ARCHIVED - Recommendations on a Human Papillomavirus Immunization Program

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Appendix 2: Table 1a

Table 1a: HPV vaccine cost-effectiveness studies, base case assumptions

Assumption	Sanders⁽³⁶⁾	Kulasingam⁽³⁵⁾	Goldie⁽³⁸⁾	Brisson⁽⁴⁰⁾	Taira⁽³⁰⁾	Elbasha⁽³²⁾	Marra⁽³⁴⁾
Type of model	State-transition	State-transition	State-transition	State-transition	Hybrid	Dynamic	Dynamic
Vaccine target HPV types	13 high-risk HPV types	70% of high-risk HPV types	HPV 16/18	HPV 16/18 HPV 6/11/16/ 18	HPV 16/18	HPV 6/11/16/18	HPV 16/18
Vaccination age group	12 years old, female	12 years old, female	12 years old, female	12 years old, female	12 years old, female ± male	12 years old, female ± male (± catch-up female ± male)	11 and 14-year-old females
Vaccination coverage	70%	100%	100%	100%	70%	70% (linear over first 5 years)	F11: 85% F14: 80%
Vaccination efficacy	75%	90%	90%	95%	90%	90%	100%
Duration of protection	10 years	10 years	Life long	Life long	10 years	Life long	Life long
Booster administration	Every 10 years	None reported	None	None	At 22 years old	None	None
Vaccine cost (three-dose administration)	$300 (2001 US$)	$200 (2001 US$)	$377 (2001 US$)	$400	$300 (2001 US$)	$360 (2001 US$)	$400
Booster cost	$100 (2001 US$)	_	_	_	$100 (2001 US$)	_	_
Outcomes measured*	HPV infection, SIL, cervical cancer, cervical cancer-related death, cost, life years, QALYs, cost per life year gained, cost per QALY gained	HPV infection, CIN, cervical cancer, cervical cancer death, cost, life years, cost per life year gained	HPV infection, LSIL, HSIL, cervical cancer, cost, QALYs, cost per QALY gained	HPV infection, CIN, cervical cancer, cervical cancer death, cost, life years, cost per life year gained	Cervical cancer, cost, life years, QALYs, cost per life year gained, cost per QALY gained	HPV infection, genital warts, CIN, cervical cancer, cost, QALYs, cost per QALY gained	HPV infection, CIN, cervical cancer, cervical cancer death, cost, life years, cost per life year gained
Perspective	Direct	Direct	Societal	Direct	Direct	Direct	Direct

*SIL = squamous intraepithelial lesion, CIN = cervical intraepithelial neoplasia, LSIL = low-grade squamous intraepithelial lesion, HSIL = high-grade intraepithelial lesion

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Date modified:: 2007-12-01