Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group

These substances were identified for action under the Chemicals Management Plan (CMP).

• Summary of publications
• Timelines
• Background

Summary of publications

Substance group	CAS RN	Common name	DSL name	Public comment on the draft screening assessment name	Final screening assessment	Conclusion on section 64 criteria	Follow-up activities
Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group	106-02-5	Exaltolide	Oxacyclohexadecan-2-one	HTML	HTML	Does not meet	None planned at this time
	109-29-5	Hexadecanolide	Oxacycloheptadecan-2-one
	502-72-7	Exaltone	Cyclopentadecanone
	541-91-3	Muskone/Muscone	Cyclopentadecanone, 3-methyl-
	542-46-1	Civetone	9-Cycloheptadecen-1-one, (Z)-
	7779-50-2	Hexadecenlactone/ Ambrettolide	Oxacycloheptadec-7-en-2-one
	28645-51-4	Isoambrettolide	Oxacycloheptadec-10-en-2-one
	37609-25-9	Musk amberol/Ambrettone	5-Cyclohexadecen-1-one
	1335-94-0	Irone	Irone
	7779-30-8	1-Methyl-α-ionone	1-Penten-3-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-
	108-94-1	Cyclohexanone	Cyclohexanone

Timelines

Date	Activity
July 6 2019	Publication of the final screening assessment. The related notice was published in the Canada Gazette, Part I: Vol. 153, No. 27.
May 19, 2018	Publication and start of 60-day public comment period on the draft screening assessment.  The related notice was published in the Canada Gazette, Part I: Vol. 152, No. 20.

Background

These 11 substances, as well as 2 other substances (CAS RNs 8001-04-5 and 68140-48-7), were identified as being part of the Musks (macro/poly cyclic) Group at the outset of the third phase of the CMP. CAS RNs 8001-04-5 and 68140-48-7 were subsequently determined to be of low concern to both human health and the environment, through other approaches. Conclusions for these 2 substances are provided in the Final Screening Assessment for Substances Identified as Being of Low Concern using the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances. The remaining 11 substances are now referred to, under the CMP, as the Macrocyclic Lactones and Ketones, Ionones and Cyclohexanone Group.