Page 13: Guidelines for Canadian Drinking Water Quality: Guideline Technical Document – Benzene

Part II. Science and Technical Considerations - Continued

12.0 References

Abernathy, D.J., Kleymenova, E.V., Rose, J., Recio, L., and Faiola, B. (2004) Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone. Toxicol. Sci., 79: 82-89.

Adams, J.Q. and Clark, R.M. (1991) Evaluating the costs of packed-tower aeration and GAC for controlling selected organics. J. Am. Water Works Assoc., 83(1): 49-57.

Aelion, C.M. and Bradley, P.M. (1991) Aerobic biodegradation potential of subsurface microorganisms from a jet fuel-contaminated aquifer. Appl. Environ. Microbiol., 57: 57-63.

Al-Bastaki, N.M. (2003) Treatment of synthetic industrial wastewater with UV/TiO2 and RO using benzene as a model hydrocarbon. Desalination, 156(1): 193-197.

Alberta Department of Environment (2005) Personal communication with K. Pongar.

Allan, G. (1988) Experiences with treatment for volatile organic contaminants. J. N. Engl. Water Works Assoc., 101(1): 13-21.

Alther, G. (2002) Using organoclays to enhance carbon filtration. Waste Manage., 22(5): 507-513.

Aoyama, K. (1986) Effects of benzene inhalation on lymphocyte subpopulations and immune response in mice. Toxicol. Appl. Pharmacol., 85(1): 92-101.

APHA, AWWA, and WEF (2005) Standard methods for the examination of water and wastewater. 21st edition. American Public Health Association, American Water Works Association, and Water Environment Federation, Washington, DC.

ATSDR (2007) Toxicological profile for benzene. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA (www.atsdr.cdc.gov/toxprofiles/tp3.html).

AWWA (1991) Organics contaminant control committee report: existing VOC treatment installations; design, operation and cost. Water Quality Division, American Water Works Association, Denver, CO (Report No. 0033986).

Ball, B.R.and Edwards, M.D. (1992) Air stripping VOCs from groundwater: process design considerations. Environ. Prog., 11(1): 39-48.

Barbaro, J.R., Barker, J.F., Lemon, L.A., Gillham, R.W., and Mayfield, C.I. (1991) In situ cleanup of benzene in groundwater by employing denitrifying bacteria. Canadian Petroleum Products Institute, Ottawa, Ontario. 48 pp. (CPPI Report No. 91-6).

Bond, G.G., McLaren, E.A., Baldwin, C.L., and Cook, R.R. (1986) An update of mortality among chemical workers exposed to benzene. Br. J. Ind. Med., 43: 685-691.

Clark, R.M. and Adams, J.Q. (1991) Evaluation of BAT for VOCs in drinking water. J. Environ. Eng., 112(2): 247-268.

Clark, R.M., Fronk, C.A., and Lykins, B.W., Jr. (1988) Removing organic contaminants from groundwater: a cost and performance evaluation. J. Environ. Sci. Technol., 22(10): 1126-1130.

Clark, R.M., Miltner, R.J., Fronk, C.A., and Speth, T.F. (1990) Unit process research for removing volatile organic chemicals from drinking water: an overview. In: Ram, N.M., Christman, R.F., and Cantor, K.P. (eds.). Significance and treatment of volatile organic compounds in water supplies. Lewis Publishers, Chelsea, MI.

CPI (2003) CPI Product Profile for benzene. Camford Information Services Inc., Scarborough, Ontario.

Crittenden, J.C., Cortright, R.D., Rick, B., Tang, S., and Perram, D. (1988) Using GAC to remove VOCs from airstripper off-gas. J. Am. Water Works Assoc., 80(5): 73-84.

Crittenden, J.C., Suri, R.P.S., Perram, D.L., and Hand, D.W. (1997) Decontamination of water using adsorption and photocatalysis. Water Res., 31(3): 411-418.

Crittenden, J.C., Trussell, R.R., Hand, D.W., Howe, K.J., and Tchobanoglous, G. (2005) Water treatment: principles and design. 2nd edition. John Wiley & Sons, Hoboken, NJ.

Cronkite, E.P. (1986) Benzene hematotoxicity and leukemogenesis. Blood Cells, 12(1): 129-137.

Cronkite, E.P., Bullis, J., Inoue, T., and Drew, R.T. (1984) Benzene inhalation produces leukemia in mice. Toxicol. Appl. Pharmacol., 75: 358-361.

Cronkite, E., Drew, R., Inoue, T., and Bullis, J. (1985) Benzene hematotoxicity and leukemogenesis. Am. J. Ind. Med., 7: 447-456.

Cronkite, E.P., Drew, R.T., Inoue, T., Hirabayashi, Y., and Bullis, J.E. (1989) Hematotoxicity and carcinogenicity of inhaled benzene. Environ. Health Perspect., 82: 97-108.

Crump, K.S. and Allen, B.C. (1984) Quantitative estimates of risk of leukemia from occupational exposure to benzene. Prepared for the Occupational Safety and Health Administration, May (OSHA Docket H-059B, Exhibit 152).

Cummins, M.D. and Westrick, J.J. (1990) Treatment technologies and costs for removing volatile organic compounds from water: aeration. In: Ram, N.M., Christman, R.F., and Cantor, K.P. (eds.). Significance and treatment of volatile organic compounds in water supplies. Lewis Publishers, Chelsea, MI.

De Nardi, I.R., Varesche, M.B.A., Zalat, M., and Foresti, E. (2002) Anaerobic degradation of BTEX in a packed-bed reactor. Water Sci. Technol., 45(10): 175-180.

Dosemeci, M., Li, G.-L., Hayes, R.B., Yin, S.-N., Linet, M., Chow, W.-H., Wang, Y.Z., Jiang, Z.L., Dai, T.R., Zhang, W.U., Chao, X.-J., Ye, P.-Z., Kou, Q.-R., Fan, Y.-H., Zhang, X.-C., Lin, X.-F., Meng, J.-F., Zho, J.-S., Wacholder, S., Kneller, R., and Blot, W.J. (1994) Cohort study among workers exposed to benzene in China: II. Exposure assessment. Am. J. Ind. Med., 26(3): 401-411.

Dosemeci, M., Yin, S.N., Linet, M., Wacholder, S., Rothman, N., Li, G.-L., Chow, W.-H., Wang, Y.-Z., Jiang, Z.- L., Dai, T.-R., Zhang, W.-U., Chao, X.-J., Ye, P.-Z., Kou, Q.-R., Fan, Y.-H., Zhang, X.-C., Lin, X.-F., Meng, J.-F., Zho, J.-S., Blot, W.J., and Hayes, R.B. (1996) Indirect validation of benzene exposure assessment by association with benzene poisoning. Environ. Health Perspect., 104(Suppl. 6): 1343-1347.

Duarte-Davidson, R., Courage, C., Rushton, L., and Levy, L. (2001) Benzene in the environment: An assessment of the potential risks to the health of the population. Occup. Environ. Med., 58(1): 2-13.

Dyksen, J.E. (2005) Aeration and air stripping. In: Baruth, E. (ed.). Water treatment plant design. 4th edition. American Society of Civil Engineers and American Water Works Association (McGraw-Hill).

Dyksen, J.E., Racsko, R.F., and Cline, G.C. (1995) Operating experiences at VOC treatment facilities. In: Proceedings of the 1995 Annual American Water Works Association Conference. American Water Works Association, Denver, CO. pp. 659-684.

Eastmond, D.A., Rupa, D.S., and Hasegawa, L.S. (1994) Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes. Mutat. Res., 322(1): 9-20.

English, C.W. and Loehr, R.C. (1991) Degradation of organic vapors in unsaturated soils. J. Hazard. Mater., 28: 55-63.

Environment Canada (2001) Ambient air measurements of benzene in Canada (1989-1998). National Air Pollution Surveillance (NAPS) Network, Environment Canada, Ottawa, Ontario (www.etc-cte.ec.gc.ca/publications/naps/benzene1989-98_e.html).

Environment Canada and Health and Welfare Canada (1993) Canadian Environmental Protection Act Priority Substances List assessment report: Benzene. Minister of Supply and Services Canada, Ottawa, Ontario (www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-lsp1/benzene/index_e.html).

Farris, G.M., Everitt, J.I., Irons, R.D., and Popp, J.A. (1993) Carcinogenicity of inhaled benzene in CBA mice. Fundam. Appl. Toxicol., 20(4): 503-507.

Fishbein, L. (1984) An overview of environmental and toxicological aspects of aromatic hydrocarbons. 1. Benzene. Sci. Total Environ., 40: 189-218.

Fleming-Jones, M.E. and Smith, R.E. (2003) Volatile organic compounds in foods: A five year study. J. Agric. Food Chem., 51(27): 8120-8127.

Franz, T.J. (1975) Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol., 64: 190-195.

Franz, T.J. (1984) Percutaneous exposure of benzene. In: Advances in modern environmental toxicology. Vol. VI. Applied toxicology of petroleum hydrocarbons. Princeton Scientific Publishers, Princeton, NJ. pp. 61-70.

Fronk, C.A. (1987) Destruction of volatile organic contaminants in drinking water by ozone treatment. Ozone Sci. Eng., 9: 265-288.

Graedel, T.C. (1978) Chemical compounds in the atmosphere. Academic Press, New York, NY. p. 105.

Hayes, R.B., Yin, S.N., Dosemeci, M., Li, G.L., Wacholder, S., Chow, W.H., Rothman, N., Wang, Y.Z., Dai, T.R., Chao, X.J., Jiang, Z.L., Ye, P.Z., Zhao, H.B., Kou, Q.R., Zhang, W.Y., Meng, J.F., Zho, J.S., Lin, X.F., Ding, C.Y., Li, C.Y., Zhang, Z.N., Li, D.G., Travis, L.B., Blot, W.J., and Linet, M.S. (1996) Mortality among benzene-exposed workers in China. Environ. Health Perspect., 104(Suppl. 6): 1349-1352.

Hayes, R.B., Yin, S.N., Dosemeci, M., Li, G.L., Wacholder, S., Travis, L.B., Li, C.-Y., Rothman, N., Hover, R.N., and Linet, M.S. (1997) Benzene and the dose-related incidence of hematologic neoplasms in China. J. Natl. Cancer Inst., 89(14): 1065-1071.

Health Canada (1986) Benzene. In: Guidelines for Canadian Drinking Water Quality supporting documentation. Bureau of Chemical Hazards, Environmental Health Directorate, Health Canada, Ottawa, Ontario.

Health Canada (2005a) Benzene: unit risks based on animal data. Unpublished report. Biostatistics Unit, Healthy Environments and Consumer Safety Branch, Ottawa, Ontario.

Health Canada (2005b) Benzene: unit risks based on human data. Unpublished report. Biostatistics Unit, Healthy Environments and Consumer Safety Branch, Ottawa, Ontario.

Hoffmann, K., Krause, C., Seifert, B., and Ullrich, D. (2000) The German Environmental Survey 1990/92 (GerES II): Sources of personal exposure to volatile organic compounds. J. Expo. Anal. Environ. Epidemiol., 10: 115-125.

Holliday, M.G. and Englehardt, F.R. (1984) Benzene. A criteria review. Report prepared under contract to the Monitoring and Criteria Division, Department of National Health and Welfare, Ottawa, Ontario. March 30.

Howard, P.H., Boethling, R.S., Jarvis, W.F., Meylan, W.M., and Michalenko, E.M. (1991) Handbook of environmental degradation rates. Lewis Publishers, Chelsea, MI.

HSDB (2005) Benzene CASRN: 71-43-2. Hazardous Substances Data Bank. National Library of Medicine (http://toxnet.nlm.nih.gov/).

IARC (1982) Benzene. In: Some industrial chemicals and dyestuffs. International Agency for Research on Cancer, Lyon, France. pp. 93-148 (IARC Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Man, Volume 29).

IARC (1987) Benzene. In: Overall evaluations of carcinogenicity: An updating of IARC Monographs volumes 1-42. International Agency for Research on Cancer, Lyon, France. p. 120 (IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Supplement 7).

IPCS (1993) Benzene. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Environmental Health Criteria 150).

IRIS (2003) Benzene (CASRN 71-43-2). Carcinogenicity assessment for lifetime exposure. Integrated Risk Information System, U.S. Environmental Protection Agency (www.epa.gov/iris/subst/0276.htm).

Jaques, A.P. (1990) National inventory of sources and emissions of benzene (1985). Environment Canada (EPS 5/AP/1).

Jian, K. and Pintauro, P.N. (1997) Asymmetric PVDF hollow-fiber membranes for organic/water pervaporation. J. Memb. Sci., 135(1): 41-53.

Johansson, I. and Ingelman-Sundberg, M. (1988) Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res., 48: 5387-5390.

Kang, J.W., Park, H., Wang, R.Y., Koga, M., Kadokami, H.K., Lee, E., and Oh, S. (1997) Effect of ozonation for treatment of micropollutants present in drinking water source. Water Sci. Technol., 36(12): 229-307.

Keller, K.A. and Snyder, C.A. (1986) Mice exposed in utero to low concentrations of benzene exhibit enduring changes in their colony forming hematopoietic cells. Toxicology, 42: 171-181.

Keller, K.A. and Snyder, C.A. (1988) Mice exposed in utero to 20 ppm benzene exhibit altered numbers of recognizable hematopoietic cells up to seven weeks after exposure. Fundam. Appl. Toxicol., 10: 224-232.

Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B.A., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Il, G., Shen, M., Yin, S., and Rappaport, S.M. (2006) Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis, 27(4): 772-781.

Koffskey, W.E. and Brodtmann, N.V. (1983) Organic contaminant removal in Lower Mississippi River drinking water by granular activated carbon. Municipal Environmental Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH (EPA 600/2-83-032).

Krishnan, K. (2004) Development of a two tier approach for evaluating the relevance of multi-route exposures in establishing drinking water goals for volatile organic chemicals. Contract report prepared for Water Quality and Health Bureau, Safe Environments Programme, Health Canada, Ottawa, Ontario.

Lan, Q., Zhang, L., Il, G., Vermeulen, R., Weinburg, R.S., Dosemeci, M., Rappaport, S.M., Shen, M., Alter, B.P., Wu, Y., Kopp, W., Waidyanatha, S., Rabkin, C., Guo, W., Chanock, S., Hayes, R.B., Linet, M., Kim, S., Yin, S., Rothman, N., and Smith, M.T. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306: 1774-1776.

Li, G.L., Yin, S.N., Watanabe, T., Nakatsuka, H., Kasahara, M., Abe, H., and Ikeda, M. (1986) Benzene-specific increase in leukocyte alkaline phosphatase activity in rats exposed to vapors of various organic solvents. J. Toxicol. Environ. Health, 19(4): 581-589.

Lindstrom, A.B., Highsmith, V.R., Buckley, T.J., Pate, W.J., and Michael, L.C. (1994) Gasoline-contaminated groundwater as a source of residential benzene exposure: A case study. Government Reports Announcements & Index (Gra&I), Issue 23.

Love, T.O., Miltner, R.J., Eilers, R.G., and Fronk-Leist, C.A. (1983) Treatment of volatile organic compounds in drinking water. Municipal Environmental Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH.

Lubicki, P., Cross, J., Jayaram, S., Zhao, J.S., and Ward, O. (1997) Removal of nitrobenzene and volatile organic compounds using electron radiation. IEEE 1997 annual report. Conference on Electrical Insulation and Dielectric Phenomena, Minneapolis, MN, October 19-22. Institute of Electrical and Electronics Engineers, Inc.

Lykins, B.W., Jr. and Clark, R.M. (1994) U.S. drinking water regulations: treatment technologies and cost. Drinking Water Research Division, U.S. Environmental Protection Agency, Cincinnati, OH (EPA-600/J-94/381).

Lykins, B.W., Jr., Geldreich, E.E., Adams, J.Q., Ireland, J.C., and Clark, R.M. (1984) Granular activated carbon for removing nontrihalomethane organics from drinking water. Municipal Environmental Research Laboratory, Drinking Water Research Division, U.S. Environmental Protection Agency, Cincinnati, OH (EPA-600/2-84-165).

Lykins, B.W., Jr., Clark, R.M., and Fronk, C.A. (1988) Reverse osmosis for removing synthetic organics from drinking water: a cost and performance evaluation. In: AWWA 1988 Annual Conference Proceedings, Orlando, FL. American Water Works Association, Denver, CO. pp. 1433-1457.

Mackay, D., Shiu, W.Y., and Ma, K.C. (1992) Illustrated handbook of physical-chemical properties and environmental fate for organic chemicals. Volume 1. Lewis Publishers, Boca Raton, FL.

Maibach, H.I. and Anjo, D.M. (1981) Percutaneous penetration of benzene contained in solvents used in the rubber industry. Arch. Environ. Health, 36: 256-260.

Maltoni, C., Conti, B., and Scarnato, C. (1982) Squamous cell carcinomas of the oral cavity in Sprague-Dawley rats following exposure to benzene by inhalation. Med. Lav., 4: 446-450.

Maltoni, C., Conti, B., and Cotti, G. (1983) Benzene: a multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology. Am. J. Ind. Med., 4: 589-630.

Maltoni, C., Conti, B., Cotti, G., and Belpoggi, F. (1985) Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncology: current results and ongoing research. Am. J. Ind. Med., 7: 415-446.

Maltoni, C., Ciliberti, A., Cotti, G., Conti, B., and Belpoggi, F. (1989) Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ. Health Perspect., 82: 109-124.

Mathews, J.M., Etheridge, A.S., and Mathews, H.B. (1998) Dose-dependent metabolism of benzene in hamsters, rats and mice. Toxicol. Sci., 44: 14-21.

McKinnon, R.J. and Dyksen, J.E (1984) Removing organics from groundwater through aeration plus GAC. J. Am. Water Works Assoc., 76: 42-47.

McKone, T.E. and Knezovich, J.P. (1991) The transfer of trichloroethylene (TCE) from a shower to indoor air: experimental measurements and their implications. J. Air Waste Manage. Assoc., 41(6): 832-837.

Ministère du Développement durable, de l'Environnement et des Parcs du Québec (2005) Personal communication with C. Robert.

Najm, N.I., Snoeyink, V.L., Lykins, B.W., Jr., and Adams, J.Q. (1991) Using powdered activated carbon: A critical review. J. Am. Water Works Assoc., 83(1): 65-75.

Nakai, J.S., Chu, I., Li-Muller, A., and Aucoin, R. (1997) Effect of environmental conditions on the penetration of benzene through human skin. J. Toxicol. Environ. Health, 51(5): 447-462.

New Brunswick Department of Environment (2008) Personal communication with K. White.

Newfoundland and Labrador Department of Environment and Conservation (2005) Personal communication with M. Goebel.

Nomiyama, K. and Nomiyama, H. (1974) Respiratory retention, uptake and excretion of organic solvents in man. Int. Arch. Arbeitsmed., 32: 75-83.

Nova Scotia Department of the Environment (2005) Personal communication with J. MacDonald.

NSF/ANSI (2005) Section 7.2.4. In: Standard 58: Reverse osmosis drinking water treatment systems. NSF International and American National Standards Institute. pp. 29-30.

NSF/ANSI (2006) Section 7.2.4. In: Standard 53: Drinking water treatment units-health effects. NSF International and American National Standards Institute. pp. 39-40.

NTP (1986) Toxicology and carcinogenesis studies of benzene (PDF Version - 13.6 MB) (CAS No. 71-43-2) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, NC (Technical Report Series No. 289; NIH Publication No. 86-2545; http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr289.pdf).

NTP (2007) Toxicology and carcinogenesis study of benzene (CAS No. 71-43-2) in genetically modified haploinsufficient p16Ink4a/p19Arf mice (gavage study). National Toxicology Program, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, NC (NTP GMM 8; NIH Publication No. 08-4425; http://ntp.niehs.nih.gov/files/GMM8_web1.pdf).

OEHHA (1997) Draft hazard identification of the developmental and reproductive toxic effects of benzene. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA, September (www.oehha.ca.gov/prop65/hazard_ident/pdf_zip/benzene.pdf).

OEHHA (2001) Public health goal for benzene in drinking water. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA, June (www.oehha.ca.gov/water/phg/pdf/BenzeneFinPHG.pdf).

Ollis, D.F., Pelizzetti, E., and Serpone, N. (1991) Photocatalyzed destruction of water contaminants. Environ. Sci. Technol., 25(9): 1523-1529.

Ontario Ministry of the Environment (2008) Personal communication with S. Deshpande.

Parmley, R. (1988) Mammals. In: Rowley, A.F. and Ratcliffe, N.A. (eds.).Vertebrate blood cells. Cambridge University Press, Cambridge, U.K. pp. 337-424.

Paustenbach, D.J., Bass, R.D., and Price, P. (1993) Benzene toxicity and risk assessment, 1972-1992: implications for future regulation. Environ. Health Perspect., 101(Suppl. 6): 177-200.

Paxton, M.B., Chinchilli, V.M., Brett, S.M., and Rodericks, J.V. (1994) Leukemia risk associated with benzene exposure in the Pliofilm cohort: I. Mortality update and exposure distribution. Risk Anal., 14(2): 147-154.

Pekari, K., Vainiotalo, S., Heikkila, P., Palotie, A., Luotamo, M., and Riihimaki, V. (1992) Biological monitoring of occupational exposure to low levels of benzene. Scand. J. Work Environ. Health, 18(5): 317-322.

Peng, M., Vane, L.M., and Liu, S.X. (2003) Recent advances in VOCs removal from water by pervaporation. J. Hazard. Mater., 98(1): 69-90.

Perbellini, L., Faccini, G.B., Pasini, F., Cazzoli, F., Pistoia, S., Rosellini, R., Valsecchi, M., and Brugnone, F. (1988) Environmental and occupational exposure to benzene by analysis of breath and blood. Br. J. Ind. Med., 45: 345-352.

Rappaport, S.M., Waidyanatha, S., Yeowell-O'Connell, K., Rothman, N., Smith, M.T., Zhang, L., Qu, Q., Shore, R., Ii, G., and Yin, S. (2005) Protein adducts as biomarkers of human benzene metabolism. Chem.-Biol. Interact., 153-154: 103-109.

Rasmussen, R.A. and Khalif, M.A.K. (1983) Atmospheric benzene and toluene. Geophys. Res. Lett., 10(11): 1096-1099.

Rinsky, R., Young, R.J., and Smith, A.B. (1981) Leukemia in benzene workers. Am. J. Ind. Med., 2: 217-245.

Rinsky, R.A., Smith, A.B., Hornung, R., Filloon, T.G., Young, R.J., Okun, A.H., and Landrigan, P.J. (1987) Benzene and leukemia: an epidemiologic risk assessment. N. Engl. J. Med., 316: 1044-1050.

Robeck, G.G. and Love, O.T., Jr. (1983) Removal of volatile organic contaminants from groundwater. Municipal Environmental Research Laboratory, Drinking Water Research Division, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH (EPA-600/D-83-011).

Rosenberg, E. and Gutnick, D.L. (1981) The hydrocarbon-oxidizing bacteria. In: Starr, M.P., Stolp, H., Trüper, H.G., Balows, A., and Schlegel, H.G. (eds.). The prokaryotes: A handbook on habitats, isolation, and identification of bacteria. Volume 1. Springer-Verlag, Berlin, Germany.

Ross, D. (2000) The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J. Toxicol. Environ. Health, 61: 357-372.

Rothman, N., Li, G.-L., Dosemeci, M., Bechtold, W.E., Marti, G.E., Wang, Y.-Z., Linet, M., Xi, L.-Q., Lu, W., Smith, M.T., Titenko-Holland, N., Zhang, L.-P., Blot, W., Yin, S.-N., and Hayes, R.B. (1996a) Hematotoxicity among Chinese workers heavily exposed to benzene. Am. J. Med., 29(3): 236-246.

Rothman, N., Smith, M.T., Hayes, R.B., Li, G.-L., Irons, R.D., Dosemeci, M., Haas, R., Stillman, W.S., Linet, M., Xi, L.-Q., Bechtold, W.E., Wiemels, J., Campleman, S., Zhang, L., Quintana, P.J.E., Titenko-Holland, N., Wang, Y.-Z., Lu, W., Kolachana, P., Meyer, K.B., and Yin, S. (1996b) An epidemiological study of early biologic effects in Chinese workers. Environ. Health Perspect., 104(Suppl. 6): 1365-1370.

Rozen, M.G. and Snyder, C.A. (1985) Protracted exposure of C57BL/6 mice to 300 ppm benzene depresses B- and T-lymphocyte numbers and mitogen responses. Evidence for thymic and bone marrow proliferation in response to the exposures. Toxicology, 37(1-2): 13-26.

Rozen, M.G., Snyder, C.A., and Albert, R.E. (1984) Depressions in B- and T-lymphocyte mitogen-induced blastogenesis in mice exposed to low concentrations of benzene. Toxicol. Lett., 20(3): 343-349.

Rudolph, J., Jebsen, C., Khedim, A., and Johnen, F.J. (1984) Measurements of the latitudinal distribution of light hydrocarbons over the Atlantic. In: Physico-chemical behaviour of atmospheric pollutants. Proceedings of the 3rd European Symposium, Varese, Italy. D. Riedel Publishing Co., Dordrecht, Holland.

Rushton, R. and Romaniuk, H. (1997) A case-control study to investigate the risk of leukemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom. Occup. Environ. Med., 54: 152-166.

Sabourin, P.J., Chen, B.T., Lucier, G., Birnbaum, L.S., Fisher, E., and Henderson, R.F. (1987) Effect of dose on the absorption and excretion of [14C]benzene administered orally or by inhalation in rats and mice. Toxicol. Appl. Pharmacol., 87: 325-336.

Saskatchewan Department of Environment and Resource Management (2005) Personal communication with S. Ferris and P. Minifie.

SCC (2003) Accredited certification bodies. Standards Council of Canada (www.scc.ca/en/programs/ product_cert/accredited_clients.shtml).

Schnatter, A.R., Armstrong, T.W., Thompson, L.S., Nicolich, M.J., Katz, A.M., Huebner, W.W., and Pearlman, E.D. (1996) The relationship between low-level benzene exposure and leukemia in Canadian petroleum distribution workers. Environ. Health Perspect., 104(Suppl. 6): 1375-1379.

Sedran, M.A., Suidan, M.T., Venosa, A., and Pruden, A. (2003) Analysis of an aerobic fluidized bed reactor degrading MTBE and BTEX at reduced EBCTs. In: Proceedings of the American Water Works Association Annual Conference. American Water Works Association, Denver, CO. pp. 1-7.

Shih, T., Wangpaichitr, M., and Suffet, M. (2005) Performance and cost evaluations of synthetic resin technology for the removal of methyl tert-butyl ether from drinking water. J. Environ. Eng., 131(3): 450-460.

Singh, H.B. and Zimmerman, P.B (1992) Atmospheric distribution and sources of nonmethane hydrocarbons. Adv. Environ. Sci. Technol., 24: 177-235.

Slaine, D.D. and Barker, J.F. (1990) The detection of naturally occurring BTX during a hydrogeologic investigation. Ground Water Monit. Rev., 10: 89-94.

Smith, M.R. (1990) The biodegradation of aromatic hydrocarbons by bacteria. Biodegradation, 1: 191-206.

Smith, M.T. (1996) Mechanistic studies of benzene toxicity-implications for risk assessment. Adv. Exp. Med. Biol., 387: 259-266.

Smith, M.T. and Fanning, E.W. (1997) Report on the workshop entitled: "Modelling chemically induced leukemia-implications for benzene risk assessment." Leukemia Res., 21(5): 361-374.

Smith, M.T. and Zhang, L. (1998) Biomarkers of leukemia risk: benzene as a model. Environ. Health Perspect., 106(Suppl. 4): 937-946.

Smith, M.T., Zhang, L., Jeng, M., Wang, Y., Guo, W., Duramad, P., Hubbard, A.E., Hostadler, G., and Holland, N.T. (2000) Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis, 21(8): 1485-1490.

Snyder, C.A., Goldstein, B.D., Sellakumar, A., Wolman, S., Bromberg, I., Erlichman, M.N., and Laskin, S. (1978) Hematotoxicity of inhaled benzene to Sprague Dawley rats and AKR mice at 300 ppm. J. Toxicol. Environ. Health, 4: 605-618.

Snyder, C.A., Goldstein, B.D., Sellakumar, A.R., Bromberg, I., Laskin, S., and Albert, R.E. (1980) The inhalation toxicology of benzene: Incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57BL/6J mice. Toxicol. Appl. Pharmacol., 54: 323-331.

Snyder, C.A., Goldstein, B.D., Sellakumar, A.R., and Albert, R.E. (1984) Evidence for hematotoxicity and tumorigenesis in rats exposed to 100 ppm benzene. Am. J. Ind. Med., 5(6): 429-434.

Snyder, R. (2000) Recent developments in the understanding of benzene toxicity and leukemogenesis. Drug Chem. Toxicol., 23: 13-25.

Snyder, R. and Hedli, C.C. (1996) An overview of benzene metabolism. Environ. Health Perspect., 104(Suppl. 6): 1165-1171.

Snyder, R. and Kalf, G.F. (1994) A perspective on benzene leukemogenesis. Crit. Rev. Toxicol., 24(3): 177-209.

Sobrinho, J.A.H., Thiem, L.T., and Alkhatib, E.A. (1997) Benzene removal by PAC in jet flocculation system. J. Environ. Eng., 123(10): 1011-1018.

Speth, T.F. (1990) Removal of volatile organic compounds from drinking water by adsorption. In: Ram, N.M., Christman, R.F., and Cantor, K.P. (eds.). Significance and treatment of volatile organic compounds in water supplies. Lewis Publishers, Chelsea, MI.

Speth, T.F. and Miltner, R.J. (1990) Technical note: adsorption capacity of GAC for synthetic organics. J. Am. Water Works Assoc., 82(2): 72-75.

Stallings, R.L., Rogers, T.N., and Mullins, M.E. (1985) Air stripping of volatile organics. J. Inst. Environ. Sci. Technol. (IEST), 28(3): 28-31.

Stenzel, M.H. and Gupta, S.G. (1985) Treatment of contaminated groundwater using granular activated carbon and air stripping. J. Air Pollut. Control Assoc., 35: 1304-1309.

Stillman, W.S., Varella-Garica, M., Gruntmeier, J.J., and Irons, R.D. (1997) The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line. Leukemia (Basingstoke), 11(9): 1540-1545.

Subrahmanyam, V.V., Ross, D., Eastmond, D.A., and Smith, M.T. (1991) Potential role of free radicals in benzene induced myelotoxicity and leukemia. Free Radic. Biol. Med., 11: 495-515.

Susten, A.S., Dames, B.L., Burg, J.R., and Niemeier, R.W. (1985) Percutaneous penetration of benzene in hairless mice: an estimate of dermal absorption during tire-building operations. Am. J. Ind. Med., 7: 323-335.

Tatrai, E., Ungvary, G.Y., Hudak, A., Rodics, K., Loerincz, M., and Barcza, G.Y. (1980) Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats. J. Hyg. Epidemiol. Microbiol. Immunol., 24: 363-371.

Taylor, J., Chen, S.S., Mulford, L.A., and Norris, D. (2000) Flat sheet, bench and pilot testing for pesticide removal using reverse osmosis. American Water Works Association Research Foundation and American Water Works Association, Denver, CO (Report No. 90808).

Thomas, K.W., Pellizzari, E.D., Clayton, C.A., Perritt, R.L., Dietz, R.N., Goodrich, R.W., Nelson, W.C., and Wallace, L.A. (1993) Temporal variability of benzene exposures for residents in several New Jersey homes with attached garages or tobacco smoke. J. Expo. Anal. Environ. Epidemiol., 3(1): 49-73.

Tiburtius, E.R.L., Peralta-Zamora, P., and Emmel, A. (2005) Treatment of gasoline contaminated waters by advanced oxidation processes. J. Hazard. Mater., B126: 86-90.

Topudurti, K., Wojciechowski, M., Anagnostopoulos, S., and Eilers, R. (1998) Field evaluation of a photocatalytic oxidation technology. Water Sci. Technol., 38(7): 117-125.

Uragami, T., Yamada, H., and Miyata, T. (2001) Removal of dilute volatile organic compounds in water through graft copolymer membranes consisting of poly (alkylmethacrylate) and poly (dimethylsiloxane) by pervaporation and their membrane morphology. J. Memb. Sci., 187(1): 255-269.

U.S. EPA (1979) Environmental monitoring of benzene. Office of Toxic Substances,.U.S. Environmental Protection Agency, Washington, DC (EPA 560/679/006).

U.S. EPA (1985a) National primary drinking water regulations, volatile synthetic organic chemicals, proposed rule making. U.S. Environmental Protection Agency. Fed. Regist., 50(219): 46902.

U.S. EPA (1985b) Technologies and cost for removal of VOCs from potable water supplies. Science and Technology Branch, Criteria Standards Division, Office of Drinking Water, U.S. Environmental Protection Agency, Washington, DC (PB86-118213).

U.S. EPA (1990) Technologies and costs for the removal of synthetic organic chemicals from potable water supplies. Office of Drinking Water and Ground Water, Criteria and Standards Division, U.S. Environmental Protection Agency, Washington, DC (PB91-143438).

U.S. EPA (1991a) Technologies for upgrading existing or designing new drinking water treatment facilities. Center for Environmental Research Information, Office of Drinking Water, U.S. Environmental Protection Agency, Cincinnati, OH.

U.S. EPA (1991b) National primary drinking water regulations-synthetic organic chemicals and inorganic chemicals; final rule. U.S. Environmental Protection Agency. Fed. Regist., 56(30): 3526.

U.S. EPA (1995) Methods for the determination of organic compounds in drinking water-Supplement III. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC. August (EPA/600/R-95/131).

U.S. EPA (1998a) Small system compliance technology list for the non-microbial contaminants regulated before 1996. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-R-98-002).

U.S. EPA (1998b) Carcinogenic effects of benzene: An update. National Centre for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC (EPA/600/P- 97/001F).

U.S. EPA (2000) EPI Suite Version 3.11. U.S. Environmental Protection Agency (www.epa.gov/oppt/exposure/pubs/updates_episuite_v3.11.revised.htm).

U.S. EPA (2002a) National primary drinking water regulations; organic chemicals, sampling and analytical requirements. Code of Federal Regulations, 40 CFR Part 141, Section 141.24, Volume 19. U.S. Environmental Protection Agency. pp. 363-372.

U.S. EPA (2002b) Announcement of the results of EPA's six year review of existing drinking water standards and request for public comment. Code of Federal Regulations, 40 CFR Part 141. U.S. Environmental Protection Agency. Fed. Regist., 67(74): 19029-19090.

U.S. EPA (2003a) Analytical feasibility support document for the six year review of existing National Primary Drinking Water Regulations (reassessment of feasibility for chemical contaminants). Targeting and Analysis Branch, Standards and Risk Management Division, Office of Groundwater and Drinking Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-R-03-003).

U.S. EPA (2003b) Water treatment technology feasibility support document for chemical contaminants; in support of EPA six-year review of National Primary Drinking Water Regulations. Targeting and Analysis Branch, Standards and Risk Management Division, Office of Ground Water and Drinking Water, U.S. Environmental Protection Agency (EPA 815-R-03-004).

U.S. FDA (2006) Data on benzene in soft drinks and other beverages. Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration (www.cfsan.fda.gov/~dms/benzdata.html).

Vaishnav, D.D. and Babeu, L. (1987) Comparison of occurrence and rates of chemical biodegradation in natural waters. Bull. Environ. Contam. Toxicol., 39: 237-244.

Valentine, J.L., Lee, S.S.T., Seaton, M.J., Asgharian, B., Farris, G., Corton, J.C., Gonzalez, F.J., and Medinsky, M.A. (1996) Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol., 141(1): 205-213.

Wallace, L.A. (1987) The TEAM study: Summary and analysis. Volume 1. U.S. Environmental Protection Agency, Washington, DC (EPA 600/6-87/002a; NTIS PB 88-100060).

Wallace, L.A. (1989a) Major sources of benzene exposure. Environ. Health Perspect., 82: 165-169.

Wallace, L.A. (1989b) The exposure of the general population to benzene. Cell Biol. Toxicol., 5(3): 297-314.

Wallace, L. (1996) Environmental exposure to benzene: an update. Environ. Health Perspect., 104(Suppl. 6): 1129-1136.

Wallace, L., Pellizzari, E., and Gordon, S. (1993) A linear model relating breath concentrations to environmental exposures: application to a chamber study of four volunteers exposed to volatile organic chemicals. J. Expo. Anal. Environ. Epidemiol., 3(1): 75-102.

Ward, C.O., Kuna, R.A., Snyder, N.K., Alsaker, R.D., Coate, W.B., and Craig, P.H. (1985) Subchronic inhalation toxicity of benzene in rats and mice. Am. J. Ind. Med., 7(5-6): 457-473.

Weber, W.J. and Pirbazari, M. (1982) Adsorption of toxic and carcinogenic compounds from water. J. Am. Water Works Assoc., 74(4): 203-209.

Westberg, H., Sexton, K., and Flyckt, D. (1981) Hydrocarbon production and photochemical ozone formation in forest burn plumes. J. Air Pollut. Control Assoc., 31: 661-664.

Whelan, J.K., Tarafa, M.E., and Hunt, J.M. (1982) Volatile C1-C8 organic compounds in macroalgae. Nature, 299: 50-52.

Whittaker, H. and Szaplonczay, T. (1985) Reverse osmosis at the Gloucester landfill. In: Proceedings of the 2nd Annual Technical Seminar on Chemical Spills, Toronto, Ontario. Sponsored by Technical Services Branch, Environmental Protection Service, Environment Canada. pp. 141-161.

WHO (2004) Chemical aspects. In: Guidelines for drinking-water quality (PDF Version - 214 K). 3rd edition. Volume 1. World Health Organization, Geneva, Switzerland. p. 24 (www.who.int/water_sanitation_health/dwq/gdwq3_8.pdf).

Witz, G., Zhang, Z., and Goldstein, B.D. (1996) Reactive ring-opened aldehyde metabolites in benzene hematotoxicity. Environ. Health Perspect., 104(Suppl. 6): 1195-1199.

Wong, O. (1987) An industry-wide study of chemical workers occupationally exposed to benzene. Br. J. Ind. Med., 44: 382-395.

Yin, S.N., Li, G.L., Tain, F.D., Fu, Z.I., Jin, C., Chen, Y.J., Luo, S.J., Ye, P.Z., Zhang, J.Z., Wang, G.C., Zhang, X.-C., Wu, H.-N., and Zhong, Q.-C. (1987) Leukaemia in benzene workers: a retrospective cohort study. Br. J. Ind. Med., 44(2): 124-128.

Yin, S.-N., Linet, M.S., Hayes, R.B., Li, G.-L., Dosemeci, M., Wang, Y.-Z., Chow, W.H., Jiang, Z.L., Wacholder, S., Zhang, W.U., Dai, T.-R., Chao, X.-J., Zhang, X.-C., Ye, P.-Z., Kou, Q.-R., Meng, J.-F., Zho, J.-S., Lin, X.-F., Ding, C.-Y., Kneller, R., and Blot, W.J. (1994) Cohort study among workers exposed to benzene in China: I. General methods and resources. Am. J. Ind. Med., 26(3): 383-400.

Yin, S.-N., Hayes, R.B., Linet, M.S., Li, G.-L., Dosemeci, M., Travis, L.B., Li, C.Y., Zhang, Z.N., Li, D.G., Chow, W.H., Wacholder, S., Wang, Y.Z., Jiang, Z.L., Dai, T.R., Zhang, W.Y., Chao, X.J., Ye, P.Z., Kou, Q.R., Zhang, X.C., Lin, X.F., Meng, J.F., Ding, C.Y., Zho, J.S., and Blot, W.J. (1996) A cohort study of cancer among benzene-exposed workers in China: Overall results. Am. J. Ind. Med., 29(3): 227-235.

Yue, Z., Mangun, C., Economy, J., Kemme, P., Cropek, D., and Maloney, S. (2001) Removal of chemical contaminants from water to below USEPS MCL using fiber glass supported activated carbon filters. Environ. Sci. Technol., 35(13): 2844-2848.

Zhang, L., Venkatesh, P., Creek, M.L.R., and Smith, M.T. (1994) Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry. Mutat. Res., 320: 315-327.

Zhang, L., Rothman, N., Wang, Y., Hayes, R.B., Bechtold, W., Venkatesh, P., Yin, S., Wang, Y., Dosemeci, M., Li, G., Lu, W., and Smith, T. (1996) Interphase cytogenetics of workers exposed to benzene. Environ. Health Perspect., 104(Suppl. 6): 1325-1329.

Zhang, L., Rothman, N., Wang, Y., Hayes, R.B., Li, G., Dosemeci, M., Yin, S., Kolachana, P., Titenko-Holland, N., and Smith, M.T. (1998) Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis, 19(11): 1955-1961.

Zhu, J., Newhook, R., Marro, L., and Chan, C.C. (2005) Selected volatile organic compounds in residential air in the city of Ottawa, Canada. Environ. Sci. Technol., 39: 3964-3971.

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