Survey report of people who inject drugs in Canada

CCDR

Volume 46–5, May 7, 2020: Nosocomial infection surveillance

Survey report

National findings from the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019

Jill Tarasuk1, Jingxuan Zhang1, Anaïs Lemyre1, François Cholette2, Maggie Bryson1, Dana Paquette1

Affiliations

1 Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON

2 National Mircrobiology Laboratory, Public Health Agency of Canada, Winnipeg, MB

Correspondence

jill.tarasuk@canada.ca

Suggested citation

Tarasuk J, Zhang J, Lemyre A, Cholette F, Bryson M, Paquette D. National findings from the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019. Can Commun Dis Rep 2020;46(5):138–48. https://doi.org/10.14745/ccdr.v46i05a07

Keywords: HIV, hepatitis C, people who inject drugs, drug use, injecting behaviours, sexual risk practices, overdose, infection status, testing, care and treatment

Abstract

Background: The Tracks survey of people who inject drugs (PWID) collected data in 14 sentinel sites across Canada (2017–2019).

Objective: To describe the prevalence of human immunodeficiency virus (HIV) and hepatitis C and associated risk behaviours and to examine trends over time.

Methods: Information regarding socio-demographics, social determinants of health, use of prevention services and testing, drug use, risk behaviours, and HIV and hepatitis C testing, care and treatment was collected through interviewer-administered questionnaires. Biological samples were tested for HIV, hepatitis C antibodies and hepatitis C ribonucleic acid (RNA). Descriptive statistics were calculated and trends over time were assessed.

Results: Of the 2,383 participants, 65.6% were cisgender male, 42.2% were Indigenous, 48.0% completed some high school or less, 62.6% lived in unstable housing and 75.7% had ever been incarcerated. Average age was 40.1 years. The majority experienced stigma and discrimination (88.7%) and physical, sexual and/or emotional abuse in childhood (85.0%) or with a sexual partner (75.9%). The majority reported use of a needle/syringe distribution program (90.1%) and tested for HIV (90.5%) and hepatitis C (90.9%).

Among participants who had ever had sex, the majority (59.2%) reported inconsistent condom use during vaginal and/or anal sex with a casual sex partner. Prevalence of HIV was 10.3% (82.9% were aware of infection status) and many (36.9%) were hepatitis C RNA-positive (50.1% were aware of infection status).

Most surveillance indicators remained relatively stable from Phase 1 to Phase 4. Changes were found in substances used, and improvements were noted related to HIV and hepatitis C prevalence and care cascade indicators.

Conclusion: Many PWID in Canada were living in unstable housing and experienced high levels of stigma and discrimination. Prevalence of HIV and hepatitis C was high in some areas. These findings contribute to the evidence base used to inform targeted prevention and control measures.

Introduction

People who inject drugs (PWID) represent an important group at risk for human immunodeficiency virus (HIV) and hepatitis C in Canada. It has been estimated that, of the 2,165 new HIV infections in 2016, the proportion attributed to injection drug use was 11.3%. This value had not decreased since the 2014 estimate of 11.2%Footnote 1. In North America, the burden of disease of hepatitis C attributable to injecting drug use is greater than for HIV, and was estimated to be 81% in 2013Footnote 2. In Canada, HIV and hepatitis C antibody prevalence was high among PWID surveyed in 2010–2012 (11.2% and 68%, respectively)Footnote 3. These findings underscore the need for prevention and treatment efforts to mitigate HIV and hepatitis C morbidity and mortality in this population. Integrated bio-behavioural surveillance, an established World Health Organization (WHO)/Joint United Nations Programme on HIV/AIDS (UNAIDS) globally-endorsed approachFootnote 4, is critical to informing response and to guiding public health interventions. This surveillance provides information about risk practices and health-seeking behaviours among the populations most at risk for HIV and is necessary to better understand the factors driving transmission.

The Public Health Agency of Canada (PHAC), in conjunction with provinces and territories including regional and/or local public health partners, monitors trends in the prevalence of HIV and hepatitis C and associated risk factors in key populations, such as PWID, through the Tracks Surveillance Systems. The Tracks survey of PWID (formerly I-Track) involves repeated cross-sectional surveys at selected sites across Canada. It was first implemented in 2003–2005 (Phase 1) in seven sentinel sites. This was followed by three subsequent data collection periods, including the most recent survey, Phase 4 (2017–2019), in 14 sentinel sites (Appendix 1).

The objective of this report is to present national surveillance findings from Phase 4 of the Tracks survey of PWID in Canada, conducted between January 1, 2017 and May 9, 2019, at participating sentinel sites in Canada. Findings include socio-demographic characteristics, social determinants of health, use of prevention services and testing, drug use and experiences with overdoses, sexual risk behaviours and HIV and hepatitis C care cascade, prevalence and awareness of infection status. Selected indicators from Phase 1 to Phase 4 of the Tracks survey of PWID are also presented to describe trends over time.

Methods

Data source and sampling methods

The data presented in this report are from the Tracks survey of PWID in Canada. The Tracks survey of PWID makes use of venue-based sampling, in which participants are recruited from settings in which they are likely to gather, most often, but not limited to, needle and syringe distribution programs. Individuals who had injected drugs six months prior to recruitment and who met the minimum age to provide consent, which was determined at each site according to local research ethics requirements, were eligible to participate in the survey. Eligible and consenting participants completed an interviewer-administered questionnaire and provided a biological sample in the form of a dried blood spot (DBS) specimen (or oral fluid exudate in the SurvUDI network sites).

The surveillance protocol and questionnaire were approved by the Health Canada/PHAC Research Ethics Board, and by local research ethics boards at each sentinel site where required. The same sampling and recruitment strategies and core questionnaire, with minor revisions, were used across all four phases to ensure comparability over time. Survey methods are described in more detail elsewhereFootnote 3.

Sentinel site selection

Sentinel sites were selected based on consultations with provincial/territorial representatives, who considered the epidemiology of HIV, hepatitis C and drug use and associated harms. Given this assessment, participating sentinel sites varied by phase of the Tracks Survey of PWID (Appendix 1). Data collection in Ottawa (Ontario) and in the province of Quebec was coordinated by the SurvUDI networkFootnote 5. The SurvUDI network sites were divided into four geographical zones for the Phase 4-specific analyses (see Appendix 1).

Interviewer-administered questionnaire

The Tracks PWID questionnaire collects information about socio-demographic characteristics, social determinants of health, use of health and prevention services (including testing), drug use and injecting behaviours, sexual behaviours and care and treatment for HIV and hepatitis C. The questionnaire was first developed for a pilot phase by an expert working group to establish face validity. To ensure comparability, each subsequent phase retained most national-level questions to monitor change over time.

The Phase 4 questionnaire included a limited number of revisions, including new national-level questions that addressed gender identity, financial strain, mental health status, experiences of stigma and discrimination, physical, sexual and/or emotional abuse, borrowing used non-injection drug paraphernalia, overdose-related experiences, use of harm reduction services, condomless sex at last paid sex, substance use before or during sex, adherence to antiretroviral treatment and viral load status.

Biological sample

Dried blood spot samples were tested for HIV (antibody and antigen) and hepatitis C (antibody and RNA). Participants were not informed of their laboratory test results because no identifying information was collected to ensure participant anonymity. Sentinel sites were asked to provide on-site testing (e.g. point of care testing, full phlebotomy) during recruitment times so that participants who were not aware of their status could get tested, should they wish. Where on-site testing was not feasible, participants were referred to local testing sites and/or health care services. Updated laboratory testing algorithms for DBS were introduced in Phase 4 (see Appendix 2). Testing algorithms for SurvUDI samples are found in Appendix 2.

Analysis

Descriptive statistics for selected indicators were computed with SAS Enterprise Guide 7.1. Selected indicators from Phase 1 to Phase 4 were compared to examine trends over time. Small cell counts were assessed to determine the risk of identifying individual participants, and were left in when it was determined that there was no risk of reidentification, as per PHAC’s Directive for the collection, use and dissemination of information relating to public health (PHAC, 2013, unpublished document). Participants who responded as “not stated”, “don’t know” or “refused” were excluded from each individual analysis.

Results

Sample sizes for Phase 1, Phase 2 and Phase 3 were 2,986, 2,982 and 2,687, respectively. A total of 2,383 individuals were eligible and consented to participate in the Phase 4 survey, among whom 2,379 (99.8%) completed a questionnaire and 2,162 (90.7%) provided a biological sample. Findings for selected indicators by socio-demographic characteristic and social determinants of health of participants are provided in Supplemental tables (A - prevention and testing indicators, B - injecting behaviours and drug use, C - sexual risk behaviours and D - selected indicators by Phase).

Socio-demographic characteristics

In Phase 4, 65.6% identified their gender as cisgender male, 32.7% as cisgender female and 1.0% as transfeminine (i.e. those assigned male at birth who identified with either female or a non-binary gender) and 0.7% transmasculine (i.e. those assigned female at birth who identified with either male or a non-binary gender) (Table 1). The average age was 40.1 years (Supplemental table D).

Table 1: Socio-demographic characteristics of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
Socio-demographic characteristics n TotalFootnote a of Table 1 %
Gender identity Cisgender female 775 2,372 32.7
Cisgender male 1,556 2,372 65.6
TransfeminineFootnote b of Table 1 24 2,372 1.0
TransmasculineFootnote c of Table 1 17 2,372 0.7
Age group Younger than 25 years 161 2,378 6.8
25 to 39 years 1,058 2,378 44.5
40 to 54 years 895 2,378 37.6
55 years or older 264 2,378 11.1
Sentinel site Whitehorse, YK 49 2,383 2.1
Central and Northern Vancouver Island, BC 179 2,383 7.5
Prince Albert, SK 184 2,383 7.7
Regina, SK 205 2,383 8.6
Winnipeg, MB 181 2,383 7.6
Thunder Bay, ON 200 2,383 8.4
London, ON 206 2,383 8.6
Hamilton, ON 157 2,383 6.6
Ottawa, ON and the region of Outaouais, QC 200 2,383 8.4
Montréal, QC 200 2,383 8.4
Québec, QC 125 2,383 5.3
Other urban sites in QuebecFootnote d of Table 1 167 2,383 7.0
New Brunswick 200 2,383 8.4
Newfoundland 130 2,383 5.5
Indigenous status First Nations, Métis, or Inuit 997 2,360 42.2
Other ethnicity 1,363 2,360 57.8
Living in a FN, Métis or Inuit communityFootnote e of Table 1 No 802 930 86.2
Yes 128 930 13.8

Of all participants, 42.2% identified as Indigenous, of whom 82.9% identified as First Nations, 14.9% Métis or 2.2% Inuit. Among all Indigenous participants, 13.8% reported living in a First Nations, Métis or Inuit community at the time of the interview. The proportion of participants who identified as other ethnicities was 57.8% of whom the majority (96.3%) identified as White. Most demographics stayed relatively stable over the four phases, while the average age increased slightly, as did the proportion who self-identified as Indigenous (Supplemental table D).

Social determinants of health

Among Phase 4 participants, just under half (48.0%) had completed some high school or less and a large proportion (86.0%) experienced financial strain (i.e. difficulty making ends meet) in the 12 months prior to the interview (Table 2). Overall, 62.6% of participants lived in unstable housing in the six months prior to the interview and 75.7% reported having ever been incarcerated. A large proportion (84.0%) reported their mental health as “fair to excellent” and 16.0% reported poor mental health status. Among Indigenous participants, 83.1% had attended a residential school themselves or had a family member who had attended a residential school.

Table 2: Social determinants of health of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
Social determinants of health n TotalFootnote a of Table 2 %
Education, highest level Less than high school 1,139 2,373 48.0
Finished high school 621 2,373 26.2
More than high school 613 2,373 25.8
Experienced financial strainFootnote b of Table 2, past 12 months No 207 1,479 14.0
Yes 1,272 1,479 86.0
Housing status, past six months Unstable housingFootnote c of Table 2 1,486 2,374 62.6
Stable housing 888 2,374 37.4
Ever incarceratedFootnote d of Table 2 No 422 1,736 24.3
Yes 1,314 1,736 75.7
Mental health Fair to excellent 1,401 1,668 84.0
Poor 267 1,668 16.0
Experience of stigma and discriminationFootnote e of Table 2, ever No 166 1,464 11.3
Yes 1,298 1,464 88.7
Experience of childhood physical, sexual, and/or emotional abuse No 220 1,463 15.0
Yes 1,243 1,463 85.0
Experience of sexual partner physical, sexual, and/or emotional abuse No 351 1,458 24.1
Yes 1,107 1,458 75.9

Experiences of stigma and discrimination (related to racial or cultural background, hepatitis C status, HIV status, sexual orientation, use of drugs or alcohol or sex work) were reported by the majority of participants (88.7%). Large proportions of participants had experienced physical, sexual and/or emotional abuse in childhood (85.0%) or with a sexual partner (75.9%).

Over the past four phases, the social determinant indicators stayed relatively stable with the exception of an increase in the proportion reporting living in unstable housing in the six months prior to the interview (51.1%–62.6%) (Supplemental table D).

Use of prevention services and testing

In Phase 4, the majority of participants (90.1%) reported using a needle and syringe distribution program in the 12 months prior to the interview, with lower proportions reporting use of methadone, suboxone or other opioid substitution therapy (47.3%) and use of a supervised injection or consumption site (13.5%). The majority of participants reported ever testing for HIV (90.5%) and hepatitis C (90.9%) (Table 3). Some (14.3%) of the participants had heard about preexposure prophylaxis (PrEP). Among participants who did not report an HIV diagnosis, 0.3% had used PrEP in the 12 months prior to the interview to reduce the risk of contracting HIV. The proportion of participants who had ever tested for HIV (90.0%–92.9%) and hepatitis C (87.5%–91.3%) was high and varied slightly across all phases (Supplemental table D).

Table 3: Use of prevention services and testing for HIV and hepatitis C of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
Use of prevention services and testing n TotalFootnote a of Table 3 %
Use of a needle and syringe distribution program, past 12 monthsFootnote b of Table 3 1,490 1,653 90.1
Use of a supervised injection or consumption site, past 12 monthsFootnote b of Table 3 223 1,652 13.5
Use of methadone, suboxone or other opioid substitution therapy, past 12 monthsFootnote b of Table 3 780 1,650 47.3
Tested for HIV, ever 2,080 2,299 90.5
Tested for HCV, ever 2,086 2,296 90.9

Injecting behaviours

In Phase 4, over one-third of participants (38.1%) reported injecting daily in the month prior to the interview and over half (52.7%) reported injecting in a public space in the six months prior to the interview. Overall, 11.6% of participants injected with used needles and/or syringes in the six months prior to the interview, of whom the majority (85.2%) borrowed needles and/or syringes from people who they knew well (i.e. family, friends or sex partners). Over one-third (38.0%) injected with other used injection equipment such as water, filters, cookers, tourniquets, swabs or acidifiers in the six months prior to the interview. Among those who borrowed used equipment, the majority (82.9%) reported borrowing from people they knew well. More than half of participants (56.0%) borrowed used non-injection drug paraphernalia such as straws, dollar bills, or pipes in the six months prior to the interview (Table 4).

Table 4: Injecting behaviours of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
Injecting behaviours n TotalFootnote a of Table 4 %
Injected daily in the past monthFootnote b of Table 4 822 2,155 38.1
Injected drugs in a public space, past six months 1,243 2,357 52.7
Borrowed used needles and/or syringes, past six months 271 2,339 11.6
Borrowed used needles and/or syringes from people known wellFootnote c of Table 4, past six months 224 263 85.2
Borrowed used other injecting equipment (i.e. water, filters, cookers, tourniquets, swabs, acidifiers), past six months 882 2,324 38.0
Borrowed used other injecting equipment from people known wellFootnote c of Table 4, past six months 710 856 82.9
Borrowed used non-injection drug paraphernalia (i.e. straws, dollar bills and pipes), past six monthsFootnote b of Table 4 1,153 2,059 56.0

The proportion of participants who reported borrowing used needles and/or syringes decreased by almost half from 20.2% in Phase 1 and 21.8% in Phase 2 to 11.6% in Phase 4. In contrast, the proportion who reported borrowing other used injection equipment (such as water, filter, cooker, spoons, tourniquets, ties, swabs and acidifiers) increased by almost a third from Phase 1 (29.8%) to Phase 4 (38.0%) (Supplemental table D).

Drug use and overdose experiences

In Phase 4, cocaine was the most commonly injected drug in the six months prior to the interview (60.0%), followed by hydromorphone (50.1%), methamphetamine (43.5%), morphine (41.6%) and heroin (32.4%). Participants consumed a wide range of non-injection drugs over the same period, most frequently cannabis (72.1%), alcohol (62.5%), crack (47.8%), cocaine (46.6%) and methamphetamine (43.0%). Opioid analgesic consumption (non-injection routes) was also reported specifically for methadone (35.0%), hydromorphone (28.2%), codeine (27.5%), morphine (24.7%), fentanyl (19.8%), heroin (19.7%) and oxycodone (15.6%) (Table 5).

Table 5: Drug use and experiences with overdoses of participants in the Tracks survey of people who inject drugs in Canada, Phase 4,2017–2019 (n=2,383)
Drug use and experiences with overdoses n TotalFootnote a of Table 5 %
Types of injection drugs used, past six monthsFootnote b of Table 5
Cocaine 1,419 2,364 60.0
Hydromorphone 1,184 2,363 50.1
Methamphetamine 1,027 2,360 43.5
Morphine 982 2,362 41.6
Heroin 764 2,357 32.4
Fentanyl 572 2,350 24.3
Amphetamines 506 2,358 21.5
Crack 473 2,362 20.0
Ritalin alone 466 2,361 19.7
Oxycodone 400 2,365 16.9
Heroin and cocaine 330 2,359 14.0
Benzodiazepines 173 2,361 7.3
Talwin and Ritalin 166 2,359 7.0
Methadone 145 2,366 6.1
Other drugsFootnote c of Table 5 237 1,751 13.5
Types of non-injection drugs used, past six monthsFootnote b of Table 5
Cannabis 1,698 2,356 72.1
Alcohol 1,472 2,355 62.5
Crack 1,125 2,352 47.8
Cocaine 1,097 2,354 46.6
Methamphetamine 1,010 2,349 43.0
Amphetamines 836 2,348 35.6
Methadone 824 2,357 35.0
Benzodiazepines 705 2,349 30.0
Hydromorphone 662 2,351 28.2
Codeine 645 2,350 27.5
Morphine 582 2,354 24.7
Fentanyl 462 2,337 19.8
Heroin 462 2,345 19.7
Oxycontin or Oxycodone 367 2,347 15.6
Ecstasy 223 2,351 9.5
Mushrooms 214 2,350 9.1
Talwin and Ritalin 213 2,352 9.1
Barbiturates 200 2,345 8.5
Other drugsFootnote c of Table 5 363 1,809 20.1
Awareness, access and use of an overdose kitFootnote d of Table 5
Heard of overdose kits 1,276 1,458 87.5
Ever used an overdose kit 408 1,274 32.0
Overdose kits are available in participants’ community
Yes 1,168 1,276 91.5
No 44 1,276 3.5
Don’t know 64 1,276 5.0
Overdose experiences
Overdosed in the past six monthsFootnote e of Table 5 374 1,652 22.6
Drugs or substances used at last overdoseFootnote b of Table 5Footnote d of Table 5Footnote f of Table 5
Fentanyl 128 298 43.0
Heroin 116 303 38.3
Methamphetamine 87 306 28.4
Cocaine 71 308 23.1
Alcohol 49 309 15.9
Cannabis 40 307 13.0
Benzodiazepines 35 305 11.5
Crack 30 305 9.8
Morphine 25 308 8.1
Methadone 23 308 7.5
Hydromorphone 20 308 6.5
Other drugsFootnote c of Table 5 85 310 27.4

Among Phase 4 participants, the majority had heard of overdose kits (87.5%) and reported that kits were available in their community (91.5%); a lower proportion had ever used one on someone else (32.0%). Nearly one-quarter (22.6%) had overdosed in the six months prior to the interview and the drugs most commonly reported at last overdose were fentanyl (43.0%), heroin (38.3%), methamphetamine (28.4%), cocaine (23.1%) and alcohol (15.9%) (Table 5).

The drug most commonly injected across all phases was cocaine (60.0%–81.6%). Between Phase 1 and 4, there was an increasing trend in injecting hydromorphone (29.9%–50.1%), methamphetamine (6.8%–43.5%), fentanyl (1.7%–24.3%) and amphetamines (7.9%–21.5%). Across all phases, non-injection use of cannabis and alcohol stayed at high levels (Supplemental table D).

Sexual risk behaviours

In Phase 4, in the six months prior to the interview, among participants who had ever had sex, 35.2% had two or more sexual partners, 59.2% had inconsistent condom use during vaginal and/or anal sex with a casual sex partner, 84.9% had inconsistent condom use during vaginal and/or anal sex with a regular sex partner and 15.7% had engaged in transactional sex at least once (Table 6). Among those that engaged in transactional sex, 30.7% did not use condoms at last transactional sex. The majority of participants (84.2%) reported substance use before or during sex (Table 6).

Table 6: Sexual risk behaviours of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
Sexual risk behaviours n TotalFootnote a of Table 6 %
Two or more sex partners, past six monthsFootnote b of Table 6 798 2,270 35.2
Inconsistent condom use during vaginal and/or anal sex with a casual sex partner, past six monthsFootnote c of Table 6 413 698 59.2
Inconsistent condom use during vaginal and/or anal sex with a regular sex partner, past six monthsFootnote c of Table 6 1,086 1,279 84.9
Engaged in transactional sex, past six months 280 1,786 15.7
Condomless sex at last transactional sexFootnote d of Table 6 66 215 30.7
Substance use before or during sex, past six monthsFootnote d of Table 6 1,088 1,292 84.2

Across all phases, of participants who had ever had sex in the six months prior to the interview, the proportion who had two or more sex partners and who had engaged in transactional sex stayed relatively stable (Supplemental table D).

HIV and hepatitis C prevalence and awareness

Based on the laboratory testing, HIV prevalence was 10.3% and of those who were HIV-positive, 82.9% were aware of their HIV-positive status (Table 7). The proportion who tested positive for hepatitis C antibodies was 64.2%, which is a measure of lifetime exposure to hepatitis C infection. Many (36.9%) were hepatitis C RNA-positive—an indicator of current hepatitis C infection—of whom, 50.1% were aware of their hepatitis C RNA positive status. Among participants who provided a biological sample of sufficient quantity for testing for both HIV antibodies and HCV RNA, 4.7% were HIV-positive and hepatitis C RNA positive; 4.3% were HIV-positive and hepatitis C RNA negative; 32.3% were HIV-negative and hepatitis C RNA positive; and 58.7% were HIV-negative and hepatitis C RNA negative.

Table 7: HIV and hepatitis C prevalence, awareness of infection status, and care cascade of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)
HIV and hepatitis C prevalence n TotalFootnote a of Table 7 %
HIV prevalence and awareness of infection status
HIV prevalenceFootnote b of Table 7Footnote c of Table 7 222 2,162 10.3
Awareness of HIV-positive statusFootnote d of Table 7 179 216 82.9
HIV care cascade (among participants aware of their HIV-positive status, n=179)
Linkage to care for HIV-related servicesFootnote e of Table 7 170 179 95.0
Ever taken ART treatment 174 179 97.2
Currently taking ART treatment 157 179 87.7
Adherence to ART, no missed doses in last monthFootnote f of Table 7 34 80 42.5
Self-reported undetectable HIV viral loadFootnote g of Table 7 59 94 62.8
Avoidance of HIV services because of stigma and discrimination, past 12 monthsFootnote f of Table 7 43 95 45.3
Hepatitis C prevalence and awareness of infection status
HCV antibody prevalenceFootnote c of Table 7Footnote h of Table 7 1,375 2,141 64.2
HCV RNA prevalenceFootnote c of Table 7Footnote i of Table 7 486 1,316 36.9
Awareness of hepatitis C RNA positive statusFootnote j of Table 7 238 475 50.1
Hepatitis C care cascade (among participants aware of their hepatitis C RNA-positive status, n=238)
Linkage to care for hepatitis CFootnote k of Table 7 115 237 48.5
Ever taken hepatitis C treatmentFootnote l of Table 7 25 236 10.6
Currently taking hepatitis C treatmentFootnote l of Table 7 9 236 3.8
HIV and hepatitis C coinfectionFootnote m of Table 7
HIV-positive and hepatitis C RNA positive 62 1,314 4.7
HIV-positive and hepatitis C RNA negative 57 1,314 4.3
HIV-negative and hepatitis C RNA positive 424 1,314 32.3
HIV-negative and hepatitis C RNA negative 771 1,314 58.7

Over the 15-year period from Phase 1 to Phase 4, HIV prevalence decreased from 14.9% to 10.3%. Among HIV-positive participants, the proportion of participants who were aware of their HIV-positive status increased slightly (77.8%–82.9%). Across all phases, the proportion who tested positive for hepatitis C antibodies was relatively stable with about two-thirds HCV antibody positive (64.2%–69.0%) (Supplemental table D).

HIV and hepatitis C care cascade

Indicators measuring the HIV care cascade were examined among participants aware of their HIV-positive status (Table 7). The majority were under the care of a doctor or health care provider for HIV-related services at the time of the interview (95.0%). The majority had also taken antiretroviral therapy (ART) (97.2%) and were currently taking ART at the time of the interview (87.7%). Adherence to ART, measured as no missed doses in the month prior to the interview, was 42.5%. Among participants currently taking ART at the time of the interview, 62.8% reported an undetectable HIV viral load. Nearly half of all participants who were aware of their HIV-positive status reported avoiding HIV services because of stigma and discrimination in the 12 months prior to the interview (45.3%).

Indicators measuring the hepatitis C care cascade were examined among participants who were aware of their current hepatitis C infection (Table 7). Nearly half (48.5%) reported being linked to care for hepatitis C; a smaller proportion (10.6%) had ever taken hepatitis C treatment; and an even smaller proportion (3.8%) were currently taking hepatitis C treatment.

From Phase 1 to Phase 4, among participants aware of their HIV-positive status, linkage to care for HIV-related services increased (88.1%–95.0%) as did the proportion of those currently taking ART treatment (52.0%–87.7%). Across all phases, only about half of the participants who were aware of their hepatitis C infection status were under the care of a doctor for their hepatitis C infection and the proportion currently taking hepatitis C treatment was very low (Supplemental table D).

Discussion

People who inject drugs represent an important risk group in Canada’s HIV and hepatitis C epidemicsFootnote 1. Information gathered from the Tracks survey of PWID in Canada help contextualize the epidemiology of HIV, hepatitis C and associated risk behaviours among this population, providing comparisons over time and new baseline data on key emerging indicators, such as experiences of stigma and discrimination, overdoses and the use of PrEP. Factors associated with increased vulnerability to HIV and hepatitis C in previous studies were also identified among this survey sample of PWID. Markers of poverty and marginalization, including high numbers living in unstable housing and/or ever incarcerated, were common. Lived experience of stigma and discrimination, as well as physical, sexual and/or emotional abuse (in childhood or with a sexual partner), were also identified by the majority of participants.

High rates of testing for HIV and hepatitis C and the use of needle and syringe distribution programs were noted. However, access to other key harm reduction services was lower, with less than half of the participants reporting the use of opioid-substitution therapy or the use of a supervised injection or consumption site in the previous year. Drug use and injecting behaviours reported in Phase 4 signalled important proportions of participants who borrow needles and/or syringes and other used injecting equipment. The majority of participants (59.2%) reported inconsistent condom use with a casual sex partner and 84.2% reported substance use before or during sex, both of which are associated with the transmission of STBBI including syphilis. Preexposure prophylaxis awareness was low among participants (14.3%), and the use of PrEP was only 0.3% among those who did not report an HIV-positive diagnosis.

Many of the national surveillance findings are consistent with the findings from other integrated bio-behavioural surveillance systems with comparable HIV and hepatitis C epidemics. Specifically, among PWID surveyed in the United States, Australia and the United Kingdom, similar levels of prevention and testing indicators (i.e. testing for HIV and hepatitis C, use of opioid substitution therapy), injecting behaviours (i.e. borrowing used needles and/or syringes, borrowing used other injection equipment) and sexual practices (i.e. transactional sex, condomless sex) were foundFootnote 6Footnote 7Footnote 8. Previous regional studies among PWID in Canada have also found similar levels of unstable housingFootnote 9Footnote 10, and high proportions who have experienced violenceFootnote 10, and abuseFootnote 9Footnote 10.

The ongoing opioid crisis and other drug-related overdose deaths have greatly affected the population of PWID in Canada. Increased use of methamphetamine, fentanyl and opioid analgesics found among Phase 4 participants echo this alarming trend. Phase 4 surveillance findings provided information regarding new overdose-related indicators. While awareness and access of overdose kits was high, 22.6% had overdosed in the six months prior to the interview with fentanyl and heroin the most commonly reported drugs used at last overdose.

While HIV prevalence among Phase 4 participants (10.3%) had decreased since Phase 1 (conducted in 2003–2005) it was nevertheless high—nearly 10-fold higher compared with rates among PWID in Australia and the United KingdomFootnote 7Footnote 8. A slightly higher proportion of participants were aware of their HIV-positive status in Phase 4 (82.9%) compared with the previous phases. For the first time, hepatitis C RNA prevalence was measured in the Tracks survey of PWID and found to be high (36.9%). In addition, only 50.1% of participants were aware of their hepatitis C RNA-positive status (i.e. current hepatitis C infection).

Nearly all participants who were aware of their HIV-positive status were linked to care for HIV-related services and were currently taking ART; however, less than two-thirds (62.8%) reported an undetectable viral load and 45.3% reported avoiding HIV services because of experienced stigma and discrimination. Much lower rates for linkage to care (48.5%) and current treatment use (3.8%) were found among participants who self-reported current infection with hepatitis C. Low numbers of PWID who are linked to hepatitis care and treatment have been observed in other regional studies in CanadaFootnote 11.

The results from the Phase 4 Tracks survey of PWID can inform evidence-based strategies to address gaps in prevention, testing and linkage to care approaches. This can include better linkage to opioid substitution therapy and supervised injection or consumption sites, and improve access to health and social services for mental health and addictionsFootnote 12. The confluence of high rates of hepatitis C combined poor awareness, continued but reduced needle sharing and inconsistent condom use despite increased rates of program uptake highlights the need harm reduction programs to continue to evolve to meet these challenges.

Strengths and limitations

The Tracks survey of PWID is a rich source of information on HIV and hepatitis C among PWID from sites across the country, and provides trends on key indicators since 2003. Notably, it is the only national source of such information, and has been used at the local, provincial and federal levels to inform and guide public health interventions in this population. However, it is important to note that the Tracks survey uses non-probability-based sampling; therefore, findings may not be representative of all PWID at any given site or in Canada. With the exception of the laboratory results, these findings were based on interviewer-administered questionnaires and self-reported data and it is possible that certain risk behaviours were over- or underrepresented.

Conclusion

High levels of unstable housing, experienced stigma and discrimination, borrowing of used injection equipment and inconsistent condom use were found. Both HIV prevalence and hepatitis C RNA-positive prevalence is high among PWID in some areas of Canada. Important gaps related to linkage to care and treatment for hepatitis C were identified. These findings highlight the need for: continued access to testing and prevention services, targeted strategies to address barriers to accessing HIV and hepatitis C treatment and care and improvements in ongoing supports for housing, mental health and addictions.

Authors’ statement

  • JT — Conceptualization, formal analysis, methodology, project administration, writing (original draft and review and editing)
  • JZ — Conceptualization, data curation, formal analysis, writing (original draft and review and editing)
  • AL — Conceptualization, formal analysis, writing (review and editing)
  • FC — Conceptualization, methodology, writing (review and editing)
  • MB — Conceptualization, methodology, project administration, writing (review and editing)
  • DP — Conceptualization, funding acquisition, methodology, writing (review and editing)

Conflict of interest

None.

Acknowledgements

The Tracks Surveillance System is possible because of the successful collaboration between the Public Health Agency of Canada (including the National Microbiology Laboratory), and provincial, regional and local health authorities, researchers and community-based organizations. The authors gratefully acknowledge the contribution of the participants, the sentinel site teams, including survey coordinators and interviewers, and the site principal investigators: M Alary; K Chokani; J DeMille; B Enns; M Gully; B Hanley; M Hennink; P Leclerc; C Mackie; S Marshall; C Morissette; É Roy; S Shaw; C Smith; A Vanderlaan; and D Warren. The authors would also like to thank C. Archibald for his advice prior to and throughout data collection and for his review of the manuscript and C Daniuk for her support with the dried blood spot testing.

Funding

The Tracks survey of people who inject drugs in Canada is supported by the Public Health Agency of Canada, with in-kind contributions provided by regional and local health authorities and community-based organizations.

Appendices

Appendix 1: Tracks survey of people who inject drugs in Canada – total number of participants and sentinel site participation, Phase 1 to Phase 4

Appendix 2: HIV and hepatitis C testing algorithms

Supplementary Tables

Table A: Prevention and testing indicators by socio-demographic characteristics and social determinants of health of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)

Table B: Injecting behaviours and drug use indicators by socio-demographic characteristics and social determinants of health of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)

Table C: Sexual risk behaviour indicators by socio-demographic characteristics and social determinants of health of participants in the Tracks survey of people who inject drugs in Canada, Phase 4, 2017–2019 (n=2,383)

Table D: Selected indicators by phase of the Tracks survey of people who inject drugs in Canada, Phase 1 to 4, 2003–2019

Appendix 1: Tracks survey of people who inject drugs in Canada – total number of participants and sentinel site participation, Phase 1 to Phase 4

Appendix 1: Tracks survey of people who inject drugs in Canada – total number of participants and sentinel site participation, Phase 1 to Phase 4
Phase details Phase 1
2003–2005
Phase 2
2005–2008
Phase 3
010–2012
Phase 4
2017–2019
Total number of participants 2,986 2,982 2,687 2,383
Number of sentinel sites 7 10 11 14
Sentinel site
Whitehorse, YK - - 55 49
Central and Northern Vancouver Island, BC - 220 - 179
Victoria, BC 253 249 - -
Prince George, BC - 156 150 -
Edmonton, AB 272 248 183 -
Prince Albert, SK - - - 184
Regina, SK 250 250 251 205
Winnipeg, MB 245 - - 181
Thunder Bay, ON - 149 138 200
Sudbury, ON 150 147 148 -
London, ON - - 204 206
Hamilton, ON - - - 157
Toronto, ON 257 255 260 -
Kingston, ON - 224 200 -
SurvUDI network, QCFootnote a of Table Appendix 1 1,559 1,084 937 692Footnote b of Table Appendix 1
New Brunswick - - - 200
Halifax, NS - - 161 -
Newfoundland - - - 130

Appendix 2: HIV and hepatitis C testing algorithms

HIV testing algorithms

For non-SurvUDI sites, HIV status was initially determined by screening dried blood spot specimens using the Bio-Rad GS HIV Combo Ag/Ab assay followed by confirmatory testing using the Roche COBAS AmpliPrep/COBAS Taqman HIV-1 Quant v2.0 assay (London) or the Roche COBAS AmpliPrep/COBAS Taqman HIV-1 Qualitative Test v2.0 (New Brunswick, Newfoundland and Regina). For the remaining non-SurvUDI sites (i.e. Vancouver Island, Thunder Bay, Whitehorse, Winnipeg, Prince Albert and Hamilton), due to recurrent low volume specimens, HIV status was determined by performing screening and confirmatory testing using two separate enzyme immunoassays (EIAs). As a result, specimen volume was sufficient for HIV and hepatitis C testing in most cases. The change in algorithms is not expected to have an impact on the results. Algorithms are described in more detail below.

London: HIV screening was performed using the Bio-Rad GS HIV Combo Ag/Ab assay. A non-reactive result indicated no HIV infection. Confirmatory testing was performed on screened reactive results using the Roche COBAS AmpliPrep/COBAS Taqman HIV-1 Quant v2.0 assay. A detected result indicated a HIV infection. In instances where the Bio-Rad GS HIV Combo Ag/Ab assay was positive, and the Roche COBAS ApliPrep/COBAS Taqman HIV-1 v2.0 assay result was not detected, a second EIA (AVIOQ HIV-1 Microelisa System) was conducted. A reactive result on both the Bio-Rad GS HIV Combo Ag/Ab assay and the AVIOQ HIV-1 Microelisa System indicated an HIV infection.

New Brunswick, Newfoundland and Regina: HIV screening was performed using the Bio-Rad GS HIV Combo Ag/Ab assay (Bio-Rad). A non-reactive result indicated no HIV infection. Confirmatory testing was performed on screened reactive results using the Roche COBAS AmpliPrep/COBAS Taqman HIV-1 Qualitative Test v2.0 (Roche). A detected result indicated an HIV infection. In instances where the Bio-Rad was reactive, and the Roche result was not detected, a second EIA, the AVIOQ HIV-1 Microelisa System (Avioq), was conducted as a tie-breaker. A reactive result on both the Bio-Rad and the Avioq indicated an HIV infection. A reactive result on the Bio-Rad, not detected result on the Roche, and a non-reactive or an indeterminate (i.e. absorbance results that were near, but did not overlap, the cut-off value for a reactive/non-reactive result) result on the Avioq, was interpreted as an overall indeterminate result.

Vancouver Island, Thunder Bay, Whitehorse, Winnipeg, Prince Albert, and Hamilton: HIV screening was performed using the Bio-Rad GS HIV Combo Ag/Ab assay (Bio-Rad). A non-reactive result indicated no HIV infection. Confirmatory testing was performed on screened reactive results using a second EIA, the AVIOQ HIV-1 Microelisa System (Avioq). A reactive result indicated an HIV infection. In instances where the Bio-Rad was reactive, and the Avioq was non-reactive or indeterminate (i.e. absorbance results that were near, but did not overlap, the cut-off value for a reactive/non-reactive result), the Roche COBAS AmpliPrep/COBAS Taqman HIV-1 Qualitative Test v2.0 (Roche) was used as a tie-breaker. A reactive result on the Bio-Rad and a detected result on the Roche indicated an HIV infection. A reactive result on the Bio-Rad, non-reactive or indeterminate result on the Avioq, and a not detected result on the Roche, was interpreted as an overall indeterminate result.

For SurvUDI network sites, oral fluid specimens were screened for HIV at the Laboratoire de santé publique du Québec, Institut national de santé publique du Québec, using the Bio-Rad GS HIV1/HIV2 PLUS O EIA, a diagnostic assay approved by Health Canada and validated in the SurvUDI study for use with oral fluid. Confirmatory testing was not performed for samples that tested repeatedly reactive. A positive result indicated an HIV infection.

Hepatitis C testing algorithms

For all non-SurvUDI network sites: hepatitis C screening testing was performed using the Ortho® HCV version 3.0 EIA (Ortho). A non-reactive result indicated never having been infected with hepatitis C. A reactive result indicated lifetime exposure to hepatitis C. Confirmatory testing was performed on screened reactive and indeterminate results (i.e. absorbance results that were near, but did not overlap, the cut-off value for a reactive/non-reactive result) using the Roche COBAS AmpliPrep/COBAS Taqman HCV Quantitative test v2.0 (Roche). A detected result indicated a current hepatitis C infection and a not detected result indicated a lifetime exposure to hepatitis C. For those that screened indeterminate on the Ortho, a detected result on the Roche indicated a current hepatitis C infection and a not detected result on the Roche was interpreted as an indeterminate result.

SurvUDI network sites: hepatitis C antibody testing for oral fluid specimens was performed using the Ortho® hepatitis C version 3.0 EIA at the Institut national de santé publique du Québec laboratories. Confirmatory testing was not performed for samples that tested positive. A positive result indicated past or present hepatitis C infection and did not discriminate acute from chronic or resolved infections. Validation of this test for use with oral fluid was performed in the SurvUDI study.

Sensitivity and specificity of laboratory tests

The specificity of the Bio-Rad GS HIV Combo Ag/Ab EIA, Avioq HIV-1 Microelisa System, and Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative Test v2.0 is ≥99.9% on DBS according to kit inserts or internal validation data. Similarly, the sensitivity of each assay is 100% except for the Bio-Rad GS HIV Combo Ag/Ab EIA which is 96.6%. The limit of quantification for the Roche COBAS/AmpliPrep TaqMan HIV-1 Quantitative Test v2.0 on DBS is 616 copies/mL.

The specificity and sensitivity of the ORTHO HCV v3.0 ELISA Test System is 100% according to internal validation data. The limit of quantification for the Roche COBAS AmpliPrep/COBAS TaqMan HCV Test v2.0 is 355 IU/mL.

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