Pathogen Safety Data Sheets: Infectious Substances – O'Nyong-Nyong virus
Organization: Public Health Agency of Canada
Published: February 2018
Section I - Infectious Agent
Synonym or Cross Reference
Epidemic polyarthritis and rash, O'Nyong-Nyong virus disease, ONN
Togaviridae (formerly group A arboviruses), genus Alphavirus; spherical, enveloped virions 60 nm in diameter, single-stranded, positive-sense RNA genome
Section II - Hazard Identification
Pathogenicity / Toxicity
Self limiting febrile viral disease; characterized by arthralgia or arthritis typically in the knee, ankle and small joints of the extremities, followed by a maculopapular rash in 60-70% of cases; buccal and palatal enanthema can occur; inapparent infections are common, immunity is long lasting.
Found in Africa
Mode of Transmission
By bite of an infective mosquito
Greater than 8 days
No evidence of person-to-person transmission
Section III - Dissemination
- Mosquitoes - Anopheles spp.
- A. funestus, A gambiae
Section IV - Stability and Viability
No antiviral available to date
Susceptibility to Disinfectants
Sensitive to 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde, sensitive to lipid solvents.
Inactivated by moist, dry heat> 58° C; Sensitive to drying.
Survival Outside Host
Unknown, less than one day in culture medium at 37° C.
Section V - First Aid / Medical
Monitor for symptoms; confirm by serological analysis and viral isolation in mice
First Aid / Treatment
Mainly supportive therapy
None available to date
Section VI - Laboratory Hazards
Laboratory - Acquired Infections
Two cases of O'Nyong Nyong virus infection were reported by 1980
Sources / Specimens
Accidental parenteral inoculation, aerosols
Section VII - Exposure Controls / Personal Protection
Risk Group Classification
Risk group 2.
Containment Level 2 facilities, equipment, and operational practices for work involving infectious or potentially infectious materials, animals, or cultures.
Laboratory coat; gloves when skin contact with infectious materials or animals is unavoidable. Eye protection must be used where there is a known or potential risk of exposure to splashes.
All procedures that may produce aerosols, or involve high concentrations or large volumes should be conducted in a biological safety cabinet (BSC). The use of needles, syringes, and other sharp objects should be strictly limited. Additional precautions should be considered with work involving animals or large scale activities.
Section VIII - Handling and Storage
Allow aerosols to settle and, wearing protective clothing, gently cover spill with paper towels and apply an appropriate disinfectant, starting at the perimeter and working towards the centre. Allow sufficient contact time before clean up.
Decontaminate all wastes that contain or have come in contact with the infectious organism before disposing by autoclave, chemical disinfection, gamma irradiation, or incineration.
The infectious agent should be stored in leak-proof containers that are appropriately labelled.
Section IX - Regulatory and Other Information
The import, transport, and use of pathogens in Canada is regulated under many regulatory bodies, including the Public Health Agency of Canada, Health Canada, Canadian Food Inspection Agency, Environment Canada, and Transport Canada. Users are responsible for ensuring they are compliant with all relevant acts, regulations, guidelines, and standards.
Centre for Biosecurity, Public Health Agency of Canada
Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.
Public Health Agency of Canada, 2018
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