differences between Tobacco and Marijuana Smoke Condensates in vitro
- Mutagenicity of Smoke Condensates from Canadian Cigarettes with Different Design Features
- Assessment of Validity of Self-Reported Smoking Status
- Sidestream Tobacco Smoke is a Male Germ Cell Mutagen
- Genetic Toxicology and Toxicogenomic Analysis of Three Cigarette Smoke Condensates In Vitro Reveals Few Differences Among Full-Flavor, Blonde, and Light Products
- The Analysis of Mainstream Smoke Emissions Of Canadian 'Super Slim' Cigarettes
Water
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