CompassRx, 10th edition : Data companion file
These data tables contain additional information pertaining to annual public drug plan expenditure in 2022/23.
Suggested citation
Suggested citation:
Patented Medicine Prices Review Board. (2025). CompassRx, 10th edition: Data companion file. Ottawa: PMPRB.
Table of contents
Table 1: 50 Top-Selling Medicines (Most Utilized Molecule/Strength/Form) by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
Table 1: 50 Top-Selling Medicines (Most Utilized Molecule/Strength/Form) by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
| Rank | Medical ingredient (strength) | Brand- or biologic-only medicine |
Total | BC | AB | SK | MB | ON | NB | NS | PE | NL | YT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aflibercept (2 mg/0.05 mL) | Yes | $463.71 | - | $11.18 | $6.65 | - | $432.92 | $9.57 | - | $1.66 | $1.02 | $0.71 |
| 2 | Infliximab (100 mg) | $351.65 | $57.59 | $35.06 | $49.20 | $38.67 | $151.44 | $6.87 | $7.85 | $1.98 | $2.52 | $0.46 | |
| 3 | Adalimumab (50 mg/mL) | $319.04 | $76.36 | $24.67 | $29.79 | $35.06 | $128.10 | $5.30 | $11.66 | $2.16 | $5.26 | $0.68 | |
| 4 | Glucose monitoring systems - continuous and flash systems | $253.44 | $26.10 | $0.51 | $1.41 | $1.35 | $223.96 | - | - | - | - | $0.12 | |
| 5 | Elexacaftor/tezacaftor/ivacaftor (100/50/75 mg) | Yes | $251.59 | $37.81 | $46.40 | $19.65 | $13.04 | $119.11 | $5.86 | - | - | $9.45 | $0.27 |
| 6 | Semaglutide (1 mg/act) | Yes | $237.78 | $25.84 | $30.09 | $5.35 | $2.92 | $165.38 | $2.94 | $3.84 | $1.06 | $0.16 | $0.21 |
| 7 | Ranibizumab (10 mg/mL) | Yes | $205.38 | - | $3.86 | $0.97 | - | $187.55 | $9.33 | - | $0.92 | $2.76 | - |
| 8 | Semaglutide (1.34 mg/mL) | Yes | $181.73 | $13.70 | $14.68 | $4.81 | $3.64 | $137.17 | $2.54 | $3.80 | $0.80 | $0.33 | $0.27 |
| 9 | Apixaban (5 mg) | $156.50 | $17.02 | $17.43 | $5.87 | $2.20 | $110.04 | $1.69 | $1.56 | $0.22 | $0.26 | $0.21 | |
| 10 | Ibrutinib (140 mg) | Yes | $137.16 | - | - | - | $4.75 | $118.02 | $3.54 | $6.84 | $0.40 | $3.62 | - |
| 11 | Sofosbuvir/velpatasvir (400/100 mg) | Yes | $135.46 | $40.18 | $8.49 | $3.38 | $1.31 | $74.18 | $2.34 | $2.35 | - | $3.02 | $0.21 |
| 12 | Test strips | $127.52 | $16.11 | $15.05 | $7.53 | $5.73 | $70.14 | - | $7.89 | $0.97 | $4.09 | $0.02 | |
| 13 | Denosumab (60 mg/mL) | Yes | $126.78 | $1.94 | $4.92 | $2.27 | $0.43 | $116.49 | $0.25 | $0.34 | $0.08 | $0.04 | $0.02 |
| 14 | Vedolizumab (300 mg) | Yes | $126.09 | $45.36 | $15.03 | $16.04 | $10.63 | $28.56 | $4.80 | $3.93 | $0.48 | $1.23 | $0.03 |
| 15 | Sitagliptin/metformin (50/1000 mg) | $120.87 | - | $9.36 | $1.20 | $0.18 | $108.92 | $0.98 | $0.21 | $0.01 | $0.01 | - | |
| 16 | Etanercept (50 mg/mL) | $118.73 | $24.66 | $10.65 | $7.94 | $9.80 | $57.97 | $2.27 | $3.69 | $0.55 | $0.99 | $0.22 | |
| 17 | Empagliflozin (10 mg) | Yes | $110.68 | $6.04 | $9.63 | $2.41 | $1.56 | $87.90 | $1.05 | $1.58 | $0.22 | $0.26 | $0.03 |
| 18 | Rivaroxaban (20 mg) | Yes | $104.77 | $11.33 | $14.19 | $5.90 | $2.59 | $63.68 | $3.09 | $2.87 | $0.35 | $0.76 | <$0.01 |
| 19 | Empagliflozin (25 mg) | Yes | $104.06 | $13.95 | $11.73 | $4.09 | $2.19 | $67.91 | $2.06 | $1.62 | $0.28 | $0.16 | $0.08 |
| 20 | Glecaprevir/pibrentasvir (100/40 mg) | Yes | $103.00 | $24.72 | $4.33 | $5.70 | $4.26 | $58.24 | $1.35 | $2.68 | - | $1.48 | $0.25 |
| 21 | Paliperidone (100 mg/mL) | Yes | $95.98 | $19.93 | $1.57 | $5.12 | $3.09 | $59.17 | $3.80 | $2.45 | $0.19 | $0.63 | $0.04 |
| 22 | Budesonide/formoterol (200/6 mcg/act) | Yes | $90.85 | $7.81 | $12.08 | $2.75 | $2.51 | $61.04 | $1.32 | $2.52 | $0.18 | $0.56 | $0.07 |
| 23 | Insulin glargine (100 U/mL) | $86.07 | $14.78 | $7.89 | $7.31 | $3.14 | $43.33 | $2.70 | $3.88 | $0.47 | $2.39 | $0.18 | |
| 24 | Osimertinib (80 mg) | Yes | $85.14 | - | - | - | $5.01 | $74.54 | $1.39 | $2.88 | $0.44 | $0.88 | - |
| 25 | Ocrelizumab (30 mg/mL) | Yes | $80.84 | $2.98 | $24.87 | $14.33 | $11.22 | $23.05 | $1.40 | $1.87 | - | $0.71 | $0.42 |
| 26 | Golimumab (100 mg/mL) | Yes | $80.50 | $15.43 | $13.95 | $11.34 | $6.38 | $22.20 | $5.06 | $3.33 | $0.41 | $2.24 | $0.15 |
| 27 | Ustekinumab (90 mg/mL) | Yes | $73.74 | $8.07 | $11.72 | $21.50 | $3.53 | $21.91 | $3.16 | $2.77 | $0.33 | $0.76 | - |
| 28 | Bictegravir/emtricitabine/tenofovir alafenamide (200/25/50 mg) | Yes | $68.26 | - | - | $6.68 | $3.89 | $54.52 | $2.60 | - | - | $0.45 | $0.11 |
| 29 | Sitagliptin (100 mg) | $67.89 | $0.01 | $6.75 | $1.98 | $0.98 | $55.96 | $1.61 | $0.52 | $0.04 | $0.06 | <$0.01 | |
| 30 | Eculizumab (10 mg/mL) | Yes | $64.68 | - | $7.43 | $5.83 | $2.89 | $47.47 | $0.54 | - | $0.51 | - | - |
| 31 | Enzalutamide (40 mg) | Yes | $64.13 | - | - | - | $4.19 | $52.80 | $2.13 | $2.90 | $0.31 | $1.80 | $0.02 |
| 32 | Pantoprazole (40 mg) | $62.04 | $4.02 | $9.61 | $2.58 | $0.83 | $39.70 | $2.85 | $1.30 | $0.55 | $0.56 | $0.06 | |
| 33 | Apalutamide (60 mg) | Yes | $61.27 | - | - | - | $5.23 | $49.83 | $1.88 | $3.97 | - | $0.29 | $0.07 |
| 34 | Insulin degludec (200 U/mL) | Yes | $61.22 | <$0.01 | $9.51 | $3.24 | $1.81 | $36.29 | $2.55 | $4.54 | $1.66 | $1.61 | <$0.01 |
| 35 | Linagliptin (5 mg) | Yes | $58.47 | $5.85 | $4.13 | $0.96 | $0.68 | $46.07 | $0.70 | $0.05 | $0.02 | $0.01 | <$0.01 |
| 36 | Fluticasone furoate/umeclidinium/vilanterol (100/62.5/25 mcg) | Yes | $58.16 | $5.35 | $7.06 | $3.58 | $1.58 | $35.17 | $1.49 | $2.48 | $0.58 | $0.83 | $0.04 |
| 37 | Nintedanib (150 mg) | Yes | $56.80 | $6.61 | $8.40 | $1.63 | $3.34 | $31.46 | $1.94 | $2.05 | $0.51 | $0.80 | $0.07 |
| 38 | Botulinum toxin (100 U) | Yes | $55.90 | $6.89 | $10.72 | $1.47 | $1.37 | $33.73 | $0.32 | $1.36 | - | - | $0.04 |
| 39 | Pegfilgrastim (6 mg/0.6 mL) | $50.98 | - | $1.90 | - | - | $47.11 | $0.77 | $0.83 | $0.06 | $0.32 | - | |
| 40 | Omalizumab (150mg) | Yes | $49.82 | $0.91 | $9.82 | $2.96 | $2.70 | $30.85 | $0.45 | $1.50 | $0.09 | $0.52 | $0.03 |
| 41 | Rizankizumab (90 mg/mL) | Yes | $49.25 | $5.95 | $7.35 | $1.32 | $2.46 | $27.64 | $1.08 | $0.89 | $0.18 | $2.37 | - |
| 42 | Secukinumab (150 mg/mL) | Yes | $49.04 | $20.88 | $8.03 | $4.53 | $6.50 | $5.29 | $0.93 | $1.13 | $0.14 | $1.46 | $0.14 |
| 43 | Dapagliflozin (10mg) | Yes | $47.66 | $2.21 | $6.98 | $1.65 | $1.40 | $34.20 | $0.82 | $0.31 | $0.01 | $0.06 | $0.01 |
| 44 | Aripiprazole (400 mg) | Yes | $44.96 | $11.83 | $0.60 | $2.38 | $0.74 | $26.60 | $1.55 | $0.94 | $0.09 | $0.22 | $0.01 |
| 45 | Benralizumab (30 mg/mL) | Yes | $44.31 | $6.03 | $7.04 | $1.22 | $1.10 | $25.89 | $1.39 | $1.13 | $0.22 | $0.30 | - |
| 46 | Mepolizumab (100 mg/mL) | Yes | $44.19 | $7.61 | $6.65 | $2.70 | $3.94 | $20.15 | $1.58 | $0.89 | $0.19 | $0.46 | $0.03 |
| 47 | Tofacitinib (5 mg) | $43.42 | $12.51 | $3.39 | $1.81 | $1.83 | $20.97 | $0.71 | $1.56 | $0.11 | $0.43 | $0.09 | |
| 48 | Ixekizumab (80 mg/mL) | Yes | $43.15 | $11.70 | $4.20 | $4.13 | $4.88 | $14.41 | $1.21 | $1.75 | $0.19 | $0.64 | $0.04 |
| 49 | Evolocumab (140 mg/mL) | Yes | $42.14 | $6.22 | $1.40 | $0.36 | $0.30 | $33.40 | $0.11 | $0.31 | - | $0.03 | $0.01 |
| 50 | Acalabrutinib (100 mg) | Yes | $41.49 | - | - | - | $4.79 | $30.65 | $4.00 | $1.80 | $0.11 | $0.16 | - |
| Brand- or biologic-only medicines share of top 50 | 68% | 60% | 70% | 60% | 57% | 71% | 78% | 64% | 64% | 71% | 62% | ||
| Total for top 50 | $5,558.30 | $622.25 | $480.30 | $293.52 | $232.63 | $3,613.06 | $117.83 | $114.60 | $19.74 | $58.95 | $5.42 | ||
| Top 50 share of all medicines | 47% | 47% | 47% | 52% | 49% | 48% | 41% | 38% | 41% | 40% | 33% |
Data source: National Prescription Drug Utilization Information System Database, Canadian Institute for Health Information.
Table 2: Top 50 Patented Medicines by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
Table 2: Top 50 Patented Medicines by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
| Rank | Medical Ingredient (Trade Name) |
Manufacturer | Total | BC | AB | SK | MB | ON | NB | NS | PE | NL | YT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aflibercept (Eylea) | Bayer Inc. | $463.71 | - | $11.18 | $6.65 | - | $432.92 | $9.57 | - | $1.66 | $1.02 | $0.71 |
| 2 | Elexacaftor/tezacaftor/ivacaftor (Trikafta) | Vertex Pharmaceuticals | $262.73 | $38.99 | $48.58 | $20.64 | $14.10 | $124.29 | $5.91 | - | - | $9.96 | $0.27 |
| 3 | Empagliflozin (Jardiance) | Boehringer Ingelheim | $214.74 | $19.99 | $21.36 | $6.50 | $3.75 | $155.81 | $3.11 | $3.19 | $0.50 | $0.41 | $0.11 |
| 4 | Adalimumab (Humira) | AbbVie Corporation | $179.78 | $1.50 | $2.64 | $25.94 | $32.25 | $101.63 | $0.02 | $8.19 | $2.08 | $4.96 | $0.57 |
| 5 | Rivaroxaban (Xarelto) | Bayer Inc. | $152.09 | $15.58 | $18.85 | $8.24 | $4.02 | $95.62 | $4.29 | $3.83 | $0.50 | $1.14 | <$0.01 |
| 6 | Ibrutinib (Imbruvica) | Janssen Inc. | $137.16 | - | - | - | $4.75 | $118.02 | $3.54 | $6.84 | $0.40 | $3.62 | - |
| 7 | Sofosbuvir/velpatasvir (Epclusa) | Gilead Sciences Canada Inc. | $135.46 | $40.18 | $8.49 | $3.38 | $1.31 | $74.18 | $2.34 | $2.35 | - | $3.02 | $0.21 |
| 8 | Vedolizumab (Entyvio) | Takeda Canada Inc. | $133.64 | $48.34 | $16.15 | $17.09 | $11.34 | $29.69 | $4.99 | $4.19 | $0.54 | $1.26 | $0.05 |
| 9 | Apixaban (Eliquis) | Bristol-Myers Squibb Canada | $132.52 | $21.45 | $21.53 | $6.02 | $2.32 | $78.50 | $1.09 | $1.06 | $0.18 | $0.22 | $0.14 |
| 10 | Denosumab (Prolia) | Amgen Canada Inc. | $126.78 | $1.94 | $4.92 | $2.27 | $0.43 | $116.49 | $0.25 | $0.34 | $0.08 | $0.04 | $0.02 |
| 11 | Glecaprevir/pibrentasvir (Maviret) | AbbVie Corporation | $103.00 | $24.72 | $4.33 | $5.70 | $4.26 | $58.24 | $1.35 | $2.68 | - | $1.48 | $0.25 |
| 12 | Palbociclib (Ibrance) | Pfizer Canada ULC | $98.38 | - | - | - | $5.04 | $81.61 | $3.93 | $4.86 | $0.94 | $1.99 | - |
| 13 | Sacubitril/valsartan (Entresto) | Novartis Pharmaceuticals Canada Inc. | $97.88 | $12.11 | $8.84 | $2.78 | $1.19 | $67.78 | $2.07 | $2.57 | $0.15 | $0.31 | $0.08 |
| 14 | Sitagliptin/metformin hydrochloride (Janumet) | Merck Canada Inc. | $97.11 | - | $7.97 | $1.05 | $0.10 | $87.04 | $0.75 | $0.18 | $0.01 | $0.01 | - |
| 15 | Paliperidone (Invega sustenna) | Janssen Inc. | $95.98 | $19.93 | $1.57 | $5.12 | $3.09 | $59.17 | $3.80 | $2.45 | $0.19 | $0.63 | $0.04 |
| 16 | Osimertinib (Tagrisso) | AstraZeneca Canada Inc. | $90.65 | - | - | - | $5.52 | $78.70 | $1.49 | $3.38 | $0.53 | $1.03 | - |
| 17 | Risankizumab (Skyrizi) | AbbVie Corporation | $83.29 | $9.10 | $13.68 | $3.90 | $7.71 | $39.93 | $2.89 | $1.87 | $0.35 | $3.84 | - |
| 18 | Ocrelizumab (Ocrevus) | Hoffmann-La Roche Limited | $80.84 | $2.98 | $24.87 | $14.33 | $11.22 | $23.05 | $1.40 | $1.87 | - | $0.71 | $0.42 |
| 19 | Sitagliptin (Januvia) | Merck Canada Inc. | $80.68 | $0.01 | $9.47 | $2.19 | $1.15 | $65.35 | $1.81 | $0.57 | $0.04 | $0.07 | $0.01 |
| 20 | Ustekinumab (Stelara) | Janssen Inc. | $73.74 | $8.07 | $11.72 | $21.50 | $3.53 | $21.91 | $3.16 | $2.77 | $0.33 | $0.76 | - |
| 21 | Nintedanib (Ofev) | Boehringer Ingelheim | $73.21 | $8.40 | $10.75 | $2.16 | $4.13 | $40.70 | $2.27 | $2.82 | $0.96 | $0.95 | $0.07 |
| 22 | Bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy) | Gilead Sciences Canada Inc. | $68.26 | - | - | $6.68 | $3.89 | $54.52 | $2.60 | - | - | $0.45 | $0.11 |
| 23 | Dapagliflozin (Forxiga) | AstraZeneca Canada Inc. | $65.56 | $2.37 | $8.83 | $1.90 | $1.65 | $49.35 | $1.01 | $0.37 | $0.01 | $0.06 | $0.01 |
| 24 | Eculizumab (Soliris) | Alexion Pharma GmbH | $64.68 | - | $7.43 | $5.83 | $2.89 | $47.47 | $0.54 | - | $0.51 | - | - |
| 25 | Enzalutamide (Xtandi) | Astellas Pharma Canada Inc. | $64.13 | - | - | - | $4.19 | $52.80 | $2.13 | $2.90 | $0.31 | $1.80 | $0.02 |
| 26 | Tofacitinib (Xeljanz) | Pfizer Canada ULC | $62.42 | $14.54 | $5.52 | $3.42 | $3.20 | $32.40 | $0.83 | $1.85 | $0.13 | $0.43 | $0.09 |
| 27 | Apalutamide (Erleada) | Janssen Inc. | $61.27 | - | - | - | $5.23 | $49.83 | $1.88 | $3.97 | - | $0.29 | $0.07 |
| 28 | Aripiprazole (Abilify) | Otsuka Pharmaceutical Co Ltd | $60.29 | $17.00 | $0.94 | $3.21 | $0.91 | $34.46 | $1.93 | $1.44 | $0.12 | $0.27 | $0.01 |
| 29 | Canagliflozin (Invokana) | Janssen Inc. | $59.25 | <$0.01 | $6.21 | $1.78 | $0.92 | $49.88 | $0.38 | $0.05 | $0.01 | $0.02 | <$0.01 |
| 30 | Linagliptin (Trajenta) | Boehringer Ingelheim | $58.47 | $5.85 | $4.13 | $0.96 | $0.68 | $46.07 | $0.70 | $0.05 | $0.02 | $0.01 | <$0.01 |
| 31 | Fluticasone furoate/umeclidinium/vilanterol (Trelegy Ellipta) | GlaxoSmithKline Inc. | $58.16 | $5.35 | $7.06 | $3.58 | $1.58 | $35.17 | $1.49 | $2.48 | $0.58 | $0.83 | $0.04 |
| 32 | Omalizumab (Xolair) | Novartis Pharmaceuticals Canada Inc. | $54.48 | $1.87 | $9.82 | $3.05 | $2.84 | $34.20 | $0.51 | $1.54 | $0.09 | $0.52 | $0.03 |
| 33 | Etanercept (Enbrel) | Immunex Corporation | $53.62 | $1.61 | - | $5.41 | $7.65 | $35.97 | $0.01 | $1.68 | $0.46 | $0.73 | $0.10 |
| 34 | Lisdexamfetamine dimesylate (Vyvanse) | Takeda Canada Inc. | $52.23 | $5.18 | $3.80 | $3.49 | $2.96 | $35.24 | $0.53 | $0.65 | $0.11 | $0.17 | $0.10 |
| 35 | Ruxolitinib (Jakavi) | Novartis Pharmaceuticals Canada Inc. | $51.15 | - | - | - | $3.41 | $42.67 | $1.98 | $2.33 | $0.07 | $0.68 | - |
| 36 | Secukinumab (Cosentyx) | Novartis Pharmaceuticals Canada Inc. | $49.04 | $20.88 | $8.03 | $4.53 | $6.50 | $5.29 | $0.93 | $1.13 | $0.14 | $1.46 | $0.14 |
| 37 | Onabotulinumtoxina (Botox) | AbbVie Corporation | $49.02 | $6.18 | $10.38 | $1.46 | $1.25 | $28.16 | $0.30 | $1.25 | - | - | $0.04 |
| 38 | Insulin glargine (Lantus) | Sanofi-Aventis Canada Inc. | $48.13 | $0.28 | - | $6.35 | $2.43 | $38.29 | - | $0.63 | $0.04 | $0.09 | $0.03 |
| 39 | Evolocumab (Repatha) | Amgen Canada Inc. | $47.54 | $6.70 | $1.62 | $0.38 | $0.30 | $38.05 | $0.12 | $0.32 | - | $0.03 | $0.02 |
| 40 | Mirabegron (Myrbetriq) | Astellas Pharma Canada Inc. | $46.83 | $0.03 | $4.41 | $1.10 | $1.27 | $38.20 | $0.68 | $0.92 | $0.08 | $0.14 | $0.01 |
| 41 | Tocilizumab (Actemra) | Hoffmann-La Roche Limited | $46.42 | $9.33 | $7.08 | $3.18 | $2.50 | $21.99 | $0.66 | $1.10 | $0.07 | $0.39 | $0.11 |
| 42 | Abatacept (Orencia) | Bristol-Myers Squibb Canada | $45.27 | $14.08 | $7.96 | $2.48 | $2.22 | $15.31 | $0.96 | $1.51 | $0.24 | $0.48 | $0.04 |
| 43 | Sitagliptin/metformin hydrochloride (Janumet XR) | Merck Canada Inc. | $44.79 | - | $2.96 | $0.27 | $0.08 | $41.15 | $0.27 | $0.05 | <$0.01 | <$0.01 | - |
| 44 | Ixekizumab (Taltz) | Eli Lilly Canada Inc. | $43.15 | $11.70 | $4.20 | $4.13 | $4.88 | $14.41 | $1.21 | $1.75 | $0.19 | $0.64 | $0.04 |
| 45 | Acalabrutinib (Calquence) | AstraZeneca Canada Inc. | $41.49 | - | - | - | $4.79 | $30.65 | $4.00 | $1.80 | $0.11 | $0.16 | - |
| 46 | Abacavir/dolutegravir/lamivudine (Triumeq) | ViiV Healthcare ULC | $41.17 | - | - | $1.26 | $2.86 | $35.88 | $0.82 | - | - | $0.24 | $0.11 |
| 47 | Benralizumab (Fasenra) | AstraZeneca Canada Inc. | $39.38 | $5.11 | $6.53 | $1.08 | $0.85 | $23.23 | $1.22 | $0.92 | $0.22 | $0.21 | - |
| 48 | Paliperidone (Invega Trinza) | Janssen Inc. | $36.37 | $9.04 | $0.41 | $0.60 | $1.05 | $22.68 | $1.54 | $0.67 | $0.02 | $0.36 | $0.01 |
| 49 | Lenalidomide (Revlimid) | Celgene Inc. | $35.79 | - | - | - | - | $35.49 | - | - | - | - | $0.30 |
| 50 | Etanercept (Brenzys) | Samsung Bioepis Co., Ltd | $33.88 | $10.97 | $3.86 | $2.05 | $1.28 | $12.26 | $1.75 | $1.45 | $0.05 | $0.18 | $0.04 |
| Total | $4,395.59 | $421.34 | $358.09 | $223.64 | $195.46 | $2,951.71 | $91.02 | $88.81 | $13.02 | $48.08 | $4.43 | ||
| Share of all patented drugs | 77% | 74% | 75% | 79% | 74% | 77% | 75% | 75% | 76% | 75% | 76% |
Data source: National Prescription Drug Utilization Information System Database, Canadian Institute for Health Information.
Table 3: Top 50 Multi-Source Generic Drugs by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
Table 3: Top 50 Multi-Source Generic Drugs by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
| Rank | Medicinal ingredient | Total | BC | AB | SK | MB | ON | NB | NS | PE | NL | YT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Atorvastatin | $65.06 | $7.58 | $8.13 | $2.31 | $1.43 | $40.83 | $1.35 | $1.98 | $0.44 | $0.89 | $0.13 |
| 2 | Rosuvastatin | $64.54 | $5.11 | $8.00 | $2.48 | $0.83 | $42.62 | $1.51 | $2.31 | $0.48 | $1.16 | $0.04 |
| 3 | Pantoprazole | $60.38 | $3.87 | $9.50 | $2.64 | $0.83 | $38.19 | $2.84 | $1.34 | $0.55 | $0.56 | $0.06 |
| 4 | Amlodipine | $48.34 | $5.44 | $5.95 | $1.78 | $1.02 | $30.71 | $0.97 | $1.53 | $0.38 | $0.49 | $0.07 |
| 5 | Apixaban | $44.23 | $2.94 | $2.99 | $2.09 | $1.06 | $32.10 | $1.51 | $1.11 | $0.16 | $0.15 | $0.12 |
| 6 | Pregabalin | $42.53 | $0.12 | $2.77 | $2.00 | $0.85 | $34.27 | $1.06 | $0.94 | $0.24 | $0.22 | $0.07 |
| 7 | Quetiapine | $40.14 | - | - | - | $4.53 | $28.32 | $2.28 | $3.45 | $0.37 | $1.19 | - |
| 8 | Candesartan | $37.97 | $5.59 | $1.88 | $0.05 | $1.76 | $25.67 | $1.22 | $1.46 | $0.01 | $0.30 | $0.01 |
| 9 | Duloxetine | $34.28 | $1.12 | $4.18 | $2.11 | $1.24 | $24.58 | $0.46 | $0.45 | $0.04 | $0.04 | $0.07 |
| 10 | Buprenorphine combinations | $30.05 | $2.70 | $3.48 | $1.46 | $0.36 | $19.88 | $0.49 | $0.90 | $0.16 | $0.56 | $0.06 |
| 11 | Escitalopram | $27.02 | $4.96 | $2.53 | $0.75 | $0.39 | $17.18 | $0.34 | $0.55 | $0.09 | $0.22 | $0.02 |
| 12 | Perindopril | $26.68 | $4.36 | $1.76 | $1.52 | $1.03 | $14.57 | $0.96 | $1.40 | $0.30 | $0.75 | $0.02 |
| 13 | Sertraline | $26.47 | $7.71 | $1.26 | $0.93 | $0.85 | $12.01 | $0.75 | $1.03 | $0.42 | $1.51 | $0.01 |
| 14 | Perindopril and diuretics | $26.12 | - | - | - | $0.52 | $24.52 | $0.33 | $0.63 | $0.02 | $0.02 | $0.08 |
| 15 | Gabapentin | $23.74 | $5.33 | $3.10 | $1.11 | $1.15 | $11.05 | $0.93 | $0.78 | $0.17 | $0.10 | $0.03 |
| 16 | Ramipril | $21.84 | $3.20 | $0.43 | $0.37 | $0.96 | $15.74 | $0.48 | $0.46 | $0.06 | $0.13 | $0.02 |
| 17 | Aripiprazole | $21.10 | $4.69 | $0.79 | $1.17 | $0.84 | $11.26 | $0.83 | $0.71 | $0.18 | $0.61 | $0.01 |
| 18 | Nabilone | $20.96 | $2.11 | $3.99 | $1.02 | $0.42 | $11.61 | $0.53 | $0.64 | $0.18 | $0.43 | $0.04 |
| 19 | Lansoprazole | $19.28 | $0.15 | $1.41 | $0.27 | $0.06 | $16.78 | $0.17 | $0.31 | $0.04 | $0.09 | <$0.01 |
| 20 | Risperidone | $18.88 | $2.21 | $1.06 | $0.88 | $0.36 | $11.51 | $0.84 | $0.94 | $0.12 | $0.93 | $0.04 |
| 21 | Mycophenolic acid | $18.57 | $0.54 | $2.14 | $0.94 | $0.25 | $12.76 | $0.65 | $0.83 | $0.07 | $0.37 | $0.01 |
| 22 | Fluticasone/salmeterol | $18.24 | $3.66 | $0.88 | $1.28 | $0.68 | $9.94 | $0.68 | $0.67 | $0.07 | $0.38 | $0.01 |
| 23 | Tamsulosin | $18.11 | $4.25 | $1.94 | $0.81 | $0.48 | $9.21 | $0.37 | $0.44 | $0.17 | $0.37 | $0.08 |
| 24 | Hydromorphone | $18.06 | $3.99 | $1.24 | $1.10 | $0.50 | $9.43 | $0.88 | $0.64 | $0.12 | $0.14 | $0.02 |
| 25 | Levodopa/decarboxylase inhibitor | $17.78 | $1.81 | $2.24 | $0.70 | $0.50 | $11.44 | $0.28 | $0.47 | $0.10 | $0.23 | $0.02 |
| 26 | Olanzapine | $17.45 | $0.29 | $1.11 | $0.14 | $0.10 | $15.63 | $0.11 | $0.05 | <$0.01 | $0.01 | $0.01 |
| 27 | Pirfenidone | $16.91 | $1.85 | $2.37 | $0.79 | $0.98 | $9.23 | $0.67 | $0.60 | $0.12 | $0.29 | - |
| 28 | Metformin | $16.38 | $2.66 | $0.59 | $0.66 | $0.85 | $9.66 | $0.88 | $0.72 | $0.13 | $0.22 | $0.01 |
| 29 | Metoprolol | $16.23 | $2.26 | $2.06 | $1.01 | $0.50 | $8.75 | $0.42 | $0.69 | $0.16 | $0.34 | $0.04 |
| 30 | Oxycodone/paracetamol | $15.74 | $3.53 | $1.16 | $1.28 | $0.80 | $7.49 | $0.40 | $0.52 | $0.12 | $0.41 | $0.02 |
| 31 | Epinephrine | $15.61 | $2.13 | $0.79 | $0.77 | $0.52 | $9.22 | $0.64 | $0.83 | $0.16 | $0.52 | $0.03 |
| 32 | Rabeprazole | $15.54 | $2.22 | $2.39 | $1.23 | $0.74 | $6.39 | $0.57 | $1.05 | $0.20 | $0.74 | $0.02 |
| 33 | Venlafaxine | $15.45 | $8.91 | $0.61 | $1.96 | $2.70 | - | $0.63 | <$0.01 | $0.03 | $0.60 | $0.02 |
| 34 | Clopidogrel | $15.35 | $2.82 | $1.42 | $0.91 | $0.60 | $7.67 | $0.62 | $0.69 | $0.13 | $0.47 | $0.02 |
| 35 | Clozapine | $15.12 | $1.50 | $0.91 | $0.45 | $0.59 | $10.72 | $0.31 | $0.38 | $0.08 | $0.14 | $0.04 |
| 36 | Valproic acid | $15.09 | $1.98 | $1.42 | $0.57 | $0.35 | $9.30 | $0.66 | $0.52 | $0.13 | $0.15 | $0.02 |
| 37 | Levetiracetam | $14.96 | $2.30 | $1.36 | $1.17 | $0.72 | $8.08 | $0.37 | $0.53 | $0.10 | $0.30 | $0.02 |
| 38 | Diltiazem | $14.78 | $1.45 | $1.43 | $0.56 | $0.33 | $9.54 | $0.42 | $0.57 | $0.09 | $0.38 | $0.01 |
| 39 | Fluoxetine | $14.49 | $1.31 | $0.46 | $0.99 | $0.42 | $8.80 | $0.18 | $1.51 | $0.06 | $0.76 | $0.01 |
| 40 | Salbutamol | $14.42 | $1.18 | $0.89 | $1.01 | $0.30 | $10.60 | $0.18 | $0.19 | $0.01 | $0.05 | <$0.01 |
| 41 | Methotrexate | $13.70 | $0.55 | $0.69 | <$0.01 | $0.43 | $10.89 | $0.46 | $0.27 | $0.08 | $0.33 | <$0.01 |
| 42 | Bupropion | $13.68 | $1.79 | $1.29 | $0.68 | $0.52 | $8.13 | $0.29 | $0.52 | $0.14 | $0.28 | $0.03 |
| 43 | Omeprazole | $13.18 | - | - | - | $0.51 | $12.25 | $0.15 | $0.20 | $0.02 | $0.06 | - |
| 44 | Gliclazide | $12.96 | $0.33 | $0.34 | $1.08 | $0.50 | $7.65 | $1.00 | $1.11 | $0.13 | $0.83 | <$0.01 |
| 45 | Risedronic acid | $12.83 | $1.62 | $0.63 | $0.52 | $0.60 | $8.23 | $0.30 | $0.48 | $0.05 | $0.37 | $0.01 |
| 46 | Irbesartan | $12.38 | $2.50 | $1.91 | $0.52 | $0.82 | $5.87 | $0.20 | $0.28 | $0.05 | $0.20 | $0.02 |
| 47 | Mirtazapine | $12.36 | $0.31 | $2.47 | $0.47 | $0.44 | $7.92 | $0.16 | $0.41 | $0.09 | $0.09 | $0.01 |
| 48 | Tenofovir disoproxil | $12.22 | $1.80 | $1.96 | $0.62 | $0.37 | $6.33 | $0.34 | $0.42 | $0.10 | $0.25 | $0.03 |
| 49 | Fentanyl | $12.16 | $0.11 | $1.05 | $0.45 | $0.14 | $9.58 | $0.27 | $0.32 | $0.04 | $0.19 | <$0.01 |
| 50 | Timolol combinations | $11.44 | $0.20 | $1.03 | $0.39 | $1.00 | $6.37 | $0.67 | $1.12 | $0.16 | $0.45 | $0.06 |
| Total | $1,150.78 | $129.01 | $101.99 | $47.99 | $38.70 | $730.44 | $33.60 | $39.97 | $7.34 | $20.26 | $1.46 | |
| Share of all multi-source generic medicines | 58% | 57% | 55% | 54% | 54% | 59% | 59% | 57% | 58% | 54% | 58% |
Data source: National Prescription Drug Utilization Information System Database, Canadian Institute for Health Information.
Table 4: Top 50 Single-Source Non-Patented Medicines by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($thousand)
Table 4: Top 50 Single-Source Non-Patented Medicines by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($thousand)
| Rank | Medical Ingredient (Trade Name) |
Manufacturer | Total | BC | AB | SK | MB | ON | NB | NS | PE | NL | YT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Semaglutide (Ozempic) | Novo Nordisk Canada Inc. | $419,515 | $39,533 | $44,764 | $10,160 | $6,566 | $302,545 | $5,484 | $7,641 | $1,860 | $487 | $476 |
| 2 | Ranibizumab (Lucentis) | Novartis Pharmaceuticals Canada Inc. | $205,383 | - | $3,855 | $970 | - | $187,547 | $9,326 | - | $923 | $2,761 | - |
| 3 | Golimumab (Simponi) | Janssen Inc. | $96,317 | $20,252 | $17,909 | $12,244 | $7,457 | $26,077 | $5,686 | $3,649 | $504 | $2,390 | $149 |
| 4 | Budesonide/formoterol fumarate dihydrate (Symbicort) | AstraZeneca Canada Inc. | $94,272 | $7,966 | $12,273 | $2,826 | $2,619 | $63,852 | $1,349 | $2,556 | $187 | $565 | $77 |
| 5 | Insulin degludec (Tresiba) | Novo Nordisk Canada Inc. | $93,572 | $7 | $14,087 | $5,007 | $2,515 | $56,285 | $3,620 | $6,561 | $2,467 | $3,018 | $6 |
| 6 | Tiotropium (Spiriva Respimat) | Boehringer Ingelheim | $63,586 | $6,191 | $9,104 | $2,662 | $1,222 | $40,759 | $1,163 | $1,762 | $194 | $376 | $154 |
| 7 | Fluticasone furoate/vilanterol (Breo Ellipta) | GlaxoSmithKline Inc. | $56,609 | $5,487 | $6,253 | $1,878 | $1,988 | $37,819 | $1,348 | $1,026 | $287 | $482 | $40 |
| 8 | Mepolizumab (Nucala) | GlaxoSmithKline Inc. | $55,718 | $9,996 | $8,714 | $3,146 | $4,642 | $25,364 | $1,902 | $1,230 | $229 | $467 | $27 |
| 9 | Tafamidis meglumine (Vyndaqel) | Pfizer Canada ULC | $53,727 | - | $16,256 | $580 | $4,429 | $31,674 | $325 | $41 | - | $422 | - |
| 10 | Certolizumab pegol (Cimzia) | UCB Canada Inc. | $36,591 | $11,127 | $4,427 | $2,797 | $1,297 | $13,732 | $643 | $1,772 | $250 | $419 | $129 |
| 11 | Goserelin (Zoladex LA) | TerSera Therapeutics, LLC | $31,727 | $5 | - | $6 | - | $28,434 | $853 | $1,650 | $203 | $464 | $111 |
| 12 | Lanreotide (Somatuline Autogel) | Ipsen Biopharmaceuticals Canada Inc. | $26,156 | - | $3,860 | $64 | $1,847 | $18,051 | $601 | $1,166 | - | $488 | $78 |
| 13 | Mometasone furoate/ formoterol fumarate dihydrate (Zenhale) | Organon Canada Inc. | $23,705 | $1,327 | $190 | $287 | $290 | $20,585 | $753 | $189 | $45 | $36 | $2 |
| 14 | Ciclesonide (Omnaris) | Covis Pharma GmbH | $19,941 | - | - | $133 | - | $19,804 | - | - | - | - | $3 |
| 15 | Dalteparin sodium (Fragmin) | Pfizer Canada ULC | $18,749 | $3,547 | $448 | $222 | $1,336 | $11,619 | $329 | $1,211 | $8 | - | $28 |
| 16 | Darbepoetin alfa (Aranesp (HSA-Free)) | Amgen Canada Inc. | $16,195 | - | $8,175 | $1,009 | - | $4,749 | $1,191 | - | - | $1,066 | $5 |
| 17 | Alglucosidase alfa (Myozyme) | Sanofi Genzyme, a division of Sanofi-Aventis Canada Inc. |
$14,841 | - | - | $656 | $1,565 | $12,393 | - | $227 | - | - | - |
| 18 | Insulin detemir (Levemir) | Novo Nordisk Canada Inc. | $12,993 | $1,990 | $1,924 | $444 | $113 | $7,907 | $111 | $406 | $12 | $77 | $11 |
| 19 | Tinzaparin sodium (Innohep) | LEO Pharma Inc. | $11,964 | $617 | $5,460 | $1,208 | - | $4,666 | - | $14 | - | - | - |
| 20 | Fusidic acid (Fucidin) | LEO Pharma Inc. | $11,600 | $953 | $566 | $268 | $220 | $9,097 | $120 | $223 | $21 | $131 | $1 |
| 21 | Insulin lispro (Humalog) | Eli Lilly Canada Inc. | $11,214 | $1,043 | $396 | $2 | $406 | $9,207 | $70 | - | $62 | $23 | $5 |
| 22 | Treprostinil (Remodulin) | United Therapeutics Corporation | $10,107 | $2,008 | - | - | $432 | $6,714 | $953 | - | - | - | - |
| 23 | Ciclesonide (Alvesco) | Covis Pharma GmbH | $9,763 | $1,112 | $1,311 | $342 | $142 | $5,607 | $440 | $390 | $249 | $163 | $5 |
| 24 | Edaravone (Radicava) | Mitsubishi Tanabe Pharma Corporation | $9,631 | $1,136 | $1,836 | - | - | $5,495 | $241 | $862 | $59 | - | - |
| 25 | Tacrolimus (Protopic) | Leo pharma Inc. | $9,563 | $147 | $167 | $108 | $112 | $8,971 | $18 | $30 | $5 | $3 | $2 |
| 26 | Levonorgestrel (Mirena) | Bayer Inc. | $7,137 | $1,591 | $216 | $427 | $243 | $4,294 | $115 | $120 | $16 | $115 | - |
| 27 | Conjugated estrogens (Premarin) | Pfizer Canada ULC | $5,639 | $854 | $946 | $348 | $108 | $2,923 | $153 | $134 | $36 | $126 | $12 |
| 28 | Dornase alfa (Pulmozyme) | Hoffmann-La Roche Limited | $5,253 | $1,642 | - | $659 | $189 | $2,280 | $208 | - | - | $261 | $14 |
| 29 | Glycerol phenylbutyrate (Ravicti) | Horizon Therapeutics Ireland DAC | $4,984 | $927 | $90 | $495 | - | $3,183 | $170 | $119 | - | - | - |
| 30 | Sirolimus (Rapamune) | Pfizer Canada ULC | $4,852 | $177 | - | $571 | $350 | $3,551 | $165 | - | - | $6 | $32 |
| 31 | Terbinafine hydrochloride (Lamisil) | Novartis Pharmaceuticals Canada Inc. | $4,607 | - | $348 | $123 | $4 | $3,924 | $59 | $82 | $4 | $58 | $4 |
| 32 | Pegvisomant (Somavert) | Pfizer Canada ULC | $4,579 | $1,243 | - | - | $185 | $3,151 | - | - | - | - | - |
| 33 | Inotersen (Tegsedi) | Akcea Therapeutics, Inc. | $4,438 | - | $861 | - | $755 | $2,822 | - | - | - | - | - |
| 34 | Insulin aspart (NovoRapid) | Novo Nordisk Canada Inc. | $4,289 | $255 | - | - | - | $4,035 | - | - | - | - | - |
| 35 | Saxagliptin/metformin hydrochloride (Komboglyze) | AstraZeneca Canada Inc. | $4,015 | $527 | $456 | $43 | $9 | $2,974 | $5 | $1 | - | - | - |
| 36 | Aprepitant (Emend Tri-Pack) | Merck Canada Inc. | $3,789 | $646 | $510 | - | $423 | $2,015 | $95 | $66 | $21 | - | $15 |
| 37 | Deferiprone (Ferriprox) | Chiesi Canada corp. | $3,654 | $984 | $265 | - | - | $2,199 | $71 | $136 | - | - | - |
| 38 | Idursulfase (Elaprase) | Takeda Canada Inc. | $3,335 | - | - | - | - | $3,335 | - | - | - | - | - |
| 39 | Degarelix (Firmagon) | Ferring Inc. | $3,252 | - | - | - | - | $2,946 | $115 | $157 | $8 | $21 | $4 |
| 40 | Pentosan polysulfate sodium (Elmiron) | Janssen Inc. | $3,168 | $1,249 | $278 | $107 | $150 | $419 | $295 | $549 | $23 | $99 | - |
| 41 | Pimecrolimus (Elidel) | Bausch Health, Canada Inc. | $3,156 | $12 | - | $29 | $11 | $3,104 | - | - | - | - | - |
| 42 | Flupentixol decanoate (Fluanxol Depot) | Lundbeck Canada Inc. | $3,070 | $434 | $77 | $189 | $117 | $1,989 | $60 | $150 | $1 | $49 | $4 |
| 43 | Interferon beta-1b (Betaseron) | Bayer Inc. | $2,901 | $272 | $330 | $334 | $508 | $1,328 | $22 | - | $44 | $64 | - |
| 44 | Pentoxifylline (Pentoxifylline SR) | Aa pharma Inc. | $2,867 | $320 | $323 | $93 | $36 | $1,951 | $35 | $27 | $12 | $69 | $1 |
| 45 | Carbidopa/levodopa/entacapone (Stalevo) | Sandoz Canada Inc. | $2,799 | $117 | $240 | $120 | - | $2,222 | $24 | $69 | $7 | $1 | - |
| 46 | Fluticasone furoate (Arnuity Ellipta) | Glaxosmithkline Inc. | $2,588 | $218 | $378 | $159 | $40 | $1,586 | $83 | $77 | $2 | $43 | $1 |
| 47 | Tobramycin/dexamethasone (Tobradex) | Novartis Pharmaceuticals Canada Inc. | $2,521 | $269 | $333 | $187 | $18 | $1,507 | $47 | $97 | $6 | $57 | $2 |
| 48 | Zuclopenthixol decanoate (Clopixol) | Lundbeck Canada Inc. | $2,447 | $790 | $52 | $256 | $55 | $1,059 | $80 | $95 | $1 | $58 | $1 |
| 49 | Triptorelin (Trelstar) | Knight Therapeutics Inc. | $2,430 | $34 | - | - | - | $2,222 | $28 | $146 | - | - | - |
| 50 | Methylprednisolone (Solu-Medrol) | Pfizer Canada ULC | $2,430 | $191 | $126 | $62 | $7 | $1,821 | $34 | $80 | $54 | $51 | $4 |
| Total | $1,507,639 | $127,195 | $167,805 | $51,221 | $42,407 | $1,021,788 | $38,390 | $34,713 | $7,801 | $14,916 | $1,402 | ||
| Share of all single-source non-patented medicines | 83% | 90% | 85% | 82% | 84% | 84% | 58% | 69% | 94% | 87% | 31% |
Data source: National Prescription Drug Utilization Information System Database, Canadian Institute for Health Information.
Table 5: Top 50 Manufacturers by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
Table 5: Top 50 Manufacturers by Drug Cost, NPDUIS Public Drug Plans, 2022/23 ($million)
| Rank | Company | Total | BC | AB | SK | MB | ON | NB | NS | PE | NL | YT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Janssen Inc. | $906.54 | $74.90 | $39.38 | $106.02 | $59.93 | $558.64 | $22.58 | $29.07 | $3.72 | $11.59 | $0.71 |
| 2 | Bayer Inc. | $655.62 | $19.09 | $31.12 | $17.02 | $7.10 | $554.82 | $14.81 | $5.23 | $2.28 | $3.42 | $0.73 |
| 3 | Novartis Pharmaceuticals Canada Inc. | $623.84 | $40.95 | $44.74 | $16.25 | $19.58 | $458.83 | $20.76 | $12.52 | $1.97 | $7.82 | $0.41 |
| 4 | Novo Nordisk Canada Inc. | $597.40 | $46.55 | $68.15 | $17.45 | $11.21 | $412.29 | $10.28 | $18.34 | $5.23 | $7.29 | $0.62 |
| 5 | AbbVie Corporation | $515.22 | $51.11 | $39.78 | $39.78 | $53.11 | $290.27 | $7.71 | $17.44 | $3.08 | $11.97 | $0.96 |
| 6 | Apotex Inc. | $505.97 | $48.67 | $32.47 | $15.40 | $12.80 | $357.33 | $14.59 | $14.14 | $2.50 | $7.47 | $0.61 |
| 7 | Boehringer Ingelheim | $503.95 | $53.07 | $55.28 | $15.77 | $11.57 | $343.98 | $8.86 | $10.31 | $2.03 | $2.68 | $0.39 |
| 8 | AstraZeneca Canada Inc. | $405.67 | $20.49 | $34.23 | $7.73 | $17.98 | $300.02 | $10.55 | $10.76 | $1.18 | $2.63 | $0.10 |
| 9 | Sandoz Canada Inc. | $319.71 | $64.37 | $41.06 | $15.03 | $8.98 | $163.73 | $8.63 | $10.75 | $1.48 | $5.23 | $0.48 |
| 10 | Pfizer Canada ULC | $316.23 | $28.74 | $29.89 | $8.00 | $19.17 | $205.55 | $7.45 | $11.44 | $1.54 | $4.24 | $0.21 |
| 11 | Glaxosmithkline Inc. | $297.95 | $37.11 | $33.36 | $13.82 | $13.12 | $177.79 | $8.29 | $8.66 | $1.51 | $3.98 | $0.30 |
| 12 | Sanis Health Inc. | $284.56 | $22.91 | $26.08 | $10.49 | $7.79 | $192.82 | $8.77 | $9.33 | $1.46 | $4.37 | $0.54 |
| 13 | Vertex Pharmaceuticals | $273.09 | $38.99 | $50.99 | $22.13 | $14.10 | $129.88 | $6.50 | - | - | $9.96 | $0.55 |
| 14 | Takeda Canada Inc. | $267.16 | $58.79 | $33.23 | $27.40 | $21.84 | $108.50 | $6.15 | $5.57 | $1.67 | $3.84 | $0.17 |
| 15 | Gilead Sciences Canada Inc. | $260.65 | $43.73 | $9.60 | $12.95 | $7.94 | $173.51 | $5.97 | $2.55 | - | $3.91 | $0.50 |
| 16 | Pharmascience Inc. | $258.37 | $34.72 | $25.29 | $14.39 | $9.29 | $150.88 | $6.03 | $10.06 | $1.72 | $5.74 | $0.26 |
| 17 | Teva Canada Limited | $254.27 | $35.75 | $21.92 | $13.02 | $11.58 | $145.94 | $8.29 | $9.30 | $1.71 | $6.42 | $0.34 |
| 18 | Merck Canada Inc. | $242.18 | $1.82 | $21.22 | $4.24 | $2.56 | $207.78 | $3.22 | $1.15 | $0.08 | $0.11 | $0.02 |
| 19 | Amgen Canada Inc. | $236.71 | $26.93 | $21.96 | $4.85 | $2.51 | $172.88 | $4.79 | $1.29 | $0.08 | $1.35 | $0.08 |
| 20 | Sivem Pharmaceuticals ULC | $192.53 | $16.31 | $23.50 | $5.76 | $6.42 | $127.05 | $4.18 | $5.61 | $2.26 | $1.42 | $0.02 |
| 21 | Hoffmann-La Roche Limited | $181.32 | $14.94 | $34.80 | $21.09 | $17.42 | $82.85 | $2.98 | $4.40 | $0.11 | $2.10 | $0.63 |
| 22 | Bristol-Myers Squibb Canada | $179.63 | $35.62 | $29.59 | $8.52 | $4.54 | $95.42 | $2.05 | $2.58 | $0.43 | $0.71 | $0.18 |
| 23 | Astellas Pharma Canada Inc. | $154.09 | $0.04 | $4.42 | $3.17 | $8.39 | $127.48 | $3.95 | $4.25 | $0.39 | $1.94 | $0.07 |
| 24 | Eli Lilly Canada Inc. | $145.41 | $36.93 | $15.13 | $12.43 | $9.56 | $54.19 | $4.84 | $6.46 | $1.31 | $4.26 | $0.30 |
| 25 | Sanofi-Aventis Canada Inc. | $130.57 | $8.60 | $7.02 | $9.46 | $5.84 | $93.31 | $2.48 | $2.71 | $0.34 | $0.77 | $0.04 |
| 26 | Celltrion Healthcare Co Ltd | $112.81 | $40.44 | $29.60 | $2.23 | $9.12 | $28.57 | $2.12 | $0.58 | $0.01 | $0.05 | $0.10 |
| 27 | Samsung Bioepis Co., Ltd | $100.66 | $45.52 | $13.12 | $4.21 | $2.88 | $22.44 | $7.38 | $4.64 | $0.12 | $0.28 | $0.08 |
| 28 | Mylan Pharmaceuticals ULC | $84.69 | $12.64 | $8.16 | $4.40 | $5.05 | $45.14 | $3.20 | $3.04 | $0.65 | $2.33 | $0.09 |
| 29 | AA Pharma Inc. | $82.85 | $17.40 | $7.59 | $4.34 | $2.80 | $42.57 | $2.39 | $3.11 | $0.52 | $2.05 | $0.09 |
| 30 | Otsuka Pharmaceutical Co Ltd | $76.09 | $18.49 | $2.35 | $3.40 | $1.38 | $46.44 | $2.08 | $1.49 | $0.12 | $0.33 | $0.01 |
| 31 | Purdue Pharma | $69.82 | $7.32 | $7.03 | $4.45 | $2.86 | $42.56 | $2.25 | $2.66 | $0.16 | $0.48 | $0.05 |
| 32 | Alexion Pharma Gmbh | $69.58 | - | $10.26 | $5.83 | $2.89 | $49.31 | $0.54 | $0.23 | $0.51 | - | - |
| 33 | ViiV Healthcare ULC | $66.98 | <$0.01 | - | $2.65 | $4.01 | $58.58 | $1.24 | - | - | $0.39 | $0.11 |
| 34 | Celgene Inc. | $64.18 | $0.01 | $0.08 | - | $1.65 | $59.61 | $0.52 | $0.78 | $0.24 | $0.99 | $0.30 |
| 35 | JAMP Pharma Corporation | $63.52 | $7.84 | $8.60 | $3.62 | $2.79 | $33.12 | $2.36 | $3.17 | $0.45 | $1.52 | $0.04 |
| 36 | BGP Pharma ULC | $62.09 | $6.74 | $6.47 | $2.24 | $1.37 | $40.71 | $1.38 | $2.29 | $0.30 | $0.53 | $0.06 |
| 37 | Immunex Corporation | $56.08 | $1.81 | $0.08 | $5.58 | $7.76 | $37.61 | $0.01 | $1.91 | $0.46 | $0.75 | $0.11 |
| 38 | Taro Pharmaceuticals Inc. | $55.10 | $4.69 | $4.58 | $2.33 | $1.88 | $37.78 | $1.06 | $1.65 | $0.30 | $0.78 | $0.04 |
| 39 | Biogen Canada Inc. | $54.23 | $10.22 | $10.14 | $2.12 | $5.18 | $22.20 | $1.60 | $1.77 | $0.07 | $0.71 | $0.22 |
| 40 | Auro Pharma Inc. | $52.78 | $9.37 | $6.30 | $2.61 | $1.52 | $28.69 | $1.12 | $2.16 | $0.27 | $0.67 | $0.08 |
| 41 | Bausch Health, Canada Inc. | $48.59 | $4.18 | $5.95 | $2.17 | $1.05 | $32.20 | $1.12 | $1.09 | $0.17 | $0.64 | $0.03 |
| 42 | UCB Canada Inc. | $47.49 | $12.60 | $4.65 | $3.21 | $1.56 | $21.88 | $0.70 | $2.04 | $0.30 | $0.43 | $0.13 |
| 43 | LEO Pharma Inc. | $43.61 | $2.58 | $7.38 | $2.30 | $0.52 | $29.56 | $0.39 | $0.38 | $0.07 | $0.41 | $0.02 |
| 44 | Ipsen Biopharmaceuticals Canada Inc. | $38.47 | $0.12 | $3.88 | $0.15 | $2.94 | $26.60 | $1.44 | $1.98 | - | $1.27 | $0.08 |
| 45 | Organon Canada Inc. | $36.26 | $3.29 | $2.44 | $0.76 | $0.50 | $26.80 | $1.34 | $0.58 | $0.11 | $0.42 | $0.02 |
| 46 | Covis Pharma Gmbh | $33.35 | $1.33 | $1.82 | $0.57 | $0.21 | $27.89 | $0.52 | $0.56 | $0.25 | $0.19 | $0.01 |
| 47 | TerSera Therapeutics LLC | $31.73 | $0.01 | - | $0.01 | - | $28.43 | $0.85 | $1.65 | $0.20 | $0.46 | $0.11 |
| 48 | Marcan Pharmaceuticals Inc. | $31.72 | $3.42 | $3.24 | $1.92 | $0.99 | $19.13 | $0.52 | $1.54 | $0.18 | $0.73 | $0.04 |
| 49 | EMD Serono, a division of EMD Inc., Canada | $30.29 | $9.08 | $5.44 | $1.52 | $1.39 | $11.29 | $0.38 | $0.39 | $0.10 | $0.68 | $0.02 |
| 50 | Sanofi Genzyme, a division Of Sanofi-Aventis Canada Inc. | $29.86 | $3.12 | $1.29 | $1.73 | $2.64 | $19.30 | $0.63 | $0.80 | $0.15 | $0.17 | $0.06 |
| Total | $10,151.50 | $1,083.30 | $924.66 | $506.48 | $429.27 | $6,524.14 | $241.84 | $254.42 | $43.78 | $132.48 | $11.13 |
Data source: National Prescription Drug Utilization Information System Database, Canadian Institute for Health Information.