FluWatch report: May 31 to June 6, 2015 (Weeks 21 and 22)

Influenza/ILI Activity (geographic spread)

In week 22, three regions reported localized activity: BC, ON(2). Fourteen regions reported sporadic activity: BC(2), AB(4), SK(2), MB, ON(2), QC, and NF(2). Thirty-eight regions have reported no activity.

Influenza and Other Respiratory Virus Detections

The number of positive influenza tests decreased from 124 in week 20 to 81 in week 21 and further decreased to 53 in week 22. The positivity rate for influenza continued to decline in weeks 21 and 22 (3.8% and 3.6% respectively). Influenza B remained the predominant virus, representing 81% of influenza detections. To date, 80% of influenza detections have been influenza A (Table 1).  Furthermore, detailed information on age and type/subtype has been received for 38,227 cases (Table 2). Adults ≥65 years of age have predominantly been affected by influenza A, accounting for 62% of influenza A detections. Influenza B, while much smaller in numbers, is affecting a greater proportion of individuals less than 65 years of age. Adults under the age of 64 years accounted for 63% of influenza B detections.

In weeks 21 and 22, detections for all other respiratory viruses decreased from the previous week and are approaching inter-seasonal levels (figure 3).

For more details, see the weekly Respiratory Virus Detections in Canada Report.

Antiviral Resistance

During the 2014-2015 influenza season, the NML has tested 1,682 influenza viruses for resistance to oseltamivir and 1,679 influenza viruses for resistance to zanamivir. All viruses were sensitive to zanamivir and one influenza A(H3N2) virus was resistant to oseltamivir. A total of 1,454 influenza A viruses (99.9%) were resistant to amantadine (Table 3). One virus was susceptible to amantadine.

Influenza Strain Characterizations

During the 2014-2015 influenza season, the National Microbiology Laboratory (NML) has characterized 1050 influenza viruses [208 A(H3N2), 21 A(H1N1) and 821 influenza B].

Influenza A (H3N2):  When tested by hemagglutination inhibition (HI) assay (n=208), one virus was antigenically similar to A/Texas/50/2012, five showed reduced titers to A/Texas/50/2012 and 202 were antigenically similar to A/Switzerland/9715293/2013, which is the influenza A(H3N2) component recommended for the 2015 Southern Hemisphere influenza vaccine. Additionally, 1,199 A(H3N2) viruses were unable to be tested by HI assay; however, sequence analysis showed that 1,197 belonged to a genetic group that typically shows reduced titers to A/Texas/50/2012.  Influenza A(H1N1): Twenty-one A(H1N1) viruses characterized were antigenically similar to A/California/7/2009. Influenza B: Of the 821 influenza B viruses characterized, 747 viruses were antigenically similar to B/Massachusetts/2/2012, three viruses showed reduced titers against B/Massachusetts/2/2012, and 74 were B/Brisbane/60/2008-like (Figure 4).

Influenza-like Illness (ILI) Consultation Rate

In week 22, the national influenza-like-illness (ILI) consultation rate decreased from the previous week to 12.8 consultations per 1,000 (Figure 5).

Influenza Outbreak Surveillance

In week 22 one new outbreak of influenza was reported in a long-term care facilities (LTCF)  (Figure 6). To date this season, 1,279 outbreaks in LTCFs have been reported and the majority of those with known subtypes were attributable to A(H3N2). There have been a higher number of reported influenza outbreaks to date this season compared to the same period in previous seasons.

Pharmacy surveillance

Pharmacy surveillance for sales of influenza antivirals has ended for the 2014-2015 influenza season (Figure 7).

Sentinel Hospital Influenza Surveillance

Paediatric Influenza Hospitalizations and Deaths (IMPACT)

In weeks 21 and 22, ten laboratory-confirmed influenza-associated paediatric (≤16 years of age) hospitalizations were reported by the Immunization Monitoring Program Active (IMPACT) network. All but one case were due to influenza B (Figure 8a). A greater proportion of cases have been reported with influenza B in recent weeks, following the trend in laboratory detections. Among the reported cases, seven were <2 years of age and three (33%) were 2 to 9 years of age. Two ICU admissions were reported.

To date this season, 705 hospitalizations have been reported by the IMPACT network, 511 (73%) of which were cases of influenza A. Among cases for which the influenza A subtype was reported, 98% (163/166) were A(H3N2)  (Table 4). To date, 94 cases were admitted to the ICU, of which 52 (55%) were 2 to 9 years of age (Figure 9a). A total of 59 ICU cases reported to have at least one underlying condition or comorbidity. Five deaths have been reported.

Note: The number of hospitalizations reported through IMPACT represents a subset of all influenza-associated paediatric hospitalizations in Canada. Delays in the reporting of data may cause data to change retrospectively.

Adult Influenza Hospitalizations and Deaths (CIRN)

Surveillance has ended for the 2014-2015 influenza season.

This season, 2,228 cases have been reported; 1,912 (86%) with influenza A. The majority of cases (81%) were among adults ≥65 years of age (Table 5). One hundred and seventy two ICU admissions have been reported and 128 cases were adults ≥65 years of age. Among the 172 ICU admissions, 27 were due to influenza B (12 in adults 45 to 64 years of age and 15 in adults over the age of 65). A total of 123 ICU cases (72%) reported to have at least one underlying condition or comorbidity. Of the 123 ICU cases with known immunization status, 40 (33%) reported not having been vaccinated this season. One hundred and thirty-five deaths have been reported, 124 (92%) of the deaths were adults >65 years of age (Figure 9B).

Note: The number of hospitalizations reported through CIRN represents a subset of all influenza-associated adult hospitalizations in Canada. Delays in the reporting of data may cause data to change retrospectively.

Provincial/Territorial Influenza Hospitalizations and Deaths

In week 22 and 23, 87 laboratory-confirmed influenza-associated hospitalizations were reported from participating provinces and territories^{Footnote *}. Of the 87 hospitalizations, 66 (76%) were due to influenza A and 46 (52%) were in patients ≥65 years of age.

Since the start of the 2014-15 season, 7,719 hospitalizations have been reported; 6,631 (86%) with influenza A. Among cases for which the subtype of influenza A was reported, 99.1% were A(H3N2). The majority of cases (70%) were ≥65 years of age (Table 6). A total of 394 ICU admissions have been reported to date: 52% (n=204) were in adults ≥65 years of age and 75% were due to influenza A. A total of 591 deaths have been reported since the start of the season: three children <5 years of age, four children 5-19 years, 45 adults 20-64 years, and 539 adults ≥65 years of age. Influenza A has been reported in 91% of deaths. Adults 65 years of age or older represent 91% of all deaths reported this season. Detailed clinical information (e.g. underlying medical conditions) is not known for these cases.

See additional data on Reported Influenza Hospitalizations and Deaths in Canada: 2009-10 to 2014-15 on the Public Health Agency of Canada website.

Emerging Respiratory Pathogens

Human Avian Influenza
Influenza A(H7N9): Since the last FluWatch report, no new laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus were reported by the World Health Organization. Globally to June 12, 2015, the WHO reported a total of 657 laboratory-confirmed human cases with avian influenza A(H7N9) virus, including 227 deaths. Documents related to the public health risk of influenza A(H7N9), as well as guidance for health professionals and advice for the public is updated regularly on the following websites:

• PHAC - Avian influenza A(H7N9)
• WHO - Avian Influenza A(H7N9)

Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Since the last FluWatch report, 150 new laboratory-confirmed cases and 24 deaths of MERS-CoV have been reported by the World Health Organization. Globally, from September 2012 to June 12, 2015, the WHO has reported a total of 1,289 laboratory-confirmed cases of infection with MERS-CoV, including 455 deaths. The public health risk posed by MERS-CoV in Canada remains low (see the PHAC Assessment of Public Health Risk) and for the latest global risk assessment posted by the WHO on June 3, 2015: WHO MERS-CoV

An outbreak is ongoing in the Republic of Korea originated from an individual who travelled to the Middle East (KSA, Qatar, UAE and Bah,rain). Secondary cases have links to healthcare settings (including health care workers, patients on the same ward). This outbreak represents the largest nosocomial oubreak outbside the Middle East. As of June 12, 2015, a total of 126 cases have been confirmed. All but one case were confirmed in the Republic of Korea. A total of 11 deaths have been reported due to this outbreak. Documents related to the public health risk of MERS-CoV, as well as guidance for health professionals and advice for the public is updated regularly on the following websites:

• PHAC - Middle East respiratory syndrome coronavirus (MERS-CoV)
• WHO - Coronavirus infections

International Influenza Reports

• World Health Organization influenza update
• World Health Organization FluNet
• WHO Influenza at the human-animal interface
• Centers for Disease Control and Prevention seasonal influenza report
• European Centre for Disease Prevention and Control - epidemiological data
• South Africa Influenza surveillance report
• New Zealand Public Health Surveillance
• Australia Influenza Report
• Pan-American Health Organization Influenza Situation Report

FluWatch definitions for the 2014-2015 season

ILI/Influenza outbreaks

Schools:

Greater than 10% absenteeism (or absenteeism that is higher (e.g. >5-10%) than expected level as determined by school or public health authority) which is likely due to ILI.
Note: it is recommended that ILI school outbreaks be laboratory confirmed at the beginning of influenza season as it may be the first indication of community transmission in an area.

Hospitals and residential institutions:

two or more cases of ILI within a seven-day period, including at least one laboratory confirmed case. Institutional outbreaks should be reported within 24 hours of identification. Residential institutions include but not limited to long-term care facilities ( LTCF) and prisons.

Workplace:

Greater than 10% absenteeism on any day which is most likely due to ILI.

Other settings:

two or more cases of ILI within a seven-day period, including at least one laboratory confirmed case; i.e. closed communities.

Note that reporting of outbreaks of influenza/ILI from different types of facilities differs between jurisdictions.

Influenza/ILI activity level

1 = No activity: no laboratory-confirmed influenza detections in the reporting week, however, sporadically occurring ILI may be reported

2 = Sporadic: sporadically occurring ILI and lab confirmed influenza detection(s) with no outbreaks detected within the influenza surveillance region ^{Footnote †}

3 = Localized:

1. evidence of increased ILI^{Footnote *} and
2. lab confirmed influenza detection(s) together with
3. outbreaks in schools, hospitals, residential institutions and/or other types of facilities occurring in less than 50% of the influenza surveillance region^{Footnote †}

4 = Widespread:

1. evidence of increased ILI^{Footnote *} and
2. lab confirmed influenza detection(s) together with
3. outbreaks in schools, hospitals, residential institutions and/or other types of facilities occurring in greater than or equal to 50% of the influenza surveillance region^{Footnote †}

Note: ILI data may be reported through sentinel physicians, emergency room visits or health line telephone calls.

We would like to thank all the Fluwatch surveillance partners who are participating in this year's influenza surveillance program.