Page 5: Guidelines for Canadian Drinking Water Quality: Guideline Technical Document - Nitrate and Nitrite

12.0 References

Agriculture and Agri-Food Canada (2010). Environmental sustainability of Canadian agriculture: Agri-Environmental Indicator Report Series--Report # 3. W. Eilers, R. MacKay, L. Graham and A. Lefebvre (eds.). Ottawa, Ontario. Available at: agriculture.canada.ca/resources/prod/doc/prog/pdf/asca-aedc_rep2010_eng.pdf

Addiscott, T.M. and Benjamin, N. (2004). Nitrate and human health. Soil Use Manage., 20(2): 98-104.

Alavantić, D., Sunjevarić, I., Cerović, G., Bozin, D. and Pecevski, J. (1988). In vivo genotoxicity of nitrates and nitrites in germ cells of male mice. II. Unscheduled DNA synthesis and sperm abnormality after treatment of spermatids. Mutat. Res., 204: 697-701.

Aly, H.A., Mansour, A.M., Abo-Salem, O.M., Abd-Ellah, H.F. and Abdel-Naim, A.B. (2010). Potential testicular toxicity of sodium nitrate in adult rats. Food Chem Toxicol. 48(2):572-8.

Anderson, L.M., Giner-Sorolla, A., Haller, I.M. and Budinger, J.M. (1985). Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure. Cancer Res., 45(8): 3561-3566.

Anderson, S., Pedersen, K.M., Bruun, N.H. and Laurberg, P. (2002). Narrow individual variations in serum T(4) and T(3) in normal subjects: A clue to the understanding of subclinical thyroid disease. J. Clin. Endocrinol. Metab. 87(3):1068-72. [cited in Miller et al., 2009].

Anderson, S., Bruun, N.H., Pedersen, K.M. and Laurberg, P. (2003). Biologic variation is important for interpretation of thyroid function tests. Thyroid 13(11):1069-78. [cited in Miller et al., 2009].

Andrews, A.W., Fornwald, J.A. and Lijinsky, W. (1980). Nitrosation and mutagenicity of some amine drugs. Toxicol. Appl. Pharmacol., 52(2): 237-244.

Andrews, D.A. and Harward, C. (1994). Isleham ion-exchange nitrate-removal plant.  J. Inst. Water Environ. Manage., 8(2): 12-127.

Aoki, Y., Belin, R.M., Clickner, R., Jeffries, R., Phillips, L. and Mahaffey, K.R. (2007). Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002). Thyroid, 17(12): 1211-1223.

Aoyagi, M., Matsukura, N. and Uchida, E. (1980). Induction of liver tumors in Wistar rats by sodium nitrite given in pellet diet. J. Natl. Cancer Inst., 65(2): 411-414.

APHA, American Water Works Association and Water Environment Federation (1992).  Standard methods for the examination of water and wastewater. 18th edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (1995). Standard methods for the examination of water and wastewater. 19th edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (1998). Standard methods for the examination of water and wastewater. 20th edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (2000). Standard methods for the examination of water and wastewater. Online edition. American Public Health Association, Washington, DC.

APHA, American Water Works Association and Water Environment Federation (2005). Standard methods for the examination of water and wastewater. 21st edition. American Public Health Association, Washington, DC.

Appelo, C.A.J. and Postma, C. (1996). Geochemistry, groundwater and pollution.A.A. Balkam Publishers, Rotterdam, Netherlands.

Arbuckle, T.E., Sherman, G.J., Corey, P.N., Walters, D. and Lo, B. (1988). Water nitrates and CNS birth defects: A population-based case-control study. Arch. Environ. Health, 43(2):162-7 :162-7.

Archer, M.C. (1989). Mechanisms of action of N-nitroso compounds. Cancer Surv., 8(2): 241-250.

Asahina, S., Friedman, M.A., Arnold, E., Millar, G.N., Mishkin, M., Bishop, Y. and Epstein, S.S. (1971). Acute synergistic toxicity and hepatic necrosis following oral administration of sodium nitrite and secondary amines to mice. Cancer Res., 31(9): 1201-1205.

Aschengrau, A., Zierler, S. and Cohen, A. (1989). Quality of community drinking water and the occurrence of spontaneous abortion. Arch. Environ. Health, 44(5): 283-290.

Aschengrau, A., Zierler, S. and Cohen, A. (1993). Quality of community drinking water and the occurrence of late adverse pregnancy outcomes. Arch. Environ. Health, 48(2): 105-113.

Astill, B.D. and Mulligan, L.T. (1977). Phenolic antioxidants and the inhibition of hepatotoxicity from N-dimethylnitrosamine formed in situ in the rat stomach. Food Cosmet. Toxicol., 15(3): 167-171.

ASTM (1997). D4327-97: Standard test method for anions in water by chemically suppressed ion chromatography. ASTM International, West Conshohocken, Pennsylvania.

ASTM (1999). D3867-99: Standard test methods for nitrite-nitrate in water. ASTM International, West Conshohocken, Pennsylvania.

ASTM (2003). D4327-03: Standard test method for anions in water by chemically suppressed ion chromatography. ASTM International, West Conshohocken, Pennsylvania.

ATSDR (2007). Case studies in environmental medicine nitrate/nitrite toxicity. Agency for Toxic Substances and Disease Registry, Centre for Disease Control, U.S. Department of Health and Human Services, Atlanta, GA. Available at: www.atsdr.cdc.gov/csem/nitrate/docs/nitrate_nitrite.pdf

Avery, A.A. (1999). Infantile methemoglobinemia: reexamining the role of drinking water nitrates. Environ. Health Perspect., 107(7): 583-586.

AWWA (1995). AWWA Manual M38 Electrodialysis and electrodialysis reversal. American Water Works Association, Denver, Colorado.

Balimandawa, M., de Meester, C. and Léonard, A. (1994). The mutagenicity of nitrite in the Salmonella/microsome test system. Mutat. Res., 321: 7-11.

Barale, R., Zucconi, D. and Loprieno, N. (1981). A mutagenicity methodology for assessing the formation of N-dimethylnitrosamine in vivo. Mutat. Res., 85(2): 57-70.

Baribeau, H. (2006). Chapter 6: Growth and inactivation of nitrifying bacteria. In: Fundamentals and control of nitrification in chloraminated drinking water distribution systems. Manual of Water Supply Practices M56. 1st edition. American Water Works Association, Denver, Colorado.

Baribeau, H. (2010). Chloramination issues: Overview of nitrification; AWWA Inorganic Contaminants Workshop, Denver, Colorado - March 2.

Barrett, J.H., Parslow, R.C., McKinney, P.A., Law, G.R. and Forman, D. (1998). Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes Control, 9(2): 153-159.

Bartholomew, B. and Hill, M.J. (1984). The pharmacology of dietary nitrate and the origin of urinary nitrate. Food Chem. Toxicol., 22(10): 789-795.

Bartsch, H., Ohshima, H. and Pignatelli, B. (1988). Inhibitors of endogenous nitrosation. Mechanisms and implications in human cancer prevention. Mutat. Res., 202(2): 307-324.

Bartsch, H., Ohshima, H., Pignatelli, B. and Calmels, S. (1989). Human exposure to endogenous N-nitroso compounds: quantitative estimates in subjects at high risk for cancer of the oral cavity, oesophagus, stomach and urinary bladder. Cancer Surv., 8(2): 335-362.

Bartsch, H., Ohshima, H., Shuker, D.E., Pignatelli, B. and Calmels, S. (1990). Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology. Mutat. Res., 238(3): 255-267.

Below, H., Zollner, H., Volzke, H. and Kramer, A. (2008). Evaluation of nitrate influence on thyroid volume of adults in a previously iodine-deficient area. Int. J. Hyg. Environ. Health, 211(1-2): 186-191.

Beresford, S.A.A. (1985). Is nitrate in the drinking water associated with the risk of cancer in the urban UK? Int. J. Epidemiol., 14(1): 57-63.

Beszedits, S. and Walker, L. (1998). Nitrate removal from drinking water supplies. B & L Information Services, Toronto, Ontario.

Bingham, S.A., Pignatelli, B., Pollock, J.R., Ellul, A., Malaveille, C., Gross, G., Runswick, S., Cummings, J.H. and O'Neill, I.K. (1996). Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis, 17(3): 515-523.

Blount, B.C., Pirkle, J.L., Osterloh, J.D., Valentin-Blasini, L. and Caldwell, K.L. (2006). Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ. Health Perspect., 114(12): 1865-1871.

Blount, B.C., Rich, D.Q., Valentin-Blasini, L., Lashley, S., Ananth, C.V., Murphy, E., Smulian, J.C., Spain, B.J., Barr, D.B., Ledoux, T., Hore, P. and Robson, M. (2009). Perinatal exposure to perchlorate, thiocyanate, and nitrate in New Jersey mothers and newborns. Environ. Sci. Technol., 43(19): 7543-7549.

Blowers, L., Preston-Martin, S. and Mack, W.J. (1997). Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA). Cancer Causes Control, 8(1): 5-12.

Bohdziewicz, J., Bodzek, M. and Wasik, E. (1999). The application of reverse osmosis and nanofiltration to the removal of nitrates from groundwater. Desalination, 121: 139-147.

Boink, A.B.T.J., Dormans, J.A.M.A., Speijers, G.J.A. and Vleeming, W. (1999). Effects of nitrates and nitrites in experimental animals. In: Managing risks of nitrates to humans and the environment. W.S. Wilson, A.S. Ball and R.H. Hinton (eds.). Royal Society of Chemistry, Cambridge. pp. 317-326.

Bolton, J.R. and Stefan, M.I. (2000). UV-photodegradation as a treatment technology for N-nitrosodimethylamine (NDMA). In: Proceedings of the American Water Works Association Water Quality and Technology Conference, Salt Lake City, UT, November 5-9, 2000. American Water Works Association, Denver, Colorado.

Bos, P.M.J., Van Den Brandt, P.A., Wedel, M. and Ockhuizen, T. (1988). The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load. Food Chem. Toxicol., 26(2): 93-97.

Brambilla, G. (1985). Genotoxic effects of drug/nitrite interaction products: evidence for the need of risk assessment. Pharmacol. Res. Commun., 17(4): 307-321.

Brambilla, G. and Martelli, A. (2005). Keynote comment: Nitrosatable drugs, cancer, and guidelines for genotoxicity. Lancet Oncol., 6(8): 538-539.

Brambilla, G. and Martelli, A. (2007). Genotoxic and carcinogenic risk to humans of drug-nitrite interaction products. Mutat. Res., 635(1): 17-52.

Brams, A., Buchet, J.P., Crutzen-Fayt, M.C., De Meester, C., Lauwerys, R. and Léonard, A. (1987). A comparative study, with 40 chemicals, of the efficiency of the Salmonella assay and the SOS chromotest (kit procedure). Toxicol. Lett., 38: 123-133.

Brender, J.D., Olive, J.M., Felkner, M., Suarez, L., Marckwardt, W. and Hendricks, K.A. (2004). Dietary nitrites and nitrates, nitrosatable drugs, and neural tube defects. Epidemiology, 15(3): 330-336.

Brown, J.L. (1999). N-Nitrosamines. Occup. Med., 14(4): 839-848.

Brunato, F., Garziera, M.G. and Briguglio, E. (2003). A severe methaemoglobinemia induced by nitrates: a case report. Eur. J. Emerg. Med., 10(4): 326-330.

Bruning-Fann, C.S. and Kaneene, J.B. (1993). The effects of nitrate, nitrite and N-nitroso compounds on human health: a review. Vet. Hum. Toxicol., 35(6): 521-538.

Budayová, E. (1985). Effects of sodium nitrite and potassium sorbate on in vitro cultured mammalian cells. Neoplasma, 32: 341-350.

Bukowski, J., Somers, G. and Bryanton, J. (2001). Agricultural contamination of groundwater as a possible risk factor for growth restriction or prematurity. J. Occup. Environ. Med., 43(4): 377-383.

Bunin, G.R., Kuijten, R.R., Boesel, C.P., Buckley, J.D. and Meadows, A.T. (1994). Maternal diet and risk of astrocytic glioma in children: a report from the Children's Cancer Group (United States and Canada). Cancer Causes Control, 5(2): 177-187.

Burkart, M.R. and Stoner, J.D. (2002). Nitrate in aquifers beneath agricultural systems. Wat Sci.and Technol. 45(9):19-29

Capen, C.C. (1997). Mechanistic data and risk assessment of selected toxic end points of the thyroid gland. Toxicol. Pathol., 25(1): 39-48.

Caron, M., Levallois, P., Gingras, S. and Phaneuf, D. (2004). Étude de la consommation d'eau dans la population adulte. Quebec City, Quebec.

Cartes, P., Jara, A., Domanet, R. and de la Luz, M. (2009). Urease activities and nitrogen mineralization kinetics as affected by temperature and urea input rate in southern Chilean andisols. J. Soil Sci. Plant Nutr., 9(1): 69-82.

Casu, A., Carlini, M., Contu, A., Bottazzo, G.F. and Songini, M. (2000). Type 1 diabetes in Sardinia is not linked to nitrate levels in drinking water. Diabetes Care, 23(7): 1043-1044.

Casey, B.M, Dashe, J.S., Wells, C.E., McIntire, D.D., Leveno, K.J. and Cunningham , F.G. (2006). Subclinical hyperthyroidism and pregnancy outcomes.  Obstet. Gynecol., 107(2 Pt 1):337-41.

CDC (1996). Spontaneous abortions possibly related to ingestion of nitrate-contaminated well water--LaGrange county, Indiana, 1991-1994. Centers for Disease Control and Prevention MMWR Morb. Mortal. Wkly. Rep., 45(26): 569-572.

CDC (1997). Methemoglobinemia attributable to nitrite contamination of potable water through boiler fluid additives--New Jersey, 1992 and 1996. Centers for Disease Control and Prevention MMWR Morb. Mortal. Wkly. Rep., 46(9): 202-204.

Cedergren, M.I., Selbing, A.J., Lofman, O. and Kallen, B.A. (2002). Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects. Environ. Res., 89(2): 124-130.

Cevaal, J.N., Suratt, W.B. and Burke, J.E. (1995). Nitrate removal and water quality improvements with reverse osmosis for Brighton, Colorado. Desalination, 103: 101-111.

Chambers, P.A., Guy, M., Roberts, E.S., Charlton, M.N., Kent, R., Gagnon, C., Grove, G. and Foster, N. (2001). Nutrients and their impact on the Canadian environment. Agriculture and Agri-Food Canada, Environment Canada, Fisheries and Oceans Canada, Health Canada and Natural Resources Canada, Ottawa, Ontario. 241 pp.

Chan, W.C. and Fong, Y.Y. (1977). Ascorbic acid prevents liver tumor production by aminopyrine and nitrite in the rat. Int. J. Cancer, 20(2): 268-270.

Chang, C.C., Tsai, S.S., Wu, T.N. and Yang, C.Y. (2010). Nitrates in municipal drinking water and non-Hodgkin lymphoma: an ecological cancer case-control study in Taiwan. J. Toxicol. Environ. Health Part A, 73(4): 330-338.

Charmandari, E., Meadows, N., Patel, M., Johnston, A. and Benjamin, N. (2001). Plasma nitrate concentrations in children with infectious and noninfectious diarrhea. J. Pediatr. Gastroenterol. Nutr., 32(4): 423-427.

Chébékoué, S.F. (2008). Évaluation du risque cancérigène associé à la contamination de l'eau potable de puits municipaux par les nitrates/nitrites dans certaines régions rurales du Québec. Faculty of Medicine, Université de Montréal, Montreal, Quebec. (Master's thesis)

Chebi, P.B. and Hamano, T. (1995). Pilot runs at Santa Ana watershed project authority using Asahi electrodialysis. Desalination, 103: 69-78.

Chen, H., Ward, M.H., Tucker, K.L., Graubard, B.I., McComb, R.D., Potischman, N.A., Weisenburger, D.D. and Heineman, E.F. (2002). Diet and risk of adult glioma in eastern Nebraska, United States. Cancer Causes Control, 13(7): 647-655.

Chen, Y.X., Zhang, Y. and Chen, G.-H. (2003). Appropriate conditions or maximizing catalytic reduction efficiency of nitrate into nitrogen gas in groundwater. Water Res., 37: 2489-2495.

Chi, J., Zhang, S-T., Lu, X., Dong, L-H. and Yao, S-L (2004). Chemical reduction of nitrate by metallic ions. Journal of Water Supply:  Research and Technology-Aqua 53(1):37-41.

Chiu, H,F., Tsai, S.S. and Yang, C.Y. (2007). Nitrate in drinking water and risk of death from bladder cancer: an ecological case-control study in Taiwan. J. Toxicol. Environ. Health Part A, 70 (12): 1000-1004.

Choi, B.C.K. (1985). N-Nitroso compounds and human cancer: a molecular epidemiologic approach. Am. J. Epidemiol., 121(5): 737.

Chow, C.K., Chen, C.J. and Gairola, C. (1980). Effect of nitrate and nitrite in drinking water on rats. Toxicol. Lett., 6(3): 199-206.

Clifford, D.A. (1990). Ion exchange and inorganic adsorption. Chapter 9. In: Water quality and treatment, Fred Pontius, ed. 4th Ed., pp. 561-639, McGraw Hill.

Clifford, D.A., Sorg, T.J. and Ghurye, G.L. (2011). Ion exchange and adsorption of inorganic contaminants. Chapter 12. In: Water quality and treatment - A handbook on drinking water, James K. Edzwald, ed. 6th Ed., McGraw-Hill.

Clifford, D. and Liu, C.X. (1995). A review of processes for removing nitrate from drinking water. In: Proceedings of the American Water Works Association Annual Conference, Anaheim, California. American Water Works Association, Denver, Colorado.

Clifford, D.A. (1999). Ion exchange and inorganic adsorption. In: Water quality and treatment--a handbook of community water supplies. R.D. Letterman, ed. 5th Ed. American Water Works Association and McGraw Hill, Inc., New York, New York. pp. 9.1-9.91.

Cocco, P., Broccia, G., Aru, G., Casula, P., Muntoni, S., Cantor, K.P. and Ward, M.H. (2003). Nitrate in community water supplies and incidence of non-Hodgkin's lymphoma in Sardinia, Italy. J. Epidemiol. Community Health, 57(7): 510-511.

Cohn, P., Cox, M. and Berger, P. (1999). Health and aesthetic aspects of water quality. In: Water quality and treatment--a handbook of community water supplies. R.D. Letterman, ed. 5th Ed. American Water Works Association and McGraw-Hill, New York, New York.

Cortas, N.K. and Wakid, N.W. (1991). Pharmacokinetic aspects of inorganic nitrate ingestion in man. Pharmacol. Toxicol., 68(3): 192-195.

Coss, A., Cantor, K.P., Reif, J.S., Lynch, C.F. and Ward, M.H. (2004). Pancreatic cancer and drinking water and dietary sources of nitrate and nitrite. Am. J. Epidemiol., 159(7): 693-701.

Craun, G.F., Greathouse, D.G. and Gunderson, D.H. (1981). Methaemoglobin levels in young children consuming high nitrate well water in the United States. Int. J. Epidemiol., 10(4): 309-317.

Crespi, M. and Ramazzotti, V. (1991). Evidence that N-nitroso compounds contribute to the causation of certain human cancers. In: Nitrate contamination: exposure, consequence, and control. I. Bogárdi, R.D. Kuzelka and W.G. Ennenga (eds.). Springer-Verlag, New York, New York. pp. 233-252.

Croen, L.A., Todoroff, K. and Shaw, G.M. (2001). Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects. Am. J. Epidemiol., 153(4): 325-331.

Crofton, K.M. (2008). Thyroid disrupting chemicals: mechanisms and mixtures. Int. J. Androl., 31(2): 209-223.

Crofton, K.M., Craft, E.S., Hedge, J.M., Gennings, C., Simmons, J.E., Carchman, R.A., Carter, W.H., Jr and DeVito, M.J. (2005). Thyroid-hormone-disrupting chemicals: Evidence for dose-dependent additivity or synergism. Environ Health Perspect 113(11):1549-54.

Cross, A.J., Pollock, J.R. and Bingham, S.A. (2003). Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Res., 63(10): 2358-2360.

Cunliffe D.A. (1991). Bacterial nitrification in chloraminated water supplies. Applied and Environmental Microbiology pp, 3399-3202.

Dahab, M.F. (1991). Nitrate treatment methods: an overview. In: Nitrate contamination: exposure, consequence, and control. I. Bogárdi, R.D. Kuzelka and W.G. Ennenga (eds.). Springer-Verlag, New York, New York. pp. 349-368.

Dahlquist, G.G., Blom, L.G., Persson, L.A., Sandstrom, A.I. and Wall, S.G. (1990). Dietary factors and the risk of developing insulin dependent diabetes in childhood. Br. Med. J., 300(6735): 1302-1306.

Darad, R., De, A.K. and Aiyar, A.S. (1983). Toxicity of nitrite and dimethylamine in rats. Toxicol. Lett., 17(1-2): 125-130.

De Escobar, G.M., Ares, S., Berbel, P., Obregón, M.J. and del Rey, F.E. (2008). The changing role of maternal thyroid hormone in fetal brain development. Semin Perinatol., 32:380-6.

De Groef, B., Decallonne, B.R., Van der Geyten, S., Darras, V.M. and Bouillon, R. (2006). Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. Eur. J. Endocrinol., 155(1): 17-25.

De Roos, A.J., Ward, M.H., Lynch, C.F. and Cantor, K.P. (2003). Nitrate in public water supplies and the risk of colon and rectum cancers. Epidemiology, 14(6): 640-649.

Department of National Health and Welfare (1993). Water treatment principles and applications. A manual for the production of drinking water. Published by the Canadian Water and Wastewater Association in cooperation with the Communication Group, Ottawa, Ontario.

DeSimone, L.A. (2009). Quality of water from domestic wells in principal aquifers of the United States, 1991-2004: U.S. Geological Survey Scientific Investigations Report 2008-5227, 139 pp. Available at: http://pubs.usgs.gov/sir/2008/5227

DeVito, M., Biegel, L., Brouwer, A., Brown, S., Brucker-Davis, F., Cheek, A.O., Christensen, R., Colborn, T., Cooke, P., Crissman, J. et al. (1999). Screening methods for thyroid hormone disruptors. Environ Health Perspect 107(5):407-15. [cited in Miller et al., 2009].

Dietrich, M., Block, G., Pogoda, J.M., Buffler, P., Hecht, S. and Preston-Martin, S. (2005). A review: Dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors. Cancer Causes Control, 16(6): 619-635.

Doel, J.J., Benjamin, N., Hector, M.P., Rogers, M. and Allaker, R.P. (2005). Evaluation of bacterial nitrate reduction in the human oral cavity. Eur. J. Oral Sci., 113(1): 14-19.

Dordelmann, O. (2009). Full-scale biological denitrification plants in Germany, Austria and Poland. In: Proceedings of the AWWA Water Quality and Technology Conference, Seattle, WA. American Water Works Association, Denver, Colorado.

Dorsch, M.M., Scragg, R.K., McMichael, A.J., Baghurst, P.A. and Dyer, K.F. (1984). Congenital malformations and maternal drinking water supply in rural South Australia: a case-control study. Am. J. Epidemiol., 119(4): 473-486.

Drewes, J., Bellona, C.L., Xu, P., Amy, G. and Oelker, G. (2008). Comparing nanofiltration and reverse osmosis for treating recycled water. American Water Works Association Research Foundation, Denver, Colorado.

Druckrey, H., Preussmann, R., Ivankovic, S. and Schmahl, D. (1967). [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats.] Z. Krebsforsch., 69(2): 103-201 (in German).

Drury, C.F., Yang, J.K., De Jong, R., Yang, X.M., Huffman, E.C., Kirkwood, V. and Reid, K. (2007). Residual soil nitrogen indicator for agricultural land in Canada. Can. J. Soil Sci., 87: 167-177.

Dubrovsky, N. and Hamilton, P. (2010). Nutrients in the nation's streams and groundwater: national findings and implications. U.S. Geological Survey, Reston, Virginia (Fact Sheet 2010-3078; pubs.usgs.gov/fs/2010/3078/).

Dubrovsky, N.M., Burow, K.R., Clark, G.M., Gronberg, J.M., Hamilton P.A., Hitt, K.J., Mueller, D.K., Munn, M.D., Nolan, B.T., Puckett, L.J., Rupert, M.G., Short, T.M., Spahr, N.E., Sprague, L.A. and Wilber, W.G. (2010). The quality of our nation's waters--Nutrients in the nation's streams and groundwater, 1992-2004: U.S. Geological Survey, Reston, Virginia. Circular 1350, 174 pp.

Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M. and Benjamin, N. (1995). Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat. Med., 1(6): 546-551.

Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., Kelly, D., Golden, M., Benjamin, N. and Leifert, C. (1997). Protection against oral and gastrointestinal diseases: importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. Comp. Biochem. Physiol. A Physiol., 118(4): 939-948.

Duranceau, S. (2001). Selection of a nitrate removal process for the City of Seymour, Texas. In: Membrane practices for water treatment. S. Duranceau (ed.). American Water Works Association, Denver, Colorado.

ECETOC (1988). Nitrate and drinking water. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels (Technical Report No. 27).

Ecobichon, D.J., Allen, M. and Hicks, R (1985). The contamination of groundwater by agrochemicals as determined by a well water quality study in Carleton County: a report, 1984-1985. New Brunswick Department of Health, Fredericton, June.

Edwards, G., Whong, W.Z. and Speciner, N. (1979). Intrahepatic mutagenesis assay: a sensitive method for detecting N-nitrosomorpholine and in vivo nitrosation of morpholine. Mutat. Res., 64(6): 415-423.

Edwards, M. and Dudi, A. (2004). Role of chlorine and chloramines in corrosion in lead-bearing plumbing materials. J. Am. Water Works Assoc., 96(10): 69.

EFSA (2008). Opinion of the Scientific Panel on Contaminants in the Food chain on a request from the European Commission to perform a scientific risk assessment on nitrate in vegetables. European Food Safety Authority. Available at: www.efsa.europa.eu/en/efsajournal/doc/contam_ej_689_nitrate_en.pdf.

Egboka, B.C.E. (1984). Nitrate contamination of shallow groundwaters in Ontario, Canada. Sci. Total Environ., 35: 53.

Eisenbrand, G., Spiegelhalder, B. and Preussmann, R. (1980). Nitrate and nitrite in saliva. Oncology, 37(4): 227-231.

El Nahas, S.M., Globus, M. and Vethamany-Globus, S. (1984). Chromosomal aberrations induced by sodium nitrite in bone marrow of adult rats and liver cells of transplacentally exposed embryos. J. Toxicol. Environ. Health, 13: 643-647.

Elhannouni, F., Belhadj, M., Taky, M., Echihabi, L., Hafsi, M., El Abbassi, H., Cherif, A.T. and El Midaoui, A. (2000). Denitrification of ground water by electrodialysis using a new anion exchange membrane. Water Supply Res. Technol.-Aqua, 49(4): 211-218.

Elmidaoui, A., Menkouchi Sahli, M.A., Takaikt, M., Chay, L., Taky, M., Elmghair, M. and Hafsi, M. (2002). Selective nitrate removal by coupling electrodialysis and a bioreactor. Desalination, 153: 389-397.

Environment Canada (1992). National Air Pollution Surveillance (NAPS) annual summary 1990. Environmental Protection Service, Environment Canada, Ottawa, Ontario (Report EPS 7/AP/23).

Environment Canada (2003). Canadian water quality guidelines for the protection of aquatic life: nitrate ion. National Guidelines and Standards Office, Water Policy and Coordination Directorate, Environment Canada. 115 pp. (Ecosystem Health: Science-based Solutions Report No. 1-6; dsp-psd.pwgsc.gc.ca/Collection/En1-34-6-2003E.pdf).

Environment Canada (2010). Trends in nitrate ion. Cooperation on emission inventories, trends, and mapping. 1 p. Available at: www.ec.gc.ca/pcmar%2Dcabmp/default.asp?lang=en&n=ACBFF19F-1.

Environment New Brunswick (1983). Chemistry of municipal water supplies in New Brunswick. Environment New Brunswick, Fredericton (Internal Report D83-01).

Ericson, A., Kallen, B. and Lofkvist, E. (1988). Environmental factors in the etiology of neural tube defects: a negative study. Environ. Res., 45: 38-47.

Eskandari S, Loo DD, Dai G, Levy O, Wright EM and Carrasco N. (1997). Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. J Biol Chem.  272(43):27230-8.

Eskiocak, S., Dundar, C., Basoglu, T. and Altaner, S. (2005). The effects of taking chronic nitrate by drinking water on thyroid functions and morphology. Clin. Exp. Med., 5(2): 66-71.

Fan, A.M. and Steinberg, V.E. (1996). Health implications of nitrate and nitrite in drinking water: an update on methemoglobinemia occurrence and reproductive and development toxicity. Regul. Toxicol. Pharmacol., 23(1 Pt 1): 35-43.

Fan, A.M., Willhite, C.C. and Book, S.A. (1987). Evaluation of the nitrate drinking water standard with reference to infant methemoglobinemia and potential reproductive toxicity. Regul. Toxicol. Pharmacol., 7(2): 135-148.

FAO/WHO (2003a). Nitrate (and potential endogenous formation of N-nitroso compounds). Food and Agriculture Organisation of the United Nations/World Health Organization, Geneva (WHO Food Additive Series 50). Available at: www.inchem.org/documents/jecfa/jecmono/v50je06.htm

FAO/WHO (2003b). Nitrite (and potential endogenous formation of N-nitroso compounds). Food and Agriculture Organisation of the United Nations/World Health Organization, Geneva (WHO Food Additive Series 50). Available at: www.inchem.org/documents/jecfa/jecmono/v50je05.htm

FDA (1980a). Evaluation of the MIT nitrite feeding study to rats. Report by the Interagency Working Group on Nitrite Research. Food and Drug Administration, Public Health Service, U.S. Department of Health and Human Services, Washington, DC.

FDA (1980b). Re-evaluation of the pathology findings of studies on nitrite and cancer: histologic lesions in Sprague-Dawley rats. Final report submitted by the Universities Associated for Research and Education in Pathology to the Food and Drug Administration, Public Health Service, U.S. Department of Health and Human Services, washington, DC.

Fewtrell, L. (2004). Drinking-water nitrate, methemoglobinemia, and global burden of disease: a discussion. Environ. Health Perspect., 112(14): 1371-1374.

Finan, A., Keenan, P., Donovan, F.O., Mayne, P. and Murphy, J. (1998). Methaemoglobinaemia associated with sodium nitrite in three siblings. Br. Med. J., 317(7166): 1138-1139.

Fitzgerald, D., Kiely, D.A., Neilson, R.D., Shaw, S., Audette, R.J., Prior, M., Ashton, E. and Allison, E. (1997). Alberta farmstead water quality survey. Prepared for CAESA Water Quality Monitoring Committee. Alberta Agriculture, Food and Rural Development, Prairie Farm Rehabilitation Administration and Alberta Health. Edmonton, Alberta. 50 pp.

Fitzgerald, D., Chanasuk, D., Neilson, D., Kiely, D. and Audette, R. (2001). Farm well water in Alberta. Water Qual. Res. J. Can., 36(3): 565-585.

Fletcher, I.J., Woodward, A.J. and Henwood, N.G. (1991). Design and construction of an ion-exchange denitrification plant in south Staffordshire.  J. Inst. Water Environ. Manage., 5(5): 566-572.

Fong, L.Y., Wong, F.W. and Chan, W.C. (1980). Do chronic urinary tract infections induce cancer in the rat fed nitrate and aminopyrine? IARC Sci. Publ., 31: 693-704.

Food Safety Network (2010). Nitrites/nitrates. In: Preservatives. Food Safety Network, University of Guelph, Guelph, Ontario. 3 pp. Available at: www.uoguelph.ca/foodsafetynetwork/preservatives

Forman, D., Al-Dabbagh, S. and Doll, R. (1985). Nitrates, nitrites and gastric cancer in Great Britain. Nature, 313(6004): 620-625.

Forman, D., Al-Dabbagh, S., Knight, T. and Doll, R. (1988). Nitrate exposure and the carcinogenic process. Ann. N. Y. Acad. Sci., 534: 597-603.

Forrest, F., Rodvang, J., Reedyk, S. and White, J. (2006). A survey of nutrients and major ions in shallow groundwater of Alberta's agricultural areas. Prepared for the Prairie Farm Rehabilitation Administration Rural Water Program, Project Number:4590-4-20-4. Alberta Agriculture, Food and Rural Development, Edmonton, Alberta. 116 pp.

Freedman, D.M., Cantor, K.P., Ward, M.H. and Helzlsouer, K.J. (2000). A case-control study of nitrate in drinking water and non-Hodgkin's lymphoma in Minnesota. Arch. Environ. Health, 55(5): 326-329.

Friedman, M.A. and Staub, J. (1976). Inhibition of mouse testicular DNA synthesis by mutagens and carcinogens as a potential simple mammalian assay for mutagenesis. Mutat. Res., 37(1): 67-76.

Friedman, M.A., Millar, G., Sengupta, M. and Epstein, S. (1972). Inhibition of mouse liver protein and nuclear RNA synthesis following combined oral treatment with sodium nitrite and dimethylamine or methylbenzylamine. Experientia, 28(1): 21-23.

Fristachi, A. and Rice, G. (2007). Estimation of the total daily oral intake of NDMA attributable to drinking water. J. Water Health, 5(3): 341-355.

Fritsch, P., de Saint Blanquat, G. and Klein, D. (1985). Excretion of nitrates and nitrites in saliva and bile in the dog. Food Chem. Toxicol., 23(7): 655-659.

Furukawa, F., Nishikawa, A., Ishiwata, H., Takahashi, M., Hayashi, Y. and Hirose, M. (2000). Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats. Jpn. J. Cancer Res., 91(2): 139-147.

Gangolli, S.D., Van Den Brandt, P.A., Feron, V.J., Janzowsky, C., Koeman, J.H., Speijers, G.J.A., Spiegelhalder, B., Walker, R. and Wishnok, J.S. (1994). Nitrate, nitrite and N-nitroso compounds. Eur. J. Pharmacol., 292(1): 1-38.

Garcia, H. and Lijinsky, W. (1973). Studies of the tumorigenic effect in feeding of nitrosamino acids and of low doses of amines and nitrite to rats. Z. Krebsforsch. Klin. Onkol. Cancer Res. Clin. Oncol., 79(3): 141-144.

Gatehouse, D.G. and Tweats, D.J. (1982). Mutagen formation after the addition of nitrite to normal human gastric juice. Carcinogenesis, 3(5): 597-598.

Gatseva, P. and Dimitrov, I. (1997). Population morbidity in a community with nitrate contamination of drinking water. Folia Med (Plovdiv), 39(4): 65-71.

Gatseva, P., Vladeva, S. and Pavlov, K. (1998). Incidence of goiter among children in a village with nitrate contamination of drinking water. Folia Med (Plovdiv), 40(3): 19-23.

Gatseva, P.D. and Argirova, M.D. (2008a). Iodine status and goitre prevalence in nitrate-exposed schoolchildren living in rural Bulgaria. Public Health, 122(5): 458-461.

Gatseva, P.D. and Argirova, M.D. (2008b). High-nitrate levels in drinking water may be a risk factor for thyroid dysfunction in children and pregnant women living in rural Bulgarian areas. Int. J. Hyg. Environ. Health, 211(5-6): 555-559.

Gelperin, A., Moses, V.K. and Bridger, C. (1975). Relationship of high nitrate community water supply to infant and fetal mortality. Ill. Med. J., 147: 155-157, 186.

George, M., Wiklund, L., Aastrup, M., Pousette, J., Thunholm, B., Saldeen, T., Wernroth, L., Zaren, B. and Holmberg, L. (2001). Incidence and geographical distribution of sudden infant death syndrome in relation to content of nitrate in drinking water and groundwater levels. Eur. J. Clin. Invest., 31(12): 1083-1094.

Globus, M. and Samuel, D. (1978). Effect of maternally administered sodium nitrite on hepatic erythropoiesis in fetal CD-1 mice. Teratology, 18(3): 367-378.

Gombar, C.T., Zubroff, J., Strahan, G.D. and Magee, P.N. (1983). Measurement of 7-methylguanine as an estimate of the amount of dimethylnitrosamine formed following administration of aminopyrine and nitrite to rats. Cancer Res., 43(11): 5077-5080.

Görsdorf S, Appel KE, Engeholm C, Obe G. (1990). Nitrogen dioxide induces DNA single-strand breaks in cultured Chinese hamster cells. Carcinogenesis. 11(1):37-41.

Goss, M.J., Barry, D.A.J. and Rudolph, D.L (1998). Contamination in Ontario farmstead domestic wells and its association with agriculture: 1. Results from drinking water wells. J Contam Hydrol, 32(3-4):267-293.

Gouvernement du Québec (2004). Étude sur la qualité de l'eau potable dans sept bassins versants en surplus de fumier et impacts potentiels sur la santé -  caractérisation de l'eau souterraine dans les sept bassins versants.   Available at : www.mddefp.gouv.qc.ca/eau/bassinversant/sept-bassins/index.htm

Gowans, W.J. (1990). Fatal methaemoglobinaemia in a dental nurse. A case of sodium nitrite poisoning. Br. J. Gen. Pract., 40(340): 470-471.

Granli, T., Dahl, R., Brodin, P. and Bockman, O.C. (1989). Nitrate and nitrite concentrations in human saliva: variations with salivary flow-rate. Food Chem. Toxicol., 27(10): 675-680.

Grant, D. and Butler, W.H. (1989). Chronic toxicity of sodium nitrite in the male F344 rat. Food Chem. Toxicol., 27(9): 565-571.

Green, L.C., Tannenbaum, S.R. and Fox, J.G. (1982). Nitrate in human and canine milk. N. Engl. J. Med., 306(22): 1367-1368.

Green, M. and Shelef, G. (1994). Treatment of nitrate contaminated groundwater. In: Groundwater contamination and control. U. Zoller (ed.). Marcel Dekker Inc., New York, New York.

Greenblatt, M. and Mirvish, S.S. (1973). Dose-response studies with concurrent administration of piperazine and sodium nitrite to strain A mice. J. Natl. Cancer Inst., 50(1): 119-124.

Greenblatt, M., Kommineni, V.R. and Lijinsky, W. (1973). Null effect of concurrent feeding of sodium nitrite and amino acids to MRC rats. J. Natl. Cancer Inst., 50(3): 799-802.

Greenblatt, M., Mirvish, S. and So, B.T. (1971). Nitrosamine studies: induction of lung adenomas by concurrent administration of sodium nitrite and secondary amines in swiss mice. J. Natl. Cancer Inst., 46(5): 1029-1034.

Greer, M.A., Goodman, G., Pleus, R.C. and Greer, S.E. (2002). Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans. Environ. Health Perspect., 110(9): 927-937.

Gros, H., Schnoor, G. and Rutten, P. (1986). Nitrate removal from groundwater by autotrophic microorganisms. Water Supply, 4: 11-21.

Gulis, G., Czompolyova, M. and Cerhan, J.R. (2002). An ecologic study of nitrate in municipal drinking water and cancer incidence in Trnava District, Slovakia. Environ. Res., 88(3): 182-187.

Gupta, S.K., Gupta, R.C., Seth, A.K., Gupta, A.B., Bassin, J.K. and Gupta, A. (1999). Adaptation of cytochrome-b5 reductase activity and methaemoglobinaemia in areas with a high nitrate concentration in drinking-water. Bull. World Health Organ., 77(9): 749-753.

Guter, G.A. (1981). Removal of nitrate from contaminated water supplies for public use. United States Environmental Protection Agency, Cincinnati, Ohio.

Guter, G.A. (1995). Nitrate removal from contaminated groundwater by anion exchange. Ion Exchange Technology. A.K. Sengupta, Ed., Technomic Publishing Company.

Hampel, R., Zollner, H., Glass, A. and Schonebeck, R. (2003). [No influence of urinary nitrate excretion on the goitre prevalence in Germany.] Med. Klin. (Munich), 98(10): 547-551 (in German).

Hansen, P.S., Brix, T.H., Sorensen, T.I., Kyvik, K.O. and Hegedus, L. (2004). Major genetic influence on the regulation of the pituitary-thyroid axis: A study of healthy danish twins. J Clin Endocrinol Metab 89(3):1181-7. [cited in Miller et al., 2009].

Hanukoglu, A. and Danon, P.N. (1996). Endogenous methemoglobinemia associated with diarrheal disease in infancy. J. Pediatr. Gastroenterol. Nutr., 23: 1-7.

Harrington, G.W., Noguera, D.R., Kandou, A.I. and Vanhoven, D.J. (2002). Pilot-scale evaluation of nitrification control strategies. J. Am. Water Works Assoc., 94(11): 78-89.

Hawkes, C.H., Cavanagh, J.B., Darling, J.L., Watkins, B.A. and Thomas, D.G.T. (1992). Chronic low-dose exposure of sodium nitrite in VM-strain mice: central nervous system changes. Hum. Exp. Toxicol., 11(4): 279-281.

Health Canada (2003a). Concentrations of nitrosamines, nitrite, and nitrate in food from Total Diet Study in Ottawa (ON), 2000. Ottawa, Ontario. Available at www.hc-sc.gc.ca/fn-an/surveill/total-diet/concentration/nitrosamine_conc_ottawa2000-eng.php

Health Canada (2003b). Concentrations of nitrosamines, nitrite, and nitrate in food from Total Diet Study in St. John's (NF), 2001. St. John's, Newfoundland. Available at www.hc-sc.gc.ca/fn-an/surveill/total-diet/concentration/nitrosamine_conc_ottawa2000-eng.php

Health Canada (2011). Guidelines for Canadian drinking water quality: Guideline technical document--N-nitrosodimethylamine. Water, Air and Climate Change Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario. Available at: www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/ndma/index-eng.php

Health Canada (2012). Personal communication from Anca-Maria Tugulea. Environmental health science and research bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.

Health Canada (2013). Guidelines for Canadian drinking water quality: Guideline technical document--Ammonia. Water, Air and Climate Change Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario. (Catalogue No H144-13/5-2013E-PDF).Available at www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/index-eng.php#tech_doc

Hegesh, E. and Shiloah, J. (1982). Blood nitrates and infantile methemoglobinemia. Clin. Chim. Acta, 125(2): 107-115.

Heindel, J.J., Chapin, R.E., Gulati, D.K., George, J.D., Price, C.J., Marr, M.C., Myers, C.B., Barnes, L.H., Fail, P.A., Grizzle, T.B., Schwetz B.A. and Yang R.S.H. (1994). Assessment of the reproductive and developmental toxicity of pesticide/fertilizer mixtures based on confirmed pesticide contamination in California and Iowa groundwater. Fundam. Appl. Toxicol., 22(4): 605-621.

Hell, F., Lahnsteiner, J., Frischherz, H. and Baumgartner, G. (1998). Experience with full-scale electrodialysis for nitrate and hardness removal. Desalination, 117: 173-180.

Helser, M.A., Hotchkiss, J.H. and Roe, D.A. (1992). Influence of fruit and vegetable juices on the endogenous formation of N-nitrosoproline and N-nitrosothiazolidine-4-carboxylic acid in humans on controlled diets. Carcinogenesis, 13(12): 2277-2280.

Heyland, A. and Moroz, L.L. (2005). Cross-kingdom hormonal signaling: An insight from thyroid hormone functions in marine larvae. J Exp Biol 208(Pt 23):4355-61. [cited in Miller et al., 2009].

Hill, C.P. and Arweiler, S. Assessment and operational responses to nitrification episodes. In: Manual of Water Supply Practices M56: Fundamentals and control of nitrification in chloraminated drinking water distribution systems. American Water Works Association, Denver, Colorado.

Hirose, M., Tanaka, H., Takahashi, S., Futakuchi, M., Fukushima, S. and Ito, N. (1993). Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res., 53(1): 32-37.

Höll, W.H. and Hagen, K. (2002). Partial demineralisation of drinking water using carbon dioxide regenerated ion exchangers. Water Sci. Technol. Water Supply, 2(1): 57-62.

Howdeshell, K.L. (2002). A model of the development of the brain as a construct of the thyroid system. Environ. Health Perspect., 110(Suppl. 3): 337-348.

Hsu, J.D., Hsu, C.L., Chou, F.P., Wen, P.H. and Wang, C.J. (1997). Potential effect of sodium nitrite on the expression of nuclear proto-oncogenes during 2-acetyl aminofluorene-induced hepatocarcinogenesis in rats. Chem. Biol. Interact., 108(1-2): 1-18.

Hunault, C.C., Lambers, A.C., Mensinga, T.T., van Isselt, J.W., Koppeschaar, H.P. and Meulenbelt, J. (2007). Effects of sub-chronic nitrate exposure on the thyroidal function in humans. Toxicol. Lett., 175(1-3): 64-70.

Huncharek, M. and Kupelnick, B. (2004). A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors. Neuroepidemiology, 23(1-2): 78-84.

Huncharek, M., Kupelnick, B. and Wheeler, L. (2003). Dietary cured meat and the risk of adult glioma: a meta-analysis of nine observational studies. J. Environ. Pathol. Toxicol. Oncol., 22(2): 129-137.

IARC (1978). Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 17, Some N-nitroso Compounds. International Agency for Research on Cancer, Lyon, France.

IARC (1987). Overall evaluation of carcinogenicity: an updating of IARC monographs volumes 1-42. International Agency for Research on Cancer, Lyon (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, Supplement 7).

IARC (2010). Ingested nitrate and nitrite and cyanobacterial peptide toxins. International Agency for Research on Cancer, Lyon. 464 pp. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 94).

Ilnitsky, A.P. and Kolpakova, A.S. (1997). The enhancing effect of sodium nitrite on virus-induced leukemia in mice. Cancer Detect. Prev., 21(4): 312-318.

Inai, K., Aoki, Y. and Tokuoka, S. (1979). Chronic toxicity of sodium nitrite in mice, with reference to its tumorigenicity. Gann, 70(2): 203-208.

Inui, N., Nishi, Y. and Hasegawa, M.M. (1980). Induction of 8-azaguanine-resistant mutation and neoplastic transformation of hamster embryonic cells by coadministration of sodium nitrite and aminopyrine. J. Cancer Res. Clin. Oncol., 97(2): 119-128.

Inui, N., Nishi, Y., Taketomi, M. and Mori, M (1979). Transplacental action of sodium nitrite on embryonic cells of Syrian golden hamster. Mutat. Res., 66: 149-158.

Inui, N., Nishi, Y., Taketomi, M. and Yamada, T. (1978). A short-term, simple method for detection of N-nitrosocompounds produced from sodium nitrite and morpholine in stomach. Biochem. Biophys. Res. Commun., 81(2): 310-314.

IPCS. (2002). N-Nitrosodimethylamine. International Programme on Chemical Safety, World Health Organization, Geneva (Concise International Chemical Assessment Document 38) Available at: www.inchem.org/documents/cicads/cicads/cicad38.htm).

Ishidate, M., Jr., Sofuni, T., Yoshikawa, K., Hayashi, M., Nohmi, T., Sawada, M. and Matsuoka, A. (1984). Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol., 22: 623-636.

Ishiguro, K., Zhu, Y.L., Shyam, K., Penketh, P.G., Baumann, R.P. and Sartorelli, A.C. (2010). Quantitative relationship between guanine O6-alkyl lesions produced by onrigin and tumor resistance by O6-alkylguanine-DNA alkyltransferase. Biochem. Pharmacol., 80(9): 1317-1325.

Jahreis, G., Hesse, V., Rohde, W., Prange, H. and Zwacka, G. (1991). Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats. Exp. Clin. Endocrinol., 97(1): 109-112.

Jakszyn, P., Bingham, S., Pera, G., Agudo, A., Luben, R., Welch, A., Boeing, H., Del Giudice, G., Palli, D., Saieva, C., Krogh, V., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Simán, H., Hallmans, G., Sanchez, M.J., Larrañaga, N., Barricarte, A., Chirlaque, M.D., Quirós, J.R., Key, T.J., Allen, N., Lund, E., Carneiro, F., Linseisen, J., Nagel, G., Overvad, K., Tjonneland, A., Olsen, A., Bueno-de-Mesquita, H.B., Ocké, M.O., Peeters, P.H., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Fenger, C., Stenling, R., Ferrari, P., Jenab, M., Norat, T., Riboli, E. and Gonzalez, C.A. (2006). Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis, 27(7): 1497-1501.

Janssen, L.H.J.M., Visser, H. and Romer, F.G. (1989). Analysis of large scale sulphate, nitrate, chloride and ammonium concentrations in the Netherlands using an aerosol measuring network. Atmos. Environ., 23(2): 2783-2796.

Johnson, C. and Kross, B. (1990). Continuing importance of nitrate contamination of groundwater and wells in rural areas. Am. J. Ind. Med., 18: 449-456.

Jones, C.S., Hill, D. and Brand, G. (2007). Use a multifaceted approach to manage high source-water nitrate. Opflow, June 2007, American Water Works Association. pp. 20-22.

Joossens, J.V., Hill, M.J., Elliott, P., Stamler, R., Stamler, J., Lesaffre, E., Dyer, A., Nichols, R. and Kesteloot, H. (1996). Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group.Int. J. Epidemiol., 25(3): 494-504.

Kamm, J.J., Dashman, T., Conney, A.H. and Burns, J.J. (1975). Effect of ascorbic acid on amine-nitrite toxicity. Ann. N. Y. Acad. Sci., 258: 169-174.

Kang, J.G., Kim, S.H. and Ahn, T.Y. (2006). Bacterial diversity in the human saliva from different ages. J. Microbiol., 44(5): 572-576.

Kapoor, A. and Viraraghavan, T. (1997). Nitrate removal from drinking water--review. J. Environ. Eng., 123(4): 317-380.

Keeney, D.R.and Hatfield, J.L (2008).The nitrogen cycle, historical perspective, and current and potential future concerns. In: Nitrogen in the Environment: Sources, Problems, and Management..J.L Hatfield and R.F Follett (eds.). Elsevier Inc.

Kelley, S.T., Oehme, F.W. and Hoffman, S.B. (1974). Effect of chronic dietary nitrates on canine thyroid function. Toxicol. Appl. Pharmacol., 27(1): 200-203.

Kemper, J.M., Westerhoff, P., Dotson, A., and Mitch, W.A. (2009) Nitrosamine, dimethylnitramine, and chloropicring formation during strong base anion-exchange treatment. Environ. Sci. Technol. 43(2):466-472.

Kirk, A.B. (2006). Environmental perchlorate: why it matters. Anal. Chim. Acta, 567(1): 4-12.

Kirmeyer, G.J., Martel, K., Thompson, G., Radder, L., Klement, W., LeChevallier, M., Baribeaa, H. and Flores, A. (2004). Optimizing chloramine treatment. American Water Works Research Foundation and American Water Works Association, Denver, Colorado.

Kirmeyer, G.J., Odell, L.H., Jacangelo, J., Wilczak, A. and Wolfe, R. (1995). Nitrification occurrence and control in chloraminated water systems. American Water Works Research Foundation and American Water Works Association, Denver, Colorado.

Kjartanson, K. (1986). Memorandum to Dr. P. Toft, Department of National Health and Welfare, dated 2 June, from K. Kjartanson, Environmental Management, Manitoba Environment and Workplace Safety and Health.

Knekt, P., Järvinen, R., Dich, J. and Hakulinen, T. (1999). Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitroso compounds: a follow-up study. Int. J. Cancer, 80(6): 852-856.

Knight, T.M., Forman, D., Al-Dabbagh, S.A. and Doll, R. (1987). Estimation of dietary intake of nitrate and nitrite in Great Britain. Food Chem. Toxicol., 25(4): 277-285.

Knobeloch, L., Salna, B., Hogan, A., Postle, J. and Anderson, H. (2000). Blue babies and nitrate-contaminated well water. Environ. Health Perspect., 108(7): 675-678.

Kociba, R.J. and Sleight, S.D. (1970). Nitrite toxicosis in the ascorbic acid-deficient guinea pig. Toxicol. Appl. Pharmacol., 16(2): 424-429.

Kodama, F., Umeda, M. and Tsutsui, T. (1976). Mutagenic effect of sodium nitrite on cultured mouse cells. Mutat. Res., 40: 119-124.

Kodama, K., Sumii, K., Kawano, M., Kido, T., Nojima, K., Sumii, M., Haruma, K., Yoshihara, M. and Chayama, K. (2003). Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk? Eur. J. Gastroenterol. Hepatol., 15(9): 987-993.

Koestner, A., Denlinger, R.H. and Wechsler ,W. (1975). Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl and ethylnitrosourea precursors to adult rats. Food Cosmet Toxicol 13(6):605-609 [Online 26 June 2010].

Kors, L.J., Moorman, J.H.N., Wind, A.P.M. and van der Hoek, J.P. (1998). Nitrification and low temperature in a raw water reservoir and rapid sand filters. Water Sci. Technol., 37(2): 169-176.

Kortboyer, J.M., Schothorst, R.C., Zeilmaker, M.J and Meulenbelt, J. (1998). Intravenous administration of sodium nitrite to healthy volunteers: a single ascending dose study. National Institute for Public Health and the Environment. RIVM Report 235802 011, Bilthoven, Netherlands.

Kortboyer, J.M., Ollling, M., Zeilmaker, M.J., Slob, W., Boink, A.B.T.J., Schothorst, R.C., Sips, A.J.A.M. and Meulenbelt, J. (1997). The oral bioavailability of sodium nitrite investigated in healthy adult volunteers. National Institute for Public Health and the Environment. RIVM Report No. 235802 007. Bilthoven, Netherlands.

Kostraba, J.N., Gay, E.C., Rewers, M. and Hamman, R.F. (1992). Nitrate levels in community drinking waters and risk of IDDM: an ecological analysis. Diabetes Care, 15(11): 1505-1508.

Kowalski, B., Miller, C.T. and Sen, N.P. (1980). Studies on the in vivo formation of nitrosamines in rats and humans after ingestion of various meals. IARC Sci. Publ., 31: 609-617.

Krishna Murthy, A.S., Baker, J.R., Smith, E.R. and Zepp, E. (1979). Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination. Int. J. Cancer, 23(2): 253-259.

Krul, C.A.M., Zeilmaker, M.J., Schothorst, R.C. and Havenaar, R. (2004). Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions. Food Chem. Toxicol., 42(1): 51-63.

Kyrtopoulos, S.A., Pignatelli, B., Karkanias, G., Golematis, B. and Esteve, J. (1991). Studies in gastric carcinogenesis. V. The effects of ascorbic acid on N-nitroso compound formation in human gastric juice in vivo and in vitro. Carcinogenesis, 12(8): 1371-1376.

L'hirondel, J. and L'hirondel, J.-L. (2002). Nitrate and man: toxic, harmless or beneficial? CABI Publishing. Wallingford, Oxon. 168 pp.

Lauch, R.P. and Guter, G.A. (1986). Ion exchange for the removal of nitrate from well water. J. Am. Water Works Assoc., 78(5): 83-88.

Law, G., Parslow, R., McKinney, P. and Cartwright, R. (1999). Non-Hodgkin's lymphoma and nitrate in drinking water: a study in Yorkshire, United Kingdom. J. Epidemiol. Community Health, 53(6): 383-384.

Leaf, C.D., Wishnok, J.S. and Tannenbaum, S.R. (1989). Mechanisms of endogenous nitrosation. Cancer Surv., 8(2): 323-334.

Lehman, S.G., Badruzzaman, M., Adham, S.S., Roberts, D.J., Clifford, D.A., Zuo, G., Patel, A., Rittmann, B.E., Ahn, C. and Van Ginkel, S. (2010). Biological destruction of perchlorate and nitrate in ion exchanges concentrate. Water Research Foundation, Denver, Colorado.

Levallois, P., Thériault, M., Rouffignat, J., Tessier, S., Landry, R., Ayotte, P., Girard, M., Gingras, S., Gauvin, D. and Chiasson, C. (1998). Groundwater contamination by nitrates associated with intensive potato culture in Québec. Sci.  Total Environ., 217:91-101.

Levallois, P., Ayotte, P., Van Maanen, J.M.S., Desrosiers, T., Gingras, S., Dallinga, J.W., Vermeer, I.T., Zee, J. and Poirier, G. (2000). Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem. Toxicol., 38(11): 1013-1019.

Licht, W.R. and Deen, W.M. (1988). Theoretical model for predicting rates of nitrosamine and nitrosamide formation in the human stomach. Carcinogenesis, 9(12): 2227-2237.

Liebscher, H., Hii, B. and McNaughton, D. (1992). Nitrate and pesticide contamination of ground water in the Abbotsford aquifer, southwestern British Columbia. Inland Waters Directorate, Environment Canada, Vancouver, B.C.

Lijinsky, W. (1984). Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite. Food Chem. Toxicol., 22(9): 715-720.

Lijinsky, W. and Greenblatt, M. (1972). Carcinogen dimethylnitrosamine produced in vivo from nitrite and aminopyrine. Nat. New Biol., 236(67): 177-178.

Lijinsky, W. and Reuber, M.D. (1980). Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite. Food Cosmet. Toxicol., 18(1): 85-87.

Lijinsky, W. and Taylor, H.W. (1977). Feeding tests in rats on mixtures of nitrite with secondary and tertiary amines of environmental importance. Food Cosmet. Toxicol., 15(4): 269-274.

Lijinsky, W., Greenblatt, M. and Kommineni, C. (1973a). Brief communication: Feeding studies of nitrilotriacetic acid and derivatives in rats. J. Natl. Cancer Inst., 50(4): 1061-1063.

Lijinsky, W., Taylor, H.W., Snyder, C. and Nettesheim, P. (1973b). Malignant tumours of liver and lung in rats fed aminopyrine or heptamethyleneimine together with nitrite. Nature, 244(5412): 176-178.

Lijinsky, W., Kovatch, R. and Riggs, C.W. (1983). Altered incidences of hepatic and hemopoietic neoplasms in F344 rats fed sodium nitrite. Carcinogenesis, 4(9):1189-1191.

Lin, J.K. and Ho, Y.S. (1992). Hepatotoxicity and hepatocarcinogenicity in rats fed squid with or without exogenous nitrite. Food Chem. Toxicol., 30(8): 695-702.

Lin, S.H. and Chang, L.W.  (1996) Removal of nitrogenous compounds from aqueous solution by ozonation and ion exchange. Wat. Res 30(8):1851-1857.

Lindsey, B.D., and Rupert, M.G., (2012). Methods for evaluating temporal groundwater quality data and results of decadal-scale changes in chloride, dissolved solids, and nitrate concentrations in groundwater in the United States, 1988-2010: U.S. Geological Survey Scientific Investigations Report 2012-5049, 46 pp.

Liu, X. and Clifford, D.A. (1996). Ion exchange with denitrified brine reuse. J. Am. Water Works Assoc., 88(11): 88-99.

Lu, N., Gao, N-Y., Deng, Y. and Li, Q-S. (2009). Nitrite formation during low pressure ultraviolet lamp irradiation of nitrate. Water Sci. Technol., 60(6): 1393-1400.

Luca, D., Luca, V., Cotor, F. and Răileanu, L. (1987). In vivo and in vitro cytogenetic damage induced by sodium nitrite. Mutat. Res., 189: 333-339.

Luk, G.K. and Au-Yeung, W.C. (2002). Experimental investigation on the chemical reduction of nitrate from groundwater. Adv. Environ. Res., 6: 441-453.

Lundberg, J.O., Weitzberg, E. and Gladwin, M.T. (2008). The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. Drug Discov., 7(2): 156-167.

Lundberg, J.O., Weitzberg, E., Cole, J.A. and Benjamin, N. (2004). Nitrate, bacteria and human health. Nat. Rev. Microbiol., 2(7): 593-602.

Mackerness, C.W., Leach, S.A., Thompson, M.H. and Hill, M.J. (1989). The inhibition of bacterially mediated N-nitrosation by vitamin C: relevance to the inhibition of endogenous N-nitrosation in the achlorhydric stomach. Carcinogenesis, 10(2): 397-399.

Maekawa, A., Ogiu, T., Onodera, H., Furuta, K., Matsuoka, C., Ohno, Y. and Odashima, S. (1982). Carcinogenicity studies of sodium nitrite and sodium nitrate in F-344 rats. Food Chem. Toxicol., 20(1): 25-33.

Magee, P.N. and Barnes, J.M. (1967). Carcinogenic nitroso compounds. Adv. Cancer Res., 10: 163-246.

Manassaram, D.M., Backer, L.C. and Moll, D.M. (2006). A review of nitrates in drinking water: maternal exposure and adverse reproductive and developmental outcomes. Environ. Health Perspect., 114(3): 320-327.

Manitoba Conservation and Water Stewardship, (2011a). Personal communication from Kim Philip.

Marquardt, H., Rufino, F. and Weisburger, J.H. (1977). On the aetiology of gastric cancer: mutagenicity of food extracts after incubation with nitrite. Food Cosmet. Toxicol., 15(2): 97-100.

Mascher, F. and Marth, E. (1993). Metabolism and effect of nitrates. Cent. Eur. J. Public Health, 1(1): 49-52.

Mateju, V., Cizinska, S., Krejci, J. and Janoch, T. (1992). Biological water denitrification--a review. Enzyme Microb. Technol., 14: 170-183.

Matos, C.T., Velizarov, S., Crespo, J.G. and Reis, M.A.M. (2005). Removal of bromate, perchlorate, and nitrate from drinking water in an ion exchange membrane bioreactor. Water Supply, 5(4): 9-14.

Mayne, S.T., Risch, H.A., Dubrow, R., Chow, W.H., Gammon, M.D., Vaughan, T.L., Farrow, D.C., Schoenberg, J.B., Stanford, J.L., Ahsan, H., West, A.B., Rotterdam, H., Blot, W.J. and Fraumeni, J.F., Jr. (2001). Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev., 10(10): 1055-1062.

McAdam, E.J. and Judd, S.J. (2006). A review of membrane bioreactor potential for nitrate removal from drinking water. Desalination, 196: 135-148.

McColl, K.E.L. (2007). Hostile environment of the gastroesophageal junction. J. Clin. Gastroenterol., 41(Suppl. 2): S102-S107.

McElroy, J.A., Trentham-Dietz, A., Gangnon, R.E., Hampton, J.M., Bersch, A.J., Kanarek, M.S. and Newcomb, P.A. (2008). Nitrogen-nitrate exposure from drinking water and colorectal cancer risk for rural women in Wisconsin, USA. J. Water Health, 6(3): 399-409.

McGreer, E.R. and Belzer, W. (1999). Contaminant sources. In: Health of the Fraser River aquatic ecosystem. Vol. 1. A synthesis of research conducted under the Fraser River Action Plan. C. Gray and T. Tuominen (eds.). Environment Canada, Vancouver, B.C. pp. 7-22 (Publication No. DOE FRAP 1998-11).

McKinney, P.A., Parslow, R. and Bodansky, H.J. (1999). Nitrate exposure and childhood diabetes. In: Managing risks of nitrates to humans and the environment. W.S. Wilson, A.S. Ball and R.H. Hinton (eds.). Royal Society of Chemistry, Cambridge. pp. 327-339.

Mensinga, T.T., Speijers, G.J.A. and Meulenbelt, J. (2003). Health implications of exposure to environmental nitrogenous compounds. Toxicol. Rev., 22(1): 41-51.

Meyer, K.J., Swaim, P.D., Bellamy, W.D., Rittmann, B.E. and Tang. Y. (2010). Biological and ion exchange nitrate removal evaluation. Water Research Foundation, Denver, Colorado (Report No. 4131).

Michaud, D.S., Holick, C.N., Batchelor, T.T., Giovannucci, E. and Hunter, D.J. (2009). Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma. Am. J. Clin. Nutr., 90(3): 570-577.

Miller, M.D., Crofton, K.M., Rice, D.C., Zoeller, R.T. (2009). Thyroid-disrupting chemicals: Interpreting upstream biomarkers of adverse outcomes. Environ Health Perspect 117(7):1033-41.

Miller, C.T. (1984). Unscheduled DNA synthesis in human leucocytes after a fish (amine source) meal with or without salad (nitrite source). IARC Sci. Publ., 57: 609-613.

Ministère du Développement durable, de l'Environnement, de la faune et des Parcs du Québec, 2010. Personal communication from Caroline Robert

Mirvish, S.S. (1975a). Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo. Ann. N. Y. Acad. Sci., 258: 175-180.

Mirvish, S.S. (1975b). Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence. Toxicol. Appl. Pharmacol., 31(3): 325-351.

Mirvish, S.S. (1983). The etiology of gastric cancer. Intragastric nitrosamide formation and other theories. J. Natl. Cancer Inst., 71(3): 629-647.

Mirvish, S.S. (1986). Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer, 58(Suppl. 8): 1842-1850.

Mirvish, S.S. (1991). The significance for human health of nitrate, nitrite and N-nitroso compounds. In: Nitrate contamination: exposure, consequence, and control. I. Bogárdi, R.D. Kuzelka and W.G. Ennenga (eds.). Springer-Verlag, New York, New York. pp. 253-266.

Mirvish, S.S. (1994). Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers. Cancer Res., 54(Suppl. 7): 1948s-1951s.

Mirvish, S.S. (1995). Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett., 93(1): 17-48.

Mirvish, S.S. (1996). Inhibition by vitamins C and E of in vivo nitrosation and vitamin C occurrence in the stomach. Eur. J. Cancer Prev., 5(Suppl. 1): 131-136.

Mirvish, S.S., Greenblatt, M. and Kommineni, V.R. (1972). Nitrosamide formation in vivo: induction of lung adenomas in Swiss mice by concurrent feeding of nitrite and methylurea or ethylurea. J. Natl. Cancer Inst., 48(5): 1311-1315.

Mirvish, S.S., Cardesa, A., Wallcave, L. and Shubik, P. (1975). Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. J. Natl. Cancer Inst., 55(3): 633-636.

Mirvish, S.S., Pelfrene, A.F., Garcia, H. and Shubik, P. (1976). Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine. Cancer Lett., 2(2): 101-108.

Mirvish, S.S., Bulay, O., Runge, R.G. and Patil, K. (1980). Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats. J. Natl. Cancer Inst., 64(6): 1435-1442.

Mirvish, S.S., Salmasi, S., Cohen, S.M., Patil, K. and Mahboubi, E. (1983). Liver and forestomach tumors and other forestomach lesions in rats treated with morpholine and sodium nitrite, with and without sodium ascorbate. J. Natl. Cancer Inst., 71(1): 81-85.

Mirvish, S.S., Grandjean, A.C., Moller, H., Fike, S., Maynard, T., Jones, L., Rosinsky, S. and Nie, G. (1992). N-Nitrosoproline excretion by rural Nebraskans drinking water of varied nitrate content. Cancer Epidemiol. Biomarkers Prev., 1(6): 455-461.

Mirvish, S.S., Grandjean, A.C., Reimers, K.J., Connelly, B.J., Chen, S.C., Gallagher, J., Rosinsky, S., Nie, G., Tuatoo, H., Payne, S., Hinman, C. and Ruby, E. I. (1995). Dosing time with ascorbic acid and nitrate, gum and tobacco chewing, fasting, and other factors affecting N-nitrosoproline formation in healthy subjects taking proline with a standard meal. Cancer Epidemiol. Biomarkers Prev., 4(7): 775-783.

Mirvish, S.S., Reimers, K.J., Kutler, B., Chen, S.C., Haorah, J., Morris, C.R., Grandjean, A.C. and Lyden, E.R. (2000). Nitrate and nitrite concentrations in human saliva for men and women at different ages and times of the day and their consistency over time. Eur. J. Cancer Prev., 9(5): 335-342.

Mirvish, S.S., Davis, M.E., Lisowyj, M.P. and Gaikwad, N.W. (2008). Effect of feeding nitrite, ascorbate, hemin, and omeprazole on excretion of fecal total apparent N-nitroso compounds in mice. Chem. Res. Toxicol., 21(12): 2344-2351.

Mitch, W.A., Sharp, J.O., Trussell, R.R., Valentine, R.L., Alvarez-Cohen, L. and Sedlak, D.L. (2003).  N-Nitrosodimethylamine (NDMA) as a drinking water contaminant: a review. Environ. Eng. Sci., 20(5):389-404.

Mokhtar, N.M., el-Aaser, A.A., el-Bolkainy, M.N., Ibrahim, H.A., Badr El-Din, N.K. and Moharram, N.Z. (1988). Effect of soybean feeding on experimental carcinogenesis--III. Carcinogenicity of nitrite and dibutylamine in mice: A histopathological study. Eur. J. Cancer Clin. Oncol., 24(3): 403-411.

Moller, H., Landt, J., Pedersen, E., Jensen, P., Autrup, H. and Jensen, O.M. (1989). Endogenous nitrosation in relation to nitrate exposure from drinking water and diet in a Danish rural population. Cancer Res., 49(11): 3117-3121.

Moltchanova, E., Rytkonen, M., Kousa, A., Taskinen, O., Tuomilehto, J. and Karvonen, M. (2004). Zinc and nitrate in the ground water and the incidence of Type 1 diabetes in Finland. Diabet. Med., 21: 256-261.

Montesano, R. (1976). Carcinogenicity of N-nitroso compounds. Ann. Nutr. Aliment., 30(5-6): 867-871.

Montesano, R. and Bartsch, H. (1976). Mutagenic and carcinogenic N-nitroso compounds: possible environmental hazards. Mutat. Res., 32(3-4): 179-228.

Montesano, R. and Magee, P.N. (1971). Evidence of formation of N-methyl-N-nitrosourea in rats given N-methylurea and sodium nitrite. Int. J. Cancer, 7(2): 249-255.

Morales-Suarez-Varela, M.M., Llopis-Gonzalez, A. and Tejerizo-Perez, M.L. (1995). Impact of nitrates in drinking water on cancer mortality in Valencia, Spain. Eur. J. Epidemiol., 11(1): 15-21.

Mueller, B.A., Newton, K., Holly, E.A. and Preston-Martin, S. (2001). Residential water source and the risk of childhood brain tumors. Environ. Health Perspect., 109(6): 551-556.

Mueller, B.A., Nielsen, S.S., Preston-Martin, S., Holly, E.A., Cordier, S., Filippini, G., Peris-Bonet, R. and Choi, N.W. (2004). Household water source and the risk of childhood brain tumours: results of the SEARCH International Brain Tumor Study. Int. J. Epidemiol., 33(6): 1209-1216.

Mukhopadhyay, S., Ghosh, D., Chatterjee, A., Sinha, S., Tripathy, S. and Chandra, A.K. (2005). Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant. Indian J. Physiol. Pharmacol., 49(3): 284-288.

Murphy, R.S., Sadler, C.J. and Blot, W.J. (1998). Trends in cured meat consumption in relation to childhood and adult brain cancer in the united states. Food Control, 9(5): 299-305.

MWH (2005). Water treatment principles and design. 2nd edition. John Wiley & Sons, New York, New York.

Nakamura, S.I., Oda, Y., Shimada, T., Oki, I. and Sugimoto, K. (1987). SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. Mutat. Res., 192: 239-246.

NAS (1981). The health effects of nitrate, nitrite, and N-nitroso compounds: part 1 of a 2-part study. Prepared by the Committee on Nitrite and Alternative Curing Agents in Food, National Academy of Sciences. National Academy Press, Washington, DC.

Newberne, P.M. (1979). Nitrite promotes lymphoma incidence in rats. Science, 204(4397): 1079-1081.

Newfoundland and Labrador Department of Environment and Conservation (2010). Personal communication from Haseen Khan. February.

Niagolova, N., McElmurry, S.P., Voice, T.C., Long, D.T., Petropoulos, E.A., Havezov, I., Chou, K. and Ganev, V. (2005). Nitrogen species in drinking water indicate potential exposure pathway for Balkan endemic nephropathy. Environ. Pollut., 134(2): 229-237.

Nolan, B., Hitt, K. and Ruddy, B. (2002). Probability of nitrate concentration of recently recharged groundwater in the conterminous United States. Environ. Sci. Technol., 36(1): 2138.

Nova Scotia Environment, (2010). Personal communication from Judy MacDonald. February.

NRC (1995). Nitrate and nitrite in drinking water. Prepared by the Subcommittee on Nitrate and Nitrite in Drinking Water, Committee on Toxicology, National Research Council. National Academy Press, Washington, DC.

NSDH (1982). Chemical quality. Municipal water supplies. Nova Scotia Department of Health, Halifax, Nova Scotia.

NSF International (2012). Nitrate/Nitrite effluent values: Summary of NSF testing experience on POU devices under NSF/ANSI Standards 53 and 58 (2005 - 2011). Report for Health Canada.  NSF International, Ann Arbor, Michigan.

NSF/ANSI (2009a). Reverse osmosis drinking water treatment systems. NSF International/American National Standards Institute Standard 58. NSF International, Ann Arbor, Michigan.

NSF/ANSI (2009b). Drinking water distillation systems. NSF International/American National Standards Institute Standard 62. NSF International, Ann Arbor, Michigan.

NSF/ANSI (2009c). Drinking water treatment units--health effects. NSF International/American National Standards Institute Standard 53. NSF International, Ann Arbor, Michigan.

NSF/ANSI (2009d). Drinking water system components--health effects. NSF International/American National Standards Institute Standard 61. NSF International, Ann Arbor, Michigan.

NTP (1990). Final Report on the Reproductive Toxicity of Sodium Nitrite (CAS No. 7632-00-0). Research Triangle Park, NC: National Toxicology Program. Report No.: NTP 90-266.

NTP (2001). Toxicology and carcinogenesis studies of sodium nitrite (CAS No. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. pp. 7-273 (Technical Report Series TR-495).

Nyakas, C., Buwalda, B., Kramers, R.J., Traber, J. and Luiten, P.G. (1994a). Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment. Neuroscience, 59(3): 541-559.

Nyakas, C., Buwalda, B., Markel, E., Korte, S.M. and Luiten, P.G. (1994b). Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine. Eur. J. Neurosci., 6(5): 746-753.

Nyakas, C., Markel, E., Bohus, B., Schuurman, T. and Luiten, P.G. (1990). Protective effect of the calcium antagonist nimodipine on discrimination learning deficits and impaired retention behavior caused by prenatal nitrite exposure in rats. Behav. Brain Res., 38(1): 69-76.

Odell, L., Kirmeyer, G., Wilzak, A., Jacangelo, J., Marchinko, J. and Wolfe, R. (1996). Controlling nitrification in chloraminated systems. J. Am. Water Works Assoc., 88(7): 86-98.

OEHHA (1997). Public health goals for nitrate and nitrite in drinking water. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California .Available at: www.oehha.ca.gov/water/phg/pdf/nit2_c.pdf.

OEHHA (2005). Air Toxics Hot Spots Program risk assessment guidelines. Part II: Technical support document for describing available cancer potency factors. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California.

OEHHA (2006). Public health goal for N-nitrosodimethylamine in drinking water. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California.

Ohshima, H. and Bartsch, H. (1981). Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine. Cancer Res., 41(9 Pt 1): 3658-3662.

Ohshima, H. and Bartsch, H. (1994). Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res., 305(2): 253-264.

Ohshima, H., Furihata, C., Matsushima, T. and Bartsch, H. (1989). Evidence of potential tumour-initiating and tumour-promoting activities of hickory smoke condensate when given alone or with nitrite to rats. Food Chem. Toxicol., 27: 511-516.

Olsen, P., Gry, J., Knudsen, I., Meyer, O. and Poulsen, E. (1984). Animal feeding study with nitrite-treated meat. IARC Sci. Publ., 57: 667-675.

Ontario Ministry of the Environment (2011). Personal communication from Satish Deshpande. September.

Paediatric Epidemiolgy Group. (1999). Nitrate in drinking water and childhood-onset insulin-dependent diabetes mellitus in Scotland and Central England. University of Leeds

Palli, D., Saieva, C., Coppi, C., Del Giudice, G., Magagnotti, C., Nesi, G., Orsi, F. and Airoldi, L. (2001). O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer. Nutr. Cancer, 39(1): 42-49.

Pant, N. and Srivastava, S.P. (2002). Testicular and spermatotoxic effect of nitrate in mice. Hum. Exp. Toxicol., 21(1): 37-41.

Parks, N.J., Krohn, K.J., Mathis, C.A., Chasko, J.H., Geiger, K.R., Gregor, M.E. and Peek, N.F. (1981). Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration. Science, 212(4490): 58-60.

Parslow, R.C., McKinney, P.A., Law, G.R., Staines, A., Williams, R. and Bodansky, H.J. (1997). Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia, 40(5): 550-556.

Paynor, L. and Fabiani, C. (1995). Anion rejection in a nitrate highly rejecting reverse osmosis thin-film composite membrane. Desalination, 104: 165-174.

Peake, E., MacLean, M.A. and Sandhu, H.S. (1988). Total inorganic nitrate (particulate nitrate and nitric acid) in the atmosphere of Edmonton, Alberta, Canada. Atmos. Environ., 22(12): 2891-2893.

Pegg, A.E. (2000). Repair of O6-alkylguanine by alkyltransferases. Mutat. Res., 462(2-3): 83-100.

Pennington, J.A.T. (1998). Dietary exposure models for nitrates and nitrites. Food Control, 9(6): 385-395.

Peto, R., Gray, R., Brantom, P. and Grasso, P. (1991a). Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res., 51(23 Pt 2): 6452-6469.

Peto, R., Gray, R., Brantom, P. and Grasso, P. (1991b). Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study. Cancer Res., 51(23 Pt 2): 6415-6451.

Pfnader, W.H., Brown, J.R. and Garner, G.B. (1993). Terminology for reporting nitrate concentration. University of Missouri Extension report G9802. Available at: http://extension.missouri.edu/publications/DisplayPub.aspx?P=G9802

Phaneuf, D., Chaussé, K., Pantako, O. and Levallois, P. (2004). Évaluation du risque à la santé pour la population exposée aux nitrates présents dans l'eau potable. Saint-Lazare, Quebec.

Pintar, K., Slawson, R. and Huck, P. (2000). Investigation of conditions and control strategies influencing nitrification in a chloraminated bench-scale distribution study. In: Proceedings of the American Water Works Association Water Quality and Technology Conference. American Water Works Association, Denver, Colorado.

Pintar, K.D.M., Anderson, W.B., Slawson, R.M., Smith, F.E. and Huck, P.M. (2005). Assessment of a distribution system nitrification critical threshold concept. J. Am. Water Works Assoc., 97(7): 116-129.

Pogoda, J.M. and Preston-Martin, S. (2001). Maternal cured meat consumption during pregnancy and risk of paediatric brain tumour in offspring: potentially harmful levels of intake. Public Health Nutr., 4(2): 183-189.

Preston-Martin, S., Pogoda, J.M., Mueller, B.A., Holly, E.A., Lijinsky, W. and Davis, R.L. (1996). Maternal consumption of cured meats and vitamins in relation to pediatric brain tumors. Cancer Epidemiol. Biomarkers Prev., 5(8): 599-605.

Prince Edward Island Department of Environment, Labour and Justice (2010). Personal communication from George Somers.

Prival, M.J., Simmon, V.F. and Mortelmans, K.E (1991). Bacterial mutagenicity testing of 49 food ingredients gives very few positive results. Mutat. Res., 260: 321-329.

Prospero, J.M. and Savoie, D.L (1989). Effect of continental sources of nitrate concentrations over the Pacific. Ocean. Nature, 339(6227): 687-689.

Rademacher, J.J., Young, T.B. and Kanarek, M.S. (1992). Gastric cancer mortality and nitrate levels in Wisconsin drinking water. Arch. Environ. Health, 47(4): 292-294.

Radikova, Z., Tajtakova, M., Kocan, A., Trnovec, T., Sebokova, E., Klimes, I. and Langer, P. (2008). Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia. Thyroid, 18(3): 353-362.

Radovanovic, Z. and Stevanovic, D. (1988). Different forms of mineral nitrogen in drinking water and the Balkan nephropathy. Arch. Environ. Contam. Toxicol., 17(6): 813-815.

Rathbone, B.J., Johnson, A.W., Wyatt, J.I., Kelleher, J., Heatley, R.V. and Losowsky, M.S. (1989). Ascorbic acid: a factor concentrated in human gastric juice. Clin. Sci., 76(3): 237-241.

Reddy, K. and Lin, J. (2000). Nitrate removal from groundwater using catalytic reduction. Water Res., 34(3): 995-1001.

Richard, Y.R. (1989). Operating experiences at full-scale biological and ion-exchange denitrification plants in France. J. Inst. Water Environ. Manage., 3(2): 154-166.

Rivett, M.O, Buss, S.R., Morgan, P., Smith, J.W.N. and Bemment, C.D. (2008). Nitrate attenuation in groundwater: a review of biogeochemical controlling processes. Water Res, 42:4215-4232.

Rogalla, F., de Larminat, G., Coutelle, J. and Godart, H. (1991). Experience with nitrate removal methods from drinking water. In: Nitrate contamination: exposure, consequence, and control. I. Bogárdi, R.D. Kuzelka and W.G. Ennenga (eds.). Springer-Verlag, New York, New York. 520 pp.

Rogers, M.A.M., Vaughan, T.L., Davis, S. and Thomas, D.B. (1995). Consumption of nitrate, nitrite, and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiol. Biomarkers Prev., 4(1): 29-36.

Roth, A.C. and Smith, M.K. (1988). Nitrite-induced iron deficiency in the neonatal rat. Toxicol. Appl. Pharmacol., 96(1): 43-51.

Roth, A.C., Herkert, G.E., Bercz, J.P. and Smith, M.K. (1987). Evaluation of the developmental toxicity of sodium nitrite in Long-Evans rats. Fundam. Appl. Toxicol., 9(4): 668-677.

Ruckart, P., Henderson, A., Black, M. and Flanders, D. (2008). Are nitrate levels in groundwater stable over time? J. Expo. Sci. Environ. Epidemiol., 18: 129-133.

Ruddell, W.S., Bone, E.S., Hill, M.J., Blendis, L.M. and Walters, C.L. (1976). Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach? Lancet, 2(7994): 1037-1039.

Ruppenthal, S. (2004). Treating water high in nitrate to supplement supply. J. Am. Water Works Assoc., 96(5): 68-70.

Ruppenthal, S. (2007). Nitrate removal solutions for drinking water: how a flexible approach can deliver reliable results. J. Am. Water Works Assoc., 99(6): 28-30.

Sahli Menkouchi, M.A., Tahaikt, M., Achary, I., Taky, M., Elhanouni, F., Hafsi, M., Elmghari, M. and Elmidaoui, A. (2006). Technical optimization of nitrate removal for groundwater by ED using a pilot plant. Desalination, 189: 200-208.

Sahli Menkouchi, M.A., Annouar, S., Mountadar, M., Soufiane, A. and Elmidaoui, A. (2008). Nitrate removal of brackish underground water by chemical adsorption and by electrodialysis. Desalination, 227: 327-333.

Salem, K., Sandeaux, J., Molenat, J., Sandeaux, R. and Gavach, C. (1995). Elimination of nitrate from drinking water by electrochemical processes. Desalination 1001:123-131.

Sanchez-Echaniz, J., Benito-Fernandez, J. and Mintegui-Raso, S. (2001). Methemoglobinemia and consumption of vegetables in infants. Pediatrics, 107(5): 1024-1028.

Sandor, J., Kiss, I., Farkas, O. and Ember, I. (2001). Association between gastric cancer mortality and nitrate content of drinking water: ecological study on small area inequalities. Eur. J. Epidemiol., 17(5): 443-447.

Santafe-Moros, A., Gozalvez-Zafrilla, J.M. and Lora-Garcia, J. (2005). Performance of commercial nanofiltration membranes in the removal of nitrate ions. Desalination, 185: 281-287.

Saskatchewan Water Security Agency, (2010). Personal communication from Sam Ferris. February.

SCC (2011). Directory of accredited product and service certification bodies. Standards Council of Canada, Ottawa, Ontario. Available at: www.scc.ca/en/programs-services/product-certification/directory-of-accredited-clients

Schock, M.R. and Lytle, D.A. (2011). Internal corrosion and deposition control. In: Water quality and treatment--a handbook of community water supplies. 6th edition. American Water Works Association and McGraw-Hill, New York, New York.

Schoeman, J.J. and Steyn, A. (2003). Nitrate removal with reverse osmosis in a rural area in South Africa. Desalination, 155: 15-26.

Scragg, R.K., Dorsch, M.M., McMichael, A.J. and Baghurst, P.A. (1982). Birth defects and household water supply. epidemiological studies in the Mount Gambier region of South Australia. Med. J. Aust., 2(12): 577-579.

Sedgwick, B. (1997). Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells. Carcinogenesis, 18(8): 1561-1567.

Seidel, C., Gorman, C. and Werner, K. (2008). Nitrate reduction by sulphur modified iron: pilot study results. Presentation at the American Water Works Association Inorganic Contaminants Workshop. American Water Works Association, Denver, Colorado.

Seidel, C.S., Gorman, C., Darby, J.L. and Jensen, V.B. (2011). An assessment of the state of nitrate treatment alternatives. Report prepared for the American Water Works Association (AWWA) Inorganic Contaminant Research and Inorganic Water Quality Joint Project Committee. American Water Works Association, Denver, Colorado. Available at: www.awwa.org/files/Resources/TECProjects/TECReportNitrateFINALRevised07272011.pdf

Sen, N.P., Smith, D.C., Moodie, C.A. and Grice, H.C. (1975). Failure to induce tumours in guinea pigs after concurrent administration of nitrite and diethylamine. Food Cosmet Toxicol 13(4):423-425 [Online 13 August 2010].

Shank, R.C. and Newberne, P.M. (1976). Dose response study of the carcinogenicity of dietary sodium nitrite and morpholine in rats and hamsters. Food Cosmet. Toxicol., 14(1): 1-8.

Shapiro, K.B., Hotchkiss, J.H. and Roe, D.A. (1991). Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans. Food Chem. Toxicol., 29(11): 751-755.

Shephard, S.E., Schlatter, C. and Lutz, W.K. (1987). Assessment of the risk of formation of carcinogenic N-nitroso compounds from dietary precursors in the stomach. Food Chem. Toxicol., 25(1): 91-108.

Shimada, T. (1989). Lack of teratogenic and mutagenic effects of nitrite on mouse fetuses. Arch. Environ. Health, 44(1): 59-63.

Shiotani, A., Iishi, H., Uedo, N., Higashino, K., Kumamoto, M., Nakae, Y. and Tatsuta, M. (2004). Hypoacidity combined with high gastric juice nitrite induced by Helicobacter pylori infection is associated with gastric cancer. Aliment. Pharmacol. Ther., 20(Suppl. 1): 48-53.

Shrimali, M. and Singh, K.P. (2001). New methods of nitrate removal from water. Environ. Pollut., 112: 351-359.

Shuval, H.I. and Gruener, N. (1972). Epidemiological and toxicological aspects of nitrates and nitrites in the environment. Am. J. Public Health, 62(8): 1045-1052.

Siddiqi, M., Kumar, R., Kaul, D., Spiegelhalder, B. and Preussmann, R. (1992). Salivary nitrate and nitrite concentrations from a sample population of children and adults in high risk area for esophageal and gastric cancers in Kashmir, India. Cancer Lett., 64(2): 133-136.

Sinha, D.P. and Sleight, S.D. (1971). Pathogenesis of abortion in acute nitrite toxicosis in guinea pigs. Toxicol. Appl. Pharmacol., 18(2): 340-347.

Skadsen, J. (1993). Nitrification in distribution system. J. Am. Water Works Assoc., 7: 95-103.

Skadsen, J. and Cohen, Y.K (2006). Operational and treatment practices to prevent nitrification. In: Manual of water supply practices M56: Fundamentals and control of nitrification in chloraminated drinking water distribution systems. American Water Works Association, Denver, Colorado.

Sleight, S.D. and Atallah, O.A. (1968). Reproduction in the guinea pig as affected by chronic administration of potassium nitrate and potassium nitrite. Toxicol. Appl. Pharmacol., 12(2): 179-185.

Smith, C.D. (2006). Monitoring for nitrification prevention and control. In: Manual of water supply practices M56: Fundamentals and control of nitrification in chloraminated drinking water distribution systems. American Water Works Association, Denver, Colorado.

Sobala, G.M., Crabtree, J.E., Dixon, M.F., Schorah, C.J., Taylor, J.D., Rathbone, B.J., Heatley, R.V. and Axon, A.T. (1991). Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut, 32(11): 1415-1418.

Spiegelhalder, B., Eisenbrand, G. and Preussmann, R. (1976). Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet. Toxicol., 14(6): 545-548.

Steindorf, K., Schlehofer, B., Becher, H., Hornig, G. and Wahrendorf, J. (1994). Nitrate in drinking water. A case-control study on primary brain tumours with an embedded drinking water survey in Germany. Int. J. Epidemiol., 23(3): 451-457.

Sugiyama, K., Tanaka, T. and Mori, H. (1979). Carcinogenicity examination of sodium nitrate in mice. Acta Schol. Med. Univ. Gifu, 27(1): 1-6.

Super, M., Heese, H. de V., MacKenzie, D., Dempster, W.S., du Plessis, J. and Ferreira, J.J. (1981). An epidemiological study of well-water nitrates in a group of south west African/Namibian infants. Water Res., 15: 1265-1270.

Suziki, H., Iijima, K., Scobie, G., Fyfe, V., McColl, K.E.L. (2005). Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut, 54: 1527-1535.

Tabacova, S., Baird, D.D. and Balabaeva, L. (1998). Exposure to oxidized nitrogen: lipid peroxidation and neonatal health risk. Arch. Environ. Health, 53(3): 214-221.

Tabacova, S., Balabaeva, L. and Little, R.E. (1997). Maternal exposure to exogenous nitrogen compounds and complications of pregnancy. Arch. Environ. Health, 52(5): 341-347.

Tajtakova, M., Semanova, Z., Tomkova, Z., Szokeova, E., Majoros, J., Radikova, Z., Sebokova, E., Klimes, I. and Langer, P. (2006). Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area. Chemosphere, 62(4): 559-564.

Tannenbaum, S.R., Weisman, M. and Fett, D. (1976). The effect of nitrate intake on nitrite formation in human saliva. Food Cosmet. Toxicol., 14(6): 549-552.

Tannenbaum, S.R., Wishnok, J.S. and Leaf, C.D. (1991). Inhibition of nitrosamine formation by ascorbic acid. Am. J. Clin. Nutr., 53(Suppl. 1):  247S-250S.

Taylor, H.W. and Lijinsky, W. (1975). Tumor induction in rats by feeding heptamethyleneimine and nitrite in water. Cancer Res., 35(3): 812-815.

Taylor, J.S. and Wiesner, M. (1999). Membranes. In: Water quality and treatment--a handbook of community water supplies. 5th edition. R.D. Letterman (ed.). American Water Works Association and McGraw-Hill, Inc. New York, New York.

Terblanche, A.P.S. (1991). Health hazards of nitrate in drinking water. Water S.A., 17(1): 77-82.

Til, H.P., Falke, H.E., Kuper, C.F. and Willems, M.I. (1988). Evaluation of the oral toxicity of potassium nitrite in a 13-week drinking-water study in rats. Food Chem. Toxicol., 26(10): 851-859.

Til, H.P., Kuper, C.F. and Falke, H.E. (1997). Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level. Food Chem. Toxicol., 35(3-4): 349-355.

Toccalino, P.L., Norman, J.E. and Hitt, K.J. (2010). Quality of source water from public-supply wells in the United States, 1993-2007: U.S. Geological Survey Scientific Investigations Report 2010-5024, 206 pp.

Tonacchera, M., Pinchera, A., Dimida, A., Ferrarini, E., Agretti, P., Vitti, P., Santini, F., Crump, K. and Gibbs, J. (2004). Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter. Thyroid, 14(12): 1012-1019.

Tricker, A.R. (1997). N-Nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. Eur. J. Cancer Prev., 6(3): 226-268.

Tsuda, H. and Hasegawa, M. (1990). Malignant transformation of mouse BALB/c3T3 cells induced by NaNO2. Carcinogenesis, 11: 595-597.

Tsuda, H. and Kato, K. (1977). High rate of endoreduplications and chromosomal aberrations in hamster cells treated with sodium nitrite in vitro. Mutat. Res., 56: 69-74.

Tsuda, H., Inui, N. and Takayama, S. (1976). In vitro transformation of newborn hamster cells induced by sodium nitrite. Gann, 67: 165-173.

Turek, B., Hlavsova, D., Tucek, J., Waldman, J. and Cerna, J. (1980). The fate of nitrates and nitrites in the organism. IARC Sci. Publ., 31: 625-632.

U.S. EPA (1993). Methods for determination of inorganic substances in environmental samples. U.S. Environmental Protection Agency, Cincinnati, Ohio (EPA 600/R-93/100).

U.S. EPA (2002a). Nitrification. Distribution system issue paper. Office of Water, Office of Ground Water and Drinking Water, U.S. Environmental Protection Agency, Washington, DC.

U.S. EPA (2002b) Guidance for implementing a point-of-use or point-of-entry treatment strategy for compliance with the Safe Drinking Water Act. Office of Water, United States Environmental Protection Agency, Washington, D.C.

U.S. EPA (2006a). Basic information about nitrate in drinking water. U.S. Environmental Protection Agency, Washington, DC. Available at: www.water.epa.gov/drink/contaminants/basicinformation/nitrate.cfm

U.S. EPA (2006b) Point-of-use or point-of-entry treatment options for small drinking water systems.Office of  Water,  United States Environmental Protection Agency, Washington, D.C.

U.S. EPA (2007a). Nitrates and nitrites. TEACH chemical summary. U.S. EPA, toxicity and exposure assessment for children's health. U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/teach/chem_summ/Nitrates_summary.pdf

U.S. EPA (2007b). Guidelines establishing test procedures for the analysis of pollutants under the Clean Water Act; National Primary Drinking Water Regulations; and National Secondary Drinking Water Regulations; analysis and sampling procedures; Final rule. 40 CFR Part 122, 136 et al. U.S. Environmental Protection Agency, Washington, DC. Available at: www.deq.state.va.us/vpdes/pdf/40CFR136-TestProcedures-FinalRule.pdf

U.S. EPA (2007c) Arsenic removal from drinking water by point of use reveres osmosis (POU RO) U.S EPA demonstration projext at Sunset Ranch development in Homedale, ID final performance evaluation report. Report prepared for National Risk Management Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Cincinnati, Ohio. EPA/600/R-07/082.

U.S. EPA (2009a). Analytical methods approved for drinking water compliance monitoring of inorganic contaminants and other inorganic constituents. U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/safewater/methods/pdfs/methods/methods_inorganic.pdf

U.S. EPA (2009b). Analytical feasibility support document for the second six-year review of existing National Primary Drinking Water Regulations. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-B-09-003).

U.S. EPA (2009c). Contaminant occurrence support document for category 2 contaminants for the second six-year review of  National Primary Drinking Water Regulations. Office of Water, U.S. Environmental Protection Agency, Washington, DC (EPA 815-B-09-011).

U.S. EPA (2010). Cooperation on emission inventories, trends, and mapping. U.S. Environmental Protection Agency, Washington, DC. Available at: www.epa.gov/airmarkets/progsregs/usca/coop.html

U.S. EPA (2011). Estimation programs interface suite™ for Microsoft® Windows, v 4.0. United States Environmental Protection Agency, Washington, DC

Urbain, V., Benoit, R. and Manem, J. (1996). Membrane bioreactor: a new treatment tool. J. Am. Water Works Assoc., 88(5): 75-86.

Van der Bruggen, B., Everaert, K., Wilms, D. and Vandecasteele, C. (2001). Application of nanofiltration for removal of pesticides, nitrate and hardness from ground water: rejection properties and economic evaluation. J. Memb. Sci., 193: 239-248

Van der Hoek, J.P., Van der Ven, P.J.M. and Klapwijk, A. (1998). Combined ion exchange/biological denitrification for nitrate removal from ground water under different process conditions. Water Res., 22(6): 679-684.

Van Duijvenboden, W. and Matthijsen, A.J.C.M. (1989). Integrated criteria document nitrate. National Institute for Public Health and the Environment (RIVM). (Report No. 758473012) [cited in WHO, 2007].

Van Leeuwen, J.A., Waltner-Toews, D., Abernathy, T., Smit, B. and Shoukri, M. (1999). Associations between stomach cancer incidence and drinking water contamination with atrazine and nitrate in Ontario (Canada) agroecosystems, 1987-1991. Int. J. Epidemiol., 28(5): 836-840.

van Logten, M.J., den Tonkelaar, E.M., Kroes, R., Berkvens, J.M. and van Esch, G.J. (1972). Long-term experiment with canned meat treated with sodium nitrite and glucono-δ-lactone in rats. Food Cosmet. Toxicol., 10(4): 475-488.

Van Loon, A.J.M., Botterweck, A.A.M., Goldbohm, R.A., Brants, H.A.M., Van Klaveren, J.D. and Van Den Brandt, P.A. (1998). Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. Br. J. Cancer, 78(1): 129-135.

Van Maanen, J.M.S., Van Dijk, A., Mulder, K., De Baets, M.H., Menheere, P.C., Van Der Heide, D., Mertens, P.L. and Kleinjans, J.C.S. (1994). Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid. Toxicol. Lett., 72(1-3): 365-374.

Van Maanen, J.M., Pachen, D.M., Dallinga, J.W. and Kleinjans, J.C. (1998). Formation of nitrosamines during consumption of nitrate- and amine-rich foods, and the influence of the use of mouthwashes. Cancer Detect. Prev., 22(3): 204-212.

Van Maanen, J.M., Albering, H.J., de Kok, T.M., van Breda, S.G., Curfs, D.M., Vermeer, I.T., Ambergen, A.W., Wolffenbuttel, B.H., Kleinjans, J.C. and Reeser, H.M. (2000). Does the risk of childhood diabetes mellitus require revision of the guideline values for nitrate in drinking water? Environ. Health Perspect., 108(5): 457-461.

Vanderpas, J. (2006). Nutritional epidemiology and thyroid hormone metabolism. Annu. Rev. Nutr., 26: 293-322.

Velizarov, S., Crespo, J.G. and Reis, M.A. (2002). Removal of nitrate from water in a novel ion exchange membrane bioreactor. Water Supply, 2(2): 161-167.

Vermeer, I.T.M. and Van Maanen, J.M.S. (2001). Nitrate exposure and the endogenous formation of carcinogenic nitrosamines in humans. Rev. Environ. Health, 16(2): 105-116.

Vermeer, I.T.M., Gerrits, M.M., Moonen, E.J.C., Engels, L.G.J.B., Dallinga, J.W., Kleinjans, J.C.S., van Maanen, J.M., Kuipers, E.J. and Kusters, J.G. (2002). Helicobacter pylori does not mediate the formation of carcinogenic N-nitrosamines. Helicobacter, 7(3): 163-169.

Vermeer, I.T.M., Moonen, E.J.C., Dallinga, J.W., Kleinjans, J.C.S. and Van Maanen, J.M.S. (1999). Effect of ascorbic acid and green tea on endogenous formation of N-nitrosodimethylamine and N-nitrosopiperidine in humans. Mutat. Res., 428(1-2): 353-361.

Vermeer, I.T.M., Pachen, D.M.F.A., Dallinga, J.W., Kleinjans, J.C.S. and Van Maanen, J.M.S. (1998). Volatile N-nitrosamine formation after intake of nitrate at the ADI level in combination with an amine-rich diet. Environ. Health Perspect., 106(8): 459-463.

Virtanen, S.M., Jaakkola, L., Rasanen, L., Ylonen, K., Aro, A., Lounamaa, R., Akerblom, H.K. and Tuomilehto, J. (1994). Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Childhood Diabetes in Finland Study Group. Diabet. Med., 11(7): 656-662.

Vleeming, W., van de Kuil, A., te Biesebeek, J.D., Meulenbelt, J. and Boink, A.B. (1997). Effect of nitrite on blood pressure in anaesthetized and free-moving rats. Food Chem. Toxicol., 35(6): 615-619.

Volkmer, B.G., Ernst, B., Simon, J., Kuefer, R., Bartsch, G., Jr., Bach, D. et al. (2005). Influence of nitrate levels in drinking water on urological malignancies: a community-based cohort study. BJU Int., 95(7): 972-976.

Vorhees, C.V., Butcher, R.E., Brunner, R.L. and Wootten, V. (1984). Developmental toxicity and psychotoxicity of sodium nitrite in rats. Food Chem. Toxicol., 22(1): 1-6.

Vulsma, T., Gons, M.H. and de Vijlder, J.J. (1989). Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N. Engl. J. Med., 321(1): 13-16.

Wachinski, A.M. (2006). Nitrate removal. In: Ion exchange treatment for water. American Water Works Association, Denver, Colorado.

Wagner, D.A., Schultz, D.S., Deen, W.M., Young, V.R. and Tannenbaum, S.R. (1983). Metabolic fate of an oral dose of 15N-labeled nitrate in humans: effect of diet supplementation with ascorbic acid. Cancer Res., 43: 1921-1925.

Wakida, F.T., and Lerner, D.N, (2005). Non-agricultural sources of groundwater nitrate: a review and case study. Water Res., 39:3-16.

Walker, R. (1990). Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications. Food Addit. Contam., 7(6): 717-768. 

Walker, R. (1996). The metabolism of dietary nitrites and nitrates. Biochem. Soc. Trans., 20: 780-785.

Walker, R. (1999). The metabolism of dietary nitrites and nitrates. Royal Society of Chemistry, Cambridge.

Walton, G. (1951). Survey of literature relating to infant methemoglobinemia due to nitrate-contaminated water. Am. J. Public Health Nation's Health, 41(8 Pt 1): 986-996.

Wang, L., Chen, A., Tong, N. and Coonfare, C.T. (2007). Arsenic removal from drinking water by ion exchange. U.S. EPA demonstration project at Fruitland, ID, six-month evaluation report. Water Supply and Water Resources Division, National Risk Management Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cinnicinati, Ohio (EPA/600/R-07/017).

Ward, M.H., Mark, S.D., Cantor, K.P., Weisenburger, D.D., Correa-Villaseñor, A. and Zahm, S.H. (1996). Drinking water nitrate and the risk of non-Hodgkin's lymphoma. Epidemiology, 7(5): 465-471.

Ward, M.H., Pan, W.H., Cheng, Y.J., Li, F.H., Brinton, L.A., Chen, C.J., Hsu, M.M., Chen, I.H., Levine, P.H., Yang, C.S. and Hildesheim, A. (2000). Dietary exposure to nitrite and nitrosamines and risk of nasopharyngeal carcinoma in Taiwan. Int. J. Cancer, 86(5): 603-609.

Ward, M.H., Cantor, K.P., Riley, D., Merkle, S. and Lynch, C.F. (2003). Nitrate in public water supplies and risk of bladder cancer. Epidemiology, 14(2): 183-190.

Ward, M.H., deKok, T.M., Levallois, P., Brender, J., Gulis, G., Nolan, B.T. and VanDerslice, J. (2005a). Workgroup report: Drinking-water nitrate and health--recent findings and research needs. Environ. Health Perspect., 113(11): 1607-1614.

Ward, M.H., Heineman, E.F., McComb, R.D. and Weisenburger, D.D. (2005b). Drinking water and dietary sources of nitrate and nitrite and risk of glioma. J. Occup. Environ. Med., 47(12): 1260-1267.

Ward, M.H., Cerhan, J.R., Colt, J.S. and Hartge, P. (2006). Risk of non-Hodgkin lymphoma and nitrate and nitrite from drinking water and diet. Epidemiology, 17(4): 375-382.

Ward, M.H., Rusiecki, J.A., Lynch, C.F. and Cantor, K.P. (2007). Nitrate in public water supplies and the risk of renal cell carcinoma. Cancer Causes Control, 18(10): 1141-1151.

Ward, M.H., Heineman, E.F., Markin, R.S. and Weisenburger, D.D. (2008). Adenocarcinoma of the stomach and esophagus and drinking water and dietary sources of nitrate and nitrite. Int. J. Occup. Environ. Health, 14(3): 193-197.

Ward, M.H., Kilfoy, B.A., Weyer, P.J., Anderson, K.E., Folsom, A.R. and Cerhan, J.R. (2010). Nitrate intake and the risk of thyroid cancer and thyroid disease. Epidemiology, 21(3): 389-395.

Warton, B., Heitz, A., Zappia, L.R., Franzmann, P.D., Joll, C.A., Alessandrino, M., Allpike, M., O'Leary, B. and Kagi, R.I. (2007). Magnetic ion exchange drinking water treatment in a large-scale facility. J. Am. Water Works 99(1):89-101

Wassenaar, L.I., Hendry, M.J. and Harrington, N. (2005). Decadal geochemical and isotopic trends for nitrate in a transboundary aquifer and implications for agricultural beneficial management practices. Environ. Sci. Technol., 40:4626-4632.

Weisburger, J.H., Marquardt, H., Hirota, N., Mori, H. and Williams, G.M. (1980). Induction of cancer of the glandular stomach in rats by an extract of nitrite-treated fish. J. Natl. Cancer Inst., 64(1): 163-167.

Weyer, P.J., Cerhan, J.R., Kross, B.C., Hallberg, G.R., Kantamneni, J., Breuer, G., Jones, M.P., Zheng, W. and Lynch, C.F. (2001). Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study. Epidemiology, 12(3): 327-338.

WHO (2007). Nitrate and nitrite in drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. World Health Organization, Geneva (WHO/SDE/WSH/07.01/16).

Whong, W.Z. and Ong, T.M. (1979). Mediated mutagenesis of dimethylnitrosamine in Neurospora crassa by various metabolic activation systems. Cancer Res., 39(5): 1525-1528.

Whong, W.Z., Speciner, N.D. and Edwards, G.S. (1979). Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite. Environ. Mutagen., 1(3): 277-282.

Wilczak, A., Jacangelo, J., Marcinko, J., Odell, L., Kirmeyer, G. and Wolf, R. (1996). Occurrence of nitrification in chloraminated distribution systems. J. Am. Water Works Assoc., 88(7): 74-85.

Witter, J.P., Gatley, S.J. and Balish, E. (1979). Distribution of nitrogen-13 from labeled nitrate (13NO3¯) in humans and rats. Science, 204(4391): 411-413.

Woodruff, T.J., Zeise, L., Axelrad, D.A., Guyton, K.Z., Janssen, S., Miller, M., Miller, G.G., Schwartz, J.M., Alexeeff, G., Anderson, H. et al. (2008). Meeting report: Moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ. Health. Perspect.116(11):1568-75.

WQA (2012). Assessment of performance of POU systems used for nitrate/nitrite reduction. Report for Health Canada. Water Quality Association. Lisle, Illinois.

Xia, S., Zhang, Y. and Zhong, F. (2009). A continuous stirred hydrogen-based polyvinyl chloride membrane biofilm reactor for the treatment of nitrate contaminated drinking water. Bioresour. Technol., 100: 6223-6228.

Xu, G., Song, P. and Reed, P.I. (1992). The relationship between gastric mucosal changes and nitrate intake via drinking water in a high-risk population for gastric cancer in Moping County, China. Eur. J. Cancer Prev., 1(6): 437-443.

Xu, J., Xu, X. and Verstraete, W. (2001). Quantitative measurement of the nitrate reductase activity in the human oral cavity. Food Chem. Toxicol., 39(4): 393-400.

Xu, Y. and Chi, H. (1990). The effect of Chinese tea on the occurrence of esophageal tumors induced by N-nitrosomethylbenzylamine formed in vivo. Biomed. Environ. Sci., 3(4): 406-412.

Yamamoto, K., Nakajima, A., Eimoto, H., Tsutsumi, M., Maruyama, H., Denda, A., Nii, H., Mori, Y. and Konishi, Y. (1989). Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in rats administered bis(2-hydroxypropyl)amine and sodium nitrite. Carcinogenesis, 10(9): 1607-1611.

Yang, C.Y., Cheng, M.F., Tsai, S.S. and Hsieh, Y.L. (1998). Calcium, magnesium, and nitrate in drinking water and gastric cancer mortality. Jpn. J. Cancer Res., 89(2): 124-130.

Yang, C.Y., Wu, D.C. and Chang, C.C. (2007). Nitrate in drinking water and risk of death from colon cancer in Taiwan. Environ. Int., 33(5): 649-653.

Yang, H. and Cheng, H. (2007). Controlling nitrite level in drinking water chlorination and chloramination. Separation and Purification Technology 56:392-396

Yoshida, A., Harada, T. and Maita, K. (1993). Tumor induction by concurrent oral administration of ethylenethiourea and sodium nitrite in mice. Toxicol. Pathol., 21(3): 303-310.

Yoshida, Y., Hirose, M., Takaba, K., Kimura, J. and Ito, N. (1994). Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N′-nitro-N-nitrosoguanidine pre-treatment. Int. J. Cancer, 56(1): 124-128.

Yukon Environmental Health Services (2010). Personal communication from Patricia Brooks. March.

Zaki, A., Ait Chaoui, A., Talibi, A., Derouiche, A.F., Aboussaouira, T., Zarrouck, K., Chait, A. and Himmi, T. (2004). Impact of nitrate intake in drinking water on the thyroid gland activity in male rat. Toxicol. Lett., 147(1): 27-33.

Zeegers, M.P., Selen, R.F.M., Kleinjans, J.C.S., Goldbohm, R.A. and van den Brandt, P.A. (2006). Nitrate intake does not influence bladder cancer risk: the Netherlands Cohort Study. Environ. Health Perspect., 114(10): 1527-1531.

Zeeman, CL, Kross, B, and Vlad, M. (2002). A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania. Environ Health Perspect, 110, 817-822.

Zeiger, E., Anderson, B., Haworth, S., Lawlor, T. and Mortelmans, K. (1992). Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ. Mol. Mutag., 19(Suppl. 21): 2-141.

Zeilmaker, M.J., Meulenbelt, J., Kortboyer, J.M. and Slob, W. (1996). Safety assessment of nitrate: Mathematical modeling of nitrite formation in man and its application in the risk assessment of nitrate. Report No. 235802002 from National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands, pp. 1-38.

Zeilmaker, M.J., Bakker, M.I., Schothorst, R. and Slob, W. (2010). Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals. Toxicol. Sci., 116(1): 323-335.

Zeisel, S.H., DaCosta, K.A. and Fox, J.G. (1985). Endogenous formation of dimethylamine. Biochem. J., 232(2): 403-408.

Zeman, C.L., Kross, B. and Vlad, M. (2002). A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania. Environ. Health Perspect., 110(8): 817-822.

Zhang, Y., Groiffin, A., Rahman, M., Camper, A. and Edward, M. (2009a). Lead contamination of the potable water due to nitrification. Environ. Sci. Technol., 43(6): 1890-1895.

Zhang, Y., Love, N. and Edwards, M. (2009b). Nitrification in drinking water systems. Crit. Rev. Environ. Sci. Technol., 39: 153-208.

Zhang, Y., Edwards, M., Pinto, A., Love, N., Camper, A., Rahman, M. and Baribeau, H. (2010). Effect of nitrification on corrosion in the distribution system. Water Research Foundation, Denver, Colorado.

Zhao, H.X., Mold, M.D., Stenhouse, E.A., Bird, S.C., Wright, D.E., Demaine, A.G. and Millward, B.A. (2001). Drinking water composition and childhood-onset type 1 diabetes mellitus in Devon and Cornwall, England. Diabet. Med., 18(9): 709-717.

Zhu, X., Choo, K.-H. and Park, J.-M. (2006). Nitrate removal from contaminated water using polyelectrolyte-enhanced ultrafiltration. Desalination, 193: 350-360.

Zoeller RT, Tyl RW, Tan SW. (2007). Current and potential rodent screens and tests for thyroid toxicants. Crit Rev Toxicol 37(1-2):55-95. [cited in Miller et al., 2009].

Zoeller, R.T. and Crofton, K.M. (2005). Mode of action: Developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil. Crit. Rev. Toxicol., 35(8-9): 771-781.

Appendix A: List of Acronyms

AAF
2-acetyl aminofluorene
ADI
acceptable daily intake
AGT
O6-alkylguanine-DNA alkyltransferase
Aln
allantoin
AMP
aminopyrine
ANSI
American National Standards Institute
ASC
ascorbate
BEN
Balkan endemic nephropathy
BHPA
bis(2-hydroxypropyl)amine
bw
body weight
CI
confidence interval
Cim
cimetidine
CPM
chlorpheniramine maleate
DDAO
N,N-dimethyldodecylamine-N-oxide
DEA
diethylamine
DMA
dimethylamine; dimethylamine hydrochloride
DNA
deoxyribonucleic acid
DPH
diphenhydramine hydrochloride
DSF
disulfiram
DW
drinking water
EPA
Environmental Protection Agency (U.S.)
eq
equivalent
ETU
ethylenethiourea
EU
ethylurea
FAO
Food and Agriculture Organization of the United Nations
HMI
heptamethyleneimine
HPT
hypothalamic-pituitary-thyroid
IDDM
insulin-dependent type 1 diabetes mellitus
IRIS
Integrated Risk Information System
JECFA
Joint FAO/WHO Expert Committee on Food Additives
LD 50
dose estimated to be lethal to half of the animals
LOAEL
lowest-observed-adverse-effect level
MAC
maximum acceptable concentration
MAni
methylaniline
MDL
method detection limit
Mor
morpholine
MU
methylurea
NADH
reduced nicotinamide adenine dinucleotide
NC
nitrosatable compound
NDEA
N-nitrosodiethylamine
NDMA
N-nitrosodimethylamine
NHL
non-Hodgkin's lymphoma
NIS
sodium/iodide symporter
NMU
N-nitroso-N-methylurea
NO 2¯
nitrite ion
NO 2-N
nitrite nitrogen
NO 3¯
nitrate ion
NO 3-N
nitrate nitrogen
NOAEL
no-observed-adverse-effect level
NOC
N-nitroso compound
NOEL
no-observed-effect level
NPRO
N-nitrosoproline
NPYR
N-nitrosopyrrolidine
NSF
NSF International
NTP
National Toxicology Program (U.S.)
OEHHA
Office of Environmental Health Hazard Assessment (California)
OR
odds ratio
Pip
piperazine
PQL
practical quantitation limit
RNA
ribonucleic acid
RR
relative risk; rate ratio
SCC
Standards Council of Canada
SD
Sprague-Dawley
SG
Syrian Golden
SM
Standard Method
Sw
Swiss
T 3
triiodothyronine
T 4
thyroxine
TD05
tumorigenic dose 05
TMA
trimethylamine
TMAO
trimethylamine-N-oxide
TSH
thyroid stimulating hormone
U
unit
UDS
unscheduled DNA synthesis
UV
ultraviolet
w/w
weight per weight
WHO
World Health Organization

Page details

Date modified: