Team Grants: Bringing Biology to Cancer Prevention
Backgrounder
The Canadian Institutes of Health Research and its partners, the Terry Fox Research Institute, the Canadian Cancer Society, the Japan Agency for Medical Research and Development, the Cancer Research Society and BioCanRx, are investing more than $41 million to support 19 research teams that will work over the next five years to develop and share new approaches that advance cancer prevention, reduce cancer risk, and improve early detection for some of the most commonly diagnosed cancers in Canada and the world.
| Lead Researcher | Project Title | Funding |
|---|---|---|
| Sheela Abraham Queen's University Kingston, ON |
Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction | $1,988,650 |
| Mark Basik Jewish General Hospital Montreal, QC |
Advancing Risk Stratification in Young Women at High Risk for Breast Cancer | $1,999,957 |
| Steven Chan University Health Network (Princess Margaret Cancer Centre) Toronto, ON |
GLP-1 Receptor Agonists as a Preventive Strategy for Clonal Hematopoiesis-Driven Hematologic Cancers | $1,999,999 |
| Maziar Divangahi Research Institute of the McGill University Health Centre Montreal, QC |
Unlocking the Power of Trained Immunity in Cancer | $2,000,000 |
| Keith Fowke University of Manitoba Winnipeg, MB |
Inflammation, Sex hormones, and Human Papilloma Virus (HPV) Expression: Assessing their Relationship in Menopausal Women and Evaluating Interventions to Prevent Cervical Cancer in Older Women | $2,000,000 |
| Vincent Fradet Université Laval Quebec, QC |
Harnessing the gut microbiome-prostate cancer crosstalk to discover predictive biomarkers of risk and potential preventive strategies | $2,000,000 |
| Aaron Goodarzi University of Calgary Calgary, AB |
Radioactive Air Pollutant Induced Disease (RAPID) Prevention - Understanding and preventing health risks from particle radiation-emitting radioisotope inhalation, as modified by genetic ancestry and mixed exposure with combustion particulates. | $2,000,000 |
| Vikki Ho Centre hospitalier de l'Université de Montréal Montreal, QC |
Environmental eXposure Profiling for Signatures of Early ColoRectal Cancer (EXPOSE-CRC) | $2,000,000 |
| Rayjean Hung Lunenfeld-Tanenbaum Research Institute Toronto, ON |
Prevention of Adiposity-related Cancers via Biology and Evidence Triangulation (PROBE) | $1,999,985 |
| David Huntsman BC Cancer Vancouver, BC |
Biologic basis of contraceptive choice associated ovarian cancer risk: from populations through cells to action | $2,000,000 |
| Alberto Martin University of Toronto Toronto, ON |
Therapeutic interventions to prevent colon cancer caused by pks+ E.coli | $2,000,000 |
| Christopher Maxwell University of British Columbia Vancouver, BC |
Targeting breast involution for the primary prevention of breast cancer among women who inherit a pathogenic variant in breast cancer 1 (BRCA1) | $1,996,790 |
| Luke McCaffrey McGill University Montreal, QC |
Decoding Breast Cancer: How Intrinsic Factors and Distinct Tissue Microenvironments Collaboratively Drive Breast Cancer Initiation | $2,000,000 |
| Rachel Murphy BC Cancer Vancouver, BC |
Ultra-processed foods and cancer: advancing evidence on the biological mechanisms linking the gut microbiome, ultra-processed foods and colorectal cancer (UPFront) | $2,000,000 |
| Faiyaz Notta University Health Network (Princess Margaret Cancer Centre) Toronto, ON |
The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy | $5,300,000 |
| Gina Ogilvie University of British Columbia Vancouver, BC |
Subsequent to LEEP Evaluation of Disease Recurrence – Systemic and Comprehensive Pan-optic Exploration (SLEEPER-SCOPE 360) – A Comprehensive Exploration of post-LEEP HPV Infection and Cervical Dysplasia Recurrence and its Associated Factors | $2,000,000 |
| Michael Pollak Jewish General Hospital Montreal, QC |
Incretin-mimetic drugs for cancer prevention: Mechanisms and clinical potential | $1,975,000 |
| Isabella Tai BC Cancer Vancouver, BC |
Bridging gastric cancer biology to prevent progression of pre-cancerous gastric lesions | $2,000,000 |
| Gustavo Ybazeta Health Sciences North Research Institute Sudbury, ON |
CANCER-WISE: Cancer Associated Nucleic acids in Community Environments-Risk Detection through Wastewater-based Integrated Surveillance and Epidemiology | $2,000,000 |