2-Methoxy-1-propanol

CAS Registry Number 1589-47-5

The Final Screening Assessment for 2-Methoxy-1-propanol was published on March 7, 2009 as part of Batch 3 of the Challenge initiative of the Chemicals Management Plan (CMP). The assessment is summarized on this page.

What is it

  • 2-Methoxy-1-propanol is a by-product in the manufacture of propylene glycol monomethyl ether (PGME).

How is it used

  • 2-Methoxy-1-propanol is found as an impurity in propylene glycol monomethyl ether (PGME), which is a solvent used in various products such as industrial and consumer paints.
  • 2-Methoxy-1-propanol may also be found as an impurity in cosmetics (nail polish and nail polish remover), at very low levels.
  • Based on the most recent data available, 2-methoxy-1-propanol is not manufactured commercially in Canada, but is imported into Canada.

Why did the Government of Canada assess it

  • 2-Methoxy-1-propanol was identified as a potential concern for human health based on its classification by an international organization as a substance that may cause harm to the developing fetus, and based on what was believed to be a moderate potential for exposure to Canadians.

How are Canadians exposed to it

  • Canadians may be exposed to 2-methoxy-1-propanol as a result of using certain cosmetics such as nail polish remover.

What is the Government of Canada doing

  • The Government of Canada has conducted a science-based evaluation of 2-methoxy-1-propanol, called a screening assessment.
  • The Government of Canada has determined that 2-methoxy-1-propanol is considered to be harmful to human health.
  • Although Canadians' exposure is currently considered to be low, the Government of Canada is taking action so that exposure remains low.
  • The Government of Canada is proposing to include 2-methoxy-1-propanol as a prohibited or restricted ingredient on Health Canada's Cosmetic Ingredient Hotlist. The Hotlist is used to communicate that certain substances may not be compliant with requirements of the Food and Drug Act or the Cosmetic Regulations. Under Canadian legislation, cosmetics that contain substances that are harmful to the user cannot be sold.
  • The Government of Canada will also investigate whether action is required to limit 2-methoxy-1-propanol in paint remover, polyurethane varnish and concrete floor primer.
  • The proposed risk management approach was published on March 7, 2009. The proposed risk management approach will be subject to a 60-day public comment period from March 7 to May 6, 2009.
  • Up-to-date information of the risk management action milestones for 2-methoxy-1-propanol is available.

What should Canadians do

  • Canadians should always read and follow safety instructions provided on product labels, particularly the advice to use in a well-ventilated area and to wear protective clothing (when applicable).
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