Changes to the Cosmetic Ingredient Hotlist

For more information on the consultation comments provided to Health Canada, please contact the Hotlist Coordinator at: cosmetics@hc-sc.gc.ca.

Changes to the Cosmetic Ingredient Hotlist:

August 2025 Changes to the Cosmetic Ingredient Hotlist

Items Amended

Cannabis, as defined in subsection 2(1) of the Cannabis Act (see the Cannabis Exemption (Food and Drugs Act) Regulations for details)

This entry was amended to Cannabis, as defined in subsection 2(1) of the Cannabis Act to reflect amendments to the Cannabis Exemption (Food and Drugs Act) Regulations.

Cannabis spp. (hemp) derivatives or a product made from those derivatives that are exempt from the application of the Cannabis Act under the Industrial Hemp Regulations
The entry was amended to reflect changes to the Industrial Hemp Regulations, including revision of title to Cannabis spp. derivatives or a product made from those derivatives that are exempt from the application of the Cannabis Act.

February 2025 Changes to the Cosmetic Ingredient Hotlist

Items Added

Retinal

This ingredient was added to the list of substances described as restricted due to therapeutic properties and risk of skin irritation. The maximum concentrations for this ingredient were calculated based on the recommended tolerable upper intake levels for vitamin A.

Thioglycolic acid esters

This ingredient was added to the list of substances described as prohibited due to risk of skin sensitization. A health protective limit could not be calculated based on available data. Additionally, there was evidence that glyceryl thioglycolate can remain on permed hair for at least 3 months after a procedure. Continuous exposure increases the risk for developing skin sensitization and long-lasting dermatitis for people who are already sensitized.

Items Amended

Mixed cresols and derivatives

The entry for mixed cresols and derivatives was amended to create separate entries for different cresols, as the substances have different risk profiles. p-Cresol and mixtures thereof remains prohibited, while new restrictions were created for m-cresol and o-cresol. Conditions for m- and o-cresol were based on a review of the available data indicating that these ingredients may affect the central nervous system when used on mucous membranes or when used at higher concentrations. Minimal risk is expected when used in lower concentrations on areas other than mucous membranes.

Peroxide and peroxide-generating compounds

This entry was amended to:

Conditions of use for oral products were not changed from the previous version.

Benzoyl peroxide

This entry was amended to indicate that the ingredient may only be used in nail products for professional use. Warnings and cautionary statements to avoid skin contact have been included due to the strong potential to cause irritation and sensitization.

Retinol and its esters

This entry was amended to reduce the maximum concentration permitted for certain products such as body lotions. Exposure from these products at the previously permitted concentrations may exceed the tolerable upper intake levels of vitamin A that are recommended by Health Canada.

May 2024 Changes to the Cosmetic Ingredient Hotlist

Items Added

Basic green 4

This ingredient was added to the list of prohibited substances due to potential developmental effects, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

Benzophenone

This ingredient was added to the list of restricted substances due to adverse maternal effects such as decreased body weight, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

p-Chloro-m-cresol

This ingredient was added to the list of restricted substances due to health concerns regarding the adrenal organs, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

Solvent violet 13

This ingredient was added to the list of restricted substances due to health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

Items Amended

Dialkanolamines, secondary

This entry was amended to include secondary alkyl- and alkanolamines and their salts for clarity. These substances have similar potential to act as precursors of carcinogenic nitrosamines.

Alpha-hydroxy acids

This entry was amended to clarify that Polyhydroxy acids (PHAs) and bionic acids with alpha-hydroxyl groups, as well as their salts, are included. They meet the chemical definition of AHAs and there is insufficient information to support that PHAs are less likely to cause irritation or sun sensitivity than other AHAs. Additionally, the maximum permitted concentration for the consumer use category was increased from 10% to 18%. The expansion of the consumer use category was a result of a retrospective analysis of Evidence of Safety data submitted to Health Canada for professional-use cosmetic products. Other amendments include updated warnings and cautionary statements and additional product-specific directions for safe use.

Hydroquinone

This entry was amended to expand the permitted nail product categories to include products for consumer use, increase the maximum concentration permitted for these products, and introduce a combined limit when both p-hydroxyanisole and hydroquinone are used in a nail product.

p-Hydroxyanisole

This entry was amended to introduce a combined limit when both p-hydroxyanisole and hydroquinone are used in a nail product.

Talc

This entry was amended to help reduce chronic inhalation exposure to talc in cosmetics that may result in non-cancer lung effects (such as inflammation or fibrosis), as well as genital exposure to the population with intact ovary/ovaries which may result in ovarian cancer, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999). Cautionary statements related to acute inhalation risks were also adjusted to include all loose powder products.

August 2022 Changes to the Cosmetic Ingredient Hotlist

Items Added

Ethylhexyl Ethylhexanoate

This ingredient was added to the list of restricted substances due to health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

Azelaic acid and its salts

These ingredients were added to the list of restricted substances due to known therapeutic properties and risk of skin irritation at concentrations above the maximum permitted concentration of 14%.

Items Amended

Retinoic acid and its salts

This entry was amended to add salts for clarity. Salts are expected to convert to retinoic acid when mixed in solution. Retinoic acid has known therapeutic action at low concentration, with marketed prescription drugs for topical use containing retinoic acid at a concentration as low as 0.01% listed in Health Canada’s Drug Product Database.

Eucalyptus oil

The entry was amended to better mitigate the risk of unintentional ingestion, particularly in pediatric populations, by introducing cautionary label statements for certain products with concentrations greater than 0.022%.

Peroxide and peroxide-generating compounds

The entry was amended to clarify that for oral cosmetics containing more than 3% hydrogen peroxide (or equivalent) hydrogen peroxide concentrations in saliva will continue to be requested but, concentrations within the soft tissue of the oral cavity will not be routinely requested. Furthermore, the statement allowing evidence that may include analog studies from recognized sources or independent clinical research was removed.

p-Hydroxyanisole

The entry was amended to expand the permitted nail product categories to include products for consumer use, and increase the maximum concentration permitted for these products.

December 2019 Changes to the Cosmetic Ingredient Hotlist

Items Amended

Dihydrocoumarin

This entry was amended from a prohibition to a restriction. The ingredient is naturally occurring in some plant derivatives at low levels. A review of the available scientific data indicated that the ingredient may cause sensitization at higher concentrations but can be used at low levels without significant risk.

Disulfiram, Thiuram, Thiuram disulfides, and Thiuram monosulfides

These entries were amended to combine the substances under a single entry for Thiurams. The revised entry also encompasses thiuram tetrasulfides which were not previously captured under the Hotlist entries. These substances were all identified to pose similar skin sensitization risks. The combined Hotlist entry was also revised from a prohibition to a restriction because a review of the available scientific data indicated that the ingredients may cause skin sensitization under certain usage conditions but can be used in latex theatrical makeup without significant risk.

Sodium bromate

This entry was amended from a restriction to a prohibition. Sodium bromate is toxicologically equivalent to potassium bromate, which has been prohibited since March 2011 due to its carcinogenic potential, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA, 1999). The two entries were combined into one entry for Bromates.

Thioglycolic acid and its salts

This entry was amended to include new conditions regarding hair dye products and products for use in the area of the eye due to changes in ingredient usage. 

September 2018 Changes to the Cosmetic Ingredient Hotlist

Items Added

Cannabis, as defined in subsection 2(1) of the Cannabis Act (see the Cannabis Exemption (Food and Drugs Act) Regulations for details)

This entry was added to the list of prohibited substances as result of the coming into force of the Cannabis Act. Previously, cannabis was subject to the Controlled Drugs and Substances Act, and these ingredients were prohibited under the Narcotics, natural and synthetic entry. Products containing these ingredients are exempted from the application of the Food and Drugs Act as a result of the Cannabis Exemption (Food and Drugs Act) Regulations.

Items Amended

Cannabis sativa seed oil and Hydrolyzed Hemp seed protein

These entries were combined into a single, broadened entry to better reflect the requirements of the Industrial Hemp Regulations: Cannabis spp. (hemp) derivatives that are exempt from the Cannabis Act under the Industrial Hemp Regulations.

June 2018 Changes to the Cosmetic Ingredient Hotlist

Items Amended

Methylisothiazolinone (MI)

This entry was amended in order to add a new condition for MI, as a prohibited substance in leave-on cosmetic products and reduce the maximum allowed concentration in rinse-off products to 0.0015% due to the risk of sensitization. If a mixture of Methylisothiazolinone and Methylchloroisothiazolinone (MI/MCI) is used in the same product as Methylisothiazolinone alone (MI), the total concentration of MCI/MI and MI, combined, cannot exceed 0.0015%.

Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI), in combination

This entry was amended to clarify that if the mixture of Methylisothiazolinone and Methylchloroisothiazolinone (MI/MCI) is used in the same product as Methylisothiazolinone alone (MI), the total concentration of MCI/MI and MI, combined, cannot exceed 0.0015%.

Oleandrin

This entry was removed. The substance is now captured by a new, expanded entry for Nerium oleander, its extracts and glycosides. All parts of the Nerium oleander plant, including the sap, are toxic.

Chloramine T

This entry was amended to add related compounds for clarity. The additional compounds are expected to convert to Chloramine T when mixed in solution. Exposure to Chloramine T can result in skin and respiratory sensitization.

Items Added

Pigment Red 4

This ingredient was added to the list of restricted substances with a maximum concentration of 3% permitted. Action was taken due to potential health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under the Canadian Environmental Protection Act, 1999 (CEPA 1999).

December 2015 Changes to the Cosmetic Ingredient Hotlist

Format Changes:

The table format has been further improved by removing repeated text and adding an extra column in the restricted table in order to highlight the maximum concentration permitted and entries have been reworded in order to ensure consistency and clarity.

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April 2014 Changes to the Cosmetic Ingredient Hotlist

Format Changes:

The Hotlist is separated into two distinct tables, one for prohibited ingredients and another for restricted ingredients

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March 2011 Changes to the Cosmetic Ingredient Hotlist

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June 2010 Changes to the Cosmetic Ingredient Hotlist

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September 2009 Changes to the Cosmetic Ingredient Hotlist

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March 2007 Changes to the Cosmetic Ingredient Hotlist

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May 2005 Changes to the Cosmetic Ingredient Hotlist

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December 2004 Changes to the Cosmetic Ingredient Hotlist

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April 2004 Changes to the Cosmetic Ingredient Hotlist

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2025-08-14