ARCHIVED: Appendix 2: The Management of the National Antiviral Stockpile: Options Report - Summary of antivirals contained and proposed for the NAS
| *Prophylaxis dosages are summarized in the Glossary of this Report, and can be found along with further technical information in CPIP, Annex E, or in the appropriate product monograph. | |||||
| Antiviral | Manufacturer | Formulation(s) | Standard Treatment Dose* | Shelf-Life (stability) | Patent Status |
|---|---|---|---|---|---|
Oseltamivir/ |
Hoffman-La Roche |
Capsules (30mg, 45mg, 75mg) Packaging: 10 capsules per blister pack Powder for oral suspension (12 mg/ml when reconstituted): 900 mg per bottle (volume of 75 ml in a 100-ml glass bottle) |
Adults: 75mg twice daily for 5 days (10 capsules) Children: Emergency compounding: 75 mg capsules with Ora-Sweet is permitted to obtain paediatric final concentration 15 mg/ml. |
Capsules: 7 years for new gov’t purchases after 2008 (formerly 5 years) Powder: 2 years stability once reconstituted, 10 days in refrigerator (at 2-8OC)
Compounded: stable for 5 weeks when stored at 25OC |
Patent expires 2016 |
Zanamivir/
|
GlaxoSmith-Kline |
ROTADISK consisting of a circular foil disk with four blisters each containing 5mg of zanamivir. A DISKHALER inhalation device is provided to administer the medication (through inhalation).
Packaging: one box contains 5 disks (equals one treatment course) |
Adults: 2 inhalations (10mg) twice daily for 5 days Children: only indicated for children aged 7+: 2 inhalations (10mg) twice daily for 5 days |
5 years
(note: GSK has guaranteed 7 years of shelf-life on government purchases by replacing expiring stock – see discussion in Current Context – Regulatory Considerations of this Report) |
Patent expires Dec 2014 |
Amantadine/ Gen-AmantadineR |
Genpharm (generic Amantadine manufacturer that supplies the F/P/T stockpiles) |
Capsules (100mg/capsule) Packaging: one bottle contains 100 capsules
Syrup (10mg/ml) |
Used in combination therapy. Dosages are stated for those with no renal impairment 1-9 years or <40kg: 5mg/kg/day once daily, or divided twice daily. Total daily dose not to exceed 150mg 65+: 100mg once daily |
Capsules: 3.5 to 4 years depending on manufacturer.
Syrup: 2 years. |
Generics available |
Page details
- Date modified: