Ethylene Glycol Ethers Group

Information sheet

These substances were identified for action under the Chemicals Management Plan (CMP). This screening assessment focuses on 7 of 9 substances referred to collectively as the Ethylene Glycol Ethers Group. Monoglyme was not identified under subsection 73(1) of the Canadian Environmental Protection Act, 1999 (CEPA 1999) but was included in this assessment as it was considered a priority based on other human health concerns.

Summary of Publications
Substance Group CAS RN Common Name DSL Name Public comments on the draft screening assessment Final Screening Assessment Conclusion on section 64 Criteria Follow-up Activities
Ethylene Glycol Ethers Group 110-71-4 Monoglyme [Ethylene glycol dimethyl ether] Ethane, 1,2-Dimethoxy- HTML HTML Does not meet Significant New Activity
111-46-6 Diethylene glycol Ethanol, 2,2'-oxybis- None planned at this time
111-90-0 Diethylene glycol monoethyl ether Ethanol, 2-(2-ethoxyethoxy)-
112-07-2 Ethylene glycol monobutyl ether acetate Ethanol, 2-butoxy-, acetate
112-27-6 Triethylene glycol Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-
112-34-5 Diethylene glycol monobutyl ether Ethanol, 2-(2-butoxyethoxy)-
112-60-7 Tetraethylene glycol Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

Follow-up activities

While exposure of the general population to monoglyme is not of concern at current levels, this substance is considered to have a health effect of concern based on its potential reproductive and developmental effects. Therefore, there may be a concern for human health if exposure levels were to increase. For this reason, the Government of Canada is proposing to apply the Significant New Activity (SNAc) provisions of CEPA 1999 to this substance. There are no follow-up activities planned for the other 6 substances included in this assessment.

Date Activity
September 1, 2018 Publication in the Canada Gazette, Part I: Vol. 152, No. 35 of the SNAc notice of intent for monoglyme, and start of 60-day public comment period.
September 1, 2018 Publication of the final screening assessment. The related notice was published in the Canada Gazette, Part I: Vol. 152, No. 35.
March 4, 2017 Publication and start of 60-day public comment period on the draft screening assessment (including follow-up activities for monoglyme). The related Notice was published in the Canada Gazette, Part I: Vol. 151, No. 9.


Two other substances (CAS RNs 111-96-6 and 112-49-2) were identified as being a part of the Ethylene Glycol Ethers Group at the outset of the third phase of the CMP.  These substances were subsequently determined to be of low concern to both human health and the environment, through other approaches. Conclusions for these 2 substances are provided in the Screening Assessment for Substances Identified as Being of Low Concern based on the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances.

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