Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group

These substances were identified for action under the Chemicals Management Plan (CMP). This screening assessment focuses on 11 of 13 substances referred to collectively as the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group.

Summary of publications
Substance group CAS RN Common name DSL name Draft screening assessment Proposed conclusion on section 64 criteria Follow-up activities
Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group 106-02-5 Exaltolide Oxacyclohexadecan-2-one HTML Does not meet None planned at this time
109-29-5 Hexadecanolide Oxacycloheptadecan-2-one
502-72-7 Exaltone Cyclopentadecanone
541-91-3 Muskone/Muscone Cyclopentadecanone, 3-methyl-
542-46-1 Civetone 9-Cycloheptadecen-1-one, (Z)-
7779-50-2 Hexadecenlactone/
Ambrettolide
Oxacycloheptadec-7-en-2-one
28645-51-4 Isoambrettolide Oxacycloheptadec-10-en-2-one
37609-25-9 Musk amberol/Ambrettone 5-Cyclohexadecen-1-one
1335-94-0 Irone Irone
7779-30-8 1-Methyl-α-ionone 1-Penten-3-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-
108-94-1 Cyclohexanone Cyclohexanone
Timelines
Date Activity
May 2019 Anticipated publication of the final screening assessment.
May 19, 2018 Publication and start of 60-day public comment period on the draft screening assessment.  The related notice was published in the Canada Gazette, Part I: Vol. 152, No. 20.

Background

Two other substances, CAS RNs 8001-04-5 and 68140-48-7, were identified as being part of the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group at the outset of the third phase of the CMP. These substances were subsequently determined to be of low concern to both human health and the environment, through other approaches. Conclusions for these 2 substances are provided in the Screening Assessment for Substances Identified as Being of Low Concern using the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances.

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