Developmental Neurotoxicity Study (DNT) Guidance Document

Health Canada's Pest Management Regulatory Agency and the United States Environmental Protection Agency (USEPA) Office of Pesticide Programs and Office of Research and Development have co-operated on the development of a guidance document for the review and interpretation of submitted Developmental Neurotoxicity Study (DNT) data, which includes providing information on how to evaluate the quality, the conduct, and resulting data derived from the behavioral methods employed in the existing Organisation for Economic Co-operation and Development (OECD) and/or United States Environmental Protection Agency DNT Guidelines.

The North American Free Trade Agreement Technical Working Group (NAFTA TWG) DNT Guidance Document is intended for use by regulatory agency scientists in the three countries who are responsible for reviewing DNT data. The overall goal is to foster better and more consistent reviews of DNT behavioral data between all NAFTA signatory countries. This notwithstanding, the guidance may also be useful for other international regulatory agencies or those interpreting data generated under the auspices of the existing OECD or USEPA DNT Guidelines.

The NAFTA TWG Developmental Neurotoxicity Study (DNT) Guidance Document is currently available for download from the USEPA website.

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