Epoxides and Glycidyl Ethers Group
These substances were identified for action under the Chemicals Management Plan (CMP). The screening assessment focuses on 5 of 12 substances referred to collectively as the Epoxides and Glycidyl Ethers Group.
|Substance group||CAS RN||Common name and acronym||DSL name||Public comments on the draft screening assessment||Final screening assessment||Conclusion on section 64 criteria||Follow-up activities|
|Epoxides and Glycidyl Ethers Group||106-92-3a||Allyl glycidyl ether (AGE)||Oxirane, [(2-propenyloxy)methyl]-||HTML||HTML||Does not meet||Significant New Activity (SNAc) provisions|
|1139-30-6||Beta-caryophyllenoxide (BCPO)||5-Oxatricyclo[8.2.0.04,6]dodecane, 4,12,12-trimethyl-9-methylene-, [1R-(1R,4R,6R,10S)]-||None planned at this time|
|2210-79-9a||o-Cresol glycidyl ether (o-CGE)||Oxirane, [(2-methylphenoxy)methyl]-||SNAc provisions|
|2451-62-9a||Triglycidyl isocyanurate (TGIC)||1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-||SNAc provisions|
|120547-52-6b||Alkyl (C12-C13) glycidyl ether (C12-C13 AGE)||Oxirane, mono[(C12-13-alkyloxy)methyl] derivs.||None planned at this time|
While AGE, o-CGE and TGIC are not considered to be harmful to human health at levels of exposure considered in the assessment, they are associated with health effects of concern. Therefore, there may be a risk if exposures were to increase. The proposed follow-up activity is to apply the SNAc provisions of the Canadian Environmental Protection Act, 1999 (CEPA 1999) to AGE, o-CGE and TGIC.
|August 8, 2020||Publication in the Canada Gazette, Part I: Vol. 154, No. 32 of the SNAc notice of intent and start of 60-day public comment period.|
|August 8, 2020||Publication of the final screening assessment. The related notice was published in the Canada Gazette, Part I: Vol. 154, No. 32.|
|November 24, 2018||Publication and start of 60-day public comment period on the draft screening assessment. The related notice was published in the Canada Gazette, Part I: Vol. 152, No. 47.|
Seven other substances were identified as being a part of the Epoxides and Glycidyl Ethers Group at the outset of the third phase of the CMP. These substances were subsequently determined to be of low concern to both human health and the environment, through other approaches. Conclusions for CAS RNs 61788-72-5, 61789-01-3, 68082-35-9 are provided in the Final Screening Assessment for Substances Identified as Being of Low Concern based on the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances. Conclusions for CAS RNs 101-90-6, 556-52-5, 28768-32-3, 66072-38-6 are provided in the Final Screening Assessment for the Rapid Screening of Substances with Limited General Population Exposure.
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