Proposal to amend List A (List of certain antimicrobial active ingredients) – Proposed List A 2022

I. Proposed additions to List A

List A will be amended by inserting new antimicrobial active pharmaceutical ingredients and antibacterial classes listed below.

Proposed additions to List A

Drugs containing any of the following:	Including (but not limited to)
Aminoglycosides	Fortimicin
	Plazomicin
Beta-lactamase inhibitors	Durlobactam
	Enmetazobactam
	Nacubactam
	Relebactam
	Taniborbactam
	Zidebactam
Benzimidazoles	Ridinilazole
Benzofuran naphthyridines	Afabicin
Carbapenems	Benapenem
	Tebipenem pivoxil
Cephalosporins - fourth generation	Cefiderocol
Diketopiperazines	Bicyclomycin (Bicozamycin)
DNA polymerase inhibitors	Ibezapolstat
Fluoroquinolones	Alalevonadifloxacin
	Antofloxacin
	Aravofloxacin
	Balofloxacin
	Clinafloxacin
	Levonadifloxacin
	Zabofloxacin
Glycopeptides	Cefilavancin
	Norvancomycin
Ketolides	Nafithromycin
Monobactams	Ancremonam
Nitrofurans	Nitrofurazone
Nitroimidazoles	Morinidazole
Oxazolidinones	Contezolid
	Contezolid acefosamil
	Delpazolid
	Sutezolid
Penems	Sulopenem etzadroxil
Peptidomimetics	Brilacidin
	Murepavaidin
Pleuromutilins	Lefamulin
Quinolinols	Nitroxoline
Quinolones	Nemonoxacin
Spiropyrimidinetriones	Zoliflodacin
Sulfonamides	Sulfabenzamide
Tetracyclines - newer generations	Eravacycline
	Omadacycline
	Sarecycline
Therapeutic agents for tuberculosis	Clofazimine
	Delaminid
	Macozinone
	Perchlozone
	Pretomanid
	Telacebec
Triazaacenaphthylenes	Gepotidacin

II. Proposed revisions to existing antimicrobial active ingredients on List A

Proposed revisions to List A

Drugs containing any of the following:	Including (but not limited to)	Amendment (comments)
Aminoglycosides	Apramycin	Old drug (re-classify previously aminocyclitols)
	Hygromycin B	Old drug (re-classify previously aminocyclitols)