Diazenedicarboxamide - information sheet

Azodicarbonamide
(Diazenedicarboxamide)
CAS Registry Number 123-77-3

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Overview

  • The Government of Canada conducted a science-based evaluation, called a screening assessment, of diazenedicarboxamide, to address the potential for harm to Canadians and to the environment.
  • Under the Canadian Environmental Protection Act, 1999 (CEPA 1999), the risk posed by a substance is determined by considering both its hazardous properties (its potential to cause adverse human health or ecological effects) and the amount of exposure there is to people and the environment. A substance may have hazardous properties; however, the risk to human health or to the environment may be low depending upon the level of exposure.
  • The ecological hazard and exposure potentials of this substance were classified using the Ecological Risk Classification of Organic Substances Approach.
  • As a result of this screening assessment, diazenedicarboxamide is proposed as not harmful to human health or the environment, at current levels of exposure.

About this substance

  • This screening assessment focuses on the substance Diazenedicarboxamide, assessed as part of the third phase of the Chemicals Management Plan.
  • Diazenedicarboxamide does not occur naturally in the environment.
  • The Government gathers information on substances, including details on sources and uses in Canada, to support the risk assessment and management of substances under the CMP.
  • In Canada, diazenedicarboxamide is used in the manufacture of polyvinyl chloride (PVC) for building or construction materials.  The substance was also reported in automotive manufacturing, and fabrication of floor coverings.
  • Diazenedicarboxamide is a permitted food additive, which may be used in bread, flour, and whole wheat flour under certain conditions.
  • Diazenedicarboxamide may also be used to manufacture certain food packaging materials, such as liners and gaskets; however, exposure is not expected as there is no direct contact with food.

Human and ecological exposures

  • Exposure of Canadians to residual levels of diazenedicarboxamide (small amount leftover from the manufacturing process) in products available to consumers made using this substance, such as products containing foam or rubber, is expected to be minimal. 
  • Dietary exposure of Canadians to diazenedicarboxamide from its use as a food additive is expected to be negligible.
  • According to information under the Ecological Risk Classification of Organic Substances Approach, diazenedicarboxamide was identified as having a low ecological exposure potential.

Key health and ecological effects (hazard)

  • To identify human health effects, international reports of data were reviewed. Diazenedicarboxamide has previously been assessed through the Organisation for Economic Co-operation and Development (OECD) Cooperative Chemicals Programme, and an OECD Screening and Information Dataset Initial Assessment Report (SIAR) is available. This report was used to inform the health effects section of this screening assessment.
  • Diazenedicarboxamide is on the European Chemicals Agency’s Candidate List of Substances of Very High Concern for Authorisation because it is associated with respiratory sensitisation (that is, an immune system response to chemical exposure that can result in effects on breathing).
  • According to information considered under the Ecological Risk Classification of Organic Substances Approach, diazenedicarboxamide was identified as having a low ecological hazard potential.

Risk assessment outcomes

  • On the basis of the information presented in this screening assessment, exposure of Canadians to diazenedicarboxamide is low, thus the risk to human health from diazenedicarboxamide is considered to be low. 
  • The Ecological Risk Classification of Organic Substances Approach characterized diazenedicarboxamide as posing a low risk of harm to the environment.
  • The Government of Canada published the Draft Screening Assessment for Diazenedicarboxamide on April 20, 2019. This publication has a 60-day public comment period ending on June 19, 2019.

Proposed screening assessment conclusions

  • As a result of this assessment, the Government is proposing that diazenedicarboxamide is not harmful to human health at current levels of exposure.
  • The Government is also proposing that diazenedicarboxamide is not entering the environment at levels that are harmful to the environment.

Related information

  • Diazenedicarboxamide may be found in products available to consumers. Canadians should follow any safety warnings and directions on product labels and dispose of products responsibly.
  • Visit Healthy Home for more information on chemical safety in and around the home.
  • Canadians who may be exposed to diazenedicarboxamide in the workplace should consult with their employer and an occupational health and safety (OHS) representative about safe handling practices, applicable laws, and requirements under OHS legislation and the Workplace Hazardous Materials Information System (WHMIS).
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