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Influenza vaccines may protect against cardiovascular diseases - Supplemental

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Volume 49-10, October 2023: Influenza vaccines may protect against cardiovascular diseases: The evidence is mounting and should be known by the Canadian public health community Download this supplement as a PDF
Published by: The Public Health Agency of Canada
Issue: Volume 49-10, October 2023: Influenza and Other Respiratory Infections
Article: Influenza vaccines may protect against cardiovascular diseases: The evidence is mounting and should be known by the Canadian public health community
Date published: October 2023
ISSN: 1481-8531
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Volume 49-10, October 2023: Influenza and Other Respiratory Infections

Supplemental material

Influenza vaccines may protect against cardiovascular diseases: The evidence is mounting and should be known by the Canadian public health community

Philippe De Wals, Michaël Desjardins

Results of first PubMed search (April 12, 2023)

Search words: influenza AND vaccin* AND (cardiovascular OR myocardial OR stroke OR arrhythmia)

Number of hits: 1,015

Selection: Review article or systematic review or meta-analysis

Number of hits: 194

Exclusion criteria: irrelevant according to population, intervention, control, outcomes and study (PICOS) (i.e. adults, influenza vaccination, vaccinated vs. unvaccinated, adverse CVD outcome, quantitative study), editorial, commentary, non-systematic narrative reviews, clinical guidelines

Excluded: 171

Retained: 25 systematic reviews with or without meta-analysis

Results of second PubMed search (July 17, 2023)

Search words: influenza AND vaccin* AND (cardiovascular OR myocardial OR stroke OR arrhythmia)

Selection: Year 2023

Number of hits: 75

Selection: Review article or systematic review or meta-analysis

Number of hits: 15

Exclusion criteria: irrelevant according to PICOS (i.e. adults, influenza vaccination, vaccinated vs. unvaccinated, adverse CVD outcome, quantitative study), editorial, commentary, non-systematic narrative reviews, clinical guidelines

Excluded: 11

Retained: 4 systematic reviews with or without meta-analysis including one duplicate with first search and one manuscript in Chinese that could not be assessed

Total assessed

First and second search: 25 + 2=27

One additional review identified through another search: 1

Total manuscript assessed: 27 + 1=28 (references 1–28)

References

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  2. Meyers DG. Could influenza vaccination prevent myocardial infarction, stroke and sudden cardiac death? Am J Cardiovasc Drugs 2003;3(4):241–4. https://doi.org/10.2165/00129784-200303040-00002
  3. Keller T, Weeda VB, van Dongen CJ, Levi M. Influenza vaccines for preventing coronary heart disease. Cochrane Database Syst Rev 2008;(3):CD005050. https://doi.org/10.1002/14651858.CD005050.pub2
  4. Loomba RS, Aggarwal S, Shah PH, Arora RR. Influenza vaccination and cardiovascular morbidity and mortality: analysis of 292,383 patients. J Cardiovasc Pharmacol Ther 2012;17(3):277–83. https://doi.org/10.1177/1074248411429965
  5. Udell JA, Zawi R, Bhatt DL, Keshtkar-Jahromi M, Gaughran F, Phrommintikul A, Ciszewski A, Vakili H, Hoffman EB, Farkouh ME, Cannon CP. Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. JAMA 2013;310(16):1711–20. https://doi.org/10.1001/jama.2013.279206
  6. Barnes M, Heywood AE, Mahimbo A, Rahman B, Newall AT, Macintyre CR. Acute myocardial infarction and influenza: a meta-analysis of case-control studies. Heart 2015;101(21):1738–47. https://doi.org/10.1136/heartjnl-2015-307691
  7. Clar C, Oseni Z, Flowers N, Keshtkar-Jahromi M, Rees K. Influenza vaccines for preventing cardiovascular disease. Cochrane Database Syst Rev 2015;2015(5):CD005050. https://doi.org/10.1002/14651858.CD005050.pub3
  8. Lee KR, Bae JH, Hwang IC, Kim KK, Suh HS, Ko KD. Effect of Influenza Vaccination on Risk of Stroke: A Systematic Review and Meta-Analysis. Neuroepidemiology 2017;48(3-4):103–10. https://doi.org/10.1159/000478017
  9. LeBras MH, Barry AR. Influenza Vaccination for Secondary Prevention of Cardiovascular Events: A Systematic Review. Can J Hosp Pharm 2017;70(1):27–34. https://doi.org/10.4212/cjhp.v70i1.1626
  10. Tsivgoulis G, Katsanos AH, Zand R, Ishfaq MF, Malik MT, Karapanayiotides T, Voumvourakis K, Tsiodras S, Parissis J. The association of adult vaccination with the risk of cerebrovascular ischemia: A systematic review and meta-analysis. J Neurol Sci 2018;386:12–8. https://doi.org/10.1016/j.jns.2018.01.007
  11. Caldeira D, Rodrigues B, David C, Costa J, Pinto FJ, Ferreira JJ. The association of influenza infection and vaccine with myocardial infarction: systematic review and meta-analysis of self-controlled case series. Expert Rev Vaccines 2019;18(11):1211–7. https://doi.org/10.1080/14760584.2019.1690459
  12. Rodrigues BS, David C, Costa J, Ferreira JJ, Pinto FJ, Caldeira D. Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies. Heart 2020;106(5):350–7. https://doi.org/10.1136/heartjnl-2019-315193
  13. Cheng Y, Cao X, Cao Z, Xu C, Sun L, Gao Y, Wang Y, Li S, Wu C, Li X, Wang Y, Leng SX. Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality. Ageing Res Rev 2020;62:101124. https://doi.org/10.1016/j.arr.2020.101124
  14. Rodrigues BS, Alves M, Duarte GS, Costa J, Pinto FJ, Caldeira D. The impact of influenza vaccination in patients with cardiovascular disease: an overview of systematic reviews. Trends Cardiovasc Med 2021;31(5):315–20. https://doi.org/10.1016/j.tcm.2020.06.003
  15. Zangiabadian M, Nejadghaderi SA, Mirsaeidi M, Hajikhani B, Goudarzi M, Goudarzi H, Mardani M, Nasiri MJ. Protective effect of influenza vaccination on cardiovascular diseases: a systematic review and meta-analysis. Sci Rep 2020;10(1):20656. https://doi.org/10.1038/s41598-020-77679-7
  16. Pérez-Rubio A, San Román JA, Eiros Bouza JM. The impact of influenza vaccination on cardiovascular diseases. Med Clin (Barc) 2021;157(1):22–32. https://doi.org/10.1016/j.medcli.2021.01.017
  17. Yedlapati SH, Khan SU, Talluri S, Lone AN, Khan MZ, Khan MS, Navar AM, Gulati M, Johnson H, Baum S, Michos ED. Effects of Influenza Vaccine on Mortality and Cardiovascular Outcomes in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis. J Am Heart Assoc 2021;10(6):e019636. https://doi.org/10.1161/JAHA.120.01963
  18. Liprandi ÁS, Liprandi MI, Zaidel EJ, Aisenberg GM, Baranchuk A, Barbosa EC, Sánchez GB, Alexander B, Zanetti FT, Santi RL, Múnera-Echeverri AG, Perel P, Piskorz D, Ruiz-Mori CE, Saucedo J, Valdez O, Juanatey JR, Piñeiro DJ, Pinto FJ, Quintana FS. Influenza Vaccination for the Prevention of Cardiovascular Disease in the Americas: Consensus document of the Inter-American Society of Cardiology and the Word Heart Federation. Glob Heart 2021;16(1):55. https://doi.org/10.5334/gh.1069
  19. Maniar YM, Al-Abdouh A, Michos ED. Influenza Vaccination for Cardiovascular Prevention: Further Insights from the IAMI Trial and an Updated Meta-analysis. Curr Cardiol Rep 2022;24(10):1327–35. https://doi.org/10.1007/s11886-022-01748-8
  20. Jaiswal V, Ang SP, Yaqoob S, Ishak A, Chia JE, Nasir YM, Anjum Z, Alraies MC, Jaiswal A, Biswas M. Cardioprotective effects of influenza vaccination among patients with established cardiovascular disease or at high cardiovascular risk: a systematic review and meta-analysis. Eur J Prev Cardiol 2022;29(14):1881–92. https://doi.org/10.1093/eurjpc/zwac152
  21. Gupta C, Sachdeva A, Khamar J, Bu C, Bartoszko J, Loeb M. Effectiveness of the influenza vaccine at reducing adverse events in patients with heart failure: A systematic review and meta-analysis. Vaccine 2022;40(25):3433–43. https://doi.org/10.1016/j.vaccine.2022.04.039
  22. Behrouzi B, Bhatt DL, Cannon CP, Vardeny O, Lee DS, Solomon SD, Udell JA. Association of Influenza Vaccination With Cardiovascular Risk: A Meta-analysis. JAMA Netw Open 2022;5(4):e228873. https://doi.org/10.1001/jamanetworkopen.2022.8873
  23. Diaz-Arocutipa C, Saucedo-Chinchay J, Mamas MA, Vicent L. Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis. Travel Med Infect Dis 2022;47:102311. https://doi.org/10.1016/j.tmaid.2022.102311
  24. Liu M, Lin W, Song T, Zhao H, Ma J, Zhao Y, Yu P, Yan Z. Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis. Front Cardiovasc Med 2022;9:970533. https://doi.org/10.3389/fcvm.2022.970533
  25. Tavabe NR, Kheiri S, Dehghani M, Mohammadian-Hafshejani A. A Systematic Review and Meta-Analysis of the Relationship between Receiving the Flu Vaccine with Acute Cerebrovascular Accident and Its Hospitalization in the Elderly. BioMed Res Int 2023;2023:2606854. https://doi.org/10.1155/2023/2606854
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