NNALs: Measuring Exposure to a Tobacco-Specific Carcinogen
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific lung carcinogen found in tobacco products and tobacco smoke.
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is produced from the breakdown of NNK in the body. It is an excellent biomarker of exposure to tobacco products and to the tobacco specific carcinogen NNK.
Tobacco products contain many naturally occurring chemicals, including those known to cause, initiate, or promote cancer ( One of these carcinogens--NNK (chemical name: 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone) has been linked specifically to the development of lung cancer in humans. 34
- Tobacco-specific N-nitrosamines (TSNAs) found in tobacco products and tobacco smoke
- N-nitrosonornicotine (NNN)
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- N-nitrosoanatabine (NAT)
- N-nitrosoanabasine (NAB)
The metabolism of NNK
NNALs as biomarkers of exposure to tobacco products
NNALs are some of the best biomarkers of exposure to tobacco. Like cotinine, NNALs are specific to tobacco products and tobacco smoke and cannot be produced from other sources, and therefore provide reliable results. However, NNALs remain much longer in the body than cotinine, so researchers can study individual tobacco use patterns. NNALs can also be used to study the exposure of individuals to the carcinogenic chemical NNK, which cannot be done using cotinine.
NNALs are some of the 91 chemicals measured by the Canadian Health Measure Survey (CHMS)--a survey done by Statistics Canada to examine the exposure of Canadians to a variety of environmental chemicals. By measuring tobacco-specific biomarkers of exposure such as NNALs, researchers can better study smoking prevalence and the exposure of Canadians to tobacco products and tobacco smoke.
Glossary of Terms
- The whole range of biochemical processes that occur within an organism. Metabolism consists of build-up and breakdown of substances.
- The substance, or product, resulting from a metabolic process.
- Related in application, or effect, to a particular chemical, structure, or process.
- Artificially produced poison or poisonous substance.
- Absorption and incorporation of a substance by live tissue.
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