Cells, Tissues And Organ Surveillance System (CTOSS), 2022

CTOSS monitors adverse events related to transplantation of cells, tissues, and organs in Canada.

2011 The system started in 2011. Currently, it only covers tissue transplants. The Project Progress Report: April 2007 – December 2013 contains a detailed methodology of surveillance.

30% of the tissues transplanted in Canada are monitored through four participating provinces in CTOSS.

72,720 tissues were transplanted during 2011-2022.

10,363 tissues were transplanted in 2022.

45 transplantation adverse events (TAEs^{Footnote 1}) were reported during 2011-2022.

7 TAEs were reported related to ocular tissues during 2022. 5 TAEs were bacterial infections. 2 TAEs were graft rejections. The incidence rate was 1.86 TAEs/1,000 grafts.

Number of tissues transplanted by sites, CTOSS 2022^{Footnote 2}

• Quebec – 6,598  
• Alberta – 2,577    
• Nova Scotia – 1,004
• New Brunswick – 184

Total tissues transplanted by tissue types, CTOSS 2022

• Bone – 4,400
• Skin – 1,537
• Ocular Tissue – 1,879
• Tendon – 1,183
• Heart Valve – 441
• Fascia – 20
• Amniotic Membrance – 611
• Other Allografts – 292
• Total – 10,363

Tissues involving adverse events (N=45), CTOSS 2011-2022

• Ocular (30, 67%)
• Bone (11, 24%)
• Tendon (3, 7%)
• Heart Valve (1, 2%)

Conclusion

With increased number of tissues transplanted in 2022, the incidence rates of TAEs in four sites remain similar.