Product Monograph Brand Safety Updates

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Product Monograph Brand Safety Updates October 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Accel-Sevelamer 205762 sevelamer carbonate Accel Pharma Inc N/A N/A N/A   N/A   N/A N/A
Airomir 206571 salbutamol sulfate Valeant Canada LP Valeant Canada S.E.C. N/A N/A N/A N/A N/A N/A N/A  
Antizol 207700 fomepizole Paladin Labs Inc N/A N/A N/A N/A N/A N/A N/A  
Asmanex Twisthaler 207491 mometasone furoate Merck Canada Inc N/A N/A N/A N/A   N/A N/A  
Ativan 207459 lorazepam Pfizer Canada Inc N/A     N/A   N/A N/A  
Avandia 189154 rosiglitazone maleate Glaxosmithkline Inc N/A   N/A   N/A   N/A  
Burinex 206137 bumetanide Leo Pharma Inc N/A N/A N/A N/A N/A N/A N/A  
Celestone Soluspan 207629 betamethasone sodium phosphate, betamethasone acetate Merck Canada Inc     N/A         N/A
Cetrotide 206074 cetrorelix acetate Emd Serono a Division of Emd Inc Canada N/A N/A N/A   N/A N/A N/A  
Coversyl 207286 perindopril erbumine Servier Canada Inc     N/A N/A   N/A N/A  
Coversyl Plus, Coversyl Plus LD, Coversyl Plus HD 207284 perindopril erbumine, indapamide Servier Canada Inc     N/A N/A   N/A N/A  
Cyanokit 206729 hydroxocobalamin Serb S.A. N/A   N/A   N/A N/A N/A  
Entresto 207731 valsartan, sacubitril Novartis Pharmaceuticals Canada Inc     N/A   N/A N/A N/A  
Exjade 207864 deferasirox Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Fibristal 205771 ulipristal acetate Allergan Pharma Co. N/A N/A N/A   N/A N/A N/A N/A
Gilenya 207380 fingolimod hydrochloride Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Hydromorph Contin 207027 hydromorphone HCl Purdue Pharma     N/A   N/A N/A    
Imbruvica 204436 ibrutinib Janssen Inc N/A           N/A  
Inomax 199061 nitric oxide Ino Therapeutics N/A   N/A   N/A N/A N/A  
Jadenu 207929 deferasirox Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Jaydess 207337 levonorgestrel Bayer Inc N/A   N/A       N/A  
Kaletra 208279 ritonavir, lopinavir Abbvie Corporation N/A N/A N/A N/A N/A N/A N/A  
Mirena 207336 levonorgestrel Bayer Inc N/A   N/A       N/A  
Nasonex 207480 mometasone furoate Merck Canada Inc N/A N/A N/A N/A   N/A N/A  
Nitroglycerin in 5% Dextrose Injection 206985 nitroglycerin, dextrose anhydrous Baxter Corporation N/A N/A N/A   N/A N/A N/A N/A
Novo-Salbutamol HFA 206839 salbutamol sulfate Teva Canada Limited N/A   N/A N/A N/A   N/A  
Ofev 207762 nintedanib Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Orkambi 207127 ivacaftor, lumacaftor Vertex Pharmaceuticals (Canada) Incorporated N/A   N/A   N/A N/A N/A  
Plan B 208163 levonorgestrel Teva Branded Pharmaceutical Products R&D Inc N/A N/A N/A N/A   N/A N/A  
Pravachol 208425 pravastatin sodium Bristol-Myers Squibb Canada N/A N/A N/A N/A N/A N/A N/A  
Prezista 206626 darunavir ethanolate Janssen Inc N/A   N/A N/A   N/A N/A  
Rapamune 208129 sirolimus Pfizer Canada Inc N/A N/A N/A   N/A N/A N/A N/A
Revatio 206732 sildenafil citrate Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A N/A
Revlimid 207072 lenalidomide Celgene Inc N/A   N/A   N/A   N/A  
Reyataz 207645 atazanavir sulfate Bristol-Myers Squibb Canada   N/A N/A N/A   N/A N/A  
Rhovane 207199 zopiclone Sandoz Canada Incorporated N/A         N/A N/A  
Silkis 206311 calcitriol Galderma Canada Inc     N/A          
Sutent 206339 sunitinib malate Pfizer Canada Inc N/A   N/A   N/A N/A N/A N/A
Tafinlar 207771 dabrafenib Novartis Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A  
Tobrex, Tobrexan 201433 tobramycin Alcon Canada Inc N/A   N/A N/A N/A N/A N/A  
Trileptal 208369 oxcarbazepine Novartis Pharmaceuticals Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Triumeq 208070 lamivudine, abacavir sulfate, dolutegravir sodium Viiv Healthcare Ulc N/A   N/A       N/A  
Vancocin 203124 vancomycin Merus Labs International Inc N/A   N/A N/A N/A N/A N/A  
Xanax, Xanax TS 207447 alprazolam Pfizer Canada Inc N/A     N/A   N/A N/A  
Zenhale 207600 mometasone furoate, formoterol fumarate dihydrate Merck Canada Inc N/A N/A N/A N/A   N/A N/A  
Zykadia 201361 ceritinib Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A N/A
Product Monograph Brand Safety Updates September 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Aerius Dual Action 12 Hour 206592 pseudoephedrine sulfate, desloratadine Bayer Inc N/A N/A N/A N/A N/A N/A
Altace 206816 ramipril Valeant Canada Lp Valeant Canada S.E.C. N/A N/A N/A N/A
Altace Hct 206915 hydrochlorothiazide, ramipril Valeant Canada Lp Valeant Canada S.E.C. N/A N/A N/A N/A
Arcosyl 207395 perindopril arginine Servier Canada Inc N/A N/A
Arcosyl Plus, Arcosyl Plus Ld 207324 indapamide, perindopril arginine Servier Canada Inc N/A N/A
Blexten 206314 bilastine Aralez Pharmaceuticals Trading Dac N/A N/A N/A N/A N/A N/A N/A
Caduet 206425 amlodipine besylate, atorvastatin calcium Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Ciprodex 206140 dexamethasone, ciprofloxacin hydrochloride monohydrate Novartis Pharmaceuticals Canada Inc N/A N/A N/A N/A N/A N/A
Claritin Allergy + Sinus 206590 pseudoephedrine sulfate, loratadine Bayer Inc N/A N/A N/A N/A N/A N/A
Claritin Allergy + Sinus Extra Strength 206591 pseudoephedrine sulfate, loratadine Bayer Inc N/A N/A N/A N/A N/A N/A
Clasteon 194371 clodronate disodium Sunovion Pharmaceuticals Canada Inc N/A
Clobex Spray 204859 clobetasol propionate Galderma Canada Inc N/A N/A N/A N/A N/A
Dexilant 206280 dexlansoprazole Takeda Canada Inc N/A N/A N/A N/A N/A
Dilaudid 206994 hydromorphone HCl Purdue Pharma N/A N/A
Epclusa 199753 sofosbuvir, velpatasvir Gilead Sciences Canada Inc N/A N/A
Erythrocin I.V. 204120 erythromycin lactobionate Amdipharm Limited N/A N/A
Evotaz 206829 atazanavir sulfate, cobicistat Bristol-Myers Squibb Canada N/A N/A N/A N/A N/A N/A
Fortaz 206545 ceftazidime Glaxosmithkline Inc N/A N/A N/A N/A N/A N/A N/A
Glyxambi 206650 linagliptin, empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A N/A N/A N/A
Hydrea 206452 hydroxyurea Bristol-Myers Squibb Canada N/A N/A N/A N/A N/A
Imbruvica 198803 ibrutinib Janssen Inc N/A N/A N/A
Jakavi 198974 ruxolitinib phosphate Novartis Pharmaceuticals Canada Inc N/A N/A N/A N/A N/A
Jevtana 198555 cabazitaxel Sanofi-Aventis Canada Inc N/A N/A N/A N/A
Kyleena 207339 levonorgestrel Bayer Inc N/A N/A N/A N/A
Lanvis 199259 thioguanine Aspen Pharmacare Canada Inc.
Lenvima 197794 lenvatinib mesylate Eisai Limited N/A N/A N/A N/A
Neurontin 206450 gabapentin Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Nexium 24hr 207640 esomeprazole magnesium trihydrate Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A N/A N/A N/A N/A
Norvasc 206420 amlodipine besylate Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Pantoloc 206282 pantoprazole Takeda Canada Inc N/A N/A N/A N/A N/A
Pediapred 207618 prednisolone sodium phosphate Sanofi-Aventis Canada Inc N/A N/A N/A N/A
Quinsair 205688 levofloxacin Horizon Pharma Ireland Ltd N/A N/A N/A N/A N/A
Stivarga 203322 regorafenib Bayer Inc N/A N/A N/A N/A
Suboxone 200964 buprenorphine hydrochloride, naloxone hydrochloride dihydrate Indivior UK Limited N/A N/A N/A N/A
Synjardy 206979 metformin HCl, empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A N/A N/A
T-Lo, Timolol Maleate-Ex 207804 timolol maleate Sandoz Canada Incorporated N/A N/A N/A N/A N/A N/A N/A
Tecta 206283 pantoprazole Takeda Canada Inc N/A N/A N/A N/A N/A
Tobramycin For Injection, Tobramycin Injection 201434 tobramycin Fresenius Kabi Canada Ltd N/A N/A N/A N/A N/A N/A
Toviaz 206539 fesoterodine fumarate Pfizer Canada Inc N/A N/A N/A N/A N/A N/A N/A
Tygacil 203906 tigecycline Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Verelan 204929 verapamil HCl Recro Gainesville Llc N/A N/A N/A N/A N/A N/A
Xalacom 207642 timolol maleate, latanoprost Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Zantac, Zantac Maximum Strength Non-Prescription 206896 ranitidine HCl Sanofi Consumer Health Inc Sanofi Sante Grand Public Inc N/A N/A N/A
Zerit 205498 stavudine Bristol-Myers Squibb Canada N/A
Zocor 206768 simvastatin Merck Canada Inc N/A N/A N/A N/A N/A
Zyvoxam 203907 linezolid Pfizer Canada Inc N/A N/A N/A N/A N/A N/A
Product Monograph Brand Safety Updates August 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Advil Headache & Migraine Caplets, Advil Headache & Migraine Tablets, Advil Headache & Migraine Extra Strength 206598 Ibuprofen Sodium Dihydrate Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A   N/A N/A   N/A N/A N/A
Advil Headache Caplets, Advil Headache Tablets, Advil Headache Extra Strength 206535 Ibuprofen Sodium Dihydrate Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A   N/A   N/A N/A N/A N/A
Advil Migraine Caplets, Advil Migraine Tablets, Advil Migraine Extra Strength 206595 Ibuprofen Sodium Dihydrate Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A   N/A   N/A N/A N/A N/A
Anoro Ellipta 204866 Umeclidinium Bromide, Vilanterol Trifenatate Glaxosmithkline Inc N/A N/A N/A   N/A N/A N/A  
Bicillin L-A 202685 Penicillin G Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A  
Bosulif 198130 Bosutinib Pfizer Canada Inc N/A   N/A     N/A N/A  
Cerubidine 203394 Daunorubicin HCl Erfa Canada 2012 Inc     N/A   N/A   N/A N/A
Clozaril 205552 Clozapine HLS Therapeutics Inc N/A   N/A N/A N/A N/A N/A  
Conray 30, Conray 43, Conray 60 203745 Iothalamate Meglumine Liebel-Flarsheim Canada Inc N/A   N/A N/A N/A N/A N/A  
Cysto-Conray Ii 203747 Iothalamate Meglumine Liebel-Flarsheim Canada Inc N/A   N/A N/A N/A N/A N/A  
Diflucan 205322 Fluconazole Pfizer Canada Inc N/A   N/A       N/A  
Dilantin 207026 Phenytoin Sodium Pfizer Canada Inc N/A N/A N/A N/A   N/A N/A N/A
Dilantin - 30 Suspension, Dilantin - 125 Suspension, Dilantin Infatabs 207011 Phenytoin Pfizer Canada Inc N/A N/A N/A N/A   N/A N/A N/A
Estalis 201794 Norethindrone Acetate, Estradiol Hemihydrate Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Estradot 201795 Estradiol Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Gastrografin 203720 Diatrizoate Sodium, Diatrizoate Meglumine Bracco Imaging Canada N/A   N/A   N/A N/A N/A  
Gentamicin Injection USP 203909 Gentamicin Sandoz Canada Incorporated N/A   N/A N/A   N/A N/A  
Halaven 197739 Eribulin Mesylate Eisai Limited N/A N/A N/A   N/A   N/A  
Holkira Pak 205905 Ritonavir, Paritaprevir, Ombitasvir, Dasabuvir Abbvie Corporation     N/A N/A   N/A N/A  
Hycamtin 207443 Topotecan HCl Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Incruse Ellipta 204867 Umeclidinium Bromide Glaxosmithkline Inc N/A N/A N/A   N/A N/A N/A  
Invega 205156 Paliperidone Janssen Inc N/A   N/A   N/A N/A    
Invega Sustenna 204831 Paliperidone Palmitate Janssen Inc N/A   N/A   N/A N/A    
Invega Trinza 205492 Paliperidone Palmitate Janssen Inc N/A   N/A   N/A N/A    
Isoptin SR 204966 Verapamil HCl BGP Pharma ULC   N/A N/A N/A   N/A N/A  
Jakavi 207662 Ruxolitinib Phosphate Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Jardiance 206321 Empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Jevtana 204990 Cabazitaxel Sanofi-Aventis Canada Inc N/A N/A N/A   N/A N/A N/A  
Keppra 205152 Levetiracetam UCB Canada Inc N/A   N/A   N/A   N/A  
Latuda 205569 Lurasidone Hydrochloride Sunovion Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Leukeran 197997 Chlorambucil Aspen Pharmacare Canada Inc. N/A           N/A  
Losec 206291 Omeprazole Magnesium Astrazeneca Canada Inc N/A   N/A N/A   N/A N/A  
Mezavant 205594 Mesalazine Shire Pharma Canada ULC N/A N/A N/A   N/A N/A N/A  
Monurol 203904 Fosfomycin Tromethamine Paladin Labs Inc N/A   N/A N/A N/A N/A N/A  
Motrimax 12 Hour 205894 Naproxen, Naproxen Sodium McNeil Consumer Healthcare Division of Johnson & Johnson Inc     N/A   N/A N/A N/A  
Naproxen Liquid Gel Capsules 205896 Naproxen, Naproxen Sodium McNeil Consumer Healthcare Division of Johnson & Johnson Inc   N/A     N/A N/A N/A  
Nexium 206288 Esomeprazole Magnesium Trihydrate Astrazeneca Canada Inc N/A   N/A N/A   N/A N/A  
Nexium 24Hr 206294 Esomeprazole Magnesium Trihydrate Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A   N/A N/A   N/A N/A  
Omnipaque 203755 Iohexol GE Healthcare Canada Inc N/A   N/A N/A N/A N/A N/A  
One-Alpha Capsules, Oral Drops and Solution for Injection 203972 Alfacalcidol Leo Pharma Inc                
Panto IV 206281 Pantoprazole Takeda Canada Inc N/A   N/A N/A   N/A N/A  
Pariet 206292 Rabeprazole Sodium Janssen Inc N/A   N/A N/A   N/A N/A  
Pat-Galantamine ER 205093 Galantamine Hydrobromide Janssen Inc N/A   N/A     N/A N/A N/A
PMS-Methotrexate 205553 Methotrexate Pharmascience Inc N/A   N/A N/A   N/A N/A  
Prevacid, Prevacid Fastab 206287 Lansoprazole Takeda Pharmaceuticals America Inc N/A   N/A N/A   N/A N/A  
Prevora Stage 1 204666 Chlorhexidine Acetate CHX Technologies Inc N/A N/A N/A N/A N/A   N/A  
Reactine Rapid Dissolve 206512 Cetirizine Hydrochloride McNeil Consumer Healthcare Division of Johnson & Johnson Inc N/A N/A N/A N/A N/A   N/A  
Rifadin 206328 Rifampin Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A    
Risperdal Consta 205302 Risperidone Janssen Inc N/A   N/A   N/A N/A    
Risperdal, Risperdal M Tab 205384 Risperidone Janssen Inc N/A   N/A   N/A N/A    
Serc 203694 Betahistine Hydrochloride BGP Pharma ULC N/A   N/A N/A N/A N/A N/A N/A
Stivarga 199667 Regorafenib Bayer Inc N/A   N/A N/A     N/A  
Technivie 205888 Ritonavir, Paritaprevir, Ombitasvir Abbvie Corporation     N/A N/A   N/A N/A  
Telebrix 38 Oral 203737 Meglumine Ioxitalamate, Sodium Ioxitalamate Liebel-Flarsheim Canada Inc N/A   N/A N/A N/A N/A N/A  
Tobi 201430 Tobramycin Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A  
Ultibro Breezhaler 198552 Glycopyrronium Bromide, Indacaterol Maleate Novartis Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A  
Uptravi 205182 Selexipag Actelion Pharmaceuticals Canada Inc     N/A N/A   N/A N/A  
Vimovo 206290 Naproxen, Esomeprazole Magnesium Trihydrate Astrazeneca Canada Inc N/A   N/A N/A   N/A N/A  
Visipaque 203750 Iodixanol GE Healthcare Canada Inc N/A   N/A N/A N/A N/A N/A  
Women's Rogaine Foam 5% 198474 Minoxidil Johnson & Johnson Inc N/A N/A N/A N/A N/A N/A N/A  
Xalkori 198322 Crizotinib Pfizer Canada Inc N/A   N/A   N/A N/A N/A  
Xeljanz 205079 Tofacitinib Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A  
Xyrem 205695 Sodium Oxybate Valeant Canada LP Valeant Canada S.E.C. N/A   N/A   N/A N/A N/A  
Product Monograph Brand Safety Updates July 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Acet 120, Acet 160, Acet 325, Acet 650 204828 Acetaminophen Pendopharm Division of De Pharmascience Inc     N/A N/A N/A N/A N/A  
Aggrastat 186324 Tirofiban HCl Correvio (UK) Ltd             N/A  
Agrylin 204532 Anagrelide Hydrochloride Shire Pharma Canada ULC N/A   N/A N/A        
Amikacin Sulfate Injection USP 203905 Amikacin Sandoz Canada Incorporated N/A   N/A   N/A      
APO-Lovastatin 200019 Lovastatin Apotex Inc N/A   N/A   N/A N/A N/A N/A
Breo Ellipta 197729 Fluticasone Furoate, Vilanterol Glaxosmithkline Inc N/A   N/A   N/A N/A N/A  
Casodex 205811 Bicalutamide AstraZeneca Canada Inc N/A   N/A N/A   N/A N/A  
Cholografin Meglumine 203716 Meglumine Iodipamide Bracco Imaging Canada N/A   N/A   N/A N/A N/A  
Constella 192714 Linaclotide Forest Laboratories Canada Inc N/A N/A N/A N/A   N/A N/A  
Cubicin, Cubicin RF 203128 Daptomycin Cubist Pharmaceuticals LLC N/A N/A N/A N/A N/A N/A N/A  
Cubicin, Cubicin RF 204525 Daptomycin Cubist Pharmaceuticals LLC N/A   N/A   N/A N/A N/A  
Cytomel 206002 Liothyronine Sodium Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A  
Duavive 199318 Conjugated Estrogens, Bazedoxifene Acetate Pfizer Canada Inc   N/A N/A N/A   N/A N/A  
Edurant 205395 Rilpivirine Hydrochloride Janssen Inc N/A   N/A     N/A N/A  
Emend IV 197185 Fosaprepitant Dimeglumine Merck Canada Inc N/A           N/A  
Femara 203017 Letrozole Novartis Pharmaceuticals Canada Inc     N/A       N/A  
Fucidin Cream And Ointment 202631 Fusidate Sodium, Fusidic Acid Leo Pharma Inc     N/A          
Galexos 197253 Simeprevir Janssen Inc N/A   N/A   N/A   N/A  
Giotrif 204816 Afatinib Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A N/A N/A N/A N/A  
Imbruvica 203931 Ibrutinib Janssen Inc N/A   N/A   N/A N/A N/A N/A
Isovue 203726 Iopamidol Bracco Imaging Canada N/A   N/A   N/A N/A N/A  
Jublia 204442 Efinaconazole Valeant Canada LP Valeant Canada S.E.C. N/A N/A N/A N/A N/A N/A N/A  
Kyprolis 197343 Carfilzomib Amgen Canada Inc N/A   N/A N/A N/A   N/A N/A
Latuda 197342 Lurasidone Hydrochloride Sunovion Pharmaceuticals Canada Inc N/A   N/A   N/A   N/A  
Lixiana 205240 Edoxaban Servier Canada Inc N/A N/A N/A     N/A N/A N/A
Macrobid 205222 Nitrofurantoin Allergan Pharma Co. N/A N/A N/A N/A N/A N/A   N/A
Mirapex 201195 Pramipexole Dihydrochloride Monohydrate Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A     N/A N/A  
Mozobil 204455 Plerixafor Sanofi-aventis Canada Inc N/A   N/A   N/A N/A N/A  
Novamoxin 196903 Amoxicillin Teva Canada Limited N/A   N/A     N/A N/A  
Oxy.IR 204097 Oxycodone HCl Purdue Pharma N/A   N/A   N/A N/A N/A  
Piperacillin Sodium / Tazobactam Sodium Powder for Injection 203127 Piperacillin Sodium, Tazobactam Sodium Sandoz Canada Incorporated N/A   N/A N/A N/A N/A N/A  
Posanol 203125 Posaconazole Merck Canada Inc N/A   N/A N/A   N/A N/A  
Sinografin 203723 Diatrizoate Meglumine, Meglumine Iodipamide Bracco Imaging Canada N/A   N/A   N/A N/A N/A  
Solu-Medrol, Solu-Medrol Act-O-Vials 205330 Methylprednisolone Sodium Succinate Pfizer Canada Inc     N/A N/A N/A N/A N/A  
Sprycel 205138 Dasatinib Bristol-Myers Squibb Canada N/A N/A N/A   N/A N/A N/A  
Tecfidera 197077 Dimethyl Fumarate Biogen Canada Inc N/A N/A N/A N/A   N/A N/A  
Tobradex 201440 Dexamethasone, Tobramycin Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Tobramycin Injection Usp 201425 Tobramycin Sandoz Canada Incorporated N/A   N/A N/A N/A N/A    
Toctino 205007 Alitretinoin Glaxosmithkline Inc N/A N/A N/A   N/A N/A N/A  
Ultravist 203727 Iopromide Bayer Inc N/A   N/A N/A N/A N/A N/A  
Zelboraf 204435 Vemurafenib Hoffmann-La Roche Limited N/A   N/A     N/A N/A  
Zerbaxa 205115 Tazobactam Sodium, Ceftolozane Sulfate Merck Canada Inc     N/A N/A N/A   N/A  
Zithromax 204622 Azithromycin Pfizer Canada Inc N/A   N/A   N/A N/A N/A  
Product Monograph Brand Safety Updates June 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Advil Liqui-Gels, Advil Extra Strength Liqui-Gels, Advil Arthritis Pain 203343 ibuprofen Pfizer Consumer Healthcare a Division of Pfizer Canada Inc N/A   N/A N/A   N/A N/A  
Alertec 204661 modafinil Teva Canada Limited N/A N/A N/A N/A N/A N/A N/A  
Atripla 203336 efavirenz, emtricitabine, tenofovir disoproxil fumarate Bristol-Myers Squibb and Gilead Sciences Llc N/A   N/A     N/A N/A  
Ceftin 203522 cefuroxime axetil Glaxosmithkline Inc N/A   N/A N/A N/A N/A N/A  
Complera 202304 emtricitabine, tenofovir disoproxil fumarate, rilpivirine hydrochloride Gilead Sciences Canada Inc N/A   N/A N/A   N/A N/A  
Concerta 204252 methylphenidate HCl Janssen Inc N/A   N/A     N/A N/A  
Cosmegen 203989 dactinomycin Recordati Rare Diseases Inc N/A N/A N/A   N/A N/A N/A  
Cotellic 196612 cobimetinib fumarate Hoffmann La Roche Limited N/A       N/A   N/A  
Cubicin RF 196316 daptomycin Cubist Pharmaceuticals Llc N/A   N/A N/A N/A   N/A  
Cyclomen 204093 danazol Sanofi-Aventis Canada Inc     N/A   N/A N/A N/A  
Dilantin 203300 phenytoin sodium Pfizer Canada Inc N/A N/A N/A     N/A N/A N/A
Dilantin Infatabs, Dilantin - 125 Suspension, Dilantin - 30 Suspension 203299 phenytoin Pfizer Canada Inc N/A N/A N/A     N/A N/A N/A
Dotarem 204205 gadoterate meglumine Guerbet N/A   N/A N/A N/A   N/A  
Erythrocin I.V. 198603 erythromycin lactobionate Amdipharm Limited N/A   N/A N/A N/A N/A N/A N/A
Esbriet 197464 pirfenidone Hoffmann La Roche Limited N/A   N/A N/A   N/A N/A  
Fucidin H Cream 202375 fusidic acid, hydrocortisone acetate Leo Pharma Inc     N/A   N/A N/A    
Giotrif 196631 afatinib Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A   N/A   N/A  
HP-Pac 204712 amoxicillin, clarithromycin, lansoprazole Takeda Pharmaceuticals America Inc N/A   N/A     N/A N/A  
Juxtapid 204338 lomitapide mesylate Aegerion Pharmaceuticals Canada Ltd N/A N/A N/A   N/A N/A N/A  
LIPITOR (Updated March 2017) 200017 atorvastatin calcium Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A N/A
Lioresal 203795 baclofen Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Lioresal Intrathecal 203841 baclofen Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Luvox 203845 fluvoxamine maleate BGP Pharma Ulc N/A   N/A N/A   N/A N/A  
Lynparza 197364 olaparib Astrazeneca Canada Inc N/A   N/A N/A     N/A  
Merrem 204438 meropenem trihydrate Astrazeneca Canada Inc N/A   N/A   N/A N/A N/A  
Nitrolingual Pumpspray 203587 nitroglycerin Sanofi-Aventis Canada Inc     N/A N/A   N/A N/A  
Ofev 202904 nintedanib Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Omniscan 204203 gadodiamide GE Healthcare Canada Inc N/A   N/A N/A N/A   N/A  
Onreltea 202300 brimonidine tartrate Galderma Canada Inc N/A   N/A   N/A      
Optimark 204201 gadoversetamide Liebel-Flarsheim Canada Inc N/A   N/A N/A N/A   N/A  
Oxyneo 204127 oxycodone HCl Purdue Pharma     N/A     N/A N/A  
Pariet 205390 rabeprazole sodium Janssen Inc N/A   N/A   N/A N/A N/A  
Prevacid, Prevacid Fastab 204711 lansoprazole Takeda Pharmaceuticals America Inc N/A   N/A     N/A N/A N/A
Remeron 203500 mirtazapine Merck Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Remeron RD 203509 mirtazapine Merck Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Remodulin 203551 treprostinil United Therapeutics Corporation N/A   N/A          
Ritalin, Ritalin SR 203594 methylphenidate HCl Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A  
Sebivo 203639 telbivudine Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Stribild 202429 emtricitabine, tenofovir disoproxil fumarate, elvitegravir, cobicistat Gilead Sciences Canada Inc N/A   N/A N/A   N/A N/A  
Tafinlar 202556 dabrafenib Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A  
Tarka 203599 verapamil HCl, trandolapril BGP Pharma Ulc     N/A N/A   N/A N/A  
Taxotere 203975 docetaxel Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Temodal 204940 temozolomide Merck Canada Inc N/A   N/A   N/A N/A N/A  
Trileptal 204016 oxcarbazepine Novartis Pharmaceuticals Canada Inc   N/A N/A N/A   N/A N/A  
Videx EC 203691 didanosine Bristol-Myers Squibb Canada N/A   N/A N/A N/A N/A N/A  
Xtandi 204169 enzalutamide Astellas Pharma Canada Inc N/A   N/A   N/A   N/A  
Zepatier 204225 grazoprevir, elbasvir Merck Canada Inc N/A N/A N/A N/A   N/A N/A  
Product Monograph Brand Safety Updates May 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
3TC 202946 Lamivudine ViiV Healthcare ULC   N/A N/A N/A   N/A N/A  
Actonel, Actonel DR 200428 Risedronate Sodium Warner Chilcott Canada Co N/A   N/A N/A N/A N/A N/A  
Advil Tablets, Advil Caplets, Advil Gel Caplets, Advil Extra Strength  Caplets, Advil Muscle and Joint, Advil 12 Hour 203345 Ibuprofen Pfizer Consumer Healthcare A Division of Pfizer Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Afinitor, Afinitor Disperz 202080 Everolimus Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A   N/A  
Aleve, Aleve Liquid Gels, Aleve Back And Body Pain 203003 Naproxen Sodium Bayer Inc Consumer Care N/A   N/A N/A   N/A N/A  
Antizol 203100 Fomepizole Paladin Labs Inc N/A   N/A   N/A N/A N/A N/A
Apo-Norflox 202159 Norfloxacin Apotex Inc N/A     N/A N/A N/A N/A  
Arthrotec 50, Arthrotec 75 202618 Diclofenac Sodium, Misoprostol Pfizer Canada Inc N/A       N/A N/A N/A N/A
Avalide 203641 Hydrochlorothiazide, Irbesartan Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A N/A
Avelox, Avelox I.V. 202157 Moxifloxacin Bayer Inc N/A     N/A N/A N/A N/A  
Biltricide 201666 Praziquantel Bayer Inc N/A N/A N/A N/A   N/A N/A  
Buscopan 202547 Hyoscine Butylbromide Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A N/A N/A N/A N/A N/A
Bydureon 204999 Exenatide AstraZeneca Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Caduet 203042 Amlodipine Besylate, Atorvastatin Calcium Pfizer Canada Inc     N/A N/A N/A N/A N/A N/A
Cancidas 202368 Caspofungin Acetate Merck Canada Inc N/A   N/A N/A N/A N/A N/A  
Caprelsa 201914 Vandetanib Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc N/A N/A N/A   N/A N/A N/A  
Celebrex 202594 Celecoxib Pfizer Canada Inc N/A       N/A N/A N/A  
Cipro XL 202154 Ciprofloxacin Bayer Inc N/A     N/A N/A N/A N/A  
Cipro XL 202739 Ciprofloxacin Hydrochloride Bayer Inc     N/A N/A     N/A  
Cipro, Cipro Oral Suspension 202151 Ciprofloxacin Bayer Inc N/A     N/A N/A N/A N/A  
Cipro, Cipro Oral Suspension 202735 Ciprofloxacin Hydrochloride Bayer Inc     N/A N/A     N/A  
Coated Daily Low Dose ASA 81 mg 203112 Acetylsalicylic Acid Apotex Inc N/A N/A N/A N/A N/A N/A N/A  
Combivir 202851 Zidovudine, Lamivudine ViiV Healthcare ULC   N/A N/A N/A   N/A N/A  
Cytovene 201511 Ganciclovir Hoffmann-La Roche Limited N/A   N/A     N/A    
Daklinza 202374 Daclatasvir Bristol-Myers Squibb Canada N/A     N/A N/A N/A N/A  
Dalacin C 202619 Clindamycin HCl Pfizer Canada Inc N/A N/A N/A N/A     N/A  
Dalacin C Flavoured Granules 202622 Clindamycin 2-Palmitate HCl Pfizer Canada Inc N/A N/A N/A N/A     N/A  
Dalacin C Phosphate 202620 Clindamycin Phosphate Pfizer Canada Inc N/A N/A N/A N/A     N/A  
Descovy 197995 Emtricitabine, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc N/A   N/A       N/A  
Diflucan One 201295 Fluconazole Pfizer Consumer Healthcare A Division of Pfizer Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Duaklir Genuair 202738 Formoterol Fumarate Dihydrate, Aclidinium Bromide AstraZeneca Canada Inc N/A N/A N/A   N/A N/A N/A  
Dymista 202447 Fluticasone Propionate, Azelastine Hydrochloride Meda Pharmaceuticals Ltd N/A   N/A N/A N/A   N/A  
Epclusa 202377 Sofosbuvir, Velpatasvir Gilead Sciences Canada Inc N/A     N/A N/A N/A N/A  
Epuris 201026 Isotretinoin Cipher Pharmaceuticals Inc N/A N/A N/A   N/A N/A N/A  
Evotaz 203191 Atazanavir Sulfate, Cobicistat Bristol-Myers Squibb Canada     N/A     N/A N/A  
Faslodex 200400 Fulvestrant Astrazeneca Canada Inc N/A N/A N/A N/A N/A   N/A  
Fosamax 200426 Alendronate Sodium Merck Canada Inc N/A   N/A N/A N/A N/A N/A  
Fosavance 200427 Vitamin D3, Alendronic Acid Merck Canada Inc N/A   N/A N/A N/A N/A N/A  
Gadovist 1.0 202823 Gadobutrol Bayer Inc N/A   N/A N/A N/A   N/A  
Genvoya 195789 Emtricitabine, Elvitegravir, Cobicistat, Tenofovir Alafenamide Hemifumarate Gilead Sciences Canada Inc     N/A          
Glyxambi 202749 Linagliptin, Empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Harvoni 199607 Ledipasvir, Sofosbuvir Gilead Sciences Canada Inc N/A   N/A   N/A   N/A  
Harvoni 202334 Ledipasvir, Sofosbuvir Gilead Sciences Canada Inc N/A     N/A N/A N/A N/A  
Heptovir 203510 Lamivudine Glaxosmithkline Inc   N/A N/A N/A   N/A N/A  
Ibrance 195948 Palbociclib Pfizer Canada Inc N/A   N/A       N/A  
Imovane 202617 Zopiclone Sanofi-Aventis Canada Inc N/A         N/A N/A  
Intelence 196519 Etravirine Janssen Inc N/A   N/A N/A     N/A  
Intralipid 10%, Intralipid 20%, Intralipid 30% 203141 Soybean Oil Fresenius Kabi Canada Ltd N/A N/A N/A N/A N/A N/A N/A  
Jurnista 203425 Hydromorphone HCl Janssen Inc N/A   N/A N/A   N/A N/A  
Kalydeco 195308 Ivacaftor Vertex Pharmaceuticals (Canada) Incorporated N/A   N/A N/A N/A   N/A  
Kivexa 202845 Lamivudine, Abacavir Sulfate ViiV Healthcare ULC   N/A N/A N/A   N/A N/A  
Magnevist 202873 Gadopentetate Dimeglumine Bayer Inc N/A   N/A N/A N/A   N/A  
Mekinist 199382 Trametinib Novartis Pharmaceuticals Canada Inc N/A       N/A      
Men's Rogaine Foam 5% 194149 Minoxidil Johnson & Johnson Inc N/A N/A N/A N/A N/A N/A N/A  
Metronidazole 5 mg/mL Injection 202113 Metronidazole Baxter Corporation N/A   N/A          
MS Contin 202457 Morphine Sulfate Purdue Pharma     N/A   N/A N/A   N/A
Multihance 202826 Gadobenate Dimeglumine Bracco Imaging Canada N/A   N/A N/A N/A   N/A  
Norvasc 202935 Amlodipine Besylate Pfizer Canada Inc     N/A N/A N/A N/A N/A  
Nuvaring 204315 Ethinyl Estradiol, Etonogestrel Merck Canada Inc N/A   N/A N/A     N/A  
Oxyneo 195400 Oxycodone HCl Purdue Pharma N/A   N/A N/A N/A N/A N/A N/A
Plaquenil 202211 Hydroxychloroquine Sulfate Sanofi-Aventis Canada Inc N/A   N/A N/A     N/A  
Precedex 202530 Dexmedetomidine HCl Hospira Healthcare Corporation N/A N/A N/A N/A N/A   N/A N/A
Primovist 202821 Gadoxetate Disodium Bayer Inc N/A   N/A N/A N/A   N/A  
Prohance 202827 Gadoteridol Bracco Imaging Canada N/A   N/A N/A N/A   N/A  
Revolade 192586 Eltrombopag Olamine Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A N/A
Revolade 195798 Eltrombopag Olamine Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Revolade 202335 Eltrombopag Olamine Novartis Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A  
Reyataz 203194 Atazanavir Bristol-Myers Squibb Canada     N/A     N/A N/A  
Sovaldi 202358 Sofosbuvir Gilead Sciences Canada Inc N/A     N/A N/A N/A N/A  
Suboxone 203547 Buprenorphine Hydrochloride, Naloxone Hydrochloride Dihydrate Indivior UK Limited N/A     N/A N/A   N/A  
Sustiva 202776 Efavirenz Bristol-Myers Squibb Canada N/A   N/A     N/A N/A  
Tafinlar 199381 Dabrafenib Novartis Pharmaceuticals Canada Inc N/A       N/A      
Targin 202525 Naloxone HCl, Oxycodone HCl Purdue Pharma     N/A     N/A N/A  
Technivie 195504 Ritonavir, Paritaprevir, Ombitasvir Abbvie Corporation N/A   N/A   N/A   N/A  
Teva-Levofloxacin 202153 Levofloxacin Teva Canada Limited N/A     N/A N/A N/A N/A  
Triquilar 28 202824 Ethinyl Estradiol, Levonorgestrel Bayer Inc N/A N/A N/A N/A N/A N/A N/A  
Triumeq 202867 Lamivudine, Abacavir Sulfate, Dolutegravir Sodium ViiV Healthcare ULC   N/A N/A N/A   N/A N/A  
Trizivir 202849 Zidovudine, Lamivudine, Abacavir Sulfate ViiV Healthcare ULC   N/A N/A N/A   N/A N/A  
Truvada 201806 Emtricitabine, Tenofovir Disoproxil Fumarate Gilead Sciences Canada Inc N/A   N/A       N/A  
Tudorza Genuair 202742 Aclidinium Bromide AstraZeneca Canada Inc N/A N/A N/A   N/A N/A N/A  
Uniphyl 203028 Theophylline Purdue Pharma     N/A     N/A    
Viread 201858 Tenofovir Disoproxil Fumarate Gilead Sciences Canada Inc N/A   N/A N/A     N/A  
Zepatier 202393 Grazoprevir, Elbasvir Merck Canada Inc N/A     N/A N/A N/A N/A  
Zestoretic 202913 Hydrochlorothiazide, Lisinopril Dihydrate AstraZeneca Canada Inc     N/A     N/A N/A  
Zestril 202914 Lisinopril Dihydrate AstraZeneca Canada Inc     N/A     N/A N/A  
Zytram XL 202562 Tramadol HCl Purdue Pharma N/A N/A N/A   N/A N/A N/A N/A
Product Monograph Brand Safety Updates April 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Aclasta 200432 zoledronic acid Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Act Etidrocal 201597 calcium carbonate, etidronate disodium Actavis Pharma Company N/A   N/A N/A N/A N/A N/A  
Act Etidronate 201916 etidronate disodium Actavis Pharma Company N/A   N/A N/A N/A N/A N/A  
Aspirin 81 mg, Aspirin 81 mg Quick Chews, Aspirin Regular Strength 202259 acetylsalicylic acid Bayer Inc Consumer Care N/A   N/A N/A   N/A N/A  
Banzel 194343 rufinamide Eisai Limited N/A   N/A   N/A N/A N/A  
Biphentin 201555 methylphenidate HCl Purdue Pharma N/A   N/A          
Caduet 201169 amlodipine besylate, atorvastatin calcium Pfizer Canada Inc N/A   N/A   N/A N/A N/A N/A
Cardura 201486 doxazosin mesylate Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A N/A
Depo-Medrol, Depo-Medrol (with preservative) 202516 methylprednisolone acetate Pfizer Canada Inc N/A N/A N/A N/A N/A   N/A N/A
Duodopa 201985 levodopa, carbidopa monohydrate Abbvie Corporation N/A N/A N/A   N/A N/A N/A N/A
Duragesic 202716 fentanyl Janssen Inc N/A   N/A N/A   N/A N/A  
Eltroxin 201136 levothyroxine sodium Aspen Pharma Trading Limited                
Emend IV 201642 fosaprepitant dimeglumine Merck Canada Inc N/A   N/A   N/A N/A N/A  
Erivedge 194933 vismodegib Hoffmann La Roche Limited N/A   N/A N/A N/A N/A N/A  
Galexos 201947 simeprevir Janssen Inc N/A     N/A N/A N/A N/A  
Inspiolto Respimat 196472 tiotropium, olodaterol hydrochloride Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A N/A N/A N/A N/A  
Invokana 194762 canagliflozin Janssen Inc N/A N/A N/A   N/A N/A N/A  
Jevtana 202244 cabazitaxel Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Metvix 180975 methyl aminolevulinate hydrochloride Galderma Canada Inc N/A       N/A   N/A  
Mezavant 201889 mesalazine Shire Pharma Canada Ulc N/A N/A N/A   N/A N/A N/A  
Multihance 188279 gadobenate dimeglumine Bracco Imaging Canada N/A   N/A   N/A   N/A  
Norvir 201368 ritonavir Abbvie Corporation     N/A     N/A N/A  
Ofev 194900 nintedanib Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A       N/A  
Orkambi 198036 ivacaftor, lumacaftor Vertex Pharmaceuticals (Canada) Incorporated N/A   N/A       N/A  
Pentasa 201731 mesalazine Ferring Inc     N/A     N/A N/A  
Pomalyst 194902 pomalidomide Celgene Inc N/A   N/A N/A     N/A  
Precedex 199357 dexmedetomidine HCl Hospira Healthcare Corporation N/A   N/A   N/A N/A N/A N/A
Prezcobix 201611 darunavir ethanolate, cobicistat Janssen Inc   N/A N/A N/A   N/A N/A  
Prezista 201621 darunavir ethanolate Janssen Inc   N/A N/A N/A   N/A N/A  
Requip 202058 ropinirole hydrochloride Glaxosmithkline Inc N/A   N/A N/A N/A N/A N/A N/A
Solu-Medrol, Solu-Medrol Act-O-Vials 202492 methylprednisolone sodium succinate Pfizer Canada Inc N/A N/A N/A N/A   N/A N/A  
Tobramycin Injection, Tobramycin for Injection 203072 tobramycin Fresenius Kabi Canada Ltd N/A N/A N/A N/A N/A N/A N/A  
Tramacet 201748 acetaminophen, tramadol HCl Janssen Inc N/A   N/A     N/A    
Uptravi 201926 selexipag Actelion Pharmaceuticals Ltd N/A   N/A N/A   N/A N/A N/A
Valcyte 201550 valganciclovir hydrochloride Hoffmann La Roche Limited     N/A     N/A    
Viacoram 201871 perindopril arginine, amlodipine Servier Canada Inc     N/A     N/A N/A  
Yondelis 202008 trabectedin Janssen Inc N/A   N/A   N/A N/A N/A N/A
Zevtera 201602 ceftobiprole medocaril Basilea Pharmaceutica International Ag N/A   N/A N/A N/A N/A N/A  
Zoloft 201862 sertraline HCl Pfizer Canada Inc N/A N/A N/A   N/A N/A N/A N/A
Zometa 200447 zoledronic acid Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Product Monograph Brand Safety Updates March 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Accupril 200979 quinapril HCl Pfizer Canada Inc     N/A N/A   N/A N/A  
Accuretic 201238 hydrochlorothiazide, quinapril HCl Pfizer Canada Inc     N/A N/A   N/A N/A  
Aclasta 201491 zoledronic acid Novartis Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A  
Agrylin 200919 anagrelide hydrochloride monohydrate Shire Pharma Canada Ulc N/A   N/A     N/A N/A  
Airomir 200916 salbutamol sulfate Valeant Canada Lp Valeant Canada S.E.C. N/A   N/A   N/A   N/A  
Aptiom 201472 eslicarbazepine acetate Sunovion Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Bonefos 200438 clodronate disodium Bayer Inc N/A   N/A N/A N/A N/A N/A  
Busulfex 200963 busulfan Otsuka Pharmaceutical Co Ltd N/A N/A N/A N/A N/A   N/A N/A
Champix 193081 varenicline tartrate Pfizer Canada Inc N/A           N/A  
Clasteon 200437 clodronate disodium Sunovion Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A  
Coumadin 200502 warfarin sodium Bristol-Myers Squibb Canada     N/A   N/A     N/A
Coversyl 201008 perindopril erbumine Servier Canada Inc     N/A     N/A N/A  
Coversyl Plus Ld, Coversyl Plus, Coversyl Plus Hd 201004 perindopril erbumine, indapamide Servier Canada Inc     N/A     N/A N/A  
Crestor 200016 rosuvastatin calcium Astrazeneca Canada Inc N/A   N/A N/A N/A N/A N/A N/A
Cyclen 201124 ethinyl estradiol, norgestimate Janssen Inc     N/A     N/A N/A  
Diane-35 201157 ethinyl estradiol, cyproterone acetate Bayer Inc     N/A N/A   N/A N/A  
Diflucan 200992 fluconazole Pfizer Canada Inc     N/A N/A N/A N/A N/A  
Faslodex 200701 fulvestrant Astrazeneca Canada Inc N/A   N/A   N/A N/A N/A  
Gelnique 198933 oxybutynin chloride Allergan Pharma Co.     N/A     N/A N/A  
Holkira Pak 201441 ritonavir, paritaprevir, ombitasvir, dasabuvir Abbvie Corporation       N/A     N/A  
Incruse Ellipta 200693 umeclidinium bromide Glaxosmithkline Inc N/A N/A N/A   N/A N/A N/A  
Jakavi 198757 ruxolitinib phosphate Novartis Pharmaceuticals Canada Inc N/A       N/A N/A N/A  
Janumet, Janumet Xr 201792 metformin HCl, sitagliptin phosphate monohydrate Merck Canada Inc N/A   N/A   N/A N/A N/A  
Januvia 201760 sitagliptin phosphate monohydrate Merck Canada Inc N/A   N/A   N/A N/A N/A  
Kaletra 201359 ritonavir, lopinavir Abbvie Corporation   N/A N/A N/A     N/A  
Narcan Nasal Spray 202248 naloxone HCl Adapt Pharma Operations Limited N/A N/A N/A N/A N/A N/A N/A  
Nidagel 200861 metronidazole Valeant Canada Lp Valeant Canada S.E.C. N/A   N/A   N/A N/A    
Nozinan 200878 methotrimeprazine HCl Sanofi-Aventis Canada Inc N/A   N/A N/A N/A N/A N/A  
Nuvaring 200891 ethinyl estradiol, etonogestrel Merck Canada Inc N/A N/A N/A N/A     N/A  
Ortho 0.5/35 201106 ethinyl estradiol, norethindrone Janssen Inc     N/A N/A   N/A N/A  
Ortho 1/35 201117 ethinyl estradiol, norethindrone Janssen Inc     N/A N/A   N/A N/A  
Ortho 7/7/7 201105 ethinyl estradiol, norethindrone Janssen Inc     N/A N/A   N/A N/A  
Pentamidine Isetionate for Injection, Bp 200751 pentamidine isetionate Hospira Healthcare Corporation N/A N/A N/A N/A N/A N/A N/A  
Pravachol 200020 pravastatin sodium Bristol-Myers Squibb Canada N/A   N/A N/A N/A N/A N/A N/A
Prezista 201394 darunavir ethanolate Janssen Inc N/A N/A N/A N/A N/A N/A N/A  
Primaquine 196046 primaquine phosphate Sanofi-Aventis Canada Inc N/A   N/A N/A N/A   N/A N/A
Renagel 200994 sevelamer hydrochloride Sanofi-Aventis Canada Inc N/A N/A N/A N/A   N/A N/A  
Renvela 200973 sevelamer carbonate Sanofi-Aventis Canada Inc N/A N/A N/A N/A   N/A N/A  
Revolade 188969 eltrombopag olamine Novartis Pharmaceuticals Canada Inc N/A           N/A  
Rifadin 200835 rifampin Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Seroquel, Seroquel Xr 200543 quetiapine fumarate Astrazeneca Canada Inc N/A   N/A N/A N/A N/A N/A  
Signifor 193942 pasireotide Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A   N/A  
Stribild 200747 emtricitabine, tenofovir disoproxil fumarate, elvitegravir, cobicistat Gilead Sciences Canada Inc N/A N/A N/A N/A   N/A N/A  
Tarceva 194018 erlotinib hydrochloride Hoffmann La Roche Limited N/A   N/A   N/A N/A N/A  
Technivie 201487 ritonavir, paritaprevir, ombitasvir Abbvie Corporation       N/A     N/A  
Tiazac 201438 diltiazem HCl Valeant Canada Lp Valeant Canada S.E.C.     N/A     N/A    
Tiazac Xc 202119 diltiazem HCl Valeant Canada Lp Valeant Canada S.E.C.     N/A     N/A    
Tri-Cyclen 201126 ethinyl estradiol, norgestimate Janssen Inc     N/A     N/A N/A  
Tri-Cyclen Lo 201134 ethinyl estradiol, norgestimate Janssen Inc     N/A     N/A N/A  
Wellbutrin Sr 200957 bupropion HCl Valeant Canada Lp Valeant Canada S.E.C. N/A   N/A   N/A N/A N/A  
Wellbutrin Xl 200959 bupropion HCl Valeant Canada Lp Valeant Canada S.E.C. N/A   N/A   N/A N/A N/A  
Xatral 200961 alfuzosin HCl Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A    
Yasmin 21, Yasmin 28 200941 ethinyl estradiol, drospirenone Bayer Inc     N/A N/A   N/A    
Yasmin Plus 200982 ethinyl estradiol, drospirenone, levomefolate calcium Bayer Inc     N/A N/A   N/A    
Yaz 200938 ethinyl estradiol, drospirenone Bayer Inc     N/A N/A   N/A    
Yaz Plus 201007 ethinyl estradiol, drospirenone, levomefolate calcium Bayer Inc     N/A N/A   N/A    
Zepatier 201181 grazoprevir, elbasvir Merck Canada Inc     N/A N/A   N/A N/A  
Zeulide Depot 180093 leuprolide acetate Pendopharm Division of Pharmascience Inc N/A   N/A   N/A   N/A  
Zocor 200021 simvastatin Merck Canada Inc N/A   N/A   N/A N/A N/A N/A
Zyban 200951 bupropion HCl Valeant Canada Lp Valeant Canada S.E.C. N/A   N/A   N/A N/A N/A  
Product Monograph Brand Safety Updates February 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Abilify 199169 Aripiprazole Bristol-Myers Squibb Canada N/A   N/A   N/A N/A N/A  
Anoro Ellipta 198790 Umeclidinium Bromide, Vilanterol Trifenatate Glaxosmithkline Inc N/A N/A N/A   N/A N/A N/A  
Apo-ASA LD 200347 Acetylsalicylic Acid Apotex Inc     N/A     N/A N/A  
Aubagio 200227 Teriflunomide Sanofi Genzyme, A Division of Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Bosulif 200815 Bosutinib Pfizer Canada Inc N/A   N/A N/A N/A N/A N/A  
Clavulin 196916 Amoxicillin, Clavulanic Acid Glaxosmithkline Inc N/A   N/A N/A N/A      
Complera 199560 Emtricitabine, Tenofovir Disoproxil Fumarate, Rilpivirine Hydrochloride Gilead Sciences Canada Inc N/A   N/A N/A N/A N/A N/A  
Copaxone 200357 Glatiramer Acetate Teva Canada Limited N/A N/A N/A   N/A N/A N/A N/A
Cotellic 199785 Cobimetinib Hoffmann-La Roche Limited N/A   N/A   N/A   N/A  
Evra 200474 Ethinyl Estradiol, Norelgestromin Janssen Inc     N/A N/A   N/A N/A  
Flagyl 200299 Metronidazole Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Flagystatin 200324 Metronidazole, Nystatin Sanofi-Aventis Canada Inc N/A   N/A   N/A N/A N/A  
Harvoni 193140 Ledipasvir, Sofosbuvir Gilead Sciences Canada Inc N/A   N/A       N/A  
Heptovir 200536 Lamivudine Glaxosmithkline Inc N/A   N/A N/A N/A N/A N/A  
Holkira Pak 192833 Ritonavir, Paritaprevir, Ombitasvir, Dasabuvir AbbVie Corporation     N/A N/A   N/A N/A  
Iclusig 199527 Ponatinib Hydrochloride Ariad Pharmaceuticals Inc N/A   N/A   N/A N/A N/A  
Imbruvica 192718 Ibrutinib Janssen Inc N/A   N/A   N/A   N/A  
Invokamet 199731 Metformin HCl, Canagliflozin Janssen Inc N/A       N/A N/A N/A  
Jevtana 194950 Cabazitaxel Sanofi-Aventis Canada Inc N/A   N/A N/A N/A   N/A N/A
Levothyroxine Sodium for Injection 197889 Levothyroxine Sodium Fresenius Kabi Canada Ltd     N/A          
Lupron Depot 193372 Leuprolide Acetate AbbVie Corporation N/A N/A N/A N/A N/A N/A N/A  
Lysodren 200001 Mitotane Bristol-Myers Squibb Canada N/A   N/A   N/A N/A N/A N/A
Micardis Plus 200158 Hydrochlorothiazide, Telmisartan Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A   N/A N/A N/A  
Oesclim 199389 Estradiol Searchlight Pharma Inc N/A N/A N/A N/A N/A N/A N/A  
Oxytrol 198930 Oxybutynin Allergan Pharma Co.     N/A     N/A N/A N/A
Prefesta 199390 Estradiol, Norgestimate Searchlight Pharma Inc N/A N/A N/A N/A N/A N/A N/A  
Pristiq 200419 Desvenlafaxine Succinate Pfizer Canada Inc N/A N/A N/A   N/A N/A N/A  
Rapamune 200932 Sirolimus Pfizer Canada Inc N/A   N/A   N/A N/A N/A N/A
Reminyl ER 200217 Galantamine Hydrobromide Janssen Inc N/A   N/A   N/A N/A N/A N/A
Revlimid 200591 Lenalidomide Celgene Inc N/A   N/A   N/A   N/A  
Tamiflu 199480 Oseltamivir Phosphate Hoffmann-La Roche Limited N/A N/A N/A N/A N/A N/A N/A  
Tecfidera 198810 Dimethyl Fumarate Biogen Canada Inc N/A   N/A   N/A N/A N/A N/A
Technivie 192844 Ritonavir, Paritaprevir, Ombitasvir AbbVie Corporation     N/A N/A   N/A N/A  
Tivicay 192462 Dolutegravir Sodium ViiV Healthcare ULC     N/A   N/A   N/A  
Treanda 199858 Bendamustine Hydrochloride Lundbeck Canada Inc N/A       N/A N/A N/A  
Triquilar 21, Triquilar 28 200226 Ethinyl Estradiol, Levonorgestrel Bayer Inc     N/A N/A   N/A    
Tybost 200692 Cobicistat Gilead Sciences Canada Inc N/A N/A N/A N/A   N/A N/A  
Tykerb 199954 Lapatinib Ditosylate Monohydrate Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Videx EC 197051 Didanosine Bristol-Myers Squibb Canada                
Vimpat 193732 Lacosamide UCB Canada Inc     N/A          
Product Monograph Brand Safety Updates January 2017
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Advair, Advair Diskus 199754 fluticasone propionate, salmeterol xinafoate GlaxoSmithKline Inc N/A N/A N/A N/A N/A N/A N/A  
Allegra-D 200316 pseudoephedrine HCl, fexofenadine HCl Sanofi-Aventis Canada Inc   N/A     N/A   N/A  
Allopurinol 198729 allopurinol Apotex Inc N/A   N/A   N/A N/A N/A  
Apo-Bisoprolol 197881 bisoprolol fumarate Apotex Inc N/A N/A N/A N/A N/A N/A N/A  
Butorphanol Nasal Spray 196224 butorphanol tartrate Aa Pharma Inc                
Depakene 200975 valproic acid BGP Pharma Ulc N/A N/A N/A     N/A N/A  
Docetaxel Injection Usp 199491 docetaxel Hospira Healthcare Corporation N/A N/A N/A          
Epival 201016 divalproex sodium BGP Pharma Ulc N/A N/A N/A     N/A N/A  
Esbriet 199306 pirfenidone Hoffmann La Roche Limited N/A   N/A N/A N/A   N/A  
Gleevec 199774 imatinib Novartis Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A  
Imbruvica 199713 ibrutinib Janssen Inc N/A N/A N/A   N/A N/A N/A  
Invokamet 198711 metformin HCl, canagliflozin Janssen Inc N/A   N/A   N/A N/A N/A  
Invokana 198712 canagliflozin Janssen Inc N/A   N/A   N/A N/A N/A  
Jadenu 194474 deferasirox Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A  
Jardiance 198914 empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A   N/A N/A N/A N/A
Lipidil Ez 198956 fenofibrate BGP Pharma Ulc N/A   N/A       N/A  
Lipidil Supra 198973 fenofibrate BGP Pharma Ulc N/A   N/A       N/A  
Marvelon 21, Marvelon 28 199319 desogestrel, ethinyl estradiol Merck Canada Inc     N/A N/A   N/A N/A  
Nersione 200095 diflucortolone valerate GlaxoSmithKline Inc N/A   N/A          
Nuvaring 199249 ethinyl estradiol, etonogestrel Merck Canada Inc     N/A N/A   N/A N/A  
Prevacid, Prevacid Fastab 200287 lansoprazole Takeda Pharmaceuticals America Inc N/A     N/A   N/A N/A  
Rupall 199706 rupatadine fumarate Pediapharm Inc                
Sunvepra 199423 asunaprevir Bristol-Myers Squibb Canada       N/A N/A   N/A  
Synjardy 199955 metformin HCl, empagliflozin Boehringer Ingelheim (Canada) Ltd Ltee N/A       N/A N/A N/A  
Telzir 198633 fosamprenavir Viiv Healthcare Ulc N/A   N/A   N/A N/A N/A  
Tramacet 196229 acetaminophen, tramadol HCl Janssen Inc                
Ultram 196230 tramadol HCl Janssen Inc                
Zelboraf 192354 vemurafenib Hoffmann La Roche Limited N/A N/A N/A   N/A N/A N/A N/A
Zyloprim 198730 allopurinol Aa Pharma Inc N/A   N/A   N/A N/A N/A  
Product Monograph Brand Safety Updates December 2016
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
3TC 197792 lamivudine Viiv Healthcare Ulc N/A   N/A     N/A N/A  
Abilify Maintena 198294 aripiprazole Otsuka Pharmaceutical Co Ltd N/A   N/A   N/A N/A N/A  
Adempas 198385 riociguat Bayer Inc N/A   N/A N/A   N/A N/A  
Amaryl 198596 glimepiride Sanofi-Aventis Canada Inc N/A N/A N/A   N/A N/A N/A  
Amiodarone Hydrochloride For Injection, Amiodarone Syringe 198348 amiodarone HCl Sandoz Canada Incorporated N/A   N/A N/A N/A N/A N/A N/A
Arcosyl Plus, Arcosyl Plus Ld 197114 indapamide, perindopril arginine Servier Canada Inc N/A   N/A N/A N/A N/A N/A  
Atripla 198437 efavirenz, emtricitabine, tenofovir disoproxil fumarate Bristol-Myers Squibb And Gilead Sciences Llc N/A   N/A N/A N/A N/A N/A  
Burinex 199138 bumetanide Leo Pharma Inc N/A   N/A N/A N/A N/A N/A N/A
Caprelsa 198802 vandetanib Sanofi Genzyme, A Division Of Sanofi-Aventis Canada Inc N/A N/A N/A N/A N/A N/A N/A  
Caripul 197550 epoprostenol sodium Actelion Pharmaceuticals Canada Inc N/A N/A N/A   N/A N/A N/A N/A
Clindamycin IV Infusion 197403 clindamycin phosphate Sandoz Canada Incorporated N/A   N/A   N/A      
Combivir 197907 zidovudine, lamivudine Viiv Healthcare Ulc N/A   N/A     N/A N/A  
Depo-Provera 198801 medroxyprogesterone acetate Pfizer Canada Inc             N/A  
Dexilant 197719 dexlansoprazole Takeda Canada Inc N/A     N/A   N/A N/A  
Duratocin 190823 carbetocin Ferring Inc     N/A     N/A    
Durela 196227 tramadol HCl Cipher Pharmaceuticals Inc                
Exjade 191351 deferasirox Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A  
Ferrlecit 195781 sodium ferric gluconate complex in sucrose injection Sanofi-Aventis Canada Inc N/A N/A N/A N/A N/A   N/A N/A
Forxiga 198838 dapagliflozin Astrazeneca Canada Inc N/A N/A N/A   N/A N/A N/A  
Fycompa 194525 perampanel Eisai Limited N/A   N/A N/A     N/A  
Genvoya 198272 emtricitabine, elvitegravir, cobicistat, tenofovir alafenamide hemifumarate Gilead Sciences Canada Inc N/A   N/A N/A   N/A N/A  
Gilenya 198247 fingolimod hydrochloride Novartis Pharmaceuticals Canada Inc N/A   N/A N/A N/A N/A N/A N/A
Hp-Pac 197727 amoxicillin, clarithromycin, lansoprazole Takeda Pharmaceuticals America Inc N/A     N/A   N/A N/A  
Imodium Calming Liquid, Imodium Caplets, Imodium Liqui-Gels, Imodium Quick Dissolve 198609 loperamide HCl Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc N/A   N/A   N/A N/A    
Imodium Complete Caplets, Imodium Complete Chewable Tablets 198510 loperamide HCl, simethicone Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc N/A N/A     N/A N/A    
Istodax 199398 romidepsin Celgene Inc N/A N/A N/A N/A N/A   N/A  
Jentadueto 198478 metformin HCl, linagliptin Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Kivexa 197786 lamivudine, abacavir sulfate Viiv Healthcare Ulc N/A   N/A       N/A  
Kyprolis 194999 carfilzomib Amgen Canada Inc N/A N/A N/A N/A N/A   N/A  
Lotensin 197116 benazepril HCl Novartis Pharmaceuticals Canada Inc N/A   N/A N/A   N/A N/A N/A
Lyrica 198215 pregabalin Pfizer Canada Inc N/A N/A N/A N/A N/A N/A   N/A
Mekinist 197849 trametinib Novartis Pharmaceuticals Canada Inc N/A   N/A       N/A  
Methotrexate 198792 methotrexate sodium Pfizer Canada Inc N/A N/A N/A     N/A N/A N/A
Movantik 198089 naloxegol oxalate Astrazeneca Canada Inc N/A   N/A       N/A  
Neurontin 198809 gabapentin Pfizer Canada Inc N/A   N/A   N/A N/A N/A  
Olmetec 198091 olmesartan  medoxomil Merck Canada Inc N/A   N/A N/A N/A N/A N/A  
Olmetec Plus 198164 hydrochlorothiazide, olmesartan  medoxomil Merck Canada Inc N/A   N/A N/A N/A N/A N/A  
Panto IV 197721 pantoprazole sodium sesquihydrate Takeda Canada Inc N/A     N/A   N/A N/A  
Pantoloc 197723 pantoprazole Takeda Canada Inc N/A     N/A   N/A N/A  
Pariet 197710 rabeprazole Janssen Inc N/A     N/A   N/A N/A  
Plavix 199386 clopidogrel bisulfate Sanofi-Aventis Canada Inc N/A N/A N/A   N/A N/A N/A  
Ralivia 196236 tramadol HCl Valeant Canada Lp Valeant Canada S.E.C.                
Remeron 197879 mirtazapine Merck Canada Inc N/A N/A N/A   N/A N/A N/A  
Remeron Rd 197936 mirtazapine Merck Canada Inc N/A N/A N/A   N/A N/A N/A  
Retrovir (Azt) 197908 zidovudine Viiv Healthcare Ulc N/A   N/A   N/A N/A N/A  
Revlimid 190743 lenalidomide Celgene Inc N/A       N/A   N/A  
Serophene 189606 clomiphene citrate Emd Serono Z Division Of Emd Inc Canada     N/A   N/A N/A   N/A
Sonovue 189455 sulfur hexafluoride Bracco Imaging Canada         N/A N/A N/A  
Suboxone 195433 buprenorphine hydrochloride, naloxone hydrochloride dihydrate Indivior Uk Limited                
Tafinlar 197867 dabrafenib Novartis Pharmaceuticals Canada Inc N/A   N/A       N/A  
Tecta 197724 pantoprazole magnesium Takeda Canada Inc N/A     N/A   N/A N/A  
Topamax 198204 topiramate Janssen Inc N/A   N/A     N/A N/A  
Torisel 199380 temsirolimus Pfizer Canada Inc N/A   N/A N/A   N/A N/A  
Trajenta 198479 linagliptin Boehringer Ingelheim (Canada) Ltd Ltee N/A   N/A   N/A N/A N/A  
Tridural 196232 tramadol HCl Paladin Labs Inc                
Triumeq 197843 lamivudine, abacavir sulfate, dolutegravir sodium Viiv Healthcare Ulc N/A   N/A     N/A N/A  
Trizivir 197841 zidovudine, lamivudine, abacavir sulfate Viiv Healthcare Ulc N/A   N/A     N/A N/A  
Ultibro Breezhaler 198299 glycopyrronium bromide, indacaterol maleate Novartis Pharmaceuticals Canada Inc N/A N/A N/A     N/A    
Viacoram 198962 perindopril arginine, amlodipine Servier Canada Inc N/A N/A N/A       N/A  
Vimpat 198678 lacosamide Ucb Canada Inc N/A   N/A   N/A N/A    
Votrient 198325 pazopanib Novartis Pharmaceuticals Canada Inc N/A   N/A   N/A N/A N/A  
Xalkori 198487 crizotinib Pfizer Canada Inc N/A N/A N/A   N/A N/A N/A  
Xigduo 198902 metformin HCl, dapagliflozin Astrazeneca Canada Inc N/A N/A N/A   N/A N/A N/A  
Ziagen 197787 abacavir sulfate Viiv Healthcare Ulc N/A   N/A     N/A N/A  
Zocor 197663 simvastatin Merck Canada Inc N/A   N/A N/A     N/A  
Zocor 199039 simvastatin Merck Canada Inc   N/A N/A N/A N/A   N/A  
Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular 198327 olanzapine, olanzapine tartrate Eli Lilly Canada Inc N/A   N/A   N/A N/A N/A  
Zytram XL 196235 tramadol HCl Purdue Pharma                
Product Monograph Brand Safety Updates November 2016
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Accutane Roche 198170 isotretinoin Hoffmann La Roche Limited N/A N/A N/A N/A N/A N/A N/A
Adcirca 197483 tadalafil Eli Lilly Canada Inc N/A N/A N/A N/A N/A N/A
Amerge 195190 naratriptan HCl GlaxoSmithKline Inc N/A N/A N/A N/A N/A N/A N/A
Apo-Doxy, Apo-Doxy-Tabs 194708 doxycycline hyclate Apotex Inc N/A N/A
Arcosyl 197113 perindopril arginine Servier Canada Inc N/A N/A N/A N/A N/A N/A
Casodex 198469 bicalutamide Astrazeneca Canada Inc N/A N/A N/A N/A N/A N/A
Cialis 197461 tadalafil Eli Lilly Canada Inc N/A N/A N/A N/A N/A N/A
Codeine Contin 196233 codeine sulfate Purdue Pharma
Cubicin 197629 daptomycin Cubist Pharmaceuticals LLC N/A N/A N/A N/A N/A N/A
Cysview 193861 hexaminolevulinate hydrochloride Biosyent Pharma Inc N/A N/A N/A N/A N/A
Daklinza 189820 daclatasvir Bristol-Myers Squibb Canada N/A N/A
Dexilant 194184 dexlansoprazole Takeda Canada Inc N/A N/A N/A N/A N/A N/A
Diabeta 197357 glyburide Sanofi-Aventis Canada Inc N/A N/A N/A N/A N/A
Dilaudid HP 195097 hydromorphone HCl Purdue Pharma
Erivedge 196987 vismodegib Hoffmann La Roche Limited N/A N/A N/A
Faslodex 197757 fulvestrant Astrazeneca Canada Inc N/A N/A N/A N/A
Fibristal 190760 ulipristal acetate Actavis Specialty Pharmaceuticals Co N/A N/A N/A
Flagyl 197442 metronidazole Sanofi-Aventis Canada Inc N/A N/A N/A N/A N/A
Flagystatin 197434 metronidazole, nystatin Sanofi-Aventis Canada Inc N/A N/A N/A N/A N/A N/A
Galexos 190665 simeprevir Janssen Inc N/A N/A N/A
Holkira Pak 190518 ritonavir, paritaprevir, ombitasvir, dasabuvir Abbvie Corporation N/A N/A N/A N/A N/A
Intralipid 10%, Intralipid 20%, Intralipid 30% 196682 soybean oil Fresenius Kabi Canada Ltd N/A N/A N/A
Iopidine 197019 apraclonidine HCl Alcon Canada Inc N/A N/A
Losec 197703 omeprazole, omeprazole magnesium Astrazeneca Canada Inc N/A N/A N/A N/A
Marvelon 197331 desogestrel, ethinyl estradiol Merck Canada Inc N/A N/A N/A N/A N/A
Mavik 197753 trandolapril BGP Pharma ULC N/A N/A N/A N/A N/A
Movantik 193483 naloxegol Astrazeneca Canada Inc N/A N/A N/A N/A N/A N/A
Nexium 197707 esomeprazole Astrazeneca Canada Inc N/A N/A N/A N/A
Nuvaring 197333 ethinyl estradiol, etonogestrel Merck Canada Inc N/A N/A N/A N/A
Ofev 196957 nintedanib Boehringer Ingelheim (Canada) Ltd Ltee N/A N/A N/A N/A N/A N/A
Paxil 195493 paroxetine HCl GlaxoSmithKline Inc N/A N/A N/A N/A N/A N/A
Paxil CR 195495 paroxetine HCl GlaxoSmithKline Inc N/A N/A N/A N/A N/A N/A
Picato 198249 ingenol mebutate Leo Pharma Inc N/A N/A N/A N/A N/A
Plan B 190655 levonorgestrel Teva Branded Pharmaceutical Products R&D Inc N/A N/A N/A N/A N/A N/A
Revolade 198151 eltrombopag olamine Novartis Pharmaceuticals Canada Inc N/A N/A N/A N/A N/A N/A
Saphris 190584 asenapine Merck Canada Inc N/A N/A N/A N/A N/A N/A
Signifor Lar 189699 pasireotide Novartis Pharmaceuticals Canada Inc N/A N/A N/A N/A N/A N/A
Talwin 195187 pentazocine HCl Sanofi-Aventis Canada Inc
Technivie 197870 ritonavir, paritaprevir, ombitasvir Abbvie Corporation N/A N/A N/A N/A N/A N/A
Thalomid 198336 thalidomide Celgene Inc N/A N/A N/A N/A N/A
Tobramycin Injection 197545 tobramycin Fresenius Kabi Canada Ltd N/A N/A N/A N/A
Toloxin 196770 digoxin Pendopharm Division of Pharmascience Inc N/A N/A N/A N/A N/A N/A
Treanda 188195 bendamustine hydrochloride Lundbeck Canada Inc N/A N/A N/A N/A N/A
Vidaza 197742 azacitidine Celgene Corporation N/A N/A N/A N/A N/A N/A
Vimovo 197709 naproxen, esomeprazole magnesium trihydrate Astrazeneca Canada Inc N/A N/A N/A N/A
Product Monograph Brand Safety Updates for Non-Prescription Submissions Cleared in 2014
Brand Name Submission Number Ingredient Manufacturer Contra-indications Warning and Precautions Serious Warnings and Precautions Box Adverse Reactions Drug Interactions Dosage and Administration Overdosage Consumer Information
Aerius, Aerius Kids 164302 Desloratadine Schering-Plough Canada Inc N/A N/A
Aspirin 81 Mg, Aspirin 81 MG Quick Chew, Aspirin Regular Strength 169398 Acetylsalicylic acid Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A N/A
Aspirin 81 MG, Aspirin 81 MG Quick Chews, Aspirin Regular Strength, Aspirin Extra Strength 172222 Acetylsalicylic acid Bayer Inc Consumer Care N/A N/A N/A N/A N/A
Bactroban 176769 Mupirocin GlaxoSmithKline Consumer Healthcare Inc N/A N/A N/A N/A N/A N/A
Claritin Allergy + Sinus Extra Strength 167087 Pseudoephedrine sulfate, loratadine Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A
Claritin Allergy + Sinus, Claritin Allergy + Sinus Extra Strength 177692 Pseudoephedrine sulfate, loratadine Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A
Claritin Allergy + Sinus 168558 Pseudoephedrine sulfate, loratadine Schering-Plough Canada Inc N/A N/A N/A N/A N/A N/A N/A
Claritin, Claritin Kids 177690 Loratadine Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A
Claritin Liquid Capsules 177693 Loratadine Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A
Claritin Rapid Dissolve 177691 Loratadine Bayer Inc Consumer Care N/A N/A N/A N/A N/A N/A
Contingency 174868 Levonorgestrel Famy Care Ltd N/A N/A N/A N/A
Heartburn Control 178335 Omeprazole Apotex Incorporated N/A N/A N/A N/A
Next Choice 174352 Levonorgestrel Cobalt Pharmaceuticals Company N/A N/A N/A N/A
Plan B 174250 Levonorgestrel Teva Women's Health Inc N/A N/A N/A N/A
Reactine Fast Melt Junior 173699 Cetirizine hydrochloride McNeil Consumer Healthcare Division Of Johnson & Johnson Inc N/A N/A N/A N/A N/A N/A
Teva-Levonorgestrel 174883 Levonorgestrel Teva Canada Limited N/A N/A N/A N/A
Voltaren Emulgel Extra Strength 172960 Diclofenac diethylamine Novartis Consumer Health Canada Inc N/A N/A N/A N/A N/A N/A
Women's Rogaine Foam 5% 165769 Minoxidil Johnson & Johnson Inc N/A
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