Monocyclic and Bicyclic Sesquiterpenes Group

Topics

• Monocyclic and Bicyclic Sesquiterpenes Group – information sheet
• Guaiazulene (for consumers)
• Sandalwood oil (for consumers)
• T&T clove oil (for consumers)

These substances were identified for action under the Chemicals Management Plan (CMP). This screening assessment focuses on 16 substances, referred to collectively under the CMP as the Monocyclic, and Bicyclic Sesquiterpenes Group, which are a part of the larger Terpenes and Terpenoids Group.

• Summary of publications
• Timelines
• Background

Summary of publications

Substance group	Subgroup	CAS RN	Common name	DSL name	Draft screening assessment	Risk management scope	Proposed conclusion on section 64 criteria	Follow-up activities
Monocyclic and Bicyclic Sesquiterpenes Group	1	495-62-5	Bisabolene	Cyclohexene, 4-(1,5-dimethyl-4-hexenylidene)-1-methyl-	HTML	None	Does not meet	None planned at this time
	1	8001-61-4Note de bas de page a, Note de bas de page b	Copaiba balsam	Balsams, copaiba
	1	8007-08-7Note de bas de page a, Note de bas de page b	Ginger oil	Oils, ginger
	1	17627-44-0	Alpha-bisabolene	Cyclohexene, 4-(1,5-dimethyl-1,4-hexadienyl)-1-methyl-
	1	65113-99-7	Sandalore	3-Cyclopentene-1-butanol, α,β,2,2,3-pentamethyl-
	1	107898-54-4	Santol pentenol	4-Penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
	2	87-44-5	Beta-caryophyllene	Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene, [1R-(1R,4E,9S)]-
	2	88-84-6	Guaiene	Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)-
	2	3691-12-1	Alpha-guaiene	Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethenyl)-, [1S-(1α,4α,7α)]-
	2	4630-07-3	Valencene	Naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, [1R-(1α,7β,8aα)]-
	2	68917-29-3Note de bas de page b	T & T clove oil	Terpenes and terpenoids, clove oil		HTML	Meets one or more of the criteria	Refer to risk management scope
	3	489-86-1	Guaiol	5-Azulenemethanol, 1,2,3,4,5,6,7,8-octahydro-α,α,3,8-tetramethyl-,[3S-(3α,5α,8α)]-		None	Does not meet	None planned at this time
	3	639-99-6	Elemol	Cyclohexanemethanol, 4-ethenyl-α,α,4-trimethyl-3-(1-methylethenyl)-, [1R-(1α,3α,4β)]-
	3	22451-73-6	Bulnesol	5-Azulenemethanol, 1,2,3,3a,4,5,6,7-octahydro-α,α,3,8-tetramethyl-, [3S-(3α,3aβ,5α)]-
	Individual	489-84-9	Guaiazulene	Azulene, 1,4-dimethyl-7-(1-methylethyl)-		HTML	Meets one or more of the criteria	Refer to risk management scope
	Individual	8006-87-9Note de bas de page a, Note de bas de page b	Sandalwood oil	Oils, sandalwood
Footnote a This substance was not identified under subsection 73(1) of the Canadian Environmental Protection Act, 1999 but was included in this assessment as it was considered a priority on the basis of other human health concerns. Return to footnote a referrer Footnote b This CAS RN is a UVCB (unknown or variable composition, complex reaction products, or biological materials). Return to footnote b referrer

Timelines

Date	Activity
May 2022	Anticipated publication of the final assessment and proposed risk management approach.
May 8, 2021	Publication and start of 60-day public comment period on the Draft Screening Assessment for Terpenes and Terpenoids Monocyclic and Bicyclic Sesquiterpenes Group and the Risk Management Scope for Certain Terpenes and Terpenoids within the Monocyclic and Bicyclic Sesquiterpenes Group. The related notice was published in the Canada Gazette, Part I: Vol. 155, No. 19.

Background

The screening assessment focuses on 16 substances referred to as the Monocyclic and Bicyclic Sesquiterpenes Group. It consists of 14 substances that have been divided into 3 subgroups based on chemical structure, properties, and/or toxicity, as well as 2 individual substances namely sandalwood oil and guaiazulene. These 16 substances are a part of a larger group of 76 substances referred to collectively under the CMP as the Terpenes and Terpenoids Group.

Three of these 76 substances were subsequently determined to be of low concern to both human health and the environment through other approaches. The conclusions for CAS RN 25428-43-7 is provided in the Final Screening Assessment for the Rapid Screening of Substances with Limited General Population Exposure. Conclusions for CAS RNs 29350-73-0 and 68916-97-2 are provided in the Final Screening Assessment of Substances Identified as Being of Low Concern using the Ecological Risk Classification of Organic Substances and the Threshold of Toxicological Concern (TTC)-based Approach for Certain Substances.

Fifteen of these 76 substances (CAS RNs 80-56-8, 1113-21-9, 8000-46-2, 8002-09-3, 8006-64-2, 8007-01-0, 8007-02-1, 8008-31-9, 8008-52-4, 8008-57-9, 8014-19-5, 8015-77-8, 8016-85-1, 8021-28-1 and 9005-90-7) were assessed as a part of the Acyclic, Monocyclic, and Bicyclic Monoterpenes Group.

Twelve of these 76 substances (CAS RNs 8006-78-8, 8016-88-4, 8022-96-6, 8024-43-9, 8024-08-6, 80-54-6, 91-51-0, 37677-14-8, 52474-60-9, 52475-86-2, 65405-84-7 and 66327-54-6) were assessed as a part of the Phenylpropanoids and Aldehydes Group.

Fourteen of these 76 substances (CAS RNs 8013-10-3, 8023-75-4, 70788-30-6, 84961-67-1, 90045-36-6, 3738-00-9, 8016-37-9, 164288-52-2, 8022-56-8, 8008-93-3, 3407-42-9, 66068-84-6, 68877-29-2 and 70955-71-4) were assessed as a part of the Fourteen Terpene and Terpenoid Substances Group.

Fourteen of these 76 substances (CAS RNs 469-61-4, 470-40-6, 489-40-7, 514-51-2, 546-28-1, 8000-27-9, 68608-32-2, 68990-83-0, 59056-62-1, 471-3-4, 4572-09-2, 8031-03-6, 84082-54-2 and 90045-38-8) were assessed as a part of the Tricyclic Sesquiterpenes and Triterpenoids Group.

Two of these 76 substances (CAS RNs 117-98-6 and 68917-65-7) were originally included in the Tricyclic Sesquiterpenes and Triterpenoids Group but have been removed to be assessed in a separate assessment.