CAS Registry Number 1589-47-5

What is it?

  • 2-Methoxy-1-propanol is a by-product in the manufacture of propylene glycol monomethyl ether (PGME).

How is it used?

  • 2-Methoxy-1-propanol is found as an impurity in propylene glycol monomethyl ether (PGME), which is a solvent used in various products such as industrial and consumer paints.
  • 2-Methoxy-1-propanol may also be found as an impurity in cosmetics (nail polish and nail polish remover), at very low levels.
  • Based on the most recent data available, 2-methoxy-1-propanol is not manufactured commercially in Canada, but is imported into Canada.

Why did the Government of Canada assess it?

  • 2-Methoxy-1-propanol was identified as a potential concern for human health based on its classification by an international organization as a substance that may cause harm to the developing fetus, and based on what was believed to be a moderate potential for exposure to Canadians.

How are Canadians exposed to it?

  • Canadians may be exposed to 2-methoxy-1-propanol as a result of using certain cosmetics such as nail polish remover.

What is the Government of Canada doing?

  • The Government of Canada has conducted a science-based evaluation of 2-methoxy-1-propanol, called a screening assessment.
  • The Government of Canada has determined that 2-methoxy-1-propanol is considered to be harmful to human health.
  • Although Canadians' exposure is currently considered to be low, the Government of Canada is taking action so that exposure remains low.
  • The Government of Canada will prevent its use in cosmetics by proposing to add 2-methoxy-1-propanol to the Cosmetic Ingredient "Hotlist".
  • The Government of Canada will also investigate whether action is required to limit 2-methoxy-1-propanol in paint remover, polyurethane varnish and concrete floor primer.
  • The final screening assessment and proposed risk management approach were published on March 7, 2009. The proposed risk management approach will be subject to a 60-day public comment period from March 7 to May 6, 2009.

What should Canadians do?

  • Canadians should always read and follow safety instructions provided on product labels, particularly the advice to use in a well-ventilated area and to wear protective clothing (when applicable).
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