Phosphoric Acid Derivatives Group - information sheet
Phenol, dimethyl-, phosphate (3:1) (Trixylyl phosphate)
CAS Registry Number 25155-23-1
9-Octadecen-1-ol, (Z)-, phosphate (Oleyl phosphate)
CAS Registry Number 37310-83-1
Phosphorous trichloride, reaction products with 1,1-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol
CAS Registry Number 119345-01-6
On this page
- About these substances
- Human and ecological exposures
- Key health and ecological effects (hazard)
- Risk assessment outcomes
- Preventive actions and reducing risk
- Related information
- The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from 3 substances in the Phosphoric Acid Derivatives Group.
- Under the Canadian Environmental Protection Act, 1999 (CEPA 1999) the risk posed by a substance is determined by considering both its hazardous properties (its potential to cause adverse human health or ecological effects) and the amount of exposure there is to people and the environment. A substance may have hazardous properties; however, the risk to human health or to the environment may be low depending upon the level of exposure.
- The ecological hazard and exposure potentials of these 3 substances were classified using the Ecological Risk Classification of Organic Substances Approach.
- Substances in the Phosphoric Acid Derivatives Group are associated with human health or ecological effects; however, the risk to Canadians and the environment is low at current levels of exposure. Therefore, it is proposed that these 3 substances are not harmful to human health or to the environment at current levels of exposure.
About these substances
- The screening assessment focuses on 3 of 6 substances referred to collectively under the Chemicals Management Plan (CMP) as the Phosphoric Acid Derivatives Group. These substances are trixylyl phosphate, oleyl phosphate, and the substance with CAS RN 119345-01-6.
- Three other substances in the Phosphoric Acid Derivatives Group were determined to be of low concern to both human health and the environment through other approaches. Conclusions for CAS RNs 68604-99-9, 68952-35-2 and 111174-61-9 are provided in the Screening Assessment for the Rapid Screening of Substances with Limited General Population Exposure.
- According to information gathered by the Government, these substances do not occur naturally in the environment.
- In Canada, trixylyl phosphate may be used as a flame retardant and in lubricants and greases. It may also be used in food packaging materials, in plasticizers, in hydraulic fluids and insulation for wires and cables.
- Oleyl phosphate is used in cosmetics, such as permanent hair dye.
- CAS RN 119345-01-6 is used in plastic and rubber materials and may also be used in food packaging materials.
Human and ecological exposures
- Canadians may be exposed to trixylyl phosphate through the environment (for example, from its presence in house dust) and from certain products available to consumers.
- Exposure of Canadians to oleyl phosphate may occur from the use of certain cosmetics.
- Canadians may be exposed to CAS RN 119345-01-6 mainly through their diet from its potential use in food packaging.
- According to information considered under the Ecological Risk Classification of Organic Substances Approach, trixylyl phosphate, oleyl phosphate, and CAS RN 119345-01-6 were identified as having low ecological exposure potential.
Key health and ecological effects (hazard)
- To inform the health effects characterization for trixylyl phosphate, international reports of data were reviewed. Trixylyl phosphate has been classified by the European Chemical Agency (ECHA) as a reproductive toxicant (may damage fertility) and is on the ECHA List of Substances of Very High Concern for reproductive toxicity. Effects on the reproductive organs and adrenal glands were considered to be the “critical” effects for the assessment of trixylyl phosphate.
- No effects on human health have been identified for oleyl phosphate.
- For CAS RN 119345-01-6, potential developmental effects in laboratory studies were considered to be the important or “critical” effects used for characterizing the risk to human health in the screening assessment.
- According to information considered under the Ecological Risk Classification of Organic Substances Approach, trixylyl phosphate was identified as having a moderate ecological hazard potential, while oleyl phosphate was identified as having a high ecological hazard potential. This was based on their potential to cause adverse effects in aquatic food webs. CAS RN 119345-01-6 was identified as having a low ecological hazard potential.
Risk assessment outcomes
- Based upon a comparison of levels to which Canadians may be exposed to trixylyl phosphate and CAS RN 119345-01-6, and levels associated with health effects, it was determined that the risk to human health from these substances is low.
- On the basis of the information presented in the draft screening assessment, the risk to human health from oleyl phosphate is also low.
- Based upon the outcome of the Ecological Risk Classification of Organic Substances Approach, trixylyl phosphate, oleyl phosphate, and CAS RN 119345-01-6 are considered unlikely to cause ecological harm.
- The Government of Canada published the Draft Screening Assessment for the Phosphoric Acid Derivatives Group on July 13, 2019. The public are invited to comment on the report during the 60-day public comment period ending on September 11, 2019.
Proposed screening assessment conclusions
- As a result of the draft assessment, the Government is proposing that trixylyl phosphate, oleyl phosphate, and CAS RN 119345-01-6 are not harmful to human health at current levels of exposure.
- The Government is also proposing that these substances are not entering the environment at concentrations that are harmful to the environment.
Preventive actions and reducing risk
- Although trixylyl phosphate is not considered to be harmful to human health at current levels of exposure, this substance is considered to have a health effect of concern based on its potential to cause effects on the reproductive system. Therefore, there may be a potential risk for human health if exposure to this substance were to increase.
- For this reason, follow-up activities to track changes in exposure or commercial use patterns for trixylyl phosphate are being considered.
- Stakeholders are encouraged to provide any information pertaining to this substance that may help inform the choice of follow-up activity, during the 60-day public comment period on the assessment. This could include information on new or planned import, manufacture or use of the substance.
- These substances may be found in products available to consumers. Canadians should follow any safety warnings and directions related to the product and dispose of productsresponsibly.
- Visit Do it for a Healthy Home for more information on chemical safety in and around the home.
- Canadians who may be exposed to these substances in the workplace should consult with their employer and an occupational health and safety (OHS) representative about safe handling practices, applicable laws, and requirements under OHS legislation and the Workplace Hazardous Materials Information System.
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